Sequelae of Pelvic Inflammatory Diseases (SPID) is a common and frequent disease in gynecology, which adversely affects women’s reproductive health and quality of life due to its prolonged course. In recent years, tr...Sequelae of Pelvic Inflammatory Diseases (SPID) is a common and frequent disease in gynecology, which adversely affects women’s reproductive health and quality of life due to its prolonged course. In recent years, traditional Chinese medicine (TCM) in China has gradually shown its clinical advantages in the treatment of SPID. Therefore, the present review summarizes the etiology and pathogenesis of SPID, the evidence typology, and the clinical application effects of moxibustion, herbal retention enema, acupoint compresses, external application of traditional Chinese medicine, auricular pressure beans, tuina massage, traditional Chinese medicine gongfu, and other commonly used Chinese medicine nursing techniques, with the aim of providing references and experiences for the subsequent related studies.展开更多
Objective:To investigate the efteets of traditional Chinese medicine.Danzhi decoction,on the expression angiogenesis factors in human endometrial cells during the sequelae of pelvic inflammatoty disease(SPID) and expl...Objective:To investigate the efteets of traditional Chinese medicine.Danzhi decoction,on the expression angiogenesis factors in human endometrial cells during the sequelae of pelvic inflammatoty disease(SPID) and explore the role of Danzhi decction in improving the blood stasis microenvironment of SPID.Methods:A three-dimensional(3D) co—culture system including human vascular endothelial cells(VECs),endometrial stromal cells and glandular epithelial cells was established in vitro and treated with Danzhi decoction,sterilized water and aspirin respectively.A Milliplex multifunctional liquid chip technique was used to measure the expression levels of vascular endothelial growth factor(VEGF)—A/C/D,fibroblast growth factor-1/2.angiopoietin-2.epidermal growth factor(EGF) HB-EGF,bone morphogenetic protein-9.endoglin.endothehn-l.granulocyte colony stimulating factor,hepatocyte growth factor,interleukin-8,follistatin.placenta growth factor and leptin.The location of angiogenesis factors was monitored by immunofluorescence labeling and confocal laser scanning microscope3 D reconstruction.Results:Endometrial stromal cells and glandular epithelial cells were isolated and primary cultured for establishing a 3D co-culture system.The levels of VEGF—A/C/D in Danzhi decoction group and aspirin group were significantly lower than those in mock group(P<0.05).while there was no significant difference between Danzhi decoction group and aspirin group(P>0.05).Furthermore,the alterative location of VEGF—A/C/D was observed in the cytoplasm of endometrial glandular epithelial cells.Conclusions:Danzhi decoction mav inhibit the expression of VEGF in the blood stasis microenvironment of SPID by targeting the cytoplasm of endometrial glandular epithelial cell.展开更多
Pelvic inflammatory disease refers to a group of female genital tr act on infec tious disease, mainly including endometritis, tubal phlogistic, oviduct ovarian abscess, if not 廿mely tr eatment of the disease is easy ...Pelvic inflammatory disease refers to a group of female genital tr act on infec tious disease, mainly including endometritis, tubal phlogistic, oviduct ovarian abscess, if not 廿mely tr eatment of the disease is easy to become chr onic, now called pelvic inflammatory disease sequelae, clinical manifestations in chronic pelvic pain, recurrent pelvic inflammatory disease, affect women's physical and mental health. TCM nursing based on the basic theory of TCM, apply the overall view, the nursing method of syndrome differentiation, the traditional Chinese medicine nursing technique is widely used in the disease, such as traditional Chinese medicine enema, Chinese medicine external treatment, moxibustion, ear acupuncture point buries a seed, methods of modern nursing, has the characteristics of simple and cheap effect, can reduce the swelling fights, promoting blood circulation to remove blood stasis, relieve the pelvic congestion, promote drainage in abdominal and pelvic cavity and the absorption of bag piece, adjust the viscera function, obvious effect and has unique advantages, further prove the uniqueness of TCM nursing and safety, provide the basis for clinical treatment.展开更多
