Objective： To observe the clinical efficacy difference between electroacupuncture at Bǎihui（百会GV 20）and Yintáng（印堂EX-HN 3） and oral administration of sertraline hydrochloride for treatment of postschizo...Objective： To observe the clinical efficacy difference between electroacupuncture at Bǎihui（百会GV 20）and Yintáng（印堂EX-HN 3） and oral administration of sertraline hydrochloride for treatment of postschizophrenic depression.Methods： Sixty patients with post-schizophrenic depression were randomly divided into electroacupuncture group and western medicine group in the proportion of 1：1, with 30 patients in each group. The patients in the two groups were all given antipsychotics as the basic treatment. Electroacupuncture at GV 20 and EX-HN 3 was performed additionally in electroacupuncture group with 30 min/time and once every other day. The treatment was given for 3 times a week, lasting for 6 weeks. Oral administration of sertraline hydrochloride was given in western medicine group additionally for once a day, lasting for6 weeks. The comprehensive conditions of patients in the two groups were evaluated before and after treatment by adopting Global Assessment Scale（GAS）. The degree of depression of patients in the two groups was assessed before treatment, after treatment for 1 week, 2 weeks and 4 weeks, after treatment as well as during follow-up visit by adopting Hamilton Depression Scale-17（HAMD-17）.Results： GAS： GAS scores of the patients in the two groups after treatment were higher than those before treatment（both P〈0.05）, but the difference of GAS scores of the patients in the two groups after treatment was not statistically significant. HAMD-17： The HAMD-17 scores of patients in electroacupuncture group reduced gradually in the six time points of before treatment, after treatment for 1 week, 2 weeks and 4 weeks, after treatment as well as during follow-up visit, and the differences of scores between the two adjacent time points were statistically significant（all P〈0.05）. The HAMD-17 scores of patients in western medicine group reduced gradually in the 6 time points, and the differences of scores between the two adjacent time points among after treatment for 2 weeks and 4 weeks, and after treatment were statistically significant（all P〈0.05）. The HAMD-17 scores of patients in electroacupuncture group were lower than that in western medicine group after treatment for 1 week. 2 weeks and 4 weeks, and the differences were statistically significant（all P〈0.05）.Conclusion： According to the comparison of the clinical efficacies of electroacupuncture at GV 20 and EXHN 3 and oral administration of sertraline hydrochloride for treatment of post-schizophrenic depression,the overall conditions were improved effectively and the difference was not statistically significant. Electroacupuncture takes effect more rapidly in treatment of depression, and its effect can last for a longer time.展开更多
基金Supported by Medical Science Foundation in Zhongshan City:2017A02056~~
文摘Objective： To observe the clinical efficacy difference between electroacupuncture at Bǎihui（百会GV 20）and Yintáng（印堂EX-HN 3） and oral administration of sertraline hydrochloride for treatment of postschizophrenic depression.Methods： Sixty patients with post-schizophrenic depression were randomly divided into electroacupuncture group and western medicine group in the proportion of 1：1, with 30 patients in each group. The patients in the two groups were all given antipsychotics as the basic treatment. Electroacupuncture at GV 20 and EX-HN 3 was performed additionally in electroacupuncture group with 30 min/time and once every other day. The treatment was given for 3 times a week, lasting for 6 weeks. Oral administration of sertraline hydrochloride was given in western medicine group additionally for once a day, lasting for6 weeks. The comprehensive conditions of patients in the two groups were evaluated before and after treatment by adopting Global Assessment Scale（GAS）. The degree of depression of patients in the two groups was assessed before treatment, after treatment for 1 week, 2 weeks and 4 weeks, after treatment as well as during follow-up visit by adopting Hamilton Depression Scale-17（HAMD-17）.Results： GAS： GAS scores of the patients in the two groups after treatment were higher than those before treatment（both P〈0.05）, but the difference of GAS scores of the patients in the two groups after treatment was not statistically significant. HAMD-17： The HAMD-17 scores of patients in electroacupuncture group reduced gradually in the six time points of before treatment, after treatment for 1 week, 2 weeks and 4 weeks, after treatment as well as during follow-up visit, and the differences of scores between the two adjacent time points were statistically significant（all P〈0.05）. The HAMD-17 scores of patients in western medicine group reduced gradually in the 6 time points, and the differences of scores between the two adjacent time points among after treatment for 2 weeks and 4 weeks, and after treatment were statistically significant（all P〈0.05）. The HAMD-17 scores of patients in electroacupuncture group were lower than that in western medicine group after treatment for 1 week. 2 weeks and 4 weeks, and the differences were statistically significant（all P〈0.05）.Conclusion： According to the comparison of the clinical efficacies of electroacupuncture at GV 20 and EXHN 3 and oral administration of sertraline hydrochloride for treatment of post-schizophrenic depression,the overall conditions were improved effectively and the difference was not statistically significant. Electroacupuncture takes effect more rapidly in treatment of depression, and its effect can last for a longer time.
