Studies reported that there is a close relationship between hepatocellular carcinoma (HCC) and testis carcinoma. Both tumors can be presented as synchronal tumors, or as testicular metastases of HCC or as hepatic meta...Studies reported that there is a close relationship between hepatocellular carcinoma (HCC) and testis carcinoma. Both tumors can be presented as synchronal tumors, or as testicular metastases of HCC or as hepatic metastases of testicular tumor[7]. HCC is one of the most common malignancies worldwide and the incidence of HCC increases with age[8]. The relationship between hepatitis B incidence and HCC rates is also well recognized. Alpha fetoprotein (AFP) is produced by 70% of HCC. Though a level of AFP ＞400 ng/mL is diagnostic for HCC, in the presence of active hepatitis B infection, the cut-off level should be considered to be at least 1000-4 000 ng/mL. Like HCC, germ cell tumors of the testis also release AFP; but it is shown that some of Sertoli cell tumors of testis can also release AFP[10].Herein we have reported about the first case of HCC in the literature which is presented concomitantly with Sertoli-Leydig tumor of testis, leading to extremely high level of AFP in a 21-year-old man.展开更多
A male 10-year-old Maltese dog with bilateral cryptorchid was presented for a mass in the left inguinal region,which was swelling and first noted by the owners about 2 months before presentation. The dog had been trea...A male 10-year-old Maltese dog with bilateral cryptorchid was presented for a mass in the left inguinal region,which was swelling and first noted by the owners about 2 months before presentation. The dog had been treated at local clinic by medication. On physical examination,he weighed 2. 4 kg and showed depressed,cutaneous ecchymotic hemorrhages,swelling prepuce and hair loss on the abdomen. A large firm mass was palpated in the left inguinal region. His body temperature was 39. 1 ℃ and his heart rate was 120 beats/min. Castration was recommended. The hematological analysis indicated the dog was suffering from a moderate leucopenia and severe thrombocytopenia (WBC: 21. 0×103/μL,PLT: 5×103/ μL). High level of estradiol-17β was determinate (estradiol-17β: 72. 96 pg/mL). Based on the hematological and hormonal examinations,testicular neoplasia was suspected. Both testicles were surgical removal by castration and histopathologically examined. Grossly,the right testis (1. 0×1. 0×0. 8 cm) was atrophic while the left (4. 0×3. 0×2. 0 cm) was irregularly ovoid and the cut surface was yellowish white and quite firm. Histological examinations confirmed the diagnosis of a Sertoli cell tumor with a diffuse distribution pattern. Postoperative treatment included blood transfusions,fluids therapy,antibiotics and Vitamin K. However,the dog kept bloody diarrhea and the following CBC test indicating a moderate nonregenerative normocytic and slightly hypochromic anemia,leucopenia as well as thrombocytopenia (hematocrit: 24. 3%,hemoglobin: 7. 7 g/dL,RBC: 3. 26×106/ μL,WBC: 0. 7×103/ μL,PLT: 4×103/ μL). Two days post operation,the dog went into a coma and died. Therefore,hormonal determination and blood transfusion may be considered before castration or other operation performance in case the CBC was suspected.展开更多
Sertoli-Leydig cell tumors (SLCTs) are rare tumors. Mass and pain are the presenting feature. The varying histopathology and differentiation of this tumor present difficulties with proper diagnosis and development of ...Sertoli-Leydig cell tumors (SLCTs) are rare tumors. Mass and pain are the presenting feature. The varying histopathology and differentiation of this tumor present difficulties with proper diagnosis and development of optimal treatment regimens. The prognosis depends on tumors grading and staging. Surgery is main stay management option. Chemotherapy and radiation options are still of choice.?We aimed?to?present Sertoli-Leydig cell tumor managed surgical at Latifa Hospital in Dubai, UAE with acceptable outcome and good patient satisfaction.展开更多
Sertoli-Leydig cell tumor of the ovary is a kind of sex cord-stromal tumor, which occurs between teens and twenties with symptoms including abdominal pain and swelling. The incidence rate is infinitely rare comprising...Sertoli-Leydig cell tumor of the ovary is a kind of sex cord-stromal tumor, which occurs between teens and twenties with symptoms including abdominal pain and swelling. The incidence rate is infinitely rare comprising less than 0.5% of all ovarian tumor. The average age of “retiform Sertoli-Leydig cell tumor” is 17 years as compared to 25 years for Sertoli-Leydig cell tumors as a group. We have experienced this rare case of retiform Sertoli-Leydig cell tumor in a 25-year-old foreign patient with the complaint of palpable mass on the right lower quadrant and an irregular menstrual period. The patient underwent right salpingo-oophorectomy and tumor stage was FIGO stage 1A. We report with a brief review of literature.展开更多
