Background:Recently,there has been a surge in research worldwide on vitamin D.based on international level,Vit.D has shown positive correlation with cardio-cerebrovascular disorders.Regarding possible role of vitamin ...Background:Recently,there has been a surge in research worldwide on vitamin D.based on international level,Vit.D has shown positive correlation with cardio-cerebrovascular disorders.Regarding possible role of vitamin D there is paucity of research in low-and middle-income nations that are nearer to the equatorial area.Despite of abundant sunlight exposure,Asian people are developing hypovitaminosis D need a special consideration to avoid excessive and unnecessary usage of it.This study aims to detect the situation of vitamin D in Nepalese population and secondly to find out the suitable normalized reference range for serum vitamin D in multi-ethnic Nepalese population.Methods:A hospital based prospective study was conducted using purposive sampling technique to select 107 subjects.In-vivo and in vitro bio-physiological method was used to collect serum vitamin D level.Result:The present study showed that 32%of participants had deficit(<15 ng/mL),48%of subjects had insufficient(15 to<30 ng/mL)and 20%of participants had sufficient serum level of Vitamin-D(>30 ng/mL).Study showed that there is a lower degree of positive relationship of body mass index(r=0.162,P=0.094)and significant association of history of chronic illness(χ2=0.10,P=0.03),timing of occurrence of stroke(χ2=11.41,P=0.017)and diagnosis(χ2=21.19,P=0.011)with serum vitamin-D level at P<0.05.Conclusion:There is a direct significant association of serum vitamin D with socio-demographic variables when international unit is considered.Neurological disorder showed positive association with serum vitamin D level.展开更多
Objective To assess vitamin D levels in eastern China by a standard measurement.Methods The data were from a 2014 Survey on the Prevalence in East China for Metabolic Diseases and Risk Factors-China data base.There we...Objective To assess vitamin D levels in eastern China by a standard measurement.Methods The data were from a 2014 Survey on the Prevalence in East China for Metabolic Diseases and Risk Factors-China data base.There were 12 662 subjects included in this cross-sectional study from February 2014 to June 2016.We assessed the vitamin D levels of natural population by展开更多
Objective To study the effect of oral vitamin D （VD） supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men. Methods Twenty-one obese men with their body mass index （BMI）〉28 k...Objective To study the effect of oral vitamin D （VD） supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men. Methods Twenty-one obese men with their body mass index （BMI）〉28 kg/m2 served as an obese group and 22 healthy normal-weight men with their BMI〈24 kg/m2 served as a control group in this study. After they were given 50 000 IU of oral VD, once a week for 8 weeks, the serum 25-hydroxyvitamin D [25（OH）D] concentration was measured with an enzyme-immunoassay kit. Results After oral VD supplementation, the serum 25（OH）D concentration significantly increased from 46.1＋9.1 nmol/L to 116.7_＋20.3 nmol/L in the obese subjects （P〈O.01） and from 52.8_＋17.8 nmol/L to 181.3_＋30.2 nmol/L in the control ones （P=0.13）. The serum high-density lipoprotein cholesterol （HDL-C） level was reduced within the normal reference range in the obese group. However, no significant change was observed in the level of other serum lipids （triglycerides, total cholesterol, and low-density lipoprotein cholesterol） in either of the two groups. Conclusion The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group. High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.展开更多
