Objective To observe the effect of Bufei Granules on the mild-to-moderate chronic obstructive pulmonary disease(COPD)stable phase patients,and to explore its mechanism from the perspective of regulating the serum leve...Objective To observe the effect of Bufei Granules on the mild-to-moderate chronic obstructive pulmonary disease(COPD)stable phase patients,and to explore its mechanism from the perspective of regulating the serum levels of interleukin-33(IL-33)/soluble ST2(s ST2)axis and related inflammatory cytokines.Methods A multicenter double-blinded randomized controlled trial was performed.Totally 271 mild-to-moderate COPD stable phase patients from 4 referral hospitals were enrolled and assigned to two groups by stratified block randomization,136 in the treatment group(TG)and 135 in the control group(CG).All the patients received disease education,self-management and integrative care.Additionally,the patients in the TG were treated with Bufei Granules,while the patients in the CG were treated with Bufei Granules placebo,10 g per package,2 packages each time,2 times per day.The therapeutic course for all was 12 weeks.The scores of COPD assessment test questionnaire(CATQ),St.George's Respiratory Questionnaire(SGRQ)and traditional Chinese medicine clinical symptoms(TCMCS)were recorded.The pulmonary function tests including forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/predicted value(FEV1%)and FEV1/FVC,and the serum levels of IL-33,s ST2,IL-4 and IL-10 of the patients were measured.Results Compared with those before treatment,the scores of CATQ,TCMCS,SGRQ(including the scores of respiratory symptoms,activity limitation,disease affect and total score),and the serum level of s ST2 in the TG decreased obviously after treatment(P<0.01),however the serum levels of IL-33,IL-4 and IL-10 increased significantly(P<0.01),meanwhile were superior to those in the CG(P<0.01).Compared between the two groups,the indexes of FEV1,FVC,FEV1% and FEV1/FVC of the TG were higher than those in the CG after treatment(P<0.05).The total effective rate of TCMCS in the TG was 75.74%(103/136),and was superior to 9.63% in the CG(13/135,X^2=120.929,P<0.01).Conclusion Bufei Granules could effectively treat the mild-to-moderate COPD stable phase patients by ameliorating the clinical symptoms,protecting the pulmonary function from deterioration and improving the life quality.Its effect mechanism might be related to the enhancment of anti-inflammation ability by increasing the serum levels of IL-33,IL-4 and IL-10,and decreasing the serum level of s ST2.展开更多
文摘Objective To observe the effect of Bufei Granules on the mild-to-moderate chronic obstructive pulmonary disease(COPD)stable phase patients,and to explore its mechanism from the perspective of regulating the serum levels of interleukin-33(IL-33)/soluble ST2(s ST2)axis and related inflammatory cytokines.Methods A multicenter double-blinded randomized controlled trial was performed.Totally 271 mild-to-moderate COPD stable phase patients from 4 referral hospitals were enrolled and assigned to two groups by stratified block randomization,136 in the treatment group(TG)and 135 in the control group(CG).All the patients received disease education,self-management and integrative care.Additionally,the patients in the TG were treated with Bufei Granules,while the patients in the CG were treated with Bufei Granules placebo,10 g per package,2 packages each time,2 times per day.The therapeutic course for all was 12 weeks.The scores of COPD assessment test questionnaire(CATQ),St.George's Respiratory Questionnaire(SGRQ)and traditional Chinese medicine clinical symptoms(TCMCS)were recorded.The pulmonary function tests including forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/predicted value(FEV1%)and FEV1/FVC,and the serum levels of IL-33,s ST2,IL-4 and IL-10 of the patients were measured.Results Compared with those before treatment,the scores of CATQ,TCMCS,SGRQ(including the scores of respiratory symptoms,activity limitation,disease affect and total score),and the serum level of s ST2 in the TG decreased obviously after treatment(P<0.01),however the serum levels of IL-33,IL-4 and IL-10 increased significantly(P<0.01),meanwhile were superior to those in the CG(P<0.01).Compared between the two groups,the indexes of FEV1,FVC,FEV1% and FEV1/FVC of the TG were higher than those in the CG after treatment(P<0.05).The total effective rate of TCMCS in the TG was 75.74%(103/136),and was superior to 9.63% in the CG(13/135,X^2=120.929,P<0.01).Conclusion Bufei Granules could effectively treat the mild-to-moderate COPD stable phase patients by ameliorating the clinical symptoms,protecting the pulmonary function from deterioration and improving the life quality.Its effect mechanism might be related to the enhancment of anti-inflammation ability by increasing the serum levels of IL-33,IL-4 and IL-10,and decreasing the serum level of s ST2.
