Relationship of High Sensitivity C-Reactive Protein with Cardiovascular, Diabetic, and Hepatic Biomarkers

Biomarkers are early predictors of various disorders, circulating level of C-reactive protein is a sensitive biomarker of systemic inflammation and may also be associated with the development of diabetic, hepatic, and cardiovascular diseases. In the present study, we aimed to investigate the association between circulating levels of high sensitive C-reactive protein (hs-CRP) and various biomarkers for hepatic, diabetic, and cardiovascular health. The retrospective analysis included 438 individuals who were tested for these panels simultaneously at Vibrant America Clinical Laboratory. The study population included free-living individuals without any preexisting clinical conditions. Among the cardiovascular markers, a positive correlation and significant association was found between high levels of hs-CRP and serum levels of triglycerides (r = 0.0964, p −0.1423, p −0.1216, p < 0.0105) with circulating levels of hs-CRP. Among all the diabetic markers, glucose (r = 0.1547, p < 0.0011) and glycated serum protein (r = 0.1725, p < 0.0003) were positively correlated with circulating hs-CRP. In the hepatic panel, AST, a transaminase that plays a vital role in amino acid metabolism, was found to have a strong positive correlation with hs-CRP (r = 0.2139, p < 0.0001). In conclusion, the results clearly show the association of hs-CRP with diabetic, hepatic, and cardiovascular risk factors indicating its central value as a key marker for several lifestyle-associated disorders.

High sensitivity C-reactive protein and cardfiac resynchronization therapy in patients with advanced heart failure

Background The data on the prognostic values of high sensitivity C-reactive protein （hsCRP） levels in patients with advanced symp-tomatic heart failure （HF） receiving cardiac resynchronization therapy （CRT） are scarce. The aim of present study was to investigate the association of serum hsCRP levels with left ventricle reverse remodeling after six months of CRT as well as long-term outcome. Methods A total of 232 CRT patients were included. The assessment of hsCRP values, clinical status and echocardiographic data were performed at baseline and after six months of CRT. Long-term follow-up included all-cause mortality and hospitalizations for HF. Results During the mean follow-up periods of 31.3 ± 31.5 months, elevated hsCRP （〉3 mg/L） prior to CRT was associated with a significant 2.39-fold increase （P=0.006） in the risk of death or HF hospitalizations. At 6-month follow-up, patients who responded to CRT showed significant reductions or maintained low in hsCRP levels （–0.5 ± 4.1 mg/L reduction） compared with non-responders （1.7 ± 6.1 mg/L increase, P=0.018）. Com-pared with patients in whom 6-month hsCRP levels were reduced or remained low, patients in whom 6-month hsCRP levels were increased or maintained high experienced a significantly higher risk of subsequent death or HF hospitalizations （Log-rank P〈0.001）. The echocardio-graphic improvement was also better among patients in whom 6-month hsCRP levels were reduced or remained low compared to those in whom 6-month hsCRP levels were raised or maintained high. Conclusions Our findings demonstrated that measurement of baseline and follow-up hsCRP levels may be useful as prognostic markers for timely potential risk stratification and subsequent appropriate treatment strategies in patients with advanced HF undergoing CRT.

The prognostic role of high-sensitivity C-reactive protein in patients with acute myocardial infarction

1 Introduction Inflammation is one of the main mechanisms in the pathogenesis of atherosclerosis,and the interest to the evaluation of inflammatory biomarkers in coronary artery disease(CAD)has been increasing over the last decade.[1,2]Destabilization of chronic artery plaques,which leads to acute coronary syndromes,has been associated with inflammatory status.[1,3]。

Relationship between high sensitivity C-reactive protein and angiographic severity of coronary artery disease