文摘Studies reported that there is a close relationship between hepatocellular carcinoma (HCC) and testis carcinoma. Both tumors can be presented as synchronal tumors, or as testicular metastases of HCC or as hepatic metastases of testicular tumor[7]. HCC is one of the most common malignancies worldwide and the incidence of HCC increases with age[8]. The relationship between hepatitis B incidence and HCC rates is also well recognized. Alpha fetoprotein (AFP) is produced by 70% of HCC. Though a level of AFP ＞400 ng/mL is diagnostic for HCC, in the presence of active hepatitis B infection, the cut-off level should be considered to be at least 1000-4 000 ng/mL. Like HCC, germ cell tumors of the testis also release AFP; but it is shown that some of Sertoli cell tumors of testis can also release AFP[10].Herein we have reported about the first case of HCC in the literature which is presented concomitantly with Sertoli-Leydig tumor of testis, leading to extremely high level of AFP in a 21-year-old man.
文摘A male 10-year-old Maltese dog with bilateral cryptorchid was presented for a mass in the left inguinal region,which was swelling and first noted by the owners about 2 months before presentation. The dog had been treated at local clinic by medication. On physical examination,he weighed 2. 4 kg and showed depressed,cutaneous ecchymotic hemorrhages,swelling prepuce and hair loss on the abdomen. A large firm mass was palpated in the left inguinal region. His body temperature was 39. 1 ℃ and his heart rate was 120 beats/min. Castration was recommended. The hematological analysis indicated the dog was suffering from a moderate leucopenia and severe thrombocytopenia (WBC: 21. 0×103/μL,PLT: 5×103/ μL). High level of estradiol-17β was determinate (estradiol-17β: 72. 96 pg/mL). Based on the hematological and hormonal examinations,testicular neoplasia was suspected. Both testicles were surgical removal by castration and histopathologically examined. Grossly,the right testis (1. 0×1. 0×0. 8 cm) was atrophic while the left (4. 0×3. 0×2. 0 cm) was irregularly ovoid and the cut surface was yellowish white and quite firm. Histological examinations confirmed the diagnosis of a Sertoli cell tumor with a diffuse distribution pattern. Postoperative treatment included blood transfusions,fluids therapy,antibiotics and Vitamin K. However,the dog kept bloody diarrhea and the following CBC test indicating a moderate nonregenerative normocytic and slightly hypochromic anemia,leucopenia as well as thrombocytopenia (hematocrit: 24. 3%,hemoglobin: 7. 7 g/dL,RBC: 3. 26×106/ μL,WBC: 0. 7×103/ μL,PLT: 4×103/ μL). Two days post operation,the dog went into a coma and died. Therefore,hormonal determination and blood transfusion may be considered before castration or other operation performance in case the CBC was suspected.
文摘Sertoli-Leydig cell tumors (SLCTs) are rare tumors. Mass and pain are the presenting feature. The varying histopathology and differentiation of this tumor present difficulties with proper diagnosis and development of optimal treatment regimens. The prognosis depends on tumors grading and staging. Surgery is main stay management option. Chemotherapy and radiation options are still of choice.?We aimed?to?present Sertoli-Leydig cell tumor managed surgical at Latifa Hospital in Dubai, UAE with acceptable outcome and good patient satisfaction.
文摘Sertoli-Leydig cell tumor of the ovary is a kind of sex cord-stromal tumor, which occurs between teens and twenties with symptoms including abdominal pain and swelling. The incidence rate is infinitely rare comprising less than 0.5% of all ovarian tumor. The average age of “retiform Sertoli-Leydig cell tumor” is 17 years as compared to 25 years for Sertoli-Leydig cell tumors as a group. We have experienced this rare case of retiform Sertoli-Leydig cell tumor in a 25-year-old foreign patient with the complaint of palpable mass on the right lower quadrant and an irregular menstrual period. The patient underwent right salpingo-oophorectomy and tumor stage was FIGO stage 1A. We report with a brief review of literature.