Objective:To investigate the clinical effect of kunfukang capsule on improving uterine microcirculation in patients with sequelae of pelvic inflammatory disease, and to observe its influence on levels of CRP, GM-CSF a...Objective:To investigate the clinical effect of kunfukang capsule on improving uterine microcirculation in patients with sequelae of pelvic inflammatory disease, and to observe its influence on levels of CRP, GM-CSF and MCP-1 in peripheral blood.Methods: 126 patients with pelvic inflammatory disease sequelae admitted to our hospital from January 2017 to June 2018 were selected and divided into control group and observation group with 63 cases in each group according to the random number table method. Patients in the control group were given azithromycin tablets orally, while patients in the observation group were treated with kunfukang capsule on the basis of control group,7days for a course of treatment, 4 courses of continuous treatment. The purpose of this study was to compare the clinical effects of treatment between the two groups, evaluate the TCM syndrome score, observe the levels of CRP, GM-CSF and MCP-1 in uterine microcirculation and peripheral blood, and record the adverse reactions of patients during treatment.Results: The effective rate of 90.48% in the observation group was significantly higher than that in the control group of 77.78%(P<0.05). After treatment, the total score of TCM syndromes was significantly lower than that in the control group (P<0.05). The improvement of uterine microcirculation was more obvious, and the PI and RI were significantly decreased compared with the control group, while Vs, Vd and Vm were increased compared with the control group (P<0.05). The levels of CRP, GM-CSF and MCP-1 in peripheral blood were significantly lower than those in the control group (P<0.05). During the treatment, the adverse reaction rate of 7.94% in the observation group was significantly lower than that of the control group of 25.40% (P<0.05).Conclusion: Kun fu kang capsule combined with azithromycin is beneficial to reduce pelvic mass in sequelae of pelvic inflammatory disease and alleviate clinical symptoms. The mechanism may be related to improving the status of uterine microcirculation and inhibiting CRP, GM-CSF and MCP-1 levels in peripheral blood to reduce inflammatory infiltration of pelvic tissue, which is safe and reliable.展开更多
With a history of more than two thousand years, the theory of preventative treatment has been closely followed by the development of modern medical theories on the basis of inheritance by medical experts in the past d...With a history of more than two thousand years, the theory of preventative treatment has been closely followed by the development of modern medical theories on the basis of inheritance by medical experts in the past dynasties, which has been constantly improved and enriched, and deeply applied in the prevention and treatment of serious and multiple diseases. It has achieved great benefits. For women with gynecological diseases, pelvic inflammatory disease patients accounted for a large proportion. Due to the lack of specificity in diagnosis and treatment, the condition is lingering and difficult to cure, so it seriously reduces the quality of life of women, thus affecting the harmony of family and society. From the perspective of prevention, according to the characteristics of each stage of the disease, this paper put forward substantive prevention suggestions and targeted treatment methods, ensuring preventing before disease, preventing progress after disease, and preventing reoccurring after recovery. It has important practical significance for the prevention and treatment of pelvic inflammatory diseases, as well as the development and inheritance of traditional Chinese medicine.展开更多
目的梳理盆腔炎性疾病后遗症(sequelae of pelvic inflammatory disease,SPID)动物模型特点,为规范造模流程、提高成模率提供参考。方法检索近40年有关SPID动物模型的文献,总结并分析动物种类、造模方法、阳性对照药、评价指标等。结果...目的梳理盆腔炎性疾病后遗症(sequelae of pelvic inflammatory disease,SPID)动物模型特点,为规范造模流程、提高成模率提供参考。方法检索近40年有关SPID动物模型的文献,总结并分析动物种类、造模方法、阳性对照药、评价指标等。结果纳入243篇文献,多采用苯酚胶浆法或微生物感染法诱导大鼠建立SPID模型,造模周期在14~16 d为主,大多以盆腔组织形态观察和苏木素-伊红(HE)染色判定模型成功与否。中医病症结合模型研究较少。结论SPID动物模型造模方法缺乏一致性的判定标准,建议综合动物行为学变化、盆腔组织形态学改变以及病理等进行评价。同时,中医证候造模缺乏有效的方法和评价标准,有待进一步研究发展。展开更多
