Basal Serum Anti-Miillerian Hormone Level as a Predictor of Clinical Outcomes in Freezing-all Embryo Transfer Program

As a novel biomarker,there is inconsistent evidence regarding the association between anti-Miillerian hormone (AMH) and live birth rate in freezing-all embryo transfer cycles.We aim to assess the prognostic effect of baseline AMH on clinical outcomes,especially live birth rate in freezing-all embryo transfer cycles.A total of 828 non-polycystic ovary patients that underwent their first frozen-thawed embryo transfers in our center between January 2010 and January 2015 were recruited in this retrospective analysis.Patients were stratified into three groups based on their baseline AMH concentration:low AMH group (<1.4ng/mL),middle AMH group (1.4-5.8 ng/mL)and high AMH group (>5.8 ng/mL).The results showed that low AMH level was associated With adverse clinical outcomes.The differences in implantation rate (21.9% vs.43.2% vs.58.8%,P<0.001),clinical pregnancy rate (32.0% vs.55.2% vs.65.7%, P<0.001),live birth delivery rate (21.8% vs.43.6% vs.52.7%,P<0.001)and miscarriage rate (31.8% vs.17.5% vs.15.4%,P=0.014)among the three groups were statistically significant.After adjusting confounders (i.e.age,baseline FSH level,AFC,endometrium thickness,endometriurn preparation protocols,number of embryos transferred,etiologies of infertility),differences in live birth rate,clinical pregnancy rate and implantation rate between groups remained significant.The further age subgroup analysis demonstrated that low AMH concentration was significantly associated with poor outcomes both in young and advanced patients.The area under the curve for serum AMH,age,AFC and FSH were 0.635,0.634,0.615 and 0.543 respectively,for predicting live birth.In conclusion, baseline AMH was an independent prognostic factor of live birth rate of freezing-all embryo transfers,but its predictive value on live birth rate was of limited clinical value.

Post Thyroidectomy Assessment of Intact Parathyroid Hormone for Early Prediction of Hypocalcaemia

Background: As the half-life of intact parathyroid hormone (iPTH) is very low, it reflects parathyroid insufficiency within minutes to hours after total thyroidectomy. Therefore, iPTH level assessment in the postoperative period can be used to predict the development of hypocalcaemia. The optimal time point to measure serum iPTH is important for the accurate prediction of hypocalcaemia. Aim: This paper aims to evaluate the ability of iPTH as an early predictive marker of hypocalcaemia and determine which time iPTH is more able to predict postoperative hypocalcaemia. Method: This prospective observational study was conducted in the Department of Otolaryngology-Head & Neck Surgery, BSMMU, Dhaka, from July 2020 to December 2021, with 67 patients who underwent total thyroidectomy. iPTH levels were measured on the day before the operation and at 1 hour, 4 hours, and 24 hours after the operation. S.calcium levels were measured on the day before the operation and 1st postoperative day. All the data were compiled and sorted properly and were analyzed statistically. Results: Postoperative hypocalcaemia developed in 18 cases, with an incidence of 26.9%. Pearson correlation showed a significant correlation between postoperative iPTH at 1 hr, 4 h, and 24 hr with 1st postoperative calcium value. The Receiver operating characteristic (ROC) curve was processed for the postoperative iPTH at 1 hr, 4 h, and 24 hr. The sensitivity, specificity, cut-off value, and mean AUC found 93.9%, 94.4%, ≤14.0, 0.988;95.9%, 94.4%, ≤09.5, 0.993 and 91.8%, 94.4%, ≤11.0, 0.993 respectively. Conclusion: iPTH can be used as an early predictor of post-thy-roidectomy hypocalcaemia. 4 hr iPTH showed more sensitivity and specificity for a cut-off value near the laboratory reference range.

