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Association of Atrial Fibrillation and Amino-terminal Pro-brain Natriuretic Peptide Concentrations in Patients After Off-Pump Coronary Artery Bypass Grafting
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作者 李君权 张庆华 +1 位作者 田伟忱 刘宏宇 《South China Journal of Cardiology》 CAS 2008年第2期61-65,共5页
Objectives To investigate the possible role of amino-terminal pro-brain natriuretic peptide (NT-proBNP) in the occurrence of atrial fibrillation (AF) after coronary artery bypass grafting (CABG). Methods This st... Objectives To investigate the possible role of amino-terminal pro-brain natriuretic peptide (NT-proBNP) in the occurrence of atrial fibrillation (AF) after coronary artery bypass grafting (CABG). Methods This study group included 70 consecutive patients scheduled for elective off-pump CABG. The patients with ejection fraction (EF) less than 0. 30, history of AF, use of class Ⅰ or Ⅲ antiarrhythmic drug, implanted pacemaker, postoperative myocardial infarction or chest reopening for pericardial tamponade were excluded. Preoperative and postoperative serum NT-proBNP levels were measured by radioimmunoassay technique. Results Postoperative AF occurred in 15 patients (21.4%); these patients had significantly higher median NT-proBNP levels when compared with those without AF after the operation ( P 〈 0. 01 ). Using multivariate logistic regression analyses, an increase in NT-proBNP level after CABG was found to be independently associated with AF ( OR = 3.78, 95% IC = 1.81 - 4. 89, P 〈 0. 01 ). Increased age, diabetes mellitus, preoperative use of β-blocker, proximal right coronary artery involvement, and longer operation time were al- so associated with AF. Conclusions These results indicated that AF was associated with higher NT-proBNP concentrations after off pump CABG; the increase in NT-proBNP after CABG may play an important role in the occurrence of AF after the operation. The further studies are needed to define the reason that lead to higher NT-proBNP concentrations among the patients who present AF after off pump CABG. 展开更多
关键词 OFF-PUMP coronary artery bypass grafting atrial fibrillation amino-terminal pro-brain natriuretic peptide
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Effect of atorvastatin on serum oxidative stress and N-terminal brain natriuretic peptide expression in rats 被引量:3
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作者 Yan Xu Yu Yang Ying-Quan Luo 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第5期398-401,共4页
Objective:To investigate the effect of atorvastatin on serum oxidative stress and N-terminal brain natriuretic peptide expression in rats.Methods:A total of 40 healthy male SD rats were randomly divided into the sham ... Objective:To investigate the effect of atorvastatin on serum oxidative stress and N-terminal brain natriuretic peptide expression in rats.Methods:A total of 40 healthy male SD rats were randomly divided into the sham group(Croup A,n=10,saline 5 mL/d),ischemia-reperfusion group(Group B,n=10,saline S mL/d),atorvastatin group(Group C,n=10.atorvastatin 20 mg/kg·d),atorvastatin + N-amino-arginine group(Group D,n=10,atorvastatin 20 mg/kg·d + N-amino arginine 15 mg/kg).Myocardial ischemia-reperfusion rat model was eslablished after 3 days of gavage.N-amino arginine 15 mg/kg was given by tail vein injection 15 min before ischemia.After reperfusion,enzymology indicators such us creatine kinase(CK) and lactate dehydrogenase and the oxidative stress parameters such as nitric oxide(NO),malondialdehyde(MDA) and total superoxide dismutase(TSOD),and n-terminal pro-brain natriuretic peptide(NT-proBNP)expression was detected by immunohistochemistry.Results:LDH and CK levels of group A were significantly lower than the outer three groups,and group B was the highest.There was significant difference between group B and group C(P<0.05),and no significant difference between group B and group D(P>0.05).MDA levels in group B were significantly higher than the other three groups.The lowest was group A,followed by group C,the difference among groups was significantly(P<0.05).TSOD and NO levels in group B was the lowest,the level in group A was the highest,followed by group C,the difference among groups was significant(P<0.05).NT-proBNP level in group B was significantly higher than the other three groups,the lowest was group A,followed by group C,the difference among groups was significant(P<0.05).Conclusions:Atorvastatin has a protective effect on the myocardial injury in the myocardial ischemia and reperfusion rats.It can increase NO synthesis and decrease MDA content,increase serum TSOD activity and the oxidative stress effect,meanwhile protect myocardial cells and reduce myocardial injury. 展开更多