目的研究单味中药及复方治疗盆腔炎性疾病后遗症的作用机制。方法对Pubmed、Web of Science、中国知网和万方等数据库进行检索,寻找建库至2023年3月以来关于中药治疗SPID及作用机制的相关文献,并对文献进行归纳整理。结果共纳入文献428...目的研究单味中药及复方治疗盆腔炎性疾病后遗症的作用机制。方法对Pubmed、Web of Science、中国知网和万方等数据库进行检索,寻找建库至2023年3月以来关于中药治疗SPID及作用机制的相关文献,并对文献进行归纳整理。结果共纳入文献428篇,从纳入文献中筛选出从调节细胞因子和炎症介质分泌水平、促进炎症细胞凋亡、抑制脂质过氧化、抑制组织纤维化、改善血液循环、调节代谢途径和细胞信号转导、调节免疫能力等方面报道单味中药及复方治疗盆腔炎性疾病的作用机制。结论为中药治疗盆腔炎性疾病后遗症作用机制进行深入研究,并对其新药研发提供参考。展开更多
文摘Sequelae of Pelvic Inflammatory Diseases (SPID) is a common and frequent disease in gynecology, which adversely affects women’s reproductive health and quality of life due to its prolonged course. In recent years, traditional Chinese medicine (TCM) in China has gradually shown its clinical advantages in the treatment of SPID. Therefore, the present review summarizes the etiology and pathogenesis of SPID, the evidence typology, and the clinical application effects of moxibustion, herbal retention enema, acupoint compresses, external application of traditional Chinese medicine, auricular pressure beans, tuina massage, traditional Chinese medicine gongfu, and other commonly used Chinese medicine nursing techniques, with the aim of providing references and experiences for the subsequent related studies.
基金supported by a grant from the National Natural Science Founlation of China(81373677)
文摘Objective:To investigate the efteets of traditional Chinese medicine.Danzhi decoction,on the expression angiogenesis factors in human endometrial cells during the sequelae of pelvic inflammatoty disease(SPID) and explore the role of Danzhi decction in improving the blood stasis microenvironment of SPID.Methods:A three-dimensional(3D) co—culture system including human vascular endothelial cells(VECs),endometrial stromal cells and glandular epithelial cells was established in vitro and treated with Danzhi decoction,sterilized water and aspirin respectively.A Milliplex multifunctional liquid chip technique was used to measure the expression levels of vascular endothelial growth factor(VEGF)—A/C/D,fibroblast growth factor-1/2.angiopoietin-2.epidermal growth factor(EGF) HB-EGF,bone morphogenetic protein-9.endoglin.endothehn-l.granulocyte colony stimulating factor,hepatocyte growth factor,interleukin-8,follistatin.placenta growth factor and leptin.The location of angiogenesis factors was monitored by immunofluorescence labeling and confocal laser scanning microscope3 D reconstruction.Results:Endometrial stromal cells and glandular epithelial cells were isolated and primary cultured for establishing a 3D co-culture system.The levels of VEGF—A/C/D in Danzhi decoction group and aspirin group were significantly lower than those in mock group(P<0.05).while there was no significant difference between Danzhi decoction group and aspirin group(P>0.05).Furthermore,the alterative location of VEGF—A/C/D was observed in the cytoplasm of endometrial glandular epithelial cells.Conclusions:Danzhi decoction mav inhibit the expression of VEGF in the blood stasis microenvironment of SPID by targeting the cytoplasm of endometrial glandular epithelial cell.
文摘Pelvic inflammatory disease refers to a group of female genital tr act on infec tious disease, mainly including endometritis, tubal phlogistic, oviduct ovarian abscess, if not 廿mely tr eatment of the disease is easy to become chr onic, now called pelvic inflammatory disease sequelae, clinical manifestations in chronic pelvic pain, recurrent pelvic inflammatory disease, affect women's physical and mental health. TCM nursing based on the basic theory of TCM, apply the overall view, the nursing method of syndrome differentiation, the traditional Chinese medicine nursing technique is widely used in the disease, such as traditional Chinese medicine enema, Chinese medicine external treatment, moxibustion, ear acupuncture point buries a seed, methods of modern nursing, has the characteristics of simple and cheap effect, can reduce the swelling fights, promoting blood circulation to remove blood stasis, relieve the pelvic congestion, promote drainage in abdominal and pelvic cavity and the absorption of bag piece, adjust the viscera function, obvious effect and has unique advantages, further prove the uniqueness of TCM nursing and safety, provide the basis for clinical treatment.