The rapid decline in circulating levels of serum 25-hydroxyvitamin D in both African Americans and Caucasians in the US population remains unexplained, and appears to parallel the obesity epidemic. The cross sectional...The rapid decline in circulating levels of serum 25-hydroxyvitamin D in both African Americans and Caucasians in the US population remains unexplained, and appears to parallel the obesity epidemic. The cross sectional data on 7349 Caucasian and African American adults between 21 and 69 years of age from the continuous National Health and Nutrition Examination Study (NHANES) 2001 to 2006 were used to model by race, with smoothing functions, the true relationship between body mass index (BMI), waist circumference and serum 25-hydroxyvitamin D in men and women. Weighted regressions of determinants of serum 25-hydroxyvitamin D levels were analyzed. Serum 25-hydroxyvitamin D is negatively associated with BMI linearly above an inflection point at 20 kg/m2 and positively associated below a BMI of 20 kg/m2. The gender- and age-adjusted regression coefficients of BMI on 25-hydroxyvitamin D levels demonstrate a 50% lower coefficient (r = –0.18 ng/ml/ BMI unit) among African Americans than among Caucasians (r = –0.36 ng/ml/BMI unit). These relationships were as great in men as in women and were replicated when waist circumference was used as a surrogate for visceral fat levels. The extent to which BMI is a strong predictor of serum 25-hydroxyvitamin D levels depends upon BMI being greater than 20 kg/m2. The hockey stick shape of the BMI 25-hydroxyvitamin D relationship needs to be taken into account when adjusting serum values for BMI. Both this inflection and reduction in serum levels of 25-hydroxyvitamin D in the population may be due to sequestration in an increasing adipose tissue reservoir. The interpretation of serum 25-hydroxyvitamin D levels as a biomarker of vitamin D adequacy requires appropriate adjustment of body fat mass.展开更多
Background: Vitamin D plays a pivotal role in supporting the immune system, helping to reduce the risk of infections and certain autoimmune diseases. Adequate vitamin D levels may be associated with a reduced risk of ...Background: Vitamin D plays a pivotal role in supporting the immune system, helping to reduce the risk of infections and certain autoimmune diseases. Adequate vitamin D levels may be associated with a reduced risk of certain health conditions like pre-eclampsia, gestational diabetes, and postpartum depression. Brittle bones, osteoporosis in the elderly, and osteomalacia in young children are all symptoms of vitamin D insufficiency. Additionally, it contributes to problems linked to gum disease, including an increase in dental cavities, alveolar bone loss around the teeth, and other problems. It could lead to depression, tiredness, and a loss of appetite. In this study, urban children and adolescents in Dhaka city, Bangladesh are examined for vitamin D deficiency, insufficiency, and sufficiency. Methods: The Study was a cross-sectional study conducted under Dhaka National Medical College and Hospital, Dhaka and additionally included two other health centers Medinova Medical Services and Monoara General Hospital Service Golap bag, Dhaka from October 2020 to November 2021. The study location was at the 3 (Three) different hospitals which was located in Dhaka City. In this cross-sectional study, Participants will be selected purposively and conveniently based on the age categories from 0 - 19 years of age at the outdoor department of the hospital. The study included the secondary dataset of ambulatory individuals who came to the 3 (three) hospitals, randomly to evaluate serum vitamin D levels on referral from a general out-patient-department (OPD). They were examined for laboratory findings of serum 25 hydroxyvitamin D levels to determine vitamin D deficiency, insufficiency, and sufficiency among children and adolescent groups of both male and female Sex. Results: A total of 6394 individuals with a diverse age group were statistically examined for laboratory findings of serum vitamin D levels. Vitamin D deficiency was observed in 40.58% of individuals with a mean log of 1.01 ± 0.18 ng/ml serum vitamin D levels, vitamin D insufficiency in 30.93% of individuals with a mean log of 1.38 ± 0.05 ng/ml serum vitamin D levels and vitamin D sufficiency in 19.49% individuals with a mean log of 1.63 ± 0.12 ng/ml serum vitamin D levels. The highest percentage of individuals deficient in vitamin D were children and adolescents of age ranging between 15 to 19 years. Conclusion: The findings of vitamin D deficiency in children and adolescents direct higher authorities in the public health sector to take immediate steps to screen, intervene and educate high-risk populations incorporating vitamin D supplements to establish preventive and therapeutic measures.展开更多