Background Coronary artery disease(CAD)remains a leading cause of morbidity and mortality.Cytokines play a potential role in atherosclerosis pathogenesis and progression.We investigated the association between high sensitive C-reactive protein(hs CRP)and severity of CAD.Methods CAD patients were stratified according to hs CRP cut-off value into high levels hs CRP group(≥8.4 mg/L)and low levels hs CRP group(<8.4 mg/L).Severity of CAD was assessed according to artery stenosis degree and the number of vessel involved.Statistical analysis was performed using Statistical Package for the Social Sciences(SPSS,version 23.0).Results The mean age was 60.3±11.0 years.The level of hs CRP was increased and ranged from 0.2 to 1020.0 mg/L.Biochemical risk factors and severity of CAD didn’t show significant differences between the two groups.In multivariate linear analysis,cardiac troponin I(c Tn I)and serum amyloid A(SAA)were predictors of hs CRP.As shown in receiver operating characteristic(ROC)curve analysis performed in patients with ST-segment elevation myocardial infarction(STEMI)and compared to myonecrosis biomarkers,hs CRP(area under the curve(AUC):0.905;95%CI:0.844-0.966;P<0.001)could be a powerful predictor marker in evaluating the infarct size after myocardial infarction but not better than c Tn I.Conclusions Hs CRP levels were not associated with the severity of CAD but could be useful in the evaluation of myocardial necrosis in patients with STEMI.

Correlation of Enhancement Degree on Contrast-enhanced Ultrasound with Histopathology of Carotid Plaques and Serum High Sensitive C-Reactive Protein Levels in Patients Undergoing Carotid Endarterectomy

This study was undertaken to investigate the correlation of the enhancement degree on contrast-enhanced ultrasound(CEUS) with the histopathology of carotid plaques and the serum high sensitive C-reactive protein(hs-CRP) levels in patients undergoing carotid endarterectomy(CEA). Carotid CEUS was performed preoperatively in 115 patients who would undergo CEA, and the enhancement degree of the carotid plaques was evaluated by both the visual semiquantitative analysis and the quantitative time-intensity curve analysis. Serum hs-CRP levels were detected using the particle-enhanced immunoturbidimetric assay also before the operation. Additionally, the carotid plaque samples were subjected to histopathological examination postoperatively. The density of neovessels and the number of macrophages in the plaques were assessed by immunohistochemistry. The results showed that among the 115 patients, grade 0 plaque contrast enhancement was noted in 35 patients, grade 1 in 48 patients and grade 2 in 32 patients. The degree of plaque enhancement, the density of neovessels, the number of macrophages, and the hs-CRP levels were highest in the grade 2 patients. Correlation analysis showed that the enhancement degree of the carotid plaques was closely related to the immunohistochemical parameters of the plaques and the serum hs-CRP levels. It was suggested that the carotid plaque enhancement on CEUS can be used to evaluate the vulnerability of carotid plaques.

Myeloperoxidase and High-Sensitivity C-Reactive Protein for Predicting Major Adverse Cardiovascular Events in Patients with Coronary Heart Disease

Background: Research has shown that high-sensitivity C-reactive protein (hs-CRP) is a major inflammatory marker for prediction of acute coronary syndrome (ACS). Myeloperoxidase (MPO) also plays an important role in atherosclerosis initiation and development. In present study, the major adverse cardiovascular events (MACEs) of patients with coronary heart disease (CHD) were investigated. Methods: MPO, hs-CRP and ACS-related risk factors from 201 ACS (78 AMI and 123 UAP) and 210 non-ACS (84 SAP and 126 non-CHD) patients confirmed by coronary angiography were detected, and the data were analyzed with receiver operating characteristic (ROC) curve and Spearman’s correlation coefficients. MACEs of 285 CHD patients were investigated during the 4-year period follow-up from March 2010 to May 2014. Results: The areas under ROC curve for diagnosing ACS were 0.888 (95% CI 0.843 - 0.933) for MPO, and 0.862 (95% CI 0.815-0.910) for hs-CRP, respectively. There were significantly correlations between MPO and hs-CRP in both ACS and non-ACS groups. Regarding to ACS patients, both MPO and hs-CRP were positively correlated with BMI, TC, TG, LDL-C and Hcy. Prospective study demonstrated that the incidences of MACEs associated significantly with elevated MPO baseline level (yes vs no, OR 7.383, 95% CI 4.095 - 13.309) and high hs-CRP baseline level (yes vs no, OR 4.186, 95% CI 2.469 - 7.097) in CHD patients. Conclusions: The present study provides the epidemiological evidence that elevated baseline MPO and hs-CRP levels are both valuable predictors of MACEs in CHD patients. MPO and hs-CRP would prompt the progression of atherosclerosis and development from SAP to ACS.