关键词 ATORVASTATIN MYOCARDIAL ISCHEMIA-REPERFUSION OXIDATIVE stress N-TERMINAL pro-brain natriuretic peptide
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Plasma N-terminal pro-brain natriuretic peptide levels in elderly patients with isolated diastolic dysfunction 被引量:2
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作者 Yixin SONG Qing LIN Xiaomin SHI Yunyun QI 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2005年第4期211-215,共5页
Objective To investigate plasma N-terminal pro-brain natriuretic peptide (NT-BNP) levels and to assess their clinical significance in elderly patients with isolated diastolic dysfunction. Methods Plasma NT-BNP level w... Objective To investigate plasma N-terminal pro-brain natriuretic peptide (NT-BNP) levels and to assess their clinical significance in elderly patients with isolated diastolic dysfunction. Methods Plasma NT-BNP level were measured by electrochemiluminescence immunoassay in 34 symptomatic patients (Group 1), 34 asymptomatic patients (Group 2) with isolated diastolic dysfunction, and in 16 elderly healthy subjects (control group, Group 3), serving controls. Colored Doppler echocardiography was performed to evaluate the patients' cardiac structures and functions. Results The plasma NT-BNP level in Group 1 was significantly higher than those in Group 2 and Group 3 and increased with the severity of heart failure. There was no significant difference of plasma NT-BNP levels between Group 2 and Group 3 (p>0.05). A NT-BNP value of 102.75 pg/mL showed a sensitivity of 88.2%, a specificity of 87.5%, and an accuracy of 88.1% for diagnosing diastolic dysfunction. Patients with restrictive filling pattern on echocardiography had higher NT-BNP levels than those of impaired relaxation pattern (1961.2±304.9 versus 460.1±92.7pg/mL, p<0.001). Conclusion The elevation of plasma NT-BNP level in elderly patients with isolated diastolic dysfunction correlates with the severity of their diastolic abnormalities. The level of plasma NT-BNP has an important clinical value in the diagnosis of elderly patients with isolated diastolic dysfunction. 展开更多
关键词 elderly ISOLATED DIASTOLIC DYSFUNCTION N-TERMINAL pro-brain natriuretic peptide ECHOCARDIOGRAPHY
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Prognostic Value of N-Terminal Pro-Brain Natriuretic Peptide in Acute Pulmonary Embolism
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作者 Abdelhakem Selem Hanan Radwan Abdelaziz M Gomaa 《Open Journal of Endocrine and Metabolic Diseases》 2012年第4期58-62,共5页
Patients with pulmonary embolism (PE) have a high risk of death and it is important to recognize factors associated with high mortality. N-Terminal pro-Brain Natriuretic Peptide (NT-pro BNP) has recently emerged as a ... Patients with pulmonary embolism (PE) have a high risk of death and it is important to recognize factors associated with high mortality. N-Terminal pro-Brain Natriuretic Peptide (NT-pro BNP) has recently emerged as a promising biomarker for risk assessment in acute pulmonary embolism (PE). The aim of this study is to detect the in hospital prognostic value of NT-pro BNP in patients with acute (PE). Methods: This study included 64 patients diagnosed as (PE) with the mean age of 59.1 ± 16.5 years, 40 patients of them (62.5%) were male. All patients were subjected to 12 leads ECG. X-ray chest, laboratory tests including D-Dimer, troponin I, NT-pro BNP, Doppler ultrasound for the venous system of both lower limbs, Echocardiograhy and 64 multislices CT pulmonary angiography. Results: According to the admission level of NT-pro BNP our patients were divided into two groups: group I included 22 patients with normal NT-pro BNP (less than 300 pg/ml), and group II included 42 patients with elevated NT-pro BNP (more than or equal 300 pg/ml). Patients in