Objective The aim of the study was to compare the efficacy and safety of whole brain radiotherapy(WBRT) used alone and combined with stereotactic radiosurgery(SRS) in the treatment of limited(1–4)brain metastases. Me...Objective The aim of the study was to compare the efficacy and safety of whole brain radiotherapy(WBRT) used alone and combined with stereotactic radiosurgery(SRS) in the treatment of limited(1–4)brain metastases. Methods We searched for randomized controlled and matched-pair analysis trials comparing WBRT plus SRS versus WBRT alone for brain metastases. The primary outcomes were the overall survival(OS), intracranial control(IC), and localcontrol(LC). The secondary outcome was radiation toxicity. The log hazard ratios(lnHRs) and their variances were extracted from published Kaplan-Meier curves and pooled using the generic inverse variance method in the RevMan 5.3 software. The non-pooled outcome measures were evaluated using descriptive analysis. Results Three randomized controlled trials and two matched-pair analysis studies were included. There was no difference in the OS for limited brain metastases between the two groups [lnHR 0.91(95% CI 0.76–1.09, P = 0.32) vs. 0.72(95% CI 0.44–1.19, P = 0.20)]. The LC and IC were significantly higher in the combined treatment group [lnHR 0.69(95% CI 0.55–0.86, P = 0.001) vs. 0.41(95% CI 0.29–0.58, P < 0.0001)]. For patients with a single lesion, one trial showed a higher survival in the combined treatment group(median OS: 6.5 months vs. 4.9 months, P = 0.04). The combined treatment was not associated with significantly higher incidence of radiation toxicity. Conclusion Combined treatment with WBRT plus SRS should be recommended for patients with limited brain metastases based on the better LC and IC without increased toxicity. It should also be considered a routine treatment option for patients with solitary brain metastases based on the prolonged OS.展开更多
以Web of Science中的SSCI数据库为情报源,对近10年SSCI收录的3种国际编辑出版类期刊Journal of Scholarly Publishing(JSP)、Learned Publishing(LP)、Serials Review(SR)发表的1200篇文献进行分析,从文献的年代与类型、国家/地区、机...以Web of Science中的SSCI数据库为情报源,对近10年SSCI收录的3种国际编辑出版类期刊Journal of Scholarly Publishing(JSP)、Learned Publishing(LP)、Serials Review(SR)发表的1200篇文献进行分析,从文献的年代与类型、国家/地区、机构、作者分布等方面全面分析了国际编辑出版类期刊发表文献的现状,并提出相关建议。研究发现,近10年来,国际范围内编辑出版领域文献发文量和影响力总体呈现逐年增长的趋势;美、英在编辑出版学领域的研究占有明显优势,其相关研究机构、作者群体均具有较强的研究能力;而中国在编辑出版学领域的研究水平有增长的趋势,但和美、英有很大差距。中国应加强与欧美发达国家和地区编辑出版学术机构的合作与交流。展开更多
文章以Web of Science中的数据库为情报源,分析SSCI收录的3种期刊学、编辑学和出版学专业期刊《Learned Publishing》（LP）、《Journal of Scholarly Publishing》（JSP）、《Serials Review》（SR）在2007—2016年发表的高被引论文（...文章以Web of Science中的数据库为情报源,分析SSCI收录的3种期刊学、编辑学和出版学专业期刊《Learned Publishing》（LP）、《Journal of Scholarly Publishing》（JSP）、《Serials Review》（SR）在2007—2016年发表的高被引论文（共计133篇）,探讨高被引论文的年度分布、研究主题、文献类型及作者国别等,希望能在科学量化指标的基础上,揭示国外编辑出版类期刊高被引论文的特点,为国内编辑出版类期刊的栏目策划、选题组稿等提供借鉴,也为编辑出版学研究提供参考。展开更多
文摘Objective The aim of the study was to compare the efficacy and safety of whole brain radiotherapy(WBRT) used alone and combined with stereotactic radiosurgery(SRS) in the treatment of limited(1–4)brain metastases. Methods We searched for randomized controlled and matched-pair analysis trials comparing WBRT plus SRS versus WBRT alone for brain metastases. The primary outcomes were the overall survival(OS), intracranial control(IC), and localcontrol(LC). The secondary outcome was radiation toxicity. The log hazard ratios(lnHRs) and their variances were extracted from published Kaplan-Meier curves and pooled using the generic inverse variance method in the RevMan 5.3 software. The non-pooled outcome measures were evaluated using descriptive analysis. Results Three randomized controlled trials and two matched-pair analysis studies were included. There was no difference in the OS for limited brain metastases between the two groups [lnHR 0.91(95% CI 0.76–1.09, P = 0.32) vs. 0.72(95% CI 0.44–1.19, P = 0.20)]. The LC and IC were significantly higher in the combined treatment group [lnHR 0.69(95% CI 0.55–0.86, P = 0.001) vs. 0.41(95% CI 0.29–0.58, P < 0.0001)]. For patients with a single lesion, one trial showed a higher survival in the combined treatment group(median OS: 6.5 months vs. 4.9 months, P = 0.04). The combined treatment was not associated with significantly higher incidence of radiation toxicity. Conclusion Combined treatment with WBRT plus SRS should be recommended for patients with limited brain metastases based on the better LC and IC without increased toxicity. It should also be considered a routine treatment option for patients with solitary brain metastases based on the prolonged OS.
文摘以Web of Science中的SSCI数据库为情报源,对近10年SSCI收录的3种国际编辑出版类期刊Journal of Scholarly Publishing(JSP)、Learned Publishing(LP)、Serials Review(SR)发表的1200篇文献进行分析,从文献的年代与类型、国家/地区、机构、作者分布等方面全面分析了国际编辑出版类期刊发表文献的现状,并提出相关建议。研究发现,近10年来,国际范围内编辑出版领域文献发文量和影响力总体呈现逐年增长的趋势;美、英在编辑出版学领域的研究占有明显优势,其相关研究机构、作者群体均具有较强的研究能力;而中国在编辑出版学领域的研究水平有增长的趋势,但和美、英有很大差距。中国应加强与欧美发达国家和地区编辑出版学术机构的合作与交流。
文摘文章以Web of Science中的数据库为情报源,分析SSCI收录的3种期刊学、编辑学和出版学专业期刊《Learned Publishing》（LP）、《Journal of Scholarly Publishing》（JSP）、《Serials Review》（SR）在2007—2016年发表的高被引论文（共计133篇）,探讨高被引论文的年度分布、研究主题、文献类型及作者国别等,希望能在科学量化指标的基础上,揭示国外编辑出版类期刊高被引论文的特点,为国内编辑出版类期刊的栏目策划、选题组稿等提供借鉴,也为编辑出版学研究提供参考。
