This study is to assess the potential factors that could affect the serum prostate-specific antigen （PSA） level in healthy younger men. We evaluated the associations of age, body mass index （BMI） and serum lipid p...This study is to assess the potential factors that could affect the serum prostate-specific antigen （PSA） level in healthy younger men. We evaluated the associations of age, body mass index （BMI） and serum lipid profile with serum PSA level in 6774 Chinese men （aged 20-49 years） who received a routine health examination. Eligible men were classified into 10-year age groups, BMI was categorized as underweight （〈18.5）, normal （18.5-22.9）, overweight （23.0-24.9）, obese （25.0-29,9） and very obese （〉30） according to the redefined World Health Organization （WHO） criteria for the Asia-Pacific region. PSA levels were compared among groups as well, In multiple linear regression analysis, PSA was positively correlated with age （P〈0.0001）. Negative correlations existed between PSA and BMI （P〈0.0001） and triglyceride level （P=0.01）. No relationship could be found between PSA and serum cholesterol （P=0.711） or high-density lipoprotein （HDL; P =0.665）. In addition, we found that serum PSA levels increased with age and decreased with BMI. Our study demonstrates that age, BMI and triglyceride levels influence the PSA level in men 〈50 years of age.展开更多
Objectives To investigate the relationship of serum leptin concentration with the lipids and body mass index （BMI） in patients with chronic congestive heart failure（CHF）. Methods The serum concentration of leptin ...Objectives To investigate the relationship of serum leptin concentration with the lipids and body mass index （BMI） in patients with chronic congestive heart failure（CHF）. Methods The serum concentration of leptin in 39 patients with CHF （14 in cardiac function class Ⅱ , 21 in class Ⅲ, 4 in classⅣ , NYHA） and in 46 patients with cardiac function class Ⅰ （NYHA） were assessed by radioimmunoassay. Results The serum concentration of leptin were 9.018±4.519 μg/l in CHF group （cardiac function class Ⅱ 11.492±5.649 μg/l, class Ⅲ 7.763±3.321 μg/l, class Ⅳ 6.100±2.657 μg/l）; 11.674± 6.911 μg/l in class Ⅰ group. The serum concentrations of leptin were significantly lower in CHF group, as compared with class Ⅰ group （P〈 0.05）. Moreover, the decrease of serum leptin concentration was significantly correlated with the decreased serum concentrations of total cholesterol, triglyceride, body mass index and left ventricular ejection fraction in CHF group, respectively （P 〈 0.05）. Conclusions The significance of the decrease in serum leptin in CHF patients needs further study.展开更多
目的探讨血脂及身体质量指数(body mass index,BMI)与结直肠息肉病理类型的相关性。方法收集2010年1月–2015年8月在首都医科大学附属北京同仁医院消化内科住院行结直肠息肉切除的246例患者,回顾性分析不同病理类型结直肠息肉与血脂及BM...目的探讨血脂及身体质量指数(body mass index,BMI)与结直肠息肉病理类型的相关性。方法收集2010年1月–2015年8月在首都医科大学附属北京同仁医院消化内科住院行结直肠息肉切除的246例患者,回顾性分析不同病理类型结直肠息肉与血脂及BMI的关系。结果绒毛状管状腺瘤及绒毛状腺瘤组高脂血症发生率为64.7%,高于管状腺瘤组(36.2%)、炎性息肉及增生性息肉组(45.9%)。绒毛状管状腺瘤及绒毛状腺瘤组血清甘油三脂(TG)水平(2.24±2.50)mmol/L高于管状腺瘤组[(1.29±0.96)mmol,P<0.05]、炎性息肉及增生性息肉组[(1.40±0.72)mmol/L,P<0.05],三组间血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平、BMI差异均无统计学意义(P>0.05)。有异型增生组血清TG水平(1.79±2.26)mmol/L高于非异型增生组[(1.38±0.86)mmol/L,P<0.05],BMI略高于无异型增生组[(24.45±4.34 vs 24.07±3.52)kg/m^2,P<0.05],两组血清TC、HDL及LDL水平差异均无统计学意义(P>0.05)。结论高TG血症可能与病理类型较差的结直肠息肉(如带绒毛结构的腺瘤或有异型增生的腺瘤)有关。展开更多