group II were found to have a significantly higher incidence of heart failure (28.6% Vs 4.6%, p = 0.025), impaired kidney function (serum creatinine was 1.7 ± 0.6 Vs 1.1 ± 0.2, p = 0.018), tachypnea (85.7% Vs 54.5%, p = 0.006) and cardiogenic shock (26.2% Vs 0%, p = 0.014) but a significantly lower incidence of chest pain (21.4% Vs 45.5%, p = 0.04) and lower left ventricular ejection fraction (51.3% ± 16.9% Vs 67.3% ± 12.8%, p = 0.043) compared to group I. There were a significantly higher treatment with thrombolytic therapy (35.7% Vs 9.1%, p=0.021) and positive inotropics (35.71% Vs 4.55%, p = 0.006) in group II compared to group I. Also group II had a higher need for mechanical ventilation (26.12% Vs 4.55%, p = 0.04) and a longer in hospital stay (19.5 ± 10.3 Vs 5.3 ± 4.5, p = 0.001) than group I. The in hospital mortality was significantly higher in group II compared to group I (19.05% Vs 0.0%, p = 0.042). Conclusion: Elevated NT-pro BNP levels in patients with (PE) are associated with worse short term prognosis in terms of higher morbidity and mortality and it could be used as a valuable prognostic parameter and good indicator for the need of more aggressive therapy. 展开更多
关键词 PULMONARY EMBOLISM N-TERMINAL pro-brain natriuretic peptide
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BUN/Cr、cTnⅠ、NT-proBNP在不同严重程度的急性左心衰竭患者中的诊断价值
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作者 李娜 曹若雪 姚丽 《中国医学创新》 CAS 2025年第1期153-157,共5页
目的:评估血尿素氮/肌酐比(blood urea nitrogen/creatinine ratio,BUN/Cr)、心肌肌钙蛋白Ⅰ(cardiac troponinⅠ,cTnⅠ)和N末端B型利钠肽原(NT-proBNP)在诊断急性左心衰竭患者的严重程度方面的有效性。方法:选取连云港市第二人民医院... 目的:评估血尿素氮/肌酐比(blood urea nitrogen/creatinine ratio,BUN/Cr)、心肌肌钙蛋白Ⅰ(cardiac troponinⅠ,cTnⅠ)和N末端B型利钠肽原(NT-proBNP)在诊断急性左心衰竭患者的严重程度方面的有效性。方法:选取连云港市第二人民医院检验科2023年1月—2024年2月接收的122份急性左心衰竭患者的血清样本作为研究样本,根据急性生理学及慢性健康状况评分Ⅱ(APACHEⅡ)将患者分为轻症组(APACHEⅡ评分≤20分,45例)、重症组(APACHEⅡ评分21~30分,42例)及极重症组(APACHEⅡ评分≥31分,35例)。比较三组患者的血清BUN/Cr、cTnⅠ及NT-proBNP水平,采用Spearman分析评估血清BUN/Cr、cTnⅠ及NT-proBNP水平与急性左心衰竭患者严重程度的相关性,并构建受试者操作特征(ROC)曲线分析血清BUN/Cr、cTnⅠ及NT-proBNP水平对极重症急性左心衰竭患者的诊断价值。结果:极重症组的血清BUN/Cr、cTnⅠ及NT-proBNP水平均高于重症组、轻症组,且重症组均高于轻症组,差异均有统计学意义(P<0.05);相关性分析结果显示,血清BUN/Cr、cTnⅠ及NT-proBNP水平与急性左心衰竭患者的严重程度呈正相关(P<0.05);ROC曲线分析结果显示,血清BUN/Cr、cTnⅠ及NT-proBNP联合检测的敏感度、特异度分别为94.3%、90.8%,ROC曲线下面积(AUC)为0.969,优于单独检测。结论:在急性左心衰竭患者中,血清BUN/Cr、cTnⅠ及NT-proBNP的水平与疾病严重程度相关,联合检测可以有效诊断急性左心衰竭患者的疾病严重程度,具有较高的敏感度和特异度。 展开更多
关键词 尿素氮 肌酐 心肌肌钙蛋白Ⅰ N末端B型利钠肽原 急性左心衰竭
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Value of Combining Left Atrial Diameter and Amino-terminal Pro-brain Natriuretic Peptide to the CHA2DS2-VASc Score for Predicting Stroke and Death in Patients with Sick Sinus Syndrome after Pacemaker Implantation 被引量:3
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作者 Bin-Feng Mo Qiu-Fen Lu +3 位作者 Shang-Biao Lu Yu-Quan Xie Xiang-Fei Feng Yi-Gang Li 《Chinese Medical Journal》 SCIE CAS CSCD 2017年第16期1902-1908,共7页
Background: The CHA2DS2-VASc score is used clinically for stroke risk stratification in patients with atrial fibrillation (AF). We sought to investigate whether the CHA2DS2-VASc score predicts stroke and death in C... Background: The CHA2DS2-VASc score is used clinically for stroke risk stratification in patients with atrial fibrillation (AF). We sought to investigate whether the CHA2DS2-VASc score predicts stroke and death in Chinese patients with sick sinus syndrome (SSS) after pacemaker implantation and to evaluate whether the predictive power of the CHA2DS2-VASc score could be improved by combining it with left atrial diameter (LAD) and amino-terminal pro-brain natriuretic peptide (NT-proBNP). Methods: A total of 481 consecutive patients with SSS who underwent pacemaker implantation from January 2004 to December 2014 in our department were included. The CHA2DS2-VASc scores were retrospectively calculated according to the hospital medical records before pacemaker implantation. The outcome data (stroke and death) were collected by pacemaker follow-up visits and telephonic follow-up until December 3 l, 2015. Results: During 2151 person-years of follow-up, 46 patients (9.6%) suffered stroke and 52 (10.8%) died. The CHA2DS2-VASc score showed a significant association with the development of stroke (hazard ratio [HR] 1.45, 95% confidence interval [CI] 1.20-1.75, P 〈 0.00 1) and death (HR 