EFFECTS OF SIMVASTAIN COMBINED WITH OMEGA-3 FATTY ACIDS ON HIGH SENSITIVE C-REACTIVE PROTEIN, LIPIDEMIA, ANDFIBRINOLYSIS IN PATIENTS WITH MIXED DYSLIPIDEMIA

Objective To evaluate the effects of simvastatin combined with omega-3 fatty acids on high sensitive C-reactive protein(HsCRP), lipidemia, and fibrinolysis in coronary heart disease (CHD) and CHD risk equivalent patients with mixed dyslipi-demia. Methods A randomized, double-blind placebo controlled and parallel group trial was conducted. Patients with CHD and CHD risk equivalents with mixed dyslipidemia were treated with 10 or 20 mg simvastatin for 6-12 weeks. Following with the treatment of patients whose low-density lipoprotein cholesterol (LDL-ch) reaching goal level (< 100 mg/dL) or close to the goal (< 130 mg/dL), while triglyceride (TG) ≥200 mg/dL and < 500 mg/dL, was combined with omega-3 fatty acids (3 g/d) or a placebo for 2 months. The effects of the treatment on HsCRP, total cholesterol (TC), LDL-ch, high-density lipoprotein cholesterol (HDL-ch), TG, lipoprotein (a) [LP (a)], apolipoprotein A1 (apoA1), apolipoprotein B (apoB), plasminogen activator inhibitor-1 (PAI-1), and tissue plasminogen activator (tPA) were investigated. Forty patients finished the study with each group consisting of twenty patients. Results (1) There were significant reductions of HsCRP, TG, TC, and TC/HDL-ch, which decreased by 2.16 ±2.77 mg/L (38.5%), 94.0 ±65.4 mg/dL (31.1%), 13.3 ±22.3 mg/dL (6.3%), 0.78 ±1.60 respectively in the omega-3 fatty acids group (P< 0.01, < 0.001, < 0.05, < 0.05) compared to the baseline. HsCRP and triglyceride reduction were more significant in omega-3 fatty acids group compared to the placebo group (P=0.021 and 0.011 respectively). (2) In the omega-3 fatty acids group, the values and percentage of TG reduction had a significantly positive relation with HsCRP reduction (r=0.51 and 0.45, P=0.021 and 0.047 respectively). Conclusion In CHD and CHD risk equivalent patients with mixed dyslipidemia, dyslipidemia’s therapeutic effect using simvastatin and omega-3 fatty acids may result from not only the combination of lipid adjustment, but also enhancement of their own nonlipid influences.

不同程度儿童1型糖尿病酮症酸中毒与血清hs-CRP、IL-10、IgE、NLR水平的相关性分析

目的探讨不同程度儿童1型糖尿病酮症酸中毒血清高敏-C反应蛋白(high-sensitivity C-reactive pro-tein,hs-CRP)、白细胞介素-10(interleukin-10,IL-10)、免疫球蛋白E(serum immunoglobulin E,IgE)、中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)水平的相关性。方法回顾性选取2022年1月—2023年5月淄博市妇幼保健院收治的52例儿童1型糖尿病酮症酸中毒患儿的临床资料,进行血清hs-CRP、IL-10、IgE、NLR检测,对检测结果进行相关性分析。结果重度酮症酸中毒患儿血清hs-CRP、IL-10高于轻度、中度患儿,IgE水平低于轻度、中度患儿,差异有统计学意义(P均<0.05)。儿童1型糖尿病酮症酸中毒的严重程度与血清hs-CRP、IL-10呈正相关,与IgE呈负相关(P均<0.05);与NLR无相关性(P>0.05)。结论对于儿童1型糖尿病酮症酸中毒的诊断中,血清hs-CRP、IL-10、IgE均发挥重要作用,NLR对于细菌感染的判断具有积极作用,可更好的对疾病进行诊断,同时监控疾病进展,是诊断和评估病情变化的重要指标。

