加味温胆汤对SAM-P/10老化痴呆鼠三个脑区递质氨基酸的影响

目的 :探讨中药加味温胆汤改善脑功能的中枢机制。方法 :采用高效液相技术系统观察SAM P 10鼠脑内皮层、海马、纹状体等与学习记忆关系密切的脑内 8种氨基酸水平的变化。结果 :加味温胆汤 1号方对于海马、纹状体异常升高的r GABA水平表现出明显降低作用。加味温胆汤预防方对皮层降低的Tau水平有明显升高 (P <0 0 1) ,1号方亦有明显升高 (P <0 0 5 ) ,2号方和西药仅表现上升趋势。结论 :加味温胆汤 1号对SAM P 10皮层、海马、纹状体的Clu等EAAS亢进状态有显著的调节作用 ,对于抑制性氨基酸IAAS的调节作用表现在对异常升高的r GABA水平的降低和使降低的Tau水平上升。

老年痴呆症药物石杉碱甲类似物研究Ⅳ（±）-8，15-二氢-去-11，15-二甲基-8-羟基石杉碱甲的合成

石杉碱甲（１）是从我国草药千层塔中分到的一个可逆性的强效乙酰胆碱酯酶抑制剂，将成为新一代治疗早老性和老年痴呆症的药物．基于乙酰胆碱酯酶的Ｘ－衍射晶体结构及石杉碱甲抑制乙酰胆碱酯酶的作用机制研究结果，设计合成了（±）－８，１５－二氢－去－１１，１５－二甲基－８－羟基石杉碱甲（９ａ，９ｂ）．

Weak central coherence in patients with Alzheimer’s disease

Central coherence refers to the ability to interpret details of information into a whole. To date, the concept of central coherence is mainly used in research of autism, Asperger＇s syndrome and recently in the research on eating disorders. The main purpose of the present study was to examine central coherence in patients with Alzheimer＇s disease. Nine Alzheimer＇s disease patients and ten age- and gender-matched control subjects, who differed significantly in neurological assessment, were shown a picture of a fire. Compared to control subjects, the Alzheimer＇s disease patients described the picture in a fragmented way by mentioning details and separate objects without perceiving the context of the fire. In conclusion, patients with Alzheimer＇s disease are at the weak end of central coherence, and hence suffer from a fragmented view of their surroundings. The findings have important clinical implications for the understanding of patients with Alzheimer＇s diseaseand also for the possibility of caregivers to meet the Alzheimer＇s disease individual in an appropriate way in the everyday care.

二十二碳六烯酸和脑的健康

二十二碳六烯酸（简称ＤＨＡ），是鱼油中最重要的生理活性成分之一，它对人脑的健康起重要作用．本文回顾了近几十年关于ＤＨＡ的研究，叙述了人体内ＤＨＡ的两个来源途径，尤其是：ＤＨＡ以磷脂形式广泛地存在于脑细胞和神经细胞中；实验动物测试记忆能力和脑中ＤＨＡ水平相关；ＤＨＡ对脑发育极为重要；ＤＨＡ对视网膜功能的影响及防治老年痴呆症具有关键作用．