Comparative evaluation of acute phase proteins by C-reactive protein(CRP)and serum amyloid A(SAA)in nonhuman primates and feline carnivores

The feasibility of a commercially available assay for C-reactive protein(CRP,CRP for humans:hCRP,and CRP for dogs:vCRP)and a trial reagent of serum amyloid A(SAA,vSAA for animals)were applied to the measurement of acute phase proteins in zoo animals,particularly in nonhuman primates and feline carnivores was evaluate.Results showed that hCRP and vSAA methods were applicable to measure CRP and SAA in Haplorhini.There was a highly signifcant correlation between both parameters with remarkably high correlation coefcient.A higher proportion of Bonnet macaques in Haplorhini,and the linear regression with good correlation between hCRP and vSAA levels were observed.Reference values in healthy Bonnet macaques were hCRP(46.86±30.97 nmol/L)and vSAA(9.06±1.95μg/mL).Although Ring-tailed lemur,which belonging to Strepsirrhini,showed low vSAA concentrations(reference values:1.08±0.47μg/mL),vSAA in patients was apparently elevated.The vCRP and vSAA methods were applicable to measurements of CRP and SAA in feline carnivores for highly signifcant correlation between both parameters.Theses two methods were also been deteded in lions,tigers and cheetahs.vSAA assays can be applied to measure SAA levels in other carnivores and herbivores.In conclusion,vSAA systems have potential utility as diagnostic tools for health screening and prediction in zoo animals.

血清甲状腺激素、NLR及CRP/ALB与肺癌术后谵妄的关系

目的分析血清甲状腺激素、中性粒细胞淋巴细胞比值(NLR)及C反应蛋白/白蛋白比值(CRP/ALB)与肺癌术后谵妄的关系。方法选取2021年1月至2022年12月于北京市第六医院进行肺癌根治术患者118例作为研究对象。根据ICU意识混乱评分法进行谵妄评估,有35例患者发生术后谵妄(谵妄组),83例患者术后未发生谵妄(非谵妄组)。分析影响肺癌患者术后谵妄的单因素,采用多元Logistic回归分析影响肺癌术后谵妄的多因素;比较谵妄组不同谵妄程度患者血清甲状腺激素、CRP/ALB、NLR水平;采用Pearson相关系数分析血清甲状腺激素、CRP/ALB、NLR与肺癌术后谵妄的相关性。结果两组性别、合并患有高血压、ASA分级以及T_4、TSH、FT_4水平等指标比较,差异无统计学意义(P>0.05);两组年龄、合并患有糖尿病、睡眠障碍以及T_(3)、FT_(3)、CRP/ALB、NLR水平比较,差异有统计学意义(P<0.05);经多元Logistic回归分析显示:年龄≥60岁、合并患有糖尿病、睡眠障碍以及T_(3)<1.31 nmol/L、FT_(3)<5.15 pmol/L、CRP/ALB>0.120、NLR≥7.79均是影响肺癌发生术后谵妄的危险因素(P<0.05);轻度、重度术后谵妄患者T_4、TSH、FT_4水平比较,差异无统计学意义(P>0.05);轻度术后谵妄患者T_(3)、FT_(3)水平高于重度术后谵妄患者,CRP/ALB、NLR水平低于重度术后谵妄患者,差异均有统计学意义(P<0.05);Pearson相关性分析显示:T_(3)、FT_(3)与肺癌术后谵妄呈负相关,CRP/ALB、NLR与肺癌术后谵妄呈正相关(P<0.05)。结论肺癌根治术患者术后T_(3)、FT_(3)、CRP/ALB、NLR水平与术后谵妄发生有一定关联,通过检测上述指标水平可为临床评估术后谵妄严重程度提供参考资料。

Correlation of Serum C-Reactive Protein with Disease Severity in Tuberculosis Patients

Purpose: To study the factors influencing sputum smear conversion including Serum C-Reactive Protein (CRP) and its correlation with disease severity in tuberculosis patients. Method: Levels of Serum-CRP concentrations were deter-mined in 60 patients with pulmonary tuberculosis, 30 healthy volunteers and patients in follow-up after completion of antitubercular treatment (DOTS therapy). Results: Serum-CRP levels were found to be significantly higher in smear-positive group as compared with the follow-up patients and smear-negative control group. The values were 43.65 ± 23.68, 9.88 ± 5.23 and 4.04 ± 3.85 mg/L respectively (P Conclusion: Serum-CRP levels are significantly correlated with disease severity in patients with active pulmonary tuberculosis. Thus these findings from the present study would certainly add new criteria for early diagnosis of TB, which may lead to development of new strategies to treat TB.