SAA/hs-CRP、NLR及PCT联合检测在肺炎支原体肺炎患儿预后中的预测价值

目的:分析血清淀粉样蛋白A(SAA)/高敏C反应蛋白(hs-CRP)、中性粒细胞与淋巴细胞比值(NLR)及降钙素原(PCT)联合检测在肺炎支原体肺炎患儿预后中的预测价值。方法:回顾性分析2020年1月至2022年12月该院收治的110例肺炎支原体肺炎患儿的临床资料,根据病情严重程度将其分为轻症组(n=72)和重症组(n=38),另选取同期110名健康体检儿童的临床资料,设为对照组。比较三组SAA/hs-CRP、NLR及PCT水平,不同预后患儿SAA/hs-CRP、NLR及PCT水平,并采用受试者工作特征(ROC)曲线分析SAA/hs-CRP、NLR及PCT单项及联合检测在肺炎支原体肺炎患儿预后中的预测价值。结果:重症组、轻症组SAA/hs-CRP、NLR及PCT水平均高于对照组,且重症组高于轻症组,差异有统计学意义(P<0.05);治疗1个月后,预后不良患儿血清SAA/hs-CRP、NLR、PCT水平均高于预后良好患儿,差异有统计学意义(P<0.05);ROC曲线结果显示,SAA/hs-CRP、NLR及PCT单项及联合检测预测肺炎支原体肺炎患儿预后的曲线下面积分别为0.718、0.799、0.743、0.825,均具有一定预测效能,其中联合检测的预测效能最高。结论:SAA/hs-CRP、NLR及PCT联合检测预测肺炎支原体肺炎患儿预后的价值高于三者单项检测的预测价值。

复方血栓通胶囊联合雷珠单抗治疗糖尿病视网膜病变的疗效及对血清hs-CRP、Ang-2水平的影响

目的:探究复方血栓通胶囊联合雷珠单抗治疗糖尿病视网膜病变(Diabetic retinopathy,DR)的疗效及对促血管生成素(Angiopoietin-2,Ang-2)以及超敏C-反应蛋白(High-sensitivity C-reactive protein,hs-CRP)水平的影响。方法:选取2019年6月至2021年12月于我院确诊120例的双眼糖尿病视网膜病变患者作为研究对象,应用随机抽样法分为观察组和对照组,各60例(120眼)。对照组采用雷珠单抗注射治疗;观察组在对照组基础上增加口服复方血栓通胶囊。比较两组患者治疗前后的hs-CRP、Ang-2水平变化、黄斑中心凹厚度(Central macular thickness,CMT)、最佳矫正视力(Best-corrected visual acuity,BCVA)以及不良反应发生率。结果:治疗6 m后,两组患者hs-CRP水平、CMT明显下降,且观察组明显低于对照组(P<0.05);两组患者Ang-2水平、视力水平明显上升,且观察组明显高于对照组(P<0.05)。治疗后,观察组视力提高占比明显高于对照组,视力下降患者占比明显少于对照组(P<0.05)。两组不良反应总发生率无明显差异(P>0.05)。结论:复方血栓通胶囊联合雷珠单抗应用于糖尿病视网膜病变患者可有效降低hs-CRP、Ang-2水平,减轻视网膜水肿,提高患者视力,改善患者视功能,大大提高患者的生活质量。