Correlation analysis of serum thyroglobulin,thyroid-stimulating hormone levels,and thyroid-cancer risk in thyroid nodule surgery

BACKGROUND Thyroglobulin(Tg)is one of the markers of thyroid cancer,and its concentration may be elevated in patients with malignant thyroid tumors.Thyroid-stimulating hormone(TSH)is secreted by the pituitary gland,which has a significant impact on thyroid gland function.Excessively high or low TSH levels may be associated with an increased risk of thyroid cancer.Thus,in-depth studies on the association of serum Tg and TSH levels with thyroid cancer risk in patients with thyroid nodules are warranted.This can help determine whether Tg and TSH levels can predict the degree of malignancy of thyroid nodules,which can in turn guide doctors in making accurate diagnoses and treatment decisions.Furthermore,such studies can provide more accurate diagnostic methods for thyroid nodules and help patients become aware of the presence of thyroid cancer as early as possible,thereby improving the success rate of treatment and prognosis.AIM To investigate the association of serum Tg and TSH levels with the risk of thyroid cancer in patients undergoing thyroid nodule surgery.METHODS The clinical data and laboratory examination results of 130 patients who underwent thyroid nodule surgery were retrospectively analyzed.Furthermore,their preoperative serum Tg and TSH levels were recorded.Histopathological examination conducted during follow-up revealed the presence of thyroid cancer.Correlation analysis were used to analyze the association of Tg and TSH levels with the risk of thyroid cancer.RESULTS Of the 130 patients,60 were diagnosed with thyroid cancer.Statistical analysis revealed a significant positive correlation between serum Tg levels and the risk of thyroid cancer(P<0.05).This suggests that high serum Tg levels are associated with an increased risk of thyroid cancer.However,no significant correlation was observed between serum TSH levels and the risk of thyroid cancer(P>0.05).CONCLUSION In patients who underwent thyroid nodule surgery,serum Tg levels exhibited a significant correlation with the risk of thyroid cancer but serum TSH levels did not.These findings suggest that serum Tg can serve as an important biomarker for assessing the risk of thyroid cancer in these patients.

The effects of consumption of raw garlic on serum lipid level, blood sugar and a number of effective hormones on lipid and sugar metabolism in hyperglycemic and/or hyperlipidemic individuals ——Benefit of raw garlic consumption

Diabetes mellitus is one of the worldwide largest growing metabolic diseases. In this study the effects of consumption of raw garlic on serum lipid level, blood sugar and a number of effective hormones on lipid and sugar metabolism (thyroid hormones and insulin) in individuals either with high level of blood sugar or lipid were investigated. Eighty five volunteers having following clinical history enrolled in the study: Group 1: having blood sugar more than 126 mg/dl (30 vo-lunteers);Group 2: having cholesterol higher than 245 mg/dl (30 volunteers);Group 3: having blood sugar over 126 mg/dl and cholesterol more than 245 mg/dl (25 volunteers). In group 1, there wasn’t a sig-nificant differences between biochemical factors be-fore and after garlic consumption, whereas, in the second group after 6 weeks of garlic consumption a decline in cholesterol (P < 0.001), FBS and TG (P < 0.01) was observed but HDL-C (P < 0.001) was in-creased. Six weeks after termination of garlic con-sumption, cholesterol (P < 0.001), FBS and TG (P < 0.05) were in- creased and HDL-C (P < 0.01) was de-creased. In the third group, total cholesterol (P < 0.001), FBS (P < 0.01) and HbA1c decreased while HDL-C was in- creased. Other factors, including thy-roid hormones (T3, T4), TSH and insulin showed no significant alte- ration. In conclusion our results shown that raw garlic consumption can reduce the FBS and Lipid in hyperglycemic and/or hyperlipidemic individuals.

Effect of daidzein on milk yield,components of milk and hormones in serum of dairy cows

Four Holstein dairy cows in the 7th month of late lactation were sampled, and self-control method was used. Daidzein was added to the concentrated feed at the dose of 10mg/kg during the treatment stage. Results showed that daidzein lessened the declining tendency of milk yield in late lactation and increased the milk yield to some extents. Lactoprotein was evidently increased (P<0.01), while milkfat was not affected evidently. The level of T4 in serum was evidently increased (P<0.05); the levels of GH, PRL, E2 and TSH in serum were prone to rising while T3 was prone to decreasing . It was concluded that daidzein could indirectly affect milk yield and components of milk by regulating the levels of intrinsic hormones.

