A CuNi/C Nanosheet Array Based on a Metal–Organic Framework Derivate as a Supersensitive Non-Enzymatic Glucose Sensor

Bimetal catalysts are good alternatives for nonenzymatic glucose sensors owing to their low cost, high activity, good conductivity, and ease of fabrication. In the present study, a self-supported CuNi/C electrode prepared by electrodepositing Cu nanoparticles on a Ni-based metal–organic framework(MOF) derivate was used as a non-enzymatic glucose sensor. The porous construction and carbon scaffold inherited from the Ni-MOF guarantee good kinetics of the electrode process in electrochemical glucose detection. Furthermore, Cu nanoparticles disturb the array structure of MOF derived films and evidently enhance their electrochemical performances in glucose detection. Electrochemical measurements indicate that the CuNi/C electrode possesses a high sensitivity of17.12 mA mM^(-1) cm^(-2), a low detection limit of 66.67 nM,and a wider linearity range from 0.20 to 2.72 mM. Additionally, the electrode exhibits good reusability, reproducibility, and stability, thereby catering to the practical use of glucose sensors. Similar values of glucose concentrations in human blood serum samples are detected with our electrode and with the method involving glucose-6-phosphate dehydrogenase; the results further demonstrate the practical feasibility of our electrode.

Promoted Non-enzymatic Glucose Sensor Based on Synergistic Effect of Hydrothermal Synthesized Ni(OH)_(2)-Graphene Nanocomposite

Although glucose electrochemical sensors based on enzymes play a dominant role in market,their stability remains a problem due to the inherent nature of enzymes.Therefore,glucose sensors that are independent on enzymes have attracted more attention for the development of stable detection devices.Here we present an enzyme-free glucose sensor based on Ni(OH)_(2)and reduced graphene oxide(rGO).The as-fabricated sensor still exhibits excellent electrocatalytic activity for detecting glucose under enzyme independent conditions.The enhanced catalytic performance may due to synergistic effect as follows:(i)the interaction between the Ni2+andπelectron of graphene induces the formation of theβ-phase Ni(OH)_(2)with higher catalytic activity;(ii)the frozen dry process works as a secondary filtration,getting rid of poorly formed Ni(OH)_(2)particles with low catalytic activity;(iii)the rGO network with good conductivity provides a good electronic pathway for promoting electron transfer to reduce the response time.Based on the synergistic effect,the sensor exhibits a wide linear detection range from 0.2µmol/L to 1.0µmol/L and a low detection limit(0.1µmol/L,S/N=3).The excellent detection performance,as well as the easy and low-cost preparation method,suggests the promising applicability of the sensor in the glucose detection market.