血清Hcy、hs-CRP、D-D水平与妊娠期高血压疾病患者病情严重程度的相关性

目的:分析血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)水平与妊娠期高血压疾病患者病情严重程度的相关性。方法:回顾性分析2022年3月至2023年3月商丘仁和中医院收治的98例妊娠期高血压疾病患者的临床资料,设为观察组,另选取同期进行日常产检的91名健康妊娠者设为对照组,比较两组血清Hcy、hs-CRP、D-D水平;并根据病情严重程度将其分为妊娠期高血压患者54例、子痫前期患者24例、子痫患者20例,比较不同严重程度妊娠期高血压疾病患者血清Hcy、hs-CRP、D-D水平,分析其与妊娠期高血压疾病患者病情严重程度的相关性。结果:观察组血清Hcy、hs-CRP、D-D水平均高于对照组,差异有统计学意义(P<0.05);血清Hcy、hs-CRP、D-D水平,妊娠期高血压患者<子痫前期患者<子痫患者,差异均有统计学意义(P<0.05);Pearson相关性分析结果显示,血清Hcy、hs-CRP、D-D水平与妊娠期高血压疾病患者病情严重程度均呈正相关(r>0,P<0.05)结论:血清Hcy、hs-CRP、D-D水平与妊娠期高血压疾病患者病情严重程度均呈正相关。

血清PC、hs-CRP及NT-proBNP在冠心病不同冠脉病变中的表达及临床意义

目的探讨血清血浆蛋白C(PC),高敏C反应蛋白(hs-CRP)及氨基末端B型脑钠肽原(NT-proBNP)在冠心病(CHD)不同冠脉病变中的表达及临床意义。方法选取80例CHD患者和80例进行健康体检的健康人群设为观察组和对照组。依据CHD临床分型将其分为稳定型心绞痛组(n=24)、不稳定型心绞痛组(n=31)和心肌梗死组(n=25)。对所有患者的血清PC、hs-CRP、NT-proBNP水平进行检测,观察组开展冠状动脉造影检查,依据冠脉病变支数将其分为单支病变组(n=22)、双支病变组(n=34)和多支病变组(n=24)。分别比较对照组和观察组、不同临床分型(稳定型心绞痛组、不稳定型心绞痛组、心肌梗死组相比较)以及不同冠脉病变支数(单支病变组、双支病变组、多支病变组)的血清PC、hs-CRP、NT-proBNP水平;建立风险评估模型,经受试者工作特征曲线(ROC)评估血清PC、hs-CRP、NT-proBNP检测冠心病心肌梗死的诊断效能。结果与对照组相比较,观察组血清PC水平较低,hs-CRP、NT-proBNP水平较高(P<0.05);与不稳定型心绞痛组、心肌梗死组相比较,稳定型心绞痛组血清PC水平较高,hs-CRP、NT-proBNP水平较低(P<0.05);多支病变组血清PC水平明显低于单支、双支病变组,且多支病变组hs-CRP、NT-proBNP水平较高(P<0.05);由ROC曲线分析,经构建风险评估模型血清PC、hs-CRP、NT-proBNP联合检测的AUC值最高,为0.958,灵敏度、特异度分别为96.00%、84.00%。结论CHD患者冠脉病变程度越严重,其血清PC水平越低,hs-CRP、NT-proBNP水平越高。血清PC、hs-CRP、NT-proBNP指标水平在评估CHD不同冠脉病变程度方面具有一定的临床价值。且血清PC、hs-CRP、NT-proBNP联合检测在诊断冠心病心肌梗死方面具有较高的诊断效能。

ASSOCIATION OF INSULIN RESISTANCE AND C-REACTIVE PROTEIN WITH CORONARY ARTERY DISEASE IN PATIENTS WITH NORMAL GLUCOSE TOLERANCE

Objective To examine insulin resistance and high sensitivity C-reactive protein （hsCRP） association with clinical and angiographic severity of coronary artery disease （CAD） in patients with normal glucose tolerance. Methods In 638 consecutive patients with normal glucose tolerance, 221 had atypical chest pain and normal coronary artery （control group）, 279 had stable angina and CAD （SAP group ）, and 138 suffered acute myocardial infarction （ MI group）. The degree of CAD was further divided into borderline lesion （ lumen diameter narrowing 50% - 69% ）, significant 1-, 2- or 3-vessel disease （ luminal diameter narrowing 〉I 70% ）. Fasting serum glucose, insulin and hsCRP levels and lipid profiles were measured, and homeostasis model assessment for insulin resistance （ HOMA-IR ） was calculated. Multivariate analysis was performed to assess risk factors for 3-vessel disease or acute MI. Results Serum hsCRP, lipoprotein （a） levels, and insulin resistance index （IRI） were higher in AMI group than those in SAP and control groups. Serum hsCRP level and IRI were also higher in 3-vessel disease than those in other groups. Multivariate regression analysis revealed that insulin resistance, cigarette smoking, serum hsCRP, and lipoprotein （a） levels were independent risk factors for acute MI. Lipoprotein （ a ） elevation was an independent risk factor for 3-vessel disease. Conclusion Insulin resistance and high serum hsCRP level were associated with occurrence of acute MI and angiographic severity of coronary disease in patients with normal glucose tolerance.