1.45, 95% CI 1.22-1.71, P 〈 0.001). The combination of increased LAD and the CHA2DS2-VASc score improved the predictive power for stroke (C-stat 0.69, 95% CI 0.61-4).77 vs. C-stat 0.66, 95% CI 0.57-0.74, P = 0.013), and the combination of increased NT-proBNP and the CHA2DS2-VASc score improved the predictive power for death (C-stat 0.70, 95% CI 0.64-0.77 vs. C-stat 0.67, 95% CI 0.60--0.75, P= 0.023). Conclusions: CHA2DS2-VASc score is valuable for predicting stroke and death risk in patients with SSS after pacemaker implantation. The addition of LAD and NT-proBNP to the CHA2DS2-VASc score improved its predictive power for stroke and death, respectively, in this patient cohort. Future prospective studies are warranted to validate the benefit of adding LAD and NT-proBNP to the CHA2DS2-VASc score for predicting stroke and death risk in non-AF populations. 展开更多
关键词 amino-terminal pro-brain natriuretic peptide CHA2DS2-VASc Score Left Atrial Diameter Risk Stratification SickSinus Syndrome
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血清NT-pro-BNP、IGFBP-7和CTRP12在慢性心力衰竭患者中的水平及意义
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作者 张媛媛 赵志杰 +2 位作者 刘青 李鹏飞 苑文娟 《检验医学与临床》 2025年第1期107-111,118,共6页
目的 探讨血清N末端脑钠肽前体(NT-pro-BNP)、胰岛素样生长因子结合蛋白-7(IGFBP-7)和C1q肿瘤坏死因子相关蛋白12(CTRP12)水平在慢性心力衰竭(CHF)患者中的水平及意义。方法 选择2019年10月至2021年3月在该院进行治疗的116例CHF患者作为... 目的 探讨血清N末端脑钠肽前体(NT-pro-BNP)、胰岛素样生长因子结合蛋白-7(IGFBP-7)和C1q肿瘤坏死因子相关蛋白12(CTRP12)水平在慢性心力衰竭(CHF)患者中的水平及意义。方法 选择2019年10月至2021年3月在该院进行治疗的116例CHF患者作为CHF组,患者按美国纽约心脏病协会(NYHA)心功能分级分为Ⅱ级(47例)、Ⅲ级(41例)、Ⅳ级(28例)。选择同期在该院体检的64例体检健康者作为对照组。检测CHF组和对照组左室舒张末期内径(LVEDD)、左室射血分数(LVEF)及血清NT-pro-BNP、IGFBP-7、CTRP12水平并进行比较分析。根据CHF患者出院后1年内主要心血管不良事件(MACE)发生情况分为MACE组、非MACE组,比较分析MACE组和非MACE组患者临床资料,采用多因素Logistic回归分析CHF患者发生MACE的影响因素,绘制受试者工作特征(ROC)曲线分析血清NT-pro-BNP、IGFBP-7、CTRP12对预测CHF患者发生MACE的效能。结果 与对照组比较,CHF组患者LVEF及血清CTRP12水平均降低,LVEDD增大,血清NT-pro-BNP、IGFBP-7、Hcy、hs-CRP水平均升高,差异均有统计学意义(P<0.05)。在不同分级CHF患者中,血清NT-pro-BNP、IGFBP-7、Hcy、hs-CRP水平及LVEDD均为Ⅱ级患者<Ⅲ级患者<Ⅳ级患者,血清CTRP12水平及LVEF均为Ⅱ级患者>Ⅲ级患者>Ⅳ级患者,且任意两个级别间比较,差异均有统计学意义(P<0.05)。与非MACE组相比,MACE组LVEF和血清CTRP12水平均降低,LVEDD增大,血清Hcy、hs-CRP、NT-pro-BNP和IGFBP-7水平升高,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,血清NT-pro-BNP、IGFBP-7和CTRP12水平均为CHF患者发生MACE的影响因素(P<0.05)。ROC曲线分析结果显示,血清NT-pro-BNP、IGFBP-7、CTRP12单项及3项联合预测CHF患者发生MACE的曲线下面积(AUC)分别为0.862(95%CI:0.786~0.919)、0.805(95%CI:0.721~0.872)、0.860(95%CI:0.784~0.918)和0.961(95%CI:0.908~0.988)。3项联合预测的AUC明显大于NT-pro-BNP、IGFBP-7、CTRP12单独预测的AUC(Z=3.050、3.883、3.218,均P<0.05)。结论 CHF患者血清NT-pro-BNP、IGFBP-7水平升高,CTRP12水平降低,且NT-pro-BNP、IGFBP-7、CTRP12水平随心功能分级变化而变化,3项联合检测对预测CHF患者发生MACE具有更好的效能。 展开更多
关键词 慢性心力衰竭 N末端脑钠肽前体 胰岛素样生长因子结合蛋白-7 C1q肿瘤坏死因子相关蛋白12 主要心血管不良事件
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H-FABP、NT-proBNP与急性心力衰竭患者容量负荷状态及预后的相关性 被引量:1
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作者 张晓丽 张海柱 +2 位作者 可海霞 王永革 魏华 《河南医学研究》 CAS 2024年第10期1834-1837,共4页
目的 研究心型脂肪酸结合蛋白(H-FABP)、氨基端脑钠肽前体(NT-proBNP)对急性心力衰竭患者容量负荷状态及预后的评估。方法 本研究为前瞻性研究,以2021年1月至2022年1月于安阳市人民医院急诊住院的老年急性心力衰竭患者83例作为研究组,... 目的 研究心型脂肪酸结合蛋白(H-FABP)、氨基端脑钠肽前体(NT-proBNP)对急性心力衰竭患者容量负荷状态及预后的评估。方法 本研究为前瞻性研究,以2021年1月至2022年1月于安阳市人民医院急诊住院的老年急性心力衰竭患者83例作为研究组,另选取83例健康者作为对照组。根据相对容量平衡水平,将以上83例患者分为容量超负荷组和非容量超负荷组,对所有出院患者随访3个月,将发生死亡的患者归为死亡组,其余为生存组。比较研究组与对照组不同容量负荷、不同预后的H-FABP、NT-proBNP水平之间的差异,研究H-FABP、NT-proBNP与生存状况以及容量负荷状态的相关性。结果 研究组患者的H-FABP、NT-proBNP水平高于对照组(P<0.001);容量超负荷组患者的H-FABP、NT-proBNP水平高于非容量超负荷组(P<0.05);死亡组患者的H-FABP、NT-proBNP水平高于生存组(P<0.05)。通过相关性分析,患者的死亡以及容量超负荷与H-FABP、NT-proBNP呈现正相关(P<0.001)。结论 H-FABP、NT-proBNP与急性心力衰竭患者容量负荷状态及预后呈现相关性,有助于评估急性心力衰竭的严重程度,对预后不良患者起到积极的指导治疗作用。 展开更多
关键词 心型脂肪酸结合蛋白 容量负荷状态 急性心力衰竭 预后 氨基端脑钠肽前体
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NT-pro BNP、Hcy及Apo-A与急性心肌梗死患者心力衰竭程度及预后的相关性 被引量:2
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作者 王璐 金烨 陈奕纬 《中国医药导刊》 2024年第4期401-406,共6页