Serum leptin level in Sudanese women with unexplained infertility and its relationship with some reproductive hormones

BACKGROUND The excessive concentration of leptin has negative effects on all aspects of female reproduction.Despite this established relationship,the exact role of leptin in women’s fertility is not clear enough and needs more clarification.AIM To evaluate the serum leptin levels in Sudanese women and to ascertain the relationship between serum leptin levels and unexplained infertility(UI).METHODS A matched(age and body mass index)case-control study was conducted from March 2021 to February 2022.The study samples were 210 women with UI and 190 fertile women of reproductive age who were attending the maternity hospitals and fertility clinics in Khartoum state Sudan.The serum concentration of leptin and other serum biomarkers were determined using enzyme-linked immunosorbent assays.RESULTS The results showed that there was a highly statistically significant difference between the two groups(P<0.001)for all examined eight biomarkers.Whereby,leptin,luteinizing hormone(LH)/follicular stimulating hormone(FSH)ratio,prolactin hormone(PRL)and testosterone(T)were significantly higher in the UI group compared with the control group.In contrast,FSH and estradiol(E2)/T ratio were significantly lower in the UI group than in the control group and the effect size test for the difference between the two groups was very large(effect size>0.80),for leptin level,LH/FSH ratio,PRL level,and E2/T ratio,and large(effect size 0.50-≤0.80)for FSH and T.CONCLUSION This study reveals that leptin could be a potential biomarker for UI in Sudanese women and it may be useful for identifying women with a high risk of infertility.

Effect of modified laparoscopic salpingectomy on ovarian reserve:Changes in the serum antimüllerian hormone levels

Objective:To retrospectively estimate the impact of modified laparoscopic salpingectomy on the ovarian reserve in infertile women.Methods:There were 74 infertile women undergone modified laparoscopic salpingectomy from June 2016 to January 2017,and their levels of serum antimüllerian hormone,basal follicle-stimulating hormone and estradiol were reviewed retrospectively.Results:No significant change was detected in serum antimüllerian hormone at 3 months after surgery compared to preoperative level(p=0.857).Similar changes were observed for the basal follicle-stimulating hormone(p=0.102)and estradiol(p=0.233)level.Conclusions:Our results revealed that modified laparoscopic salpingectomy might be a valuable treatment for hydrosalpinx before in vitro fertilization.

Effect of thyroid hormone on serum NO concentration and iNOS activity of intestinal mucosa in septic rats

Objective To investigate the effect of exogenous thyroid hormone on serum NO and iNOS activity of intestinal mucosa in septic rats. Methods Septic model was established by cecal ligation puncture (CLP) in male SD rats. Triiodothyronine ( T3 ) was administered intraperitoneally to correct the low T3 syndrome of septic rats. Blood was collected to examine serum NO and thyroid hormone concentration. Intestinal mucosa iNOS activity was assayed using immunochemical stain. Results Mortality rate in the prevention group was significantly lower than the septic group (Log rank = 3. 85, P 【 0.05). Serum NO concentration was significantly lower in the prevention group (F=19.6,F【0.01). The degree of inflammatory injury of intestinal mucosa was much milder in the prevention group than in the septic group (x2 = 5.303,P【0. 05). Mucosa iNOS activity was also significantly lower in the prevention group (x2 = 4. 876, P【0. 01). Conclusion Thyroid hormone protects the intestinal mucosa barrier inhibiting the expression of