Combined effects of serum C-reactive protein and A Body Shape Index(ABSI)on ischemic stroke incidence among Inner Mongolians in China

Objective We aimed to evaluate the combined effect of high serum C-reactive protein (CRP) and high A Body Shape Index (ABSI) on ischemic stroke incidence in an Inner Mongolian population in China.Methods A prospective cohort study was conducted among 2,589 participants from June 2002 to July 2012 in Inner Mongolia, China.

血清CRP、PCT与血常规WBC检验在儿童细菌性感染疾病中的鉴别价值研究

目的研究血清C反应蛋白(C Reactive Protein,CRP)、降钙素原(Procalcitonin,PCT)、血常规白细胞计数(White Blood Cell Count,WBC)联合用于检验儿童细菌性感染疾病的价值。方法回顾性选取2021年1月—2023年12月山东单县东大医院诊治细菌性感染疾病43例患儿的临床资料作为观察组,回顾性选取同期于本院进行体检的健康儿童43名的临床资料作为对照组,对比两组血清CRP、PCT及血常规WBC指标检验结果,计算单一指标、三项指标联合检验的灵敏度、特异度及准确度。结果经检验,观察组感染患儿CRP、PCT及血常规WBC指标水平均明显高于对照组,差异有统计学意义(P均<0.05)。另外三项指标联合检验疾病的灵敏度95.35%、准确度94.19%均明显高于单一指标检验,差异有统计学意义(P均<0.05)。结论临床鉴别诊断儿童细菌性感染疾病可通过CRP、PCT、血常规WBC指标三项结合检验的方式,相比单一指标分析准确性更高,为后续治疗提供数据支持。

肺炎支原体感染儿童血清肺炎支原体IgG、IgM抗体、CRP及D-D水平及临床意义分析

目的探究肺炎支原体感染儿童血清肺炎支原体免疫球蛋白(Ig)G、Ig M抗体、C-反应蛋白(CRP)及D-二聚体(D-D)水平及预测预后的临床价值。方法选择2021年3月~2023年3月于本院接受治疗的肺炎支原体感染儿童220例,作为观察组,并选取同时期体检健康儿童30例,作为对照组。比较两组血清Ig G、Ig M抗体、CRP及D-D水平,并采用单因素及多因素分析其与儿童肺炎支原体感染预后之间的关系,绘制受试者工作特征曲线(ROC)分析血清Ig G、Ig M抗体、CRP及D-D水平预测患儿预后的临床价值。结果观察组Ig G抗体、Ig M抗体、CRP和D-D含量均高于对照组(P<0.05)。观察组中治疗预后不佳56例(25.45%),单因素分析发现,预后不佳与预后良好组住院时间、是否集体生活、有无抗菌药物应用、Ig G抗体、Ig M抗体、CRP及D-D含量等指标的差异均有统计学意义(P<0.05);Logistic多因素分析显示Ig G抗体、Ig M抗体、CRP和D-D均为肺炎支原体感染儿童预后的独立影响因素(P<0.05)。ROC曲线分析显示Ig G、Ig M抗体、CRP及D-D水平预测肺炎支原体感染儿童预后不佳的AUC分别为0.644、0.849、0.752和0.861(P<0.05),敏感度分别为0.625、0.857、0.768和0.768,特异度分别是0.628、0.811、0.701和0.927,均有一定预测价值。结论血清肺炎支原体Ig G、Ig M抗体、CRP及D-D水平与儿童肺炎支原体感染及预后密切相关,其中CRP预测患儿预后效果最好,建议临床上予以密切监测。

血清PCT联合CRP检测对脓毒症的诊断意义

目的探究血清PCT和CRP联合检测对脓毒症患者的诊断价值。方法选取2022年3月—2023年3月本院收治的100例脓毒症患者作为观察组,同时选取100例健康人作为对照组,采用电化学发光分析仪检测血清PCT,采用全自动生化分析仪检测血清CRP,并比较血清PCT、CRP及PCT+CRP在诊断脓毒症中的敏感性与特异性。结果观察组患者的PCT水平为(11.3±9.35)ng/mL,而对照组为(0.02±0.01)ng/mL,两组比较,观察组PCT水平显著升高,差异具有统计学意义(P<0.05);观察组患者的CRP水平为(78.95±16.64)mg/L,而对照组为(3.79±0.35)mg/L,两组比较,观察组CRP水平显著升高,差异具有统计学意义(P<0.05);根据得到的PCT、CRP水平计算出各自试验结果对脓毒症诊断的敏感性和特异性指标,结果显示:PCT、CRP和PCT+CRP联合诊断脓毒症中的敏感性与特异性分别为88%与74%、93%与37%和97%与84%,PCT+CRP联合诊断脓毒症中的敏感性与特异性明显高于PCT、CRP单独诊断,差异非常明显,具有统计学意义(P<0.05)。结论相比较于单独检测,血清PCT和CRP联合检测能提高脓毒症诊断的特异性和敏感性,对脓毒症患者的诊断价值更大,值得推广。