目的:探究N-末端脑钠肽前体(NT-pro BNP)、同型半胱氨酸(Hcy)及载脂蛋白A(Apo-A)与急性心肌梗死(AMI)患者心力衰竭(HF)程度及预后的相关性。方法:选择我院2021年1月至2023年12月收治的100例AMI患者作为研究对象,按有无合并HF设为HF组(n=... 目的:探究N-末端脑钠肽前体(NT-pro BNP)、同型半胱氨酸(Hcy)及载脂蛋白A(Apo-A)与急性心肌梗死(AMI)患者心力衰竭(HF)程度及预后的相关性。方法:选择我院2021年1月至2023年12月收治的100例AMI患者作为研究对象,按有无合并HF设为HF组(n=44)与非HF组(n=56)。检测全部患者血清NT-pro BNP、Hcy及Apo-A水平,以Killip分级评估HF组患者HF程度,将HF组患者按预后情况分为预后良好组(n=24)与预后不良组(n=20)。采用单因素及多因素分析影响AMI患者预后不良的因素,并采用受试者工作曲线(ROC)分析血清NT-pro BNP、Hcy及Apo-A水平预测AMI合并HF患者预后的价值。结果:HF组患者血清NT-pro BNP、Hcy及Apo-A水平高于非HF组(P<0.05)。HFⅣ级组患者血清NT-pro BNP、Hcy及Apo-A水平高于Ⅲ级组、Ⅱ级组,且Ⅲ级组高于Ⅱ级组(P<0.05)。经Spearson相关性分析显示,血清NT-pro BNP、Hcy及Apo-A水平与HF程度均呈正相关(r=0.612、0.505、0.649,P<0.05)。预后良好组与预后不良组患者年龄、高脂血症史、心界扩大、NT-pro BNP、Hcy及Apo-A水平比较,差异有统计学意义(P<0.05)。Logistic回归分析显示,年龄、NT-pro BNP、Hcy及Apo-A为AMI合并HF患者预后的影响因素(P<0.05)。血清NT-pro BNP水平预测水平AMI合并HF患者预后的AUC为0.769(0.617~0.882),灵敏度75.00%,特异度79.17%(P<0.05);血清Hcy水平预测AMI合并HF患者预后的AUC为0.833(0.690~0.928),灵敏度95.00%,特异度58.33%(P<0.05);血清Apo-A水平预测AMI合并HF患者预后的AUC为0.877(0.743~0.957),灵敏度85.00%,特异度91.67%(P<0.05)。结论:血清NT-pro BNP、Hcy及Apo-A水平随AMI患者HF级别递增而上升,且与患者预后密切相关,具有较高预测价值。 展开更多
关键词 急性心肌梗死 心力衰竭 N-末端脑钠肽前体 同型半胱氨酸 载脂蛋白A
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冻干重组人脑利钠肽对缺血性心肌病心力衰竭患者NT⁃proBNP、AngⅡ、NE水平、心室重构和炎症因子的影响
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作者 朱慧 彭杰成 马成亮 《分子诊断与治疗杂志》 2024年第8期1433-1436,共4页
目的探讨缺血性心肌病(ICM)心力衰竭(HF)患者应用冻干重组人脑利钠肽治疗对N末端脑钠肽前体(NT⁃proBNP)、血管紧张素Ⅱ(AngⅡ)、去甲肾上腺素(NE)水平、心室重构和炎症因子的影响。方法于2020年10月至2023年2月从宿松县人民医院选择86例... 目的探讨缺血性心肌病(ICM)心力衰竭(HF)患者应用冻干重组人脑利钠肽治疗对N末端脑钠肽前体(NT⁃proBNP)、血管紧张素Ⅱ(AngⅡ)、去甲肾上腺素(NE)水平、心室重构和炎症因子的影响。方法于2020年10月至2023年2月从宿松县人民医院选择86例ICM HF患者分为对照组和试验组,均43例,以随机数字表法分组。对照组和试验组分别予以常规治疗和冻干重组人脑利钠肽联合常规治疗,均治疗2周。比较两组疗效(治疗2周后)、血清NT⁃proBNP、AngⅡ、NE、心室重构指标和炎症因子水平(治疗前和治疗2周后)。结果治疗2周后,较对照组(74.42%),试验组总有效率(93.02%)更高,差异有统计学意义(χ^(2)=5.460,P<0.05)。两组治疗2周后的血清NT⁃proBNP、AngⅡ、NE、TNF⁃α、IL⁃6、IL⁃8和LVTWP、PWS、IVSS较治疗前降低,试验组更低,差异有统计学意义(t=5.672、20.016、55.416、6.742、5.851、5.258、5.940、6.681、5.865,P<0.05)。结论ICM HF患者应用冻干重组人脑利钠肽治疗可降低血清NT⁃proBNP、AngⅡ、NE水平,改善神经分泌功能,同时可抑制心室重构及机体炎症,疗效显著。 展开更多
关键词 缺血性心肌病 心力衰竭 重组人脑利钠肽 N末端脑钠肽前体 血管紧张素Ⅱ 去甲肾上腺素 心室重构
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血清D-二聚体与纤维蛋白原比值联合血清NT-proBNP水平对急性肺栓塞患者预后的预测价值
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作者 麻利娟 马婕 张海燕 《临床和实验医学杂志》 2024年第13期1381-1385,共5页
目的探讨血清D-二聚体/纤维蛋白原比值(DFR)联合N末端脑钠肽前体(NT-proBNP)对急性肺栓塞患者预后的预测价值。方法采用回顾性研究,将2019年1月至2022年12月河北北方学院附属第一医院收治的急性肺栓塞患者作为研究对象。共入组108例患者... 目的探讨血清D-二聚体/纤维蛋白原比值(DFR)联合N末端脑钠肽前体(NT-proBNP)对急性肺栓塞患者预后的预测价值。方法采用回顾性研究,将2019年1月至2022年12月河北北方学院附属第一医院收治的急性肺栓塞患者作为研究对象。共入组108例患者,按30 d预后情况将其分为死亡组(n=29)与存活组(n=79)。比较两组血清D-二聚体、纤维蛋白原、DFR、NT-proBNP水平等临床资料差异;采用多因素Logistic回归分析影响急性肺栓塞患者预后的因素;采用受试者操作特征(ROC)曲线评定血清DFR、NT-proBNP水平对急性肺栓塞患者预后的价值。结果死亡组年龄为(72.87±11.25)岁,大于存活组[(66.47±12.46)岁],差异有统计学意义(P<0.05),两组其他一般资料比较,差异均无统计学意义(P>0.05)。死亡组的血清hs-CRP、D-二聚体、纤维蛋白原、DFR及NT-proBNP水平分别为(4.51±1.36)mg/L、(1.05±0.29)mg/L、(5.14±1.21)g/L、0.25±0.08、(2084.51±619.74)ng/L,均高于存活组[(3.84±1.21)mg/L、(0.81±0.22)mg/L、(4.54±0.78)g/L、0.18±0.05、(1547.46±413.69)ng/L],差异均有统计学意义(P<0.05);两组白细胞、中性粒细胞等比较,差异均无统计学意义(P>0.05)。Logistic回归分析,得出年龄较大、较高DFR及NT-proBNP水平是急性肺栓塞患者30 d死亡的危险因素(OR=2.389,95%CI:1.194~4.782;OR=1.906,95%CI:1.236~2.939;OR=1.610,95%CI:1.129~2.295;P<0.05)。ROC曲线分析得出,血清DFR、NT-proBNP均对急性肺栓塞患者30 d死亡有一定预测能力,其AUC分别为0.828、0.763,二者联合的AUC达到0.907。结论血清DFR、NT-proBNP水平与急性肺栓塞患者30 d预后相关,均可作为患者30 d死亡的预测标志物。 展开更多
关键词 急性肺栓塞 D-二聚体 纤维蛋白原 N末端脑钠肽前体 预后
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慢性心力衰竭患者白蛋白降低与NT-proBNP升高和长期预后不良的相关性分析
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作者 孙明 胡贤军 韩永生 《中国循证心血管医学杂志》 2024年第12期1546-1549,共4页
目的分析慢性心力衰竭(CHF)患者白蛋白降低与N末端脑钠肽前体(NT-proBNP)升高和长期预后不良的相关性。方法选取2020年3月至2022年3月于安徽医科大学心血管内科及全科医学科CHF住院患者176例,根据白蛋白中位数分为高白蛋白组96例和低白... 目的分析慢性心力衰竭(CHF)患者白蛋白降低与N末端脑钠肽前体(NT-proBNP)升高和长期预后不良的相关性。方法选取2020年3月至2022年3月于安徽医科大学心血管内科及全科医学科CHF住院患者176例,根据白蛋白中位数分为高白蛋白组96例和低白蛋白组80例,比较两组患者的临床资料,Spearman分析白蛋白和NT-proBNP的相关性,计算2年内全因再住院和全因死亡率的累计发生率和发病密度,Cox分析白蛋白对2年内全因再住院和全因死亡率的影响。结果患者白蛋白中位数为37.16 g/L,高白蛋白组体质指数(BMI)和白蛋白水平高于低白蛋白组,NT-proBNP水平低于低白蛋白组,白蛋白与NT-proBNP-log10转换呈负相关(r=-0.217,P<0.001)。低白蛋白组全因死亡和全因再住院的发病密度和累计发病率均高于高白蛋白组。白蛋白降低是CHF患者全因再住院和全因死亡率增加的相关因素,且不受性别、心功能、NT-proBNP和β受体阻滞剂的影响。结论CHF患者白蛋白降低与NT-proBNP升高和长期预后不良有关,临床需对CHF患者的营养状况给予足够的关注。 展开更多
关键词 慢性心力衰竭 白蛋白 NT-proBNP 全因再住院 全因死亡率
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LDH、NT-proBNP、ALB水平对不完全性川崎病的早期诊断价值
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作者 李喆 彭博 +1 位作者 王艳梅 王文君 《中国医学创新》 CAS 2024年第23期135-139,共5页