Relationship between coronary atherosclerosis plaque characteristics and high sensitivity C-reactive proteins, interleukin-6

Background The relationship between inflammatory markers and the characteristics of coronary atherosclerosis plaques is uncertain. The aim of the present study was to evaluate the relationship between the characteristics of coronary atherosclerosis plaques and inflammatory markers such as high sensitivity C-reactive proteins （Hs-CRP） and interleukin-6 （IL-6）. Methods All patients suspected of having coronary heart disease （CHD） underwent Siemens 64-slice CT angiography （64-SCTA） to distinguish the quality of plaque of coronary artery lesions. Blood samples were taken to measure levels of serum Hs-CRP and IL-6 in different plaque groups and the control group and compared with the value of 64-SCTA for detection of coronary artery plaque. Results The sensitivity of detecting coronary artery plaque by 64-SCTA was 87.4%, the specificity was 87.1%, the positive predictive value was 82.2%, and the negative predictive value was 91.0%. Comparing the levels of serum Hs-CRP and IL-6 among plaque groups, the mean levels of serum Hs-CRP and IL-6 in three plaque groups were significantly higher than those in the control group （P 〈0.01）. The mean levels of serum Hs-CRP and IL-6 in the soft plaque group and mixed plaque group were significantly higher than those in hard plaque group （P〈0.01）. Plaque burden in the soft plaque group and mixed plaque group was significantly higher than in the hard plaque group （P 〈0.01）, but there was no statistical difference between the soft plaque group and mixed plaque group （P=-0.246）. There was a negative correlation between the CT scale and Hs-CRP and IL-6 levels in the soft plaque group （r= -0.621, P〈0.01, and r= -0.593, P 〈0.01 respectively）. There was a positive correlation between the plaque burden and Hs-CRP and IL-6 levels in the soft plaque group （r=0.579, P〈0.05 and r=0.429, P〈0.05 respectively）. Conclusions 64-SCTA is an effective way to distinguish the different quality of coronary atherosclerosis plaque. Serum Hs-CRP and IL-6 levels can be considered as the indexes to judge the degree of CHD and may reflect the activity of plaque in CHD patients. Thus it is important for clinical diagnosis and risk evaluation of acute coronary syndrome （ACS） patients.

Comparision of high sensitivity C-reactive protein and matrix metalloproteinase 9 in patients with unstable angina between with and without significant coronary artery plaques

Background Inflammation within vulnerable coronary plaques may cause unstable angina by promoting rupture and erosion. C-reactive protein （CRP） is the most reliable and accessible test method for clinical use for identifying coronary artery disease event. Matrix metalloproteinase 9 （MMP-9） is highly over-expressed in the vulnerable regions of a plaque. Our aim was to evaluate the plasma levels of MMP-9 and hsCRP in subjects with both unstable angina and coronary plaques, as well as in those with unstable angina without coronary plaques.