Background: Recent studies suggested that vitamin D deficiency among children is widespread worldwide. Most of the Asian countries are suffering from high prevalence of vitamin D deficiency, especially in children. Ho...Background: Recent studies suggested that vitamin D deficiency among children is widespread worldwide. Most of the Asian countries are suffering from high prevalence of vitamin D deficiency, especially in children. However, the vitamin D deficiency of Bangladeshi children has not been investigated yet. The objective of the study was to assess the prevalence of vitamin D deficiency among children in Dhaka city, Bangladesh. Methods: A cross-sectional study was designed. Children aged 0 month to 16 years attended Pediatrics’ clinics with minor illness were conveniently recruited. After obtaining informed written consent, venous blood was taken and serum 25(OH)D levels were determined by direct enzyme-linked immunosorbent assay. Descriptive statistics were performed for age, sex, biochemical parameters. Socio-economic status (SES) was estimated using a wealth index, producing a weighted score. Scores were categorized into quintiles, with category 1 representing the poorest and category 5 the richest. Serum 25(OH)D was categorized: deficient as Results: 31.88% children of 0 - 1 year had deficient serum 25(OH)D level and 52.17% children had insufficient level. Among 2 - 5 years’ group, 38.16% were deficient and 50% were insufficient. Among the 6 - 11 years group, 41.02% were deficient and 52.56% were insufficient. Among 12 - 16 years group, 46.75% were deficient and 51.95% were insufficient. That means, serum 25-hydroxyvitamin D deficiency and insufficiency rate is found very high among Bangladeshi children. Conclusions: The prevalence of vitamin D deficiency and insufficiency among children in Bangladesh is high. The study recommended that vitamin D supplementation in Bangladeshi children should be formally launched from first day of birth up to adolescence.展开更多
目的探讨过敏性鼻炎患者血清辅助性T细胞17(Th17)/调节性T细胞(Treg)值与血清甲壳质酶蛋白-40(YKL-40)水平及维生素D水平的相关性。方法选择过敏性鼻炎患者99例(观察组)及同期体检健康者99例(对照组),采集空腹外周静脉血9 m L,采用酶联...目的探讨过敏性鼻炎患者血清辅助性T细胞17(Th17)/调节性T细胞(Treg)值与血清甲壳质酶蛋白-40(YKL-40)水平及维生素D水平的相关性。方法选择过敏性鼻炎患者99例(观察组)及同期体检健康者99例(对照组),采集空腹外周静脉血9 m L,采用酶联免疫吸附试验检测外周血25(OH)D_(3),采用流式细胞术检测外周血CD4^(+)IL-17+Th17细胞、CD4^(+)CD25^(+)Foxp3^(+)Treg细胞占CD4^(+)T细胞的百分比,采用双抗体夹心酶联免疫吸附法测定血清YKL-40,比较两组CD4^(+)IL-17+Th17细胞、CD4^(+)CD25^(+)Foxp3^(+)Treg细胞占CD4^(+)T细胞的百分比、YKL-40及维生素D水平。结果观察组血清25(OH)D_(3)水平和CD4^(+)CD25^(+)Foxp3^(+)Treg细胞占CD4^(+)T细胞的百分比低于对照组(P均<0.05),CD4^(+)IL-17+Th17细胞占CD4^(+)T细胞的百分比、Th17/Treg值及血清YKL-40水平高于对照组(P均<0.05)。观察组血清Th17/Treg值与YKL-40水平呈正相关(r=0.429,P<0.05),与血清25(OH)D_(3)水平呈负相关(r=-0.735,P<0.05);血清YKL-40与25(OH)D_(3)水平呈负相关(r=-0.450,P<0.05)。结论过敏性鼻炎患者血清25(OH)D_(3)水平降低,YKL-40水平升高,二者异常表达可能与Th17/Treg值失调有关,共同参与过敏性鼻炎的发生发展。展开更多
文摘Background:Recently,there has been a surge in research worldwide on vitamin D.based on international level,Vit.D has shown positive correlation with cardio-cerebrovascular disorders.Regarding possible role of vitamin D there is paucity of research in low-and middle-income nations that are nearer to the equatorial area.Despite of abundant sunlight exposure,Asian people are developing hypovitaminosis D need a special consideration to avoid excessive and unnecessary usage of it.This study aims to detect the situation of vitamin D in Nepalese population and secondly to find out the suitable normalized reference range for serum vitamin D in multi-ethnic Nepalese population.Methods:A hospital based prospective study was conducted using purposive sampling technique to select 107 subjects.In-vivo and in vitro bio-physiological method was used to collect serum vitamin D level.Result:The present study showed that 32%of participants had deficit(<15 ng/mL),48%of subjects had insufficient(15 to<30 ng/mL)and 20%of participants had sufficient serum level of Vitamin-D(>30 ng/mL).Study showed that there is a lower degree of positive relationship of body mass index(r=0.162,P=0.094)and significant association of history of chronic illness(χ2=0.10,P=0.03),timing of occurrence of stroke(χ2=11.41,P=0.017)and diagnosis(χ2=21.19,P=0.011)with serum vitamin-D level at P<0.05.Conclusion:There is a direct significant association of serum vitamin D with socio-demographic variables when international unit is considered.Neurological disorder showed positive association with serum vitamin D level.