目的:探讨乳酸脱氢酶(LDH)、N末端脑钠肽前体(NT-proBNP)、白蛋白(ALB)水平对不完全性川崎病(IKD)的早期诊断价值。方法:选取巴彦淖尔市医院2020年1月—2023年1月收治的80例IKD患儿作为IKD组,选取本院同期收治的80例典型川崎病(KD)患儿... 目的:探讨乳酸脱氢酶(LDH)、N末端脑钠肽前体(NT-proBNP)、白蛋白(ALB)水平对不完全性川崎病(IKD)的早期诊断价值。方法:选取巴彦淖尔市医院2020年1月—2023年1月收治的80例IKD患儿作为IKD组,选取本院同期收治的80例典型川崎病(KD)患儿作为KD组。所有患儿入院后检测LDH、NT-proBNP、ALB水平,对比IKD组与KD组一般情况和LDH、NT-proBNP、ALB水平。通过受试者操作特征(ROC)曲线分析LDH、NT-proBNP、ALB水平对IKD的早期诊断价值。同时将80例IKD患儿依照冠脉损伤情况分为两个亚组,即无损伤组(n=30)和损伤组(n=50),对比两组LDH、NT-proBNP、ALB水平。结果:IKD组和KD组性别、年龄及高热、多形性皮疹、口腔黏膜变化占比对比,差异均无统计学意义(P>0.05);IKD组发热时间长于KD组,指端改变、结膜充血、颈部淋巴结肿大占比低于KD组,差异均有统计学意义(P<0.05);IKD组LDH、NT-proBNP、ALB水平均明显高于KD组,差异均有统计学意义(P<0.05);LDH、NT-proBNP、ALB三者联合对IKD的诊断效能优于单一检测;损伤组LDH、NT-proBNP、ALB水平均明显高于无损伤组,差异均有统计学意义(P<0.05)。结论:LDH、NT-proBNP、ALB水平对IKD的早期诊断价值较高,且临床可考虑通过LDH、NT-proBNP、ALB三者联合来诊断IKD。 展开更多
关键词 乳酸脱氢酶 N末端脑利钠肽前体 白蛋白 不完全性川崎病 早期诊断 冠脉损伤
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Association of N-terminal pro-brain natriuretic peptide with the severity of coronary artery disease in patients with normal left ventricular ejection fraction 被引量:23
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作者 Wu NQ Guo YL +10 位作者 Li XL Liu J Qing P Xu RX Zhu CG Jia Y J Liu G Dong Q Jiang LX Li J J Ma FL 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第4期627-632,共6页
Backround N-terminal pro-brain natriuretic peptide (NT-proBNP) is a reliable predictor in acute coronary artery disease (CAD). Little is known about patients with stable CAD, especially Chinese patients with CAD. ... Backround N-terminal pro-brain natriuretic peptide (NT-proBNP) is a reliable predictor in acute coronary artery disease (CAD). Little is known about patients with stable CAD, especially Chinese patients with CAD. The aim of the present study was to investigate the association of NT-proBNP levels with the severity of CAD in patients with normal left ventricular ejection fraction. Methods A total of 658 consecutive patients were divided into two groups based on angiograms: CAD group (n=484) and angiographic normal control group (n=174). The severity of CAD was evaluated by modified Gensini score, and its relationship with NT-proBNP was analyzed. Results The prevalence of risk factors such as age, male gender, diabetes mellitus (DM), dyslipidemia, smoking, and family history of CAD in the CAD group were higher than that in the control group. In multivariate regression model analysis, age, gender, and DM were determinants of the presence of CAD. NT-pro BNP was found to be an independent predictor for CAD (OR:1.66 (95% CI: 1.06-2.61), P 〈0.05). In a receiver operating characteristic (ROC)curve analysis, an NT-proBNP value of 641.15 pmol/L was identified as a cut-off value in the diagnosis or exclusion of CAD (area under curve (AUC)=0.56, 95% CI: 0.51-0.61). Furthermore, NT-proBNP was positively correlated with Gensini score (r=0.14, P 〈0.001) in patients with CAD. Conclusion NT-proBNP was an independent predictor for Chinese patients with CAD, suggesting that the NT-proBNP level might be associated with the presence and the severity of CAD. 展开更多
关键词 N-terminal pro-brain natriuretic peptide coronary artery disease risk factors modified Gensini score
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开窍活血汤联合阿替普酶对急性脑梗死患者认知功能及血清NT-proBNP和sICAM-1的影响 被引量:5
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作者 朱智恒 罗凯 +2 位作者 刘用 王璐 李春辉 《中国药业》 CAS 2024年第5期54-58,共5页
目的探讨开窍活血汤联合阿替普酶(rt-PA)对急性脑梗死(ACI)患者认知功能及血清N-末端B型脑钠肽前体(NT-proBNP)、可溶性细胞间黏附分子-1(sICAM-1)水平的影响。方法选取湖南中医药大学第一附属医院2022年1月至12月收治的ACI患者100例,... 目的探讨开窍活血汤联合阿替普酶(rt-PA)对急性脑梗死(ACI)患者认知功能及血清N-末端B型脑钠肽前体(NT-proBNP)、可溶性细胞间黏附分子-1(sICAM-1)水平的影响。方法选取湖南中医药大学第一附属医院2022年1月至12月收治的ACI患者100例,按随机数字表法分为观察组和对照组,各50例。两组患者均予rt-PA溶栓治疗联合常规治疗,观察组患者加用开窍活血汤,两组患者均治疗2周。结果观察组总有效率为96.00%,显著高于对照组的82.00%(P<0.05)。治疗后,两组患者的口舌歪斜、半身不遂、言语謇涩、面色皎白、舌质暗淡、脉沉细等中医证候积分均显著降低,且观察组显著低于对照组(P<0.05);两组患者美国国立卫生研究院卒中量表(NIHSS)评分显著降低,简易智能精神状态评估量表(MMSE)评分显著升高,且观察组显著优于对照组(P<0.05);两组患者NT-proBNP和sICAM-1水平均显著降低(P<0.05),且观察组显著低于对照组(P<0.05)。观察组患者治疗期间不良反应发生率为6.00%,显著低于对照组的20.00%(P<0.05)。结论开窍活血汤联合rt-PA治疗ACI的临床疗效显著,可有效缓解患者的临床症状和体征,改善其神经功能及认知功能,降低血清NT-proBNP和sICAM-1水平,且安全性良好。 展开更多
关键词 开窍活血汤 阿替普酶 急性脑梗死 N-末端B型脑钠肽前体 可溶性细胞间黏附分子-1
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Predictive value of N-terminal pro-brain natriuretic peptide in combination with the sequential organ failure assessment score in sepsis 被引量:11
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作者 JU Min-jie ZHU Du-ming +4 位作者 TU Guo-wei HE Yi-zhou XUE Zhang-gang LUO Zhe WU Zhao-guang 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第11期1893-1898,共6页