文摘Objective:To investigate the clinical effect of kunfukang capsule on improving uterine microcirculation in patients with sequelae of pelvic inflammatory disease, and to observe its influence on levels of CRP, GM-CSF and MCP-1 in peripheral blood.Methods: 126 patients with pelvic inflammatory disease sequelae admitted to our hospital from January 2017 to June 2018 were selected and divided into control group and observation group with 63 cases in each group according to the random number table method. Patients in the control group were given azithromycin tablets orally, while patients in the observation group were treated with kunfukang capsule on the basis of control group,7days for a course of treatment, 4 courses of continuous treatment. The purpose of this study was to compare the clinical effects of treatment between the two groups, evaluate the TCM syndrome score, observe the levels of CRP, GM-CSF and MCP-1 in uterine microcirculation and peripheral blood, and record the adverse reactions of patients during treatment.Results: The effective rate of 90.48% in the observation group was significantly higher than that in the control group of 77.78%(P<0.05). After treatment, the total score of TCM syndromes was significantly lower than that in the control group (P<0.05). The improvement of uterine microcirculation was more obvious, and the PI and RI were significantly decreased compared with the control group, while Vs, Vd and Vm were increased compared with the control group (P<0.05). The levels of CRP, GM-CSF and MCP-1 in peripheral blood were significantly lower than those in the control group (P<0.05). During the treatment, the adverse reaction rate of 7.94% in the observation group was significantly lower than that of the control group of 25.40% (P<0.05).Conclusion: Kun fu kang capsule combined with azithromycin is beneficial to reduce pelvic mass in sequelae of pelvic inflammatory disease and alleviate clinical symptoms. The mechanism may be related to improving the status of uterine microcirculation and inhibiting CRP, GM-CSF and MCP-1 levels in peripheral blood to reduce inflammatory infiltration of pelvic tissue, which is safe and reliable.
基金National Natural Science Foundation of China Youth Science Fund Project (81904245, 81903998)Jiangsu Province Key Research and Development Project (BE2019766)Jiangsu Province Science and Technology Project Basic Research Program (Natural Science Foundation) General Project (BK20171511)。
文摘With a history of more than two thousand years, the theory of preventative treatment has been closely followed by the development of modern medical theories on the basis of inheritance by medical experts in the past dynasties, which has been constantly improved and enriched, and deeply applied in the prevention and treatment of serious and multiple diseases. It has achieved great benefits. For women with gynecological diseases, pelvic inflammatory disease patients accounted for a large proportion. Due to the lack of specificity in diagnosis and treatment, the condition is lingering and difficult to cure, so it seriously reduces the quality of life of women, thus affecting the harmony of family and society. From the perspective of prevention, according to the characteristics of each stage of the disease, this paper put forward substantive prevention suggestions and targeted treatment methods, ensuring preventing before disease, preventing progress after disease, and preventing reoccurring after recovery. It has important practical significance for the prevention and treatment of pelvic inflammatory diseases, as well as the development and inheritance of traditional Chinese medicine.
文摘目的研究单味中药及复方治疗盆腔炎性疾病后遗症的作用机制。方法对Pubmed、Web of Science、中国知网和万方等数据库进行检索,寻找建库至2023年3月以来关于中药治疗SPID及作用机制的相关文献,并对文献进行归纳整理。结果共纳入文献428篇,从纳入文献中筛选出从调节细胞因子和炎症介质分泌水平、促进炎症细胞凋亡、抑制脂质过氧化、抑制组织纤维化、改善血液循环、调节代谢途径和细胞信号转导、调节免疫能力等方面报道单味中药及复方治疗盆腔炎性疾病的作用机制。结论为中药治疗盆腔炎性疾病后遗症作用机制进行深入研究,并对其新药研发提供参考。