GCS评分、CT评分联合血清CRP水平对颅脑损伤患者损伤程度及预后的应用价值

目的探讨格拉斯哥昏迷评分(GCS)、计算机断层扫描评分(CT)联合血清C反应蛋白(CRP)水平对评价颅脑损伤(TBI)患者损伤程度及预后的应用价值。方法选择2019年3月至2021年9月莲花县人民医院收治的TBI患者98例,所有患者均按照GCS评分进行病情程度分级,并计算CT评分,检测CRP水平。比较不同病情程度、不同预后患者GCS评分、CRP水平与CT评分的差异,分析患者三项指标与病情程度、疾病预后的相关性。结果三组患者GCS评分相比,重度组<中度组<轻度组;三组CRP水平、CT评分相比,重度组>中度组>轻度组,差异有统计学意义(P<0.001);预后良好组GCS评分高于预后不良组,CRP水平、CT评分均低于预后不良组,差异有统计学意义(P<0.001)。经Pearson相关性分析显示,GCS评分与病情程度呈负相关(r=-0.459,P<0.05),CRP、CT评分与病情程度呈正相关(r值分别为0.361和0.245,P<0.05);GCS评分与预后呈正相关(r=0.538,P<0.05),CRP、CT评分与预后呈负相关(r=-0.546、-0.396,均P<0.05)。结论GCS、CT评分、CRP水平与TBI患者损伤程度及预后均存在密切关系,可用于临床早期诊断、疗效评估及预后判断。

Serum IL-1β and IL-18 correlate with ESR and CRP in multidrug-resistant tuberculosis patients

Dear Editor： The emergence of multidrug-resistant tuberculosis （MDR-TB） is bringing new challenges. MDR-TB is caused by Mycobacterium tuberculosis （M. tuberculosis） that is resistant to isoniazid and rifampicin, with or with- out resistance to other anti-tuberculosis drugs. Approximately 450,000 people developed MDR-TB worldwide in 2012 and an estimated 170,000 people died from the disease. Bacterial burden is not strictly corre- lated with disease progression, and several hallmarks of severe tuberculosis suggest that insufficiently controlled inflammation plays an important role in pathogenesis.

The prognostic potential of pretreatment C-reactive protein to albumin ratio in stage IE/IIE extranodal natural killer/T-cell lymphoma

Objective The aim of this study was to determine the prognostic significance of the C-reactive protein-toalbumin ratio (CRP/Alb) for stage IE/IIE upper aerodigestive tract extranodal NK/T cell lymphoma patients. Methods One hundred and fourteen patients diagnosed with extranodal NK/T cell lymphoma at Sichuan Cancer Hospital from September 2011 to November 2016 were retrospectively reviewed. An optimal cutoff value of CRP/Alb for overall survival rate as an endpoint was obtained using the receiver operating curve (ROC). Results The optimal cutoff value of CRP/Alb was 0.15. For the low CRP/Alb group, the 3-year progression-free survival (PFS) was 78.6% and the 3-year overall survival (OS) was 80.7%. The 3-year PFS and OS values for the high CRP/Alb group were 41.6% and 45.2%, respectively. Differences for PFS (P < 0.001) and OS (P < 0.001) between the two groups were statistically significant. Univariate analysis showed that ECOG, IPI, CRP, GPS, and CRP/Alb were significantly associated with PFS. Similarly, all five were also significantly associated with OS. Multivariate analysis further confirmed that ECOG and CRP/ Alb were independent prognostic factors for both PFS and OS. Moreover, the cutoff value of CRP/Alb showed superior prognostic ability in discriminating between patients with different outcomes in low-risk group based on GPS, IPI, and KPI scores. Conclusion CRP/Alb is a promising prognostic marker for early-stage extranodal NK/T cell lymphoma.

