The study of land surface temperature(LST)is of great significance for ecosystem monitoring and ecological environmental protection in the Qinling Mountains of China.In view of the contradicting spatial and temporal r...The study of land surface temperature(LST)is of great significance for ecosystem monitoring and ecological environmental protection in the Qinling Mountains of China.In view of the contradicting spatial and temporal resolutions in extracting LST from satellite remote sensing(RS)data,the areas with complex landforms of the Eastern Qinling Mountains were selected as the research targets to establish the correlation between the normalized difference vegetation index(NDVI)and LST.Detailed information on the surface features and temporal changes in the land surface was provided by Sentinel-2 and Sentinel-3,respectively.Based on the statistically downscaling method,the spatial scale could be decreased from 1000 m to 10 m,and LST with a Sentinel-3 temporal resolution and a 10 m spatial resolution could be retrieved.Comparing the 1 km resolution Sentinel-3 LST with the downscaling results,the 10 m LST downscaling data could accurately reflect the spatial distribution of the thermal characteristics of the original LST image.Moreover,the surface temperature data with a 10 m high spatial resolution had clear texture and obvious geomorphic features that could depict the detailed information of the ground features.The results showed that the average error was 5 K on April 16,2019 and 2.6 K on July 15,2019.The smaller error values indicated the higher vegetation coverage of summer downscaling result with the highest level on July 15.展开更多
目的研究通痹颗粒对胶原诱导性关节炎(collagen-induced arthritis,CIA)大鼠铁调素(hepcidin,Hepc)、Janus激酶(janus kinase,JAK)2/信号转导子和转录激活子(signal transduction and activator of transcription,STAT)3信号通路的影响...目的研究通痹颗粒对胶原诱导性关节炎(collagen-induced arthritis,CIA)大鼠铁调素(hepcidin,Hepc)、Janus激酶(janus kinase,JAK)2/信号转导子和转录激活子(signal transduction and activator of transcription,STAT)3信号通路的影响。方法选取36只雌性SD大鼠随机分成空白组、模型组、阳性对照组和通痹颗粒低、中、高剂量组,每组6只。空白组不予处理,其余组用牛Ⅱ型胶原建立CIA模型。造模完成后,空白组、模型组予生理盐水灌胃,其余各组分别以巴瑞替尼片和低、中、高剂量通痹颗粒灌胃。每天1次,连续4周。HE染色行滑膜组织病理学观察;酶联免疫吸附法测定血清Hepc、白细胞介素6(interleukin 6,IL-6)水平;逆转录-聚合酶链反应法测定滑膜中JAK2、STAT3、细胞信号因子传导抑制体(suppressor of cytokine signaling,SOCS)1、SOCS3的mRNA相对表达量;Western blot法检测滑膜中JAK2、p-JAK2、STAT3、p-STAT3、SOCS1、SOCS3的蛋白表达量。结果模型组见滑膜上皮结构缺损,滑膜重度增生,排列紊乱,并有大量炎症细胞浸润和多个血管翳形成;各给药组滑膜炎症均有所减轻,阳性对照组优于通痹颗粒高剂量组,通痹颗粒中、高剂量组优于低剂量组。与模型组相比,各给药组关节炎指数评分、血清Hepc和IL-6水平均显著降低(P<0.01);与阳性对照组相比,通痹颗粒中、低剂量组关节炎指数评分、血清Hepc和IL-6水平均升高(P<0.05)。与模型组比较,阳性对照组和通痹颗粒低、中、高剂量组JAK2、STAT3 mRNA和蛋白以及p-JAK2、p-STAT3的蛋白表达量均降低(P<0.05),而通路抑制因子SOCS1、SOCS3 mRNA和蛋白的表达均升高(P<0.05);与阳性对照组比较,通痹颗粒各剂量组JAK2、STAT3 mRNA和蛋白以及p-JAK2、p-STAT3的蛋白表达量均升高(P<0.05),而SOCS1、SOCS3 mRNA和蛋白的表达均降低(P<0.05)。结论通痹颗粒能够改善CIA大鼠滑膜炎症,其机制可能与抑制JAK2/STAT3信号通路而减少Hepc的表达有关。展开更多
基金Supported by the National Key R&D Plan(2018YFC1506500)Open Research Fund Project of Key Laboratory of Ecological Environment Meteorology of Qinling Mountains and Loess Plateau of Shaanxi Provincial Meteorological Bureau(2020Y-13)+1 种基金Open Research Fund of Shangluo Key Laboratory of Climate Adaptable City(SLSYS2022007)Shangluo Demonstration Project of Qinling Ecological Monitoring Service System(2020-611002-74-01-006200)。
文摘The study of land surface temperature(LST)is of great significance for ecosystem monitoring and ecological environmental protection in the Qinling Mountains of China.In view of the contradicting spatial and temporal resolutions in extracting LST from satellite remote sensing(RS)data,the areas with complex landforms of the Eastern Qinling Mountains were selected as the research targets to establish the correlation between the normalized difference vegetation index(NDVI)and LST.Detailed information on the surface features and temporal changes in the land surface was provided by Sentinel-2 and Sentinel-3,respectively.Based on the statistically downscaling method,the spatial scale could be decreased from 1000 m to 10 m,and LST with a Sentinel-3 temporal resolution and a 10 m spatial resolution could be retrieved.Comparing the 1 km resolution Sentinel-3 LST with the downscaling results,the 10 m LST downscaling data could accurately reflect the spatial distribution of the thermal characteristics of the original LST image.Moreover,the surface temperature data with a 10 m high spatial resolution had clear texture and obvious geomorphic features that could depict the detailed information of the ground features.The results showed that the average error was 5 K on April 16,2019 and 2.6 K on July 15,2019.The smaller error values indicated the higher vegetation coverage of summer downscaling result with the highest level on July 15.