Background The prognostic power of n-terminal pro-brain natriuretic peptide (NT-proBNP) in sepsis is disputable and unstable among different models. We attempt to evaluate the prognostic potential of NT-proBNP in co... Background The prognostic power of n-terminal pro-brain natriuretic peptide (NT-proBNP) in sepsis is disputable and unstable among different models. We attempt to evaluate the prognostic potential of NT-proBNP in combination with the sequential organ failure assessment (SOFA) score in sepsis. Methods In this retrospective study, 100 consecutive sepsis patients were enrolled. Clinical data such as admission SOFA, the Acute Physiologic and Chronic Health Evaluation score, shock prevalence, use of lung protective ventilation, vasopressors, and glucocorticoids were recorded. Additionally, serum creatinine (Scrl and Scr3) and NT-proBNP (NT-proBNP1 and NT-proBNP3) were assayed and evaluated at admission and on day 3 respectively. Results ANT-proBNP (NT-proBNP3 minus NT-proBNP1) (P 〈0.001, Hazard ratio (HR)=1.245, 95% confidence interval (CI), 1.137-1.362) and admission SOFA (P 〈0.001, HR=1.197, 95% CI, 1.106-1.295) were independently related to in-hospital mortality. Their combination was a more robust predictor for in-hospital mortality than either of them individually. Patients with high ANT-proBNP and SOFA had the poorest prognosis. Conclusions In our study, both ANT-proBNP and SOFA were independent predictors of septic patients' prognosis. Moreover, the combination of ,~NT-proBNP and admission SOFA provided a novel strategy that contained information regarding both the response to treatment and sepsis severity. 展开更多
关键词 SEPSIS proGNOSIS N-terminal pro-brain natriuretic peptide sequential organ failure assessment score COMBINATION
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Association between plasma brain natriuretic peptide/N-terminal pro-brain natriuretic peptide levels and atrial fibrillation: evidence from a meta-analysis 被引量:4
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作者 Liu Yaowu Xiao Yunyun +1 位作者 Chen Xinguang Zhang Fengxiang 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第15期2824-2828,共5页
Background Several small sample-size observational studies evaluated the association of plasma brain natriuretic peptide (BNP) or N-terminal pro-brain natriuretic peptide (NT-proBNP) with atrial fibrillation (AF... Background Several small sample-size observational studies evaluated the association of plasma brain natriuretic peptide (BNP) or N-terminal pro-brain natriuretic peptide (NT-proBNP) with atrial fibrillation (AF),but the results were contradictory.We aimed to perform a meta-analysis of relevant studies to evaluate the availability of this association.Methods We performed an extensive literature search on PubMed,Web of Science (WOS) and the Cochrane Library databases.Pooled standardized mean difference (SMD) and 95% confidence interval (CI) were calculated to assess the strength of association using random effects models.We performed sensitivity and subgroup analyses to explore the potential sources of heterogeneity.We also estimated publication biases.Statistical analyses were performed using the STATA 12.0 software.Results A total of 11 studies including 777 cases and 870 controls were finally analyzed.Overall,the brain natriuretic peptide/N-terminal pro-brain natriuretic peptide levels were higher in atrial fibrillation patients than controls without atrial fibrillation.Results showed that the SMD in the natriuretic peptide levels between cases and controls was 2.68 units (95%CI 1.76 to 3.60); test for overall effect z-score=5.7 (P 〈0.001).There was significant heterogeneity between individual studies (I2=97.8%; P 〈0.001).Further analysis revealed that differences in the assay of natriuretic peptide possibly account for this heterogeneity.Conclusions Increased BNP/NT-proBNP levels were associated with the presence of atrial fibrillation.This finding indicates that BNP/NT-proBNP may prove to be a biomarker of an underlying predisposition to AF. 展开更多
关键词 atrial fibrillation brain natriuretic peptide N-terminal pro-brain natriuretic peptide META-ANALYSIS
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Association between high-sensitivity cardiac troponin T and N-terminal pro-brain natriuretic peptide in a community based population 被引量:2