SAA、hs-CRP、IL-6对儿童过敏性紫癜的联合诊断价值

目的探讨血清淀粉样蛋白A(SAA)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)对儿童过敏性紫癜(HSP)的联合诊断价值。方法选取2018年9月至2022年10月于安徽医科大学附属巢湖医院儿科确诊为HSP患儿98例作为观察组,并选取同期健康儿童98名作为对照组,比较两组患儿的一般资料以及SAA、hs-CRP、IL-6水平,并通过多因素Logistic回归分析HSP的独立影响因素,采用受试者工作特征曲线(ROC)分析SAA、hs-CRP、IL-6单独以及联合检测对HSP的诊断价值。结果观察组患儿的SAA、hs-CRP、IL-6水平均明显高于对照组,差异具有统计学意义(t=31.566、29.430、26.857,P<0.05)。单因素分析结果显示,Hp感染、药物过敏史、家族史与HSP发生有关(χ^(2)=27.000、11.696、5.548,P<0.05)。多因素Logistic回归分析结果显示,血清SAA、hs-CRP、IL-6、HP感染为HSP的独立危险因素(P<0.05)。ROC曲线结果显示,SAA、hs-CRP、IL-6单独检测以及联合检测诊断HSP的曲线下面积(AUC)为0.894、0.701、0.769、0.920。结论SAA、hs-CRP、IL-6联合检测对儿童HSP具有较高的诊断价值,值得临床进行推广。

A study on the relationship between changes in serum hs-CRP levels and Chinese ischemic stroke subclassification

Objective: To study the relationship between changes in serum high sensitivity C-reactive protein (hs-CRP) levels and Chinese ischemic stroke subclassification (CISS), and explore the action mechanism of hs-CRP in the pathogenetic process of ischemic stroke. Methods: The serum hs-CRP level was measured in all subjects (including the healthy). As to 177 ischemic stroke patients, they were subclassified based on causes and pathogenesis to explore the relationship between the serum hs-CRP level and CISS. Results: The serum hs-CRP level in the ischemic stroke group was significantly higher than that in the control group (p < .05). The difference of the serum hs-CRP levels in different Chinese ischemic stroke subtypes was of statistical significance (p < .05). Conclusions: The level of serum hs-CRP is closely associated with the incidence of the ischemic stroke, and the difference of the serum hs-CRP levels in different Chinese ischemic stroke subtypes is of statistical significance.

Changes of hs-CRP, S100B and NSE levels in serum and cerebrospinal fluid of children with epilepsy and their correlation with the nerve cell apoptosis

Objective:To study the changes of hs-CRP, S100B and NSE levels in serum and cerebrospinal fluid of children with epilepsy and their correlation with the nerve cell apoptosis.Methods:The children who were diagnosed with epilepsy in this hospital between March 2015 and February 2017 were selected as epilepsy group, and the children who underwent operation due to hernia during the same period were selected as control group. The cerebrospinal fluid was collected to determine the contents of hs-CRP, S100B and NSE, and the serum was collected to detect the contents of hs-CRP, S100B, NSE, apoptosis molecules and Sirtuins family molecules.Results: hs-CRP, S100B and NSE levels in serum and cerebrospinal fluid of epilepsy group were significantly higher than those of control group, Bim, Bax, Caspase-3, Caspase-4 and Caspase-9 levels in cerebrospinal fluid were significantly higher than those of control group, and XIAP, Bcl-2, SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 and SIRT7 levels in cerebrospinal fluid were significantly lower than those of control group;hs-CRP, S100B and NSE levels in serum and cerebrospinal fluid of children with epilepsy were positively correlated with Bim, Bax, Caspase-3, Caspase-4 and Caspase-9 levels in cerebrospinal fluid, and negatively correlated with XIAP, Bcl-2, SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 and SIRT7 levels in cerebrospinal fluid.Conclusion: The abnormally elevated hs-CRP, S100B and NSE in serum and cerebrospinal fluid of children with epilepsy are closely related to the excessive apoptosis of nerve cells.