不同精液质量男性生殖激素水平与氧化应激的临床分析

目的分析不同精液质量男性生殖激素和抗氧化水平,探讨生殖激素及抗氧化对男性精液质量的影响。方法在北华大学附属医院生殖中心筛选28名单纯少精子症、36名单纯弱精子组和28名少弱精子症患者精液。精液分析按照世界卫生组织的标准进行。化学发光免疫法测定血清促卵泡生成素(FSH)、促黄体生成素、泌乳素、雌二醇、睾酮(T)浓度。黄嘌呤氧化酶法检测超氧化物歧化酶(SOD)活性,采用活性氧试剂盒检测精浆中活性氧(ROS)水平。结果不育组男性精液浓度、前向运动精子率、精子总活力和精子不活动率与对照组差异有统计学意义(P<0.05)。不育组患者血清中T浓度明显低于对照组,差异有统计学意义(P<0.05);少弱精症组中FSH明显高于对照组,差异有统计学意义(P<0.05)。不育组SOD活力和ROS水平与对照组相比差异有统计学意义(P<0.05)。结论睾酮合成下降与男性不育有关,少精、弱精、少弱精的重要原因可能是氧化应激中抗氧化剂与ROS的脂质过氧化损伤的不平衡。

红外热成像精准电参数刺激治疗早发型卵巢功能不全的临床研究

目的:探讨采用红外热成像精准电参数刺激治疗早发型卵巢功能不全的临床效果。方法:选取100例早发性卵巢功能不全患者作为研究对象,按照不同治疗方法分为对照组与研究组,每组各50例。对照组采用雌孕激素进行治疗;研究组采用红外热成像精准电参数刺激治疗。比较治疗前及治疗后1、2、3个月两组患者血清激素[促卵泡生成素(FSH)、促黄体生成素(LH)、雌二醇(E2)及抗苗勒氏管激素(AMH)]水平、血流情况[卵巢血管收缩期峰值血流速度(PSV)、计算搏动指数(PI)及阻力指数(RI)]、基础窦卵泡数及卵巢体积,并比较两组患者不良反应发生情况及临床疗效。结果:治疗1、2、3个月后,两组患者FSH及LH水平均下降,且研究组低于对照组;E2及AMH水平均升高,且研究组高于对照组(P<0.05)。治疗3个月后,两组患者PSV水平均升高,PI水平均降低,且研究组RI水平低于治疗前(P<0.05)。治疗2、3个月后,两组患者基础窦卵泡数及两侧卵巢体积水平均呈上升趋势;治疗3个月后,研究组基础窦卵泡数及两侧卵巢体积水平均高于对照组(P<0.05),治疗有效率高于对照组(P<0.05),不良反应发生率低于对照组(P<0.05)。结论:采用红外热成像精准电参数刺激治疗早发性卵巢功能不全的患者安全性较高,利于改善患者性激素水平,并可增加基础窦卵泡数及增大卵巢体积,具有较好的临床疗效,可以在基层医院临床推广应用。

血清甲状腺激素、NLR及CRP/ALB与肺癌术后谵妄的关系

目的分析血清甲状腺激素、中性粒细胞淋巴细胞比值(NLR)及C反应蛋白/白蛋白比值(CRP/ALB)与肺癌术后谵妄的关系。方法选取2021年1月至2022年12月于北京市第六医院进行肺癌根治术患者118例作为研究对象。根据ICU意识混乱评分法进行谵妄评估,有35例患者发生术后谵妄(谵妄组),83例患者术后未发生谵妄(非谵妄组)。分析影响肺癌患者术后谵妄的单因素,采用多元Logistic回归分析影响肺癌术后谵妄的多因素;比较谵妄组不同谵妄程度患者血清甲状腺激素、CRP/ALB、NLR水平;采用Pearson相关系数分析血清甲状腺激素、CRP/ALB、NLR与肺癌术后谵妄的相关性。结果两组性别、合并患有高血压、ASA分级以及T_4、TSH、FT_4水平等指标比较,差异无统计学意义(P>0.05);两组年龄、合并患有糖尿病、睡眠障碍以及T_(3)、FT_(3)、CRP/ALB、NLR水平比较,差异有统计学意义(P<0.05);经多元Logistic回归分析显示:年龄≥60岁、合并患有糖尿病、睡眠障碍以及T_(3)<1.31 nmol/L、FT_(3)<5.15 pmol/L、CRP/ALB>0.120、NLR≥7.79均是影响肺癌发生术后谵妄的危险因素(P<0.05);轻度、重度术后谵妄患者T_4、TSH、FT_4水平比较,差异无统计学意义(P>0.05);轻度术后谵妄患者T_(3)、FT_(3)水平高于重度术后谵妄患者,CRP/ALB、NLR水平低于重度术后谵妄患者,差异均有统计学意义(P<0.05);Pearson相关性分析显示:T_(3)、FT_(3)与肺癌术后谵妄呈负相关,CRP/ALB、NLR与肺癌术后谵妄呈正相关(P<0.05)。结论肺癌根治术患者术后T_(3)、FT_(3)、CRP/ALB、NLR水平与术后谵妄发生有一定关联,通过检测上述指标水平可为临床评估术后谵妄严重程度提供参考资料。