Changes of serum CRP, serum uric acid and immunoglobulin in patients with renal damage of systemic lupus erythematosus

Objective: To observe the expression level of serum CRP, serum uric acid and immunoglobulin (IgG, IgA and IgM) in patients with renal damage of systemic lupus erythematosus, and explore their clinical application value. Methods: A total of 95 patients with SLE were divided into lupus nephritis group (LN group, n = 64) and non-lupus nephritis group (NLN group n=31) according to the diagnostic criteria of lupus nephritis, and another 35 healthy subjects were selected as normal control group. Blood samples were collected from all subjects before treatment. Serum CRP and serum uric acid concentrations were measured by ELISA. The levels of serum immunoglobulins were detected by immunoturbidimetry in the same time. Finally, the results were analyzed statistically. Results: The levels of serum CRP and serum uric acid in patients with SLE were significantly higher than those in control group. The levels of serum CRP and serum uric acid in LN group of SLE patients were significantly higher than those in NLN group and control group. Serum CRP level in NLN group was significantly higher than that in control group. Serum uric acid level in NLN group was slightly higher than that of the control group, but the difference was not statistically significant. The level of serum immunoglobulin in SLE patients was higher than that in control group. The levels of serum immunoglobulin IgG, IgA and IgM in LN group of SLE patients were significantly higher than those in NLN group and control group. The levels of serum immunoglobulin IgG, IgA and IgM in NLN group of SLE patients were all higher than those in control group. Conclusion: Humoral immune of SLE patients with renal injury was activated at different degree, B-cell hyperthyroidism, severe systemic inflammatory response and kidney damage at varying degrees. Serum CRP, serum uric acid and immunoglobulin (IgG, IgA and IgM) may be involved in SLE renal injury pathological process, which is the early diagnosis of reference indicators.

脓毒症患者hs-CRP/ALB和hs-CRP/PA与膈肌功能障碍的相关性

目的探讨超敏C反应蛋白与血清白蛋白比值(hs-CRP/ALB)和超敏C反应蛋白与前白蛋白比值(hs-CRP/PA)与脓毒症膈肌功能障碍的相关性。方法采用前瞻性观察性研究方法,选择2020年1月至2021年5月入住宁夏医科大学总医院重症医学科(ICU)的80例脓毒症患者为研究对象,以入ICU第1天床旁超声测量膈肌位移(diaphragmatic excursion,DE)<10 mm诊断为膈肌功能障碍,将其分为脓毒症膈肌功能障碍组(n=29)和脓毒症非膈肌功能障碍组(n=51),并选择年龄、性别与研究对象相匹配的30例普通术后非脓毒症患者和15例健康志愿者为术后对照组和正常对照组。收集临床资料,动态观察脓毒症患者超敏C反应蛋白(hyper-sensitive C-reactive protein,hs-CRP)、血清白蛋白(albumin,ALB)、前白蛋白(prealbumin,PA)等指标,计算hs-CRP/ALB和hs-CRP/PA。并用间接测热法测量脓毒症患者静息能量消耗水平,计算静息能量消耗水平与实际给予能量的差值,即能量缺失值。结果①入ICU第1天,脓毒症膈肌功能障碍组、脓毒症非膈肌功能障碍组和术后对照组DE均低于正常对照组(均P<0.05),且脓毒症膈肌功能障碍组DE低于脓毒症非膈肌功能障碍组和术后对照组[mm:8.8(6.7,9.3)vs.13.3(12.3,17.8)和12.9(10.5,15.7),P<0.05];脓毒症膈肌功能障碍组能量缺失值高于脓毒症非膈肌功能障碍组(P<0.05)。②入ICU第1、3、7天,脓毒症膈肌功能障碍组hs-CRP/ALB高于脓毒症非膈肌功能障碍组[第1天:7.73(3.95,9.15)vs.5.44(2.76,8.14);第3天:4.63(3.12,6.17)vs.2.60(1.04,5.09);第7天:2.21(0.84,5.84)vs.0.81(0.52,2.36),均P<0.05]。脓毒症膈肌功能障碍组hs-CRP和hs-CRP/PA仅入ICU第3天高于脓毒症非膈肌功能障碍组[hs-CRP(mg/L):150.0(92.4,169.0)vs.62.5(30.3,152.0);hs-CRP/PA:1.74(1.12,2.73)vs.0.78(0.21,1.97),均P<0.05]。两组间各时相点ALB、PA比较差异均无统计学意义(均P>0.05)。脓毒症膈肌功能障碍组入ICU第1天hs-CRP/ALB、hs-CRP/PA均高于第7天(P<0.05)。③脓毒症患者DE与各指标相关分析:入ICU第1、3、7天,DE均与hs-CRP/ALB呈负相关(r分别为-0.241、-0.373、-0.465,均P<0.05);入ICU第3、7天,DE均与hs-CRP/PA呈负相关(r分别为-0.325、-0.468,均P<0.05)。结论脓毒症患者血清hs-CRP/ALB、hs-CRP/PA与膈肌功能障碍呈负相关。

