Sodium homeostasis disorder is one of the most common abnormal symptoms of elderly patients in intensive care unit(ICU),which may lead to physiological disorders of many organs.The current prediction of serum sodium i...Sodium homeostasis disorder is one of the most common abnormal symptoms of elderly patients in intensive care unit(ICU),which may lead to physiological disorders of many organs.The current prediction of serum sodium in ICU is mainly based on the subjective judgment of doctors’experience.This study aims at this problem by studying the clinical retrospective electronic medical record data of ICU to establish a machine learning model to predict the short-term serum sodium value of ICU patients.The data set used in this study is the open-source intensive care medical information set Medical Information Mart for Intensive Care(MIMIC)-IV.The time point of serum sodium detection was selected from the ICU clinical records,and the ICU records of 25risk factors related to serum sodium were extracted from the patients within the first 12 h for statistical analysis.A prediction model of serum sodium value within 48 h was established using a feedforward neural network,and compared with previous methods.Our research results show that the neural network learning model can predict the development of serum sodium in patients using physiological indicators recorded in clinical electronic medical records within 12 h,and has better prediction effect than the serum sodium formula and other machine learning models.展开更多
In pH 5.5 phosphate buffer solution, N-n-undecyl-N＇-（sodium-p-amino-benzenesulfonate） thiourea （UPT） produced a pair of redox peaks on the bare glassy carbon electrode. At the multi-walled carbon nanotube （MWNT...In pH 5.5 phosphate buffer solution, N-n-undecyl-N＇-（sodium-p-amino-benzenesulfonate） thiourea （UPT） produced a pair of redox peaks on the bare glassy carbon electrode. At the multi-walled carbon nanotube （MWNT） modified electrode, the electrochemical behavior of UPT enhanced greatly. In the presence of bovine serum albumin （BSA）, the peak currents of UPT decreased linearly due to the formation of a super-molecular complex. This method was successfully applied to the determination of BSA in a bovine serum sample.展开更多
Objective： To analyze the relationship of severity of heart failure and the concentration of serum sodium（Na^ ＋ ） and chlorine（Cl^- ） and to explore the effect of supplying sodium and chlorine on patients with C...Objective： To analyze the relationship of severity of heart failure and the concentration of serum sodium（Na^ ＋ ） and chlorine（Cl^- ） and to explore the effect of supplying sodium and chlorine on patients with Congestive heart failure. Methods： 80 patients with congestive heart failure were divided into two groups, namely supplying and control group. Serum sodium and chlorine were roeasured in all these patients. All treatments but supplying sodium and chlorine were same between the supplying and control groups. Results： According to NYHA, patients who were in class Ⅳ had lower level of serum sodium and chlorine than those in class Ⅱ （ P 〈0.05）. The heart function was improved after the level of serum sodium and chlorine were raised. Conclusions： The concentration of serum sodium and chlorine relates to the severity of heart failure. The therapy of supplying sodium and chlorine is an effective way to decrease death rate.展开更多
Objective: To evaluate the ameliorating effects of Raphanus sativus leaves(RSL)against sodium arsenite(Sa)-induced adverse effects through mice experiments.Methods: Swiss albino mice were divided into four equal group...Objective: To evaluate the ameliorating effects of Raphanus sativus leaves(RSL)against sodium arsenite(Sa)-induced adverse effects through mice experiments.Methods: Swiss albino mice were divided into four equal groups: control, Sa, RSL,RSL + Sa. Sa(10 mg/kg body weight/day), and powder form of RSL(50 mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric methods.Results: It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities were significantly(P < 0.05)higher in Sa-treated mice than those in the control group. RSL significantly reduced Sainduced elevation of the activities of these enzymes in serum significantly(P < 0.05).Serum butyrylcholinesterase activity and high density lipoproteins cholesterol levels in Satreated mice were significantly(P < 0.05) lower than the control group, and the food supplementation of RSL could significantly(P < 0.05) prevent the reduction of Sa-mediated serum butyryl cholinesterase activity and high density lipoproteins cholesterol levels. RSL could also reduce the Sa-induced elevation of serum urea level significantly(P < 0.05).Conclusions: Results of this study suggest the protective or ameliorating effects of RSL on Sa-induced perturbation of blood indices are related to the hepatic, cardiovascular and kidney dysfunction. Therefore, RSL may be useful to reduce arsenic toxicity in human in the future.展开更多
Objective:To investigate the prognostic value of electrolyte disturbances in patients with traumatic brain injury(TBI).Methods:Cases of TBI patients admitted to the Department of Neurosurgery at Dezhou Second People’...Objective:To investigate the prognostic value of electrolyte disturbances in patients with traumatic brain injury(TBI).Methods:Cases of TBI patients admitted to the Department of Neurosurgery at Dezhou Second People’s Hospital from September 2015 to September 2021 were analyzed to examine the impact of electrolyte disturbances on patient prognosis and to establish a risk prediction model.Results:Patients with electrolyte disturbances had poorer prognoses,with serum sodium and serum calcium levels significantly affecting the outcomes of patients with traumatic brain injury.Conclusion:Serum sodium and calcium levels may serve as potential prognostic markers in patients with traumatic brain injury.展开更多
目的评价黄疸、溶血、脂血、尿毒症等异常标本中内源性干扰物质对酶法测定血清中钾钠氯结果的影响。方法依据美国国家临床实验室标准化委员会(NCCLS)的EP 7-P文件,分别用间接离子选择性电极(ISE)和酶法测定正常对照组(非黄疸、溶血、脂...目的评价黄疸、溶血、脂血、尿毒症等异常标本中内源性干扰物质对酶法测定血清中钾钠氯结果的影响。方法依据美国国家临床实验室标准化委员会(NCCLS)的EP 7-P文件,分别用间接离子选择性电极(ISE)和酶法测定正常对照组(非黄疸、溶血、脂血)、黄疸组、溶血组、脂血组、尿毒症组标本中钾钠氯,对结果进行统计学分析。结果正常对照组,酶法钠氯均高于ISE(P<0.05),钾在两种方法间无差异;溶血、黄疸对酶法测定钾钠氯均无干扰(P>0.05);脂血(TG<15mm o l/L)对酶法测定钾氯无干扰,钠呈负偏差,但酶法不能测定严重脂血标本(TG>15 mm o l/L)中钾钠氯,脂血标本中钠偏倚与甘油三酯、胆固醇浓度不相关(r=0.06,r=0.10);尿毒症组样品中钾与对照组呈负偏差(P<0.05),与CREA、BUN的浓度间弱相关(r=0.31,r=0.26),而尿毒症组标本中钠氯较正常对照组呈正偏差(P<0.05),与CREA、BUN浓度间无相关性(r=0.07,r=0.05)。结论溶血、黄疸、轻中度脂血对酶法测定钾钠氯无干扰,但不能用于分析严重脂血标本、尿毒症标本的钾钠氯测定。展开更多
基金supported by the National Natural Science Foundation of China(No.12345678)。
文摘Sodium homeostasis disorder is one of the most common abnormal symptoms of elderly patients in intensive care unit(ICU),which may lead to physiological disorders of many organs.The current prediction of serum sodium in ICU is mainly based on the subjective judgment of doctors’experience.This study aims at this problem by studying the clinical retrospective electronic medical record data of ICU to establish a machine learning model to predict the short-term serum sodium value of ICU patients.The data set used in this study is the open-source intensive care medical information set Medical Information Mart for Intensive Care(MIMIC)-IV.The time point of serum sodium detection was selected from the ICU clinical records,and the ICU records of 25risk factors related to serum sodium were extracted from the patients within the first 12 h for statistical analysis.A prediction model of serum sodium value within 48 h was established using a feedforward neural network,and compared with previous methods.Our research results show that the neural network learning model can predict the development of serum sodium in patients using physiological indicators recorded in clinical electronic medical records within 12 h,and has better prediction effect than the serum sodium formula and other machine learning models.
基金the National Natural Science Foundation of China(No.20575077).
文摘In pH 5.5 phosphate buffer solution, N-n-undecyl-N＇-（sodium-p-amino-benzenesulfonate） thiourea （UPT） produced a pair of redox peaks on the bare glassy carbon electrode. At the multi-walled carbon nanotube （MWNT） modified electrode, the electrochemical behavior of UPT enhanced greatly. In the presence of bovine serum albumin （BSA）, the peak currents of UPT decreased linearly due to the formation of a super-molecular complex. This method was successfully applied to the determination of BSA in a bovine serum sample.
