Background:Hand,foot,and mouth disease(HFMD)caused by enterovirus 71(EV71)is a potentially life-threatening infectious disease that commonly occurs in children.Diagnosis of HFMD caused by EV71 largely depends on clini...Background:Hand,foot,and mouth disease(HFMD)caused by enterovirus 71(EV71)is a potentially life-threatening infectious disease that commonly occurs in children.Diagnosis of HFMD caused by EV71 largely depends on clinical manifestations and rare serological biomarkers used to identify children suffering from HFMD.Serum cholinesterase(SChE)activity has frequently been reported as a potential biomarker for solid central nervous system tumors,chronic heart failure,and liver cirrhosis.However,its potential value in the diagnosis of neurotropic virus infections,such as HFMD caused by EV71,remains to be determined.Findings:In our study,220 children hospitalized with HFMD caused by EV71,34 inpatients infected with coxsackievirus A16(CVA16),and 43 undefined enterovirus-infected HFMD inpatients were recruited at the Anhui Provincial Children’s Hospital between January 2011 and December 2012.SChE activity was measured.The non-parametric Mann–Whitney U test showed that SChE activity in children diagnosed with HFMD caused by EV71 was significantly higher than in healthy controls(p<0.001),as well as in children with upper respiratory tract infections(p=0.011),bronchopneumonia(p<0.001),septicemia(p<0.001),amygdalitis(p<0.001),and appendicitis(p<0.001).In addition,higher SChE activity was observed in male inpatients with HFMD caused by EV71(47.7%positivity)compared to female inpatients(26.1%positivity)(chi-square test,p=0.002).In our study,no significant differences in SChE levels were observed among different ages(up to 120 months)(r=-0.112,p>0.05).An important finding was that SChE activity declined in the recovery phase of HFMD caused by EV71 compared to the acute phase(p<0.001).Conclusions:Elevated SChE activity was observed in patients with severe HFMD caused by EV71.Therefore,SChE might be a potential assistant biomarker for the diagnosis of HFMD caused by EV71 in children.展开更多
目的探讨经皮肾镜（percutaneous nephrolithotomy,PCNL）术后并发感染性休克、多器官功能障碍综合征（multiple organ dysfunction syndrone,MODS）的预警指标及防治对策。方法选取2004年1月~2014年12月在广西医科大学第八附属医院治...目的探讨经皮肾镜（percutaneous nephrolithotomy,PCNL）术后并发感染性休克、多器官功能障碍综合征（multiple organ dysfunction syndrone,MODS）的预警指标及防治对策。方法选取2004年1月~2014年12月在广西医科大学第八附属医院治疗的经皮肾镜（PCNL）术后并发感染性休克及多器官功能障碍综合征（MODS）患者30例为观察组,同时选取PCNL术后未发生MODS患者35例作为对照组,检测两组患者血小板（PLT）、D-二聚体（DD）、血清白蛋白（ALB）、胆碱酯酶（CHE）及肌钙蛋白T（TNT）水平。结果观察组患者入院24 h PLT、CHE、ALB分别为（103.25±35.27）×109/L、（2313.38±231.65）U/L和（22.43±5.38）g/L,明显低于对照组,而TNT和DD为（0.67±0.17）ng/m L和（2.56±0.93）mg/L,明显高于对照组,差异均有统计学意义（P〈0.05）;观察组患者中死亡患者PLT、CHE、ALB分别为（87.32±21.27）×109/L、（2109.26±219.41）U/L和（19.38±4.28）g/L,明显低于未死亡患者,而TNT和DD为（0.78±0.13）ng/ml和（3.04±0.77）mg/L,明显高于未死亡患者,差异均有统计学意义（P〈0.05）;器官功能障碍数为2个的患者病死率为41.67%,器官功能障碍数为3个的患者病死率为44.44%,器官功能障碍数≥4个的患者病死率为100%。结论血小板、D-二聚体、血清白蛋白、胆碱酯酶、肌钙蛋白、器官功能障碍数目可作为经皮肾镜术后并发感染性休克及多器官功能障碍综合征患者的预警指标。展开更多
基金supported by the National Natural Science Foundation of China(No:81271826).
文摘Background:Hand,foot,and mouth disease(HFMD)caused by enterovirus 71(EV71)is a potentially life-threatening infectious disease that commonly occurs in children.Diagnosis of HFMD caused by EV71 largely depends on clinical manifestations and rare serological biomarkers used to identify children suffering from HFMD.Serum cholinesterase(SChE)activity has frequently been reported as a potential biomarker for solid central nervous system tumors,chronic heart failure,and liver cirrhosis.However,its potential value in the diagnosis of neurotropic virus infections,such as HFMD caused by EV71,remains to be determined.Findings:In our study,220 children hospitalized with HFMD caused by EV71,34 inpatients infected with coxsackievirus A16(CVA16),and 43 undefined enterovirus-infected HFMD inpatients were recruited at the Anhui Provincial Children’s Hospital between January 2011 and December 2012.SChE activity was measured.The non-parametric Mann–Whitney U test showed that SChE activity in children diagnosed with HFMD caused by EV71 was significantly higher than in healthy controls(p<0.001),as well as in children with upper respiratory tract infections(p=0.011),bronchopneumonia(p<0.001),septicemia(p<0.001),amygdalitis(p<0.001),and appendicitis(p<0.001).In addition,higher SChE activity was observed in male inpatients with HFMD caused by EV71(47.7%positivity)compared to female inpatients(26.1%positivity)(chi-square test,p=0.002).In our study,no significant differences in SChE levels were observed among different ages(up to 120 months)(r=-0.112,p>0.05).An important finding was that SChE activity declined in the recovery phase of HFMD caused by EV71 compared to the acute phase(p<0.001).Conclusions:Elevated SChE activity was observed in patients with severe HFMD caused by EV71.Therefore,SChE might be a potential assistant biomarker for the diagnosis of HFMD caused by EV71 in children.
文摘目的探讨经皮肾镜（percutaneous nephrolithotomy,PCNL）术后并发感染性休克、多器官功能障碍综合征（multiple organ dysfunction syndrone,MODS）的预警指标及防治对策。方法选取2004年1月~2014年12月在广西医科大学第八附属医院治疗的经皮肾镜（PCNL）术后并发感染性休克及多器官功能障碍综合征（MODS）患者30例为观察组,同时选取PCNL术后未发生MODS患者35例作为对照组,检测两组患者血小板（PLT）、D-二聚体（DD）、血清白蛋白（ALB）、胆碱酯酶（CHE）及肌钙蛋白T（TNT）水平。结果观察组患者入院24 h PLT、CHE、ALB分别为（103.25±35.27）×109/L、（2313.38±231.65）U/L和（22.43±5.38）g/L,明显低于对照组,而TNT和DD为（0.67±0.17）ng/m L和（2.56±0.93）mg/L,明显高于对照组,差异均有统计学意义（P〈0.05）;观察组患者中死亡患者PLT、CHE、ALB分别为（87.32±21.27）×109/L、（2109.26±219.41）U/L和（19.38±4.28）g/L,明显低于未死亡患者,而TNT和DD为（0.78±0.13）ng/ml和（3.04±0.77）mg/L,明显高于未死亡患者,差异均有统计学意义（P〈0.05）;器官功能障碍数为2个的患者病死率为41.67%,器官功能障碍数为3个的患者病死率为44.44%,器官功能障碍数≥4个的患者病死率为100%。结论血小板、D-二聚体、血清白蛋白、胆碱酯酶、肌钙蛋白、器官功能障碍数目可作为经皮肾镜术后并发感染性休克及多器官功能障碍综合征患者的预警指标。