血清pro-BNP hs-CRP FIB水平对AECOPD合并呼吸衰竭的诊断及预后评估研究

目的:探讨血清脑钠肽前体(pro-BNP)、超敏C-反应蛋白(hs-CRP)、血浆纤维蛋白原(FIB)水平对慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭的诊断及预后评估研究。方法:将我院从2017年1月至2021年12月期间入院的72例AECOPD合并呼吸衰竭患者作为A组、71例AECOPD未合并呼吸衰竭患者作为B组和71例同时期复诊的稳定期COPD患者作为C组,检测三组患者治疗前的第1秒用力呼气容积(FEV1)和呼气流量峰值(PEF),采血分离血清检测pro-BNP、hs-CRP和FIB,分析AECOPD合并呼吸衰竭患者、单纯AECOPD和稳定期COPD患者上述指标差异,研究AECOPD合并呼吸衰竭患者pro-BNP、hs-CRP和FIB与FEV1和PEF的关系,探究pro-BNP、hs-CRP和FIB指导AECOPD合并呼吸衰竭诊断的价值,根据存活情况,分为生存组和死亡组,将其入院后检测的实验室指标进行归类记录,探究pro-BNP、hs-CRP和FIB指导AECOPD合并呼吸衰竭预后预测的价值。结果:A、B组的FEV1/FVC和PEF均低于C组(P<0.05),且A组的FEV1/FVC和PEF均低于B组(P<0.05);A、B组的pro-BNP、hs-CRP和FIB均高于C组(P<0.05),A组的pro-BNP、hs-CRP和FIB均高于B组(P<0.05);pro-BNP约登指数最大时诊断AECOPD合并呼吸衰竭对应cut-off为299.95ng/L,AUC为0.878,诊断敏感度、特异性为86.36%、86.21%;hs-CRP约登指数最大时对应cut-off为12.01mg/L,AUC为0.838,预测敏感度、特异性分别为70.00%、88.89%;FIB约登指数最大时对应cut-off为4.89g/L,AUC为0.772,诊断敏感度、特异性为75.21%、75.93%;预测预后效能:死亡组的pro-BNP、hs-CRP和FIB均高于存活组(P<0.05),且pro-BNP预测AECOPD合并呼吸衰竭不良预后约登指数最大时对应cut-off为367.03ng/L,AUC为0.854,诊断敏感度、特异性为88.24%、84.44%;hs-CRP约登指数最大时对应cut-off为17.69mg/L,AUC为0.795,预测敏感度、特异性分别为76.47%、86.67%;FIB约登指数最大时对应cut-off为5.99g/L,AUC为0.781,诊断敏感度、特异性为82.35%、82.22%。结论:AECOPD合并呼吸衰竭患者的血清pro-BNP、hs-CRP和FIB水平的异常升高,均与肺功能指标FEV1/FVC和PEF相关,且血清pro-BNP、hs-CRP和FIB对诊断AECOPD合并呼吸衰竭及其预后评估有较高的价值。

血清Hcy、hs-CRP、D-D水平检测在急性脑梗死诊断中的临床价值

目的 探讨血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)水平检测在急性脑梗死诊断中的临床价值。方法 选择我院2018年1月至2019年6月收治的60例急性脑梗死患者作为本次研究入组对象,另选取2018年1月至2019年6月在我院进行体检的结果显示健康的60名健康志愿者作为对照组。比较两组血清Hcy、hs-CRP、D-D水平以及不同梗死面积的急性脑梗死患者血清Hcy、hs-CRP、D-D水平差异。结果 急性脑梗死组和健康对照组血清Hcy、hs-CRP、D-D水平对比,研究组患者经血清检测Hcy、hs-CRP、D-D均高于对照组,组间差异有统计学意义(P<0.05)。急性脑梗死不同梗死面积血清Hcy、hs-CRP、D-D水平对比,大面积梗死患者的血清Hcy、hs-CRP、D-D均高于中、小梗死患者,组间差异有统计学意义(P<0.05)。急性脑梗死不同梗死程度血清Hcy、hs-CRP、D-D水平对比,重度梗死患者的血清Hcy、hs-CRP、D-D均高于轻、中度梗死患者,组间差异有统计学意义(P<0.05)。结论 血清Hcy、hs-CRP、D-D水平检测在急性脑梗死诊断中的临床应用价值高,不同大小的梗死面积和不同程度的梗死对患者影响不同,临床预后大不相同,经血清Hcy、hs-CRP、D-D水平检测可实现对梗死面积及程度的判断,为临床诊治和预后判断提供重要参考。