目的探讨肥胖大学生体质量指数(body mass index,BMI)与血脂、血清同型半胱氨酸(homocysteine,Hcy)的相关性及其临床意义。方法 2010年入学体检大学生中以自愿参加方式,分组BMI≥25kg/m2大学生55例设为肥胖组(n=55),BMI<25kg/m2大学...目的探讨肥胖大学生体质量指数(body mass index,BMI)与血脂、血清同型半胱氨酸(homocysteine,Hcy)的相关性及其临床意义。方法 2010年入学体检大学生中以自愿参加方式,分组BMI≥25kg/m2大学生55例设为肥胖组(n=55),BMI<25kg/m2大学生92例设为对照组(n=92),两组学生均无慢性内科疾患。测定两组血脂,直接竞争ELISA法测定血清同型半胱氨酸水平。结果两组比较,肥胖组血清TG水平高于对照组,HDL-c低于对照组,差异有统计学意义(P<0.01);两组比较TC、LDL-c无显著差异(P>0.05);肥胖组血清Hcy高于对照组;肥胖组大学生BMI与TG水平呈正相关(r=0.325,P<0.05),BMI与血清Hcy水平呈正相关(r=0.321,P<0.05)。结论肥胖大学生易发生动脉粥样硬化性疾病,防治大学生肥胖是高校教育需重视的问题。展开更多
文摘This study is to assess the potential factors that could affect the serum prostate-specific antigen （PSA） level in healthy younger men. We evaluated the associations of age, body mass index （BMI） and serum lipid profile with serum PSA level in 6774 Chinese men （aged 20-49 years） who received a routine health examination. Eligible men were classified into 10-year age groups, BMI was categorized as underweight （〈18.5）, normal （18.5-22.9）, overweight （23.0-24.9）, obese （25.0-29,9） and very obese （〉30） according to the redefined World Health Organization （WHO） criteria for the Asia-Pacific region. PSA levels were compared among groups as well, In multiple linear regression analysis, PSA was positively correlated with age （P〈0.0001）. Negative correlations existed between PSA and BMI （P〈0.0001） and triglyceride level （P=0.01）. No relationship could be found between PSA and serum cholesterol （P=0.711） or high-density lipoprotein （HDL; P =0.665）. In addition, we found that serum PSA levels increased with age and decreased with BMI. Our study demonstrates that age, BMI and triglyceride levels influence the PSA level in men 〈50 years of age.
文摘Objectives To investigate the relationship of serum leptin concentration with the lipids and body mass index （BMI） in patients with chronic congestive heart failure（CHF）. Methods The serum concentration of leptin in 39 patients with CHF （14 in cardiac function class Ⅱ , 21 in class Ⅲ, 4 in classⅣ , NYHA） and in 46 patients with cardiac function class Ⅰ （NYHA） were assessed by radioimmunoassay. Results The serum concentration of leptin were 9.018±4.519 μg/l in CHF group （cardiac function class Ⅱ 11.492±5.649 μg/l, class Ⅲ 7.763±3.321 μg/l, class Ⅳ 6.100±2.657 μg/l）; 11.674± 6.911 μg/l in class Ⅰ group. The serum concentrations of leptin were significantly lower in CHF group, as compared with class Ⅰ group （P〈 0.05）. Moreover, the decrease of serum leptin concentration was significantly correlated with the decreased serum concentrations of total cholesterol, triglyceride, body mass index and left ventricular ejection fraction in CHF group, respectively （P 〈 0.05）. Conclusions The significance of the decrease in serum leptin in CHF patients needs further study.
文摘目的探讨血脂及身体质量指数(body mass index,BMI)与结直肠息肉病理类型的相关性。方法收集2010年1月–2015年8月在首都医科大学附属北京同仁医院消化内科住院行结直肠息肉切除的246例患者,回顾性分析不同病理类型结直肠息肉与血脂及BMI的关系。结果绒毛状管状腺瘤及绒毛状腺瘤组高脂血症发生率为64.7%,高于管状腺瘤组(36.2%)、炎性息肉及增生性息肉组(45.9%)。绒毛状管状腺瘤及绒毛状腺瘤组血清甘油三脂(TG)水平(2.24±2.50)mmol/L高于管状腺瘤组[(1.29±0.96)mmol,P<0.05]、炎性息肉及增生性息肉组[(1.40±0.72)mmol/L,P<0.05],三组间血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平、BMI差异均无统计学意义(P>0.05)。有异型增生组血清TG水平(1.79±2.26)mmol/L高于非异型增生组[(1.38±0.86)mmol/L,P<0.05],BMI略高于无异型增生组[(24.45±4.34 vs 24.07±3.52)kg/m^2,P<0.05],两组血清TC、HDL及LDL水平差异均无统计学意义(P>0.05)。结论高TG血症可能与病理类型较差的结直肠息肉(如带绒毛结构的腺瘤或有异型增生的腺瘤)有关。
文摘目的探讨肥胖大学生体质量指数(body mass index,BMI)与血脂、血清同型半胱氨酸(homocysteine,Hcy)的相关性及其临床意义。方法 2010年入学体检大学生中以自愿参加方式,分组BMI≥25kg/m2大学生55例设为肥胖组(n=55),BMI<25kg/m2大学生92例设为对照组(n=92),两组学生均无慢性内科疾患。测定两组血脂,直接竞争ELISA法测定血清同型半胱氨酸水平。结果两组比较,肥胖组血清TG水平高于对照组,HDL-c低于对照组,差异有统计学意义(P<0.01);两组比较TC、LDL-c无显著差异(P>0.05);肥胖组血清Hcy高于对照组;肥胖组大学生BMI与TG水平呈正相关(r=0.325,P<0.05),BMI与血清Hcy水平呈正相关(r=0.321,P<0.05)。结论肥胖大学生易发生动脉粥样硬化性疾病,防治大学生肥胖是高校教育需重视的问题。