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作者 Xu RY Ye P +6 位作者 Luo LM Sheng L Wu HM Xiao WK Zheng J Wang F Xiao TH 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第4期638-644,共7页
Background N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) are excellent biomarkers for detecting heart failure and subclinical myocardial injury.However,it ... Background N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) are excellent biomarkers for detecting heart failure and subclinical myocardial injury.However,it remains unclear whether subclinical myocardial injury is associated with NT-proBNP elevation in a community based population.Methods In a community based study,levels of hs-cTnT and of NT-proBNP were determined in 1 497 participants older than 45 years.The lower detection limit of the hs-cTnT assay used in the present study was 0.003 ng/ml.The association of hs-cTnT levels and NT-proBNP levels was analyzed.Results When the subjects with undetectable (〈0.003 ng/ml),intermediate (0.003-0.014 ng/ml),and elevated (≥0.014 ng/ml) levels of hs-cTnT were compared (r=0.175,P 〈0.001),a strong association between the hs-cTnT levels and NT-proBNP levels was observed (β=-0.206,P 〈0.001; β=-0.118,P 〈0.001,respectively).In multivariable analyses,older age and hs-cTnT were positively and independently associated with NT-proBNP levels (β=0.341,P 〈0.001; β=0.143,P 〈0.001,respectively),and male gender and the levels of eGFR were inversely and independently associated with NT-proBNP levels.When the subjects with normal or elevated NT-proBNP were analyzed separately,the hs-cTnT level was not an independent predictor for the NT-proBNP level in the normal NT-proBNP group,whereas the hs-cTnT level was the only independent predictor for NT-proBNP level in the elevated NT-proBNP group (β=0.399,P 〈0.01).Conclusions In this community based population,NT-proBNP elevation was common.In addition to female gender and older age,subclinical myocardial injury indicated by the hs-cTnT level was another important factor in NT-proBNP elevation. 展开更多
关键词 N-terminal pro-brain natriuretic peptide cardiac troponin T myocardial injury
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脓毒症中医证型分布、死亡因素分析及AT-Ⅲ联合NT-proBNP、SOFA评分对预后的评估价值 被引量:1
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作者 叶森青 苏懿 +2 位作者 张云海 马明远 张斌 《新中医》 CAS 2024年第7期86-91,共6页
目的:探讨脓毒症中医证型分布规律及影响脓毒症患者预后的因素,并分析抗凝血酶原-Ⅲ(AT-Ⅲ)、N-末端脑钠肽前体(NT-proBNP)及序贯性器官衰竭(SOFA)评分对脓毒症患者预后的评估价值。方法:选取148例脓毒症患者作为研究对象,总结中医证型... 目的:探讨脓毒症中医证型分布规律及影响脓毒症患者预后的因素,并分析抗凝血酶原-Ⅲ(AT-Ⅲ)、N-末端脑钠肽前体(NT-proBNP)及序贯性器官衰竭(SOFA)评分对脓毒症患者预后的评估价值。方法:选取148例脓毒症患者作为研究对象,总结中医证型分布规律。根据预后情况分为存活组115例及死亡组33例。通过单因素及多因素逻辑(logistic)回归分析影响脓毒症患者预后的相关因素。绘制受试者工作特征(ROC)曲线评价AT-Ⅲ、NT-proBNP及SOFA评分对其预后的评估价值。结果:148例脓毒症患者的中医证型分布按频次从高到低排序依次为急性虚证64例(43.24%)、毒热证35例(23.65%)、血瘀证31例(20.95%)、腑气不通证18例(12.16%)。死亡组患者中急性虚证比例高于存活组(P<0.05)。急性虚证、AT-Ⅲ降低、NT-proBNP升高、SOFA评分、男性均为脓毒症患者死亡的危险因素(P<0.05)。AT-Ⅲ、NTproBNP、SOFA评分预测脓毒症患者死亡的ROC曲线下面积分别为0.676、0.715、0.724。当三者联合诊断时,ROC曲线下面积提高到0.8,敏感度高达90.9%。结论:脓毒症中医证型分布依次是急性虚证、毒热证、血瘀证和腑气不通证,急性虚证、AT-Ⅲ降低、NT-proBNP升高、SOFA评分、男性均为脓毒症患者死亡的危险因素。AT-Ⅲ联合NT-proBNP及SOFA评分可有效提升脓毒症患者死亡的早期预测准确性。 展开更多
关键词 脓毒症 中医证型 抗凝血酶原-Ⅲ N-末端脑钠肽前体 序贯性器官衰竭评分 预后
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心电图的碎裂QRS波联合血清pro-BNP对急性前壁心肌梗死患者心力衰竭的预测价值 被引量:1
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作者 何佩娟 武金盼 +1 位作者 胡娟娟 宋小青 《河北医学》 CAS 2024年第2期277-281,共5页
目的:探究心电图的碎裂QRS波(fQRS波)联合血清前体脑钠肽(pro-BNP)对急性前壁心肌梗死(AAMI)患者心力衰竭的预测价值。方法:选取2020年2月至2023年2月医院收治的145例AAMI患者作为研究对象,根据患者经皮冠状动脉介入术(PCI)术后3个月的... 目的:探究心电图的碎裂QRS波(fQRS波)联合血清前体脑钠肽(pro-BNP)对急性前壁心肌梗死(AAMI)患者心力衰竭的预测价值。方法:选取2020年2月至2023年2月医院收治的145例AAMI患者作为研究对象,根据患者经皮冠状动脉介入术(PCI)术后3个月的心力衰竭发生情况将患者分为两组,统计心力衰竭组与非心力衰竭组患者一般资料,两组均进行常规12导联心电图检查与血清pro-BNP水平检测,分别采用Logistic回归分析与受试者工作特征(ROC)曲线分析AAMI患者心力衰竭的影响因素与fQRS波、pro-BNP及两者联合对心力衰竭发生的预测价值。结果:145例患者中共76例(52.41%)患者发生心力衰竭,其余69例(47.59%)未发生心力衰竭;心力衰竭组血肌酐(Scr)水平、发病后治疗时间窗高于非心力衰竭组,术前病变支数多于非心力衰竭组(P<0.05);心力衰竭组存在心电图fQRS波的患者数多于非心力衰竭组,pro-BNP水平高于非心力衰竭组(P<0.05);心电图fQRS波、pro-BNP为AAMI患者心力衰竭的影响因素(P<0.05);心电图fQRS波、血清pro-BNP及联合对心力衰竭发生进行预测时,以pro-BNP的曲线下面积(AUC)值最高为0.800,敏感度、特异度分别为50.00%与85.65%,两者联合后敏感度显著升高,为84.21%,特异度为69.57%。结论:心电图QRS波、pro-BNP为AAMI患者合并心力衰竭的影响因素,且心电图QRS波、pro-BNP在AAMI患者心力衰竭中预测效能较高,两者联合可显著提升敏感度,预测价值更高,可作为辅助检测指标。 展开更多
关键词 急性前壁心肌梗死 心力衰竭 心电图 碎裂QRS波 前体脑钠肽 预测价值
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