C-reactive protein and cardiovascular diseases

Recently many new disease markers and risk factors have been proposed, but it is not yet clear how far the new markers are validated as predictive risk factors enable us to increase accuracy as well as enhancing our ability to predict cardiovascular (CV) events and to plan prevention and therapy.

Inflammation and vascular disease: the role of C-reactive protein

Inflammation is an important component of active atherosclerotic disease. C-reactive protein (CRP)is a non-specific inflammatory marker that is increased in inflammatory conditions. Newer more sensitive assays (high sensitivity CRP) can detect the low levels of inflammation associated with vascular disease. CRP levels can give further risk assessment to individuals beyond predictions from traditional risk factors. This measurement is most useful in helping to discriminate risk in intermediate risk patients such as metabolic syndrome patients. Exercise and weight loss have been shown to significantly lower CRP levels. Lipid lowering therapies, especially with the statin class of medications, also lower CRP levels. A reduction in inflammation may be an important component of plaque stabilization and contribute to cardiovascular risk reduction.

Clinical perspective on C-reactive protein in prognostication of major adverse cardiac events in the elderly with established coronary heart disease

The systemic response to tissue injury, regardless of cause is characterized by a cytokine-mediated alteration in the hepatic synthesis of a number of different plasma proteins,known collectively as 'acute phase reactants'. These proteins include C-reactive protein, serum amyloid A protein, alphal glycoprotein, ceruloplasmin, alpha macroglobulins, complement components (C1-C4, factor B, C9, C11), alpha1antitrypsin, alpha1 antichymotrypsin, fibrinogen, prothrombin,factor Ⅷ, plasminogen, haptoglobin, ferritin, immunoglobulins and lipoproteins. The initiation of the acute phase response is linked to the production of hormone-like polypeptide mediators now called cytokines, namedly, interleukin 1(IL-1),tumor necrosis factor, interferon gamma, interleukin 6 (IL-6),leukemia inhibitory factor, ciliary neurotropic factor, oncostatin M, and interleukin 11 (IL- 11).……

A Preliminary Study of C-reactive Protein in the Diagnosis and Monitoring of Lyme Disease

Concentrations of C-reactive protein (CRP) in the serum of 14 patients suffering from Lyme diseasc were measured. 86% of these patients were found to have abnormally high concentrations of serum CRP (range 14-158 mg/L). The CRP concentration of a 60-yearold patient abated from 29 mg/L to 13 mg/L after treatrnent. Results suggest that serum CRP concentration can provide a valuable and accurate means for the clinical diagnosis and monitoring of Lyme disease

血清PA、CRP、PCT水平联合检测在老年细菌性肺炎患者诊断中的效果评价

目的 以血清前白蛋白(prealbumin, PA)、C反应蛋白(C-reactive protein, CRP)、降钙素原(procalcitonin,PCT)水平检测数据进行老年细菌性肺炎的联合诊断工作,评价其具体效果。方法 随机选取2019年10月—2021年12月聊城市中医医院收治的老年肺炎患者100例为观察组,其中含有细菌感染者50例为细菌感染者组、非细菌感染者50例为非细菌感染组。再抽取同一时间段内于本院接受健康体检的人员100例为对照组。受试者均行以血清PA、CRP、PCT水平的单一、联合检测,根据检测结果开展各自组间的差异性比较。结果 与对照组相比,观察组的血清CRP、PCT水平更高,PA水平更低,差异有统计学意义(P<0.05)。与非细菌感染组相比,细菌感染者组的血清CRP、PCT水平更高,PA水平更低,差异有统计学意义(P<0.05)。100例老年肺炎患者经血清PA确诊为老年细菌性肺炎患者有40例(40.00%),经血清CRP确诊35例(35.00%),经血清PCT确诊45例(45.00%),经血清PA、CRP、PCT水平的联合检测确诊50例(50.00%)。和血清PA、CRP、PCT水平的单一检测结果相比,显示血清PA、CRP、PCT水平的联合检测结果的灵敏度更高,漏诊率更低,阴性预测值更高,差异有统计学意义(P<0.05)。结论 以血清PA、CRP、PCT水平检测数据进行老年细菌性肺炎的联合诊断工作,能够得到较高的灵敏度与阴性预测值,更低的误诊率、漏诊率,还能准确区分细菌性感染者、非细菌性感染者,应用价值极高。