肥猪散对育肥猪生长性能、血清生化指标、抗氧化水平和生长激素水平的影响

为了解肥猪散对育肥猪生长性能、血清生化指标、抗氧化水平和生长激素水平的影响,试验选取160头体重相近的育肥猪,随机分为4组,对照组饲喂基础饲粮,试验1、2、3组分别在饲粮中添加1%、2%、4%肥猪散,试验期35 d。试验期间对育肥猪的生长情况进行测定和记录,检测第0、35天的血清生化指标、抗氧化水平和生长激素水平。结果显示:与对照组相比,试验1、2、3组增重和平均日增重极显著增加(P<0.01),试验2、3组平均日采食量显著增加(P<0.05),各组间的料重比差异不显著(P>0.05);使用肥猪散35 d后,试验1、2、3组血清尿素氮含量显著降低(P<0.05),葡萄糖含量极显著升高(P<0.01),超氧化物歧化酶活性有上升的趋势(0.05<P<0.10),皮质醇含量显著降低(P<0.05)。综上,育肥猪饲料中添加肥猪散具有提高生长性能,改善血清生化指标,提高抗氧化水平和生长激素水平的作用,推荐添加剂量为2%。

子宫内膜异位症生育指数联合血清AMH对子宫内膜异位症患者自然妊娠结局的预测价值

目的 探究子宫内膜异位症生育指数(EFI)联合血清抗米勒管激素(AMH)对子宫内膜异位症(EMT)患者自然妊娠结局的预测价值。方法 选择行腹腔镜手术治疗的113例子宫内膜异位症患者作为研究对象,均于术前及术后对其EFI、AMH进行检测,然后随访2年,根据自然妊娠结局将其分为自然妊娠成功组(70例)和自然妊娠失败组(43例)。统计113例患者术后EFI评分及术前、术后AMH水平;比较自然妊娠成功组和自然妊娠失败组的一般资料及术后EFI评分、AMH水平;分析EFI、AMH单独检测及联合检测对子宫内膜异位症患者自然妊娠结局的预测价值。结果 113例子宫内膜异位症患者术后的EFI评分为(5.63±1.38)分;患者术前AMH水平为(2.30±0.64)ng/ml,术后为(4.16±0.59)ng/ml,术后的AMH水平高于术前(P<0.05)。术后随访2年,其中有70例患者自然妊娠成功(自然妊娠成功组),成功率为61.95%;43例自然妊娠失败(自然妊娠失败组),失败率为38.05%。自然妊娠成功组和自然妊娠失败组的年龄、不孕病程、体质量指数、不孕类型比较,无明显差异(P>0.05)。术后,自然妊娠成功组的EFI评分(6.03±0.72)分、AMH水平(4.32±0.55)ng/ml均比自然妊娠失败组的(4.33±1.26)分、(3.89±0.87)ng/ml高(P<0.05)。联合检测的曲线下面积(AUC)为0.902、特异度为97.33%,均比EFI、AMH单独检测的0.816、90.54%及0.802、93.45%高。结论 子宫内膜异位症患者经腹腔镜手术治疗后EFI、AMH水平较高者的自然妊娠成功率更高, EFI、AMH可对自然妊娠结局进行预测,两者联合的预测价值更高。