文摘Objective： To analyze the relationship of severity of heart failure and the concentration of serum sodium（Na^ ＋ ） and chlorine（Cl^- ） and to explore the effect of supplying sodium and chlorine on patients with Congestive heart failure. Methods： 80 patients with congestive heart failure were divided into two groups, namely supplying and control group. Serum sodium and chlorine were roeasured in all these patients. All treatments but supplying sodium and chlorine were same between the supplying and control groups. Results： According to NYHA, patients who were in class Ⅳ had lower level of serum sodium and chlorine than those in class Ⅱ （ P 〈0.05）. The heart function was improved after the level of serum sodium and chlorine were raised. Conclusions： The concentration of serum sodium and chlorine relates to the severity of heart failure. The therapy of supplying sodium and chlorine is an effective way to decrease death rate.
基金financially supported by the University of Rajshahi[No.A-892-5/52/BIMOK/BIGGAN(1)/2011]
文摘Objective: To evaluate the ameliorating effects of Raphanus sativus leaves(RSL)against sodium arsenite(Sa)-induced adverse effects through mice experiments.Methods: Swiss albino mice were divided into four equal groups: control, Sa, RSL,RSL + Sa. Sa(10 mg/kg body weight/day), and powder form of RSL(50 mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric methods.Results: It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities were significantly(P < 0.05)higher in Sa-treated mice than those in the control group. RSL significantly reduced Sainduced elevation of the activities of these enzymes in serum significantly(P < 0.05).Serum butyrylcholinesterase activity and high density lipoproteins cholesterol levels in Satreated mice were significantly(P < 0.05) lower than the control group, and the food supplementation of RSL could significantly(P < 0.05) prevent the reduction of Sa-mediated serum butyryl cholinesterase activity and high density lipoproteins cholesterol levels. RSL could also reduce the Sa-induced elevation of serum urea level significantly(P < 0.05).Conclusions: Results of this study suggest the protective or ameliorating effects of RSL on Sa-induced perturbation of blood indices are related to the hepatic, cardiovascular and kidney dysfunction. Therefore, RSL may be useful to reduce arsenic toxicity in human in the future.
文摘Objective:To investigate the prognostic value of electrolyte disturbances in patients with traumatic brain injury(TBI).Methods:Cases of TBI patients admitted to the Department of Neurosurgery at Dezhou Second People’s Hospital from September 2015 to September 2021 were analyzed to examine the impact of electrolyte disturbances on patient prognosis and to establish a risk prediction model.Results:Patients with electrolyte disturbances had poorer prognoses,with serum sodium and serum calcium levels significantly affecting the outcomes of patients with traumatic brain injury.Conclusion:Serum sodium and calcium levels may serve as potential prognostic markers in patients with traumatic brain injury.
文摘目的评价黄疸、溶血、脂血、尿毒症等异常标本中内源性干扰物质对酶法测定血清中钾钠氯结果的影响。方法依据美国国家临床实验室标准化委员会(NCCLS)的EP 7-P文件,分别用间接离子选择性电极(ISE)和酶法测定正常对照组(非黄疸、溶血、脂血)、黄疸组、溶血组、脂血组、尿毒症组标本中钾钠氯,对结果进行统计学分析。结果正常对照组,酶法钠氯均高于ISE(P<0.05),钾在两种方法间无差异;溶血、黄疸对酶法测定钾钠氯均无干扰(P>0.05);脂血(TG<15mm o l/L)对酶法测定钾氯无干扰,钠呈负偏差,但酶法不能测定严重脂血标本(TG>15 mm o l/L)中钾钠氯,脂血标本中钠偏倚与甘油三酯、胆固醇浓度不相关(r=0.06,r=0.10);尿毒症组样品中钾与对照组呈负偏差(P<0.05),与CREA、BUN的浓度间弱相关(r=0.31,r=0.26),而尿毒症组标本中钠氯较正常对照组呈正偏差(P<0.05),与CREA、BUN浓度间无相关性(r=0.07,r=0.05)。结论溶血、黄疸、轻中度脂血对酶法测定钾钠氯无干扰,但不能用于分析严重脂血标本、尿毒症标本的钾钠氯测定。