小儿肺炎不同感染病原体类型外周血WBC和血清CRP、PCT水平特点及分析

目的探讨小儿肺炎不同感染病原体类型外周血白细胞计数(white blood cell count,WBC)、血清C反应蛋白(serum C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)的水平特点。方法选择2021年1月—2022年12月仪征市人民医院收诊治疗的小儿肺炎患儿142例作为观察组,其中包括48例细菌性肺炎患儿、47例支原体肺炎患儿、47例病毒性肺炎患儿,选择同期于本院接受体检的健康儿童48例作为对照组,均进行外周血WBC、血清CRP、PCT指标检测,对比观察组不同感染病原体类型患儿与对照组检查结果差异,同时结合观察组肺炎患儿病情程度分析3项指标检查结果的差异性。结果细菌性肺炎患儿WBC、CRP、PCT均高于支原体肺炎、病毒性肺炎患儿及健康体检儿童,差异有统计学意义(P<0.05)。另外,重症肺炎患儿外周血WBC水平(14.01±2.38)×109/L、血清CRP水平(60.38±5.29)mg/L、PCT水平(3.81±0.55)ng/mL高于轻症肺炎患儿,差异有统计学意义(t=14.982、48.368、42.067,P<0.05)。结论临床可通过检测外周血WBC、血清CRP、PCT水平用于鉴别诊断不同感染病原体类型的小儿肺炎疾病,同时辅助鉴别病情程度,为临床提供数据支持,值得运用推广。

Hp根除治疗慢性胃炎患者的效果及与hs-CRP的相关性

目的探讨幽门螺杆菌(H.pylori,Hp)根除治疗对慢性胃炎患者肠道菌群的影响及其与血清超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)水平的相关性。方法选择2019年9月—2021年9月于福建省建瓯市立医院内科收治的慢性胃炎患者中50例作为研究对象,均予以Hp根除治疗,药物包括枸橼酸铋钾胶囊、雷贝拉唑钠肠溶胶囊、克拉霉素片、阿莫西林克拉维酸钾片,对其治疗有效率和Hp根除率进行评估,比较治疗前后患者的症状积分、各类菌群数量和血清hs-CRP水平变化,同时对其治疗后肠道菌群数量与血清hs-CRP水平的相关性。结果治疗总有效率和Hp根除率均超过90.00%;治疗后的肠道肠球菌、葡萄球菌数量较治疗前高,肠杆菌、乳杆菌、双歧杆菌数量和血清hs-CRP水平则较治疗前低(P<0.05);各类菌群和患者血清hs-CRP水平无相关(P>0.05)。结论采取Hp根除治疗慢性胃炎,可以有效改善患者症状,提高Hp根除率,促进血清hs-CRP水平下降,但会打破患者肠道菌群平衡,而肠道菌群数量与血清hs-CRP水平无相关,需临床制定更加合理有效的用药方案来保护其肠道菌群,提高整体用药安全性。

血清PCT和全血hs-CRP在慢阻肺急性加重期早期诊断中的应用价值

目的观察血清PCT和全血hs-CRP在慢阻肺急性加重期早期诊断中的应用价值。方法选取本院2019年1月-2022年6月收治的慢性阻塞性肺疾病患者60例为研究对象,检测其血清PCT和全血hs-CRP水平,并将采集指标3d内发生急性加重的患者13例纳入加重组,而将另47例患者纳入稳定组。比较两组患者的血清PCT和全血hs-CRP水平是否存在差异,并评价血清PCT和全血hs-CRP水平在慢阻肺急性加重期早期诊断中的应用价值。结果本研究中,加重组患者的血清PCT和全血hs-CRP水平均显著高于稳定组,差异具有统计学意义(P<0.05)。在慢阻肺急性加重期早期诊断上,血清PCT和全血hs-CRP联合检测的诊断价值相对于单一检测PCT或hs-CRP的价值更高,差异具有统计学意义(P<0.05)。结论在慢阻肺急性加重期早期诊断中,血清PCT检测和全血hs-CRP检测具有较高的灵敏度与特异度,尤其是联合检查方式,检测效果理想,可对稳定期患者进行早期预测,以便在早期实施针对性治疗,值得临床推广。