参芪补气散对亚健康西门塔尔犊牛血清生化、激素及部分免疫指标的影响

研究参芪补气散对亚健康西门塔尔犊牛发病率、血清生化、激素与免疫指标的影响。选择3月龄亚健康西门塔尔犊牛105头,随机分为对照组、参芪补气散低剂量组、参芪补气散高剂量组3个组,每组35头。对照组每日饲喂基础饲粮,给药组在基础饲粮基础上分别每日添加精料15 g/kg(低剂量组)和30 g/kg(高剂量组)的参芪补气散,连续饲喂21 d,观察每组犊牛腹泻、感冒的发生情况。试验结束后每组犊牛采集血液用于血清生化、激素、免疫指标检测。与对照组相比,参芪补气散高、低剂量组犊牛的感冒、腹泻发病率呈降低趋势,高剂量组降低明显。与对照组相比,参芪补气散低剂量组犊牛的甘油三酯、尿素、三碘甲状腺原氨酸、甲状腺素、免疫球蛋白A均显著升高(P<0.05),总胆红素、结合胆红素均显著降低(P<0.05);与对照组相比,参芪补气散高剂量组犊牛的甘油三酯、血清总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血钾、三碘甲状腺原氨酸、甲状腺素、免疫球蛋白A和免疫球蛋白M含量均显著升高(P<0.05);总胆红素、结合胆红素均显著降低(P<0.05)。说明参芪补气散可以明显改善亚健康西门塔尔犊牛的血清生化、激素及免疫相关指标,防病增重效果确切。

热应激对金定鸭生产性能、生殖激素水平及免疫指标的影响

试验旨在研究热应激对金定鸭生产性能、血液生殖激素、卵巢生殖相关基因表达量及免疫指标的影响。试验选用产蛋期400日龄的金定鸭,设置对照组(常温组)、试验组(热应激)。对照组环境温度(25±2)℃,试验组环境温度(35±2)℃;测定热应激下金定鸭生产指标、血清生殖激素指标和免疫指标、卵巢生殖基因表达量。结果显示:与对照组相比,试验组产蛋率、总蛋重和平均蛋重极显著降低(P<0.01);血清促卵泡生成素(FSH)含量显著降低(P<0.05);卵巢促性腺素释放激素(GnRH)基因表达量显著降低(P<0.05),促黄体生成素(LH)基因表达量极显著降低(P<0.05);血清IgG含量极显著降低(P<0.01),肿瘤坏死因子-α(TNF-α)含量显著升高(P<0.05)。由此可见,热应激对金定鸭生产性能、生殖激素水平及免疫指标产生不利影响,其中产蛋率、总蛋重、平均蛋重、血清FSH及卵巢LH、GnRH基因表达量均显著降低,蛋鸭炎性因子水平显著增加,机体免疫力显著下降。

血清抗苗勒管激素水平对不同年龄患者IVF/ICSI临床结局的影响

目的探讨低血清抗苗勒管激素(AMH≤1.1 ng/ml)对不同年龄阶段女性的胚胎质量、临床妊娠率、流产率、活产率及流产胚胎绒毛染色体非整倍性的影响。方法回顾性分析2015年1月至2022年12月于广东省第二人民医院生殖医学中心行IVF/ICSI助孕治疗的患者资料,共纳入20886个取卵周期、17218个胚胎移植周期,以及124例移植后妊娠流产绒毛染色体检查病例。根据AMH水平分为观察组(AMH≤1.1 ng/ml)和对照组(AMH>1.1 ng/ml),并按年龄段分层(年龄≤30岁、30岁<年龄≤35岁、35岁<年龄≤38岁、38岁<年龄≤40岁、年龄>40岁),分析不同年龄段不同AMH组间胚胎质量、妊娠率、活产率、流产率以及流产患者胚胎绒毛染色体检查结果。结果相较于对照组,观察组在各年龄段的正常受精率、D3优胚率、D3可利用胚胎率、囊胚形成率均显著降低(P<0.05),且临床妊娠率和活产率亦显著降低(P<0.05);流产率随着年龄的增加逐渐升高,但仅>40岁患者中观察组流产率显著高于对照组(P<0.05);全部14例>40岁患者的流产胎儿组织染色体均检测出异常。结论AMH和年龄共同影响辅助生殖技术治疗患者的胚胎质量和妊娠结局。

安徽省维持性血液透析患者血清磷水平及其影响因素分析

目的分析维持性血液透析(maintenance hemodialysis,MHD)患者血清磷水平现状及其与临床指标的关系,探讨血清磷水平的相关影响因素。方法本研究为多中心横断面研究。纳入2019~2020年安徽医科大学第二附属医院血液净化中心等27家透析中心2667例MHD患者,收集相关人口学特征、原发病、实验室检查等资料。按照血清磷水平分为低血磷组(磷<1.13mmol/L),正常血磷组(1.13≤磷≤1.78 mmol/L)和高血磷组(磷>1.78 mmol/L)。单因素方差分析3组间临床指标的差异,多元线性回归分析血清磷水平的相关影响因素。结果MHD患者中,低血磷组、正常血磷组、高血磷组分别占比7.6%、35.3%和57.1%。Spearman相关分析发现,年龄(r=-0.167,P<0.001)与血磷水平呈负相关,体重(r=0.09,P<0.001)、体重指数(r=0.088,P<0.001)、血红蛋白(r=0.099,P<0.001)、尿素氮(r=0.4,P<0.001)、肌酐(r=0.357,P<0.001)、血镁(r=0.253,P<0.001)、血清白蛋白(r=0.117,P<0.001)、尿酸(r=0.253,P<0.001)、甲状旁腺激素(r=0.299,P<0.001)、总胆固醇(r=0.1,P<0.001)、三酰甘油(r=0.09,P<0.001)、低密度脂蛋白胆固醇(r=0.043,P=0.027)、老年营养风险指数(r=0.162,P<0.001)呈正相关;多元线性回归发现,MHD患者血磷水平与体重指数(β=0.163,P<0.001)、血红蛋白(β=0.06,P=0.001)、尿素氮(β=0.238,P<0.001)、肌酐(β=0.152,P<0.001)、血镁(β=0.117,P<0.001)、甲状旁腺激素(β=0.196,P<0.001)独立相关。结论MHD患者高磷水平占比较高,血红蛋白、尿素氮、肌酐、血钙、血镁、甲状旁腺激素是影响MHD患者血磷水平下降的独立因素。

HRT-FET周期中雌激素水平与妊娠期高血压发生的关系

目的:探讨替代方案冻胚移植(HRT-FET)周期中患者补充孕激素前的雌激素水平对妊娠期高血压疾病(HDP)发生的影响。方法:回顾分析2017年5月至2022年5月于山东大学生殖医学中心经HRT-FET获单胎活产的3506例患者的临床资料。根据E 2水平将患者分成3组:组1(E_(2)≤137pg/mL,≤25%,866例),组2(137pg/mL<E_(2)≤240pg/mL,25.01%~75%,1806例),组3(E_(2)>240pg/mL,>75%,834例)。比较3组患者的妊娠期并发症及新生儿结局。结果:组3患者的HDP发生率明显高于组1(aOR=0.653,95%CI为0.463~0.920,P=0.015)及组2(aOR=0.750,95%CI为0.566~0.994,P=0.045)。各组间妊娠期糖尿病、前置胎盘、产后出血等妊娠期并发症及早产、过期产、SGA(小于胎龄儿)、LGA(大于胎龄儿)等新生儿不良结局发生率无显著差异。结论:替代方案冻胚移植周期中转化内膜前的高雌激素水平是妊娠期高血压疾病发生的独立风险因素。