文摘Objective To assess vitamin D levels in eastern China by a standard measurement.Methods The data were from a 2014 Survey on the Prevalence in East China for Metabolic Diseases and Risk Factors-China data base.There were 12 662 subjects included in this cross-sectional study from February 2014 to June 2016.We assessed the vitamin D levels of natural population by
基金supported by grants from Danone Institute,China Diet Nutrition Research & Communication (DIC2010-03)National Natural Science Foundation of China (81172669)+1 种基金Medical Scientific Research Foundation of Guangdong Province (A2012581)National Key Technology Research and Development Program of China (2012BAI02B02)
文摘Objective To study the effect of oral vitamin D （VD） supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men. Methods Twenty-one obese men with their body mass index （BMI）〉28 kg/m2 served as an obese group and 22 healthy normal-weight men with their BMI〈24 kg/m2 served as a control group in this study. After they were given 50 000 IU of oral VD, once a week for 8 weeks, the serum 25-hydroxyvitamin D [25（OH）D] concentration was measured with an enzyme-immunoassay kit. Results After oral VD supplementation, the serum 25（OH）D concentration significantly increased from 46.1＋9.1 nmol/L to 116.7_＋20.3 nmol/L in the obese subjects （P〈O.01） and from 52.8_＋17.8 nmol/L to 181.3_＋30.2 nmol/L in the control ones （P=0.13）. The serum high-density lipoprotein cholesterol （HDL-C） level was reduced within the normal reference range in the obese group. However, no significant change was observed in the level of other serum lipids （triglycerides, total cholesterol, and low-density lipoprotein cholesterol） in either of the two groups. Conclusion The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group. High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.
文摘The rapid decline in circulating levels of serum 25-hydroxyvitamin D in both African Americans and Caucasians in the US population remains unexplained, and appears to parallel the obesity epidemic. The cross sectional data on 7349 Caucasian and African American adults between 21 and 69 years of age from the continuous National Health and Nutrition Examination Study (NHANES) 2001 to 2006 were used to model by race, with smoothing functions, the true relationship between body mass index (BMI), waist circumference and serum 25-hydroxyvitamin D in men and women. Weighted regressions of determinants of serum 25-hydroxyvitamin D levels were analyzed. Serum 25-hydroxyvitamin D is negatively associated with BMI linearly above an inflection point at 20 kg/m2 and positively associated below a BMI of 20 kg/m2. The gender- and age-adjusted regression coefficients of BMI on 25-hydroxyvitamin D levels demonstrate a 50% lower coefficient (r = –0.18 ng/ml/ BMI unit) among African Americans than among Caucasians (r = –0.36 ng/ml/BMI unit). These relationships were as great in men as in women and were replicated when waist circumference was used as a surrogate for visceral fat levels. The extent to which BMI is a strong predictor of serum 25-hydroxyvitamin D levels depends upon BMI being greater than 20 kg/m2. The hockey stick shape of the BMI 25-hydroxyvitamin D relationship needs to be taken into account when adjusting serum values for BMI. Both this inflection and reduction in serum levels of 25-hydroxyvitamin D in the population may be due to sequestration in an increasing adipose tissue reservoir. The interpretation of serum 25-hydroxyvitamin D levels as a biomarker of vitamin D adequacy requires appropriate adjustment of body fat mass.
文摘Background: Vitamin D plays a pivotal role in supporting the immune system, helping to reduce the risk of infections and certain autoimmune diseases. Adequate vitamin D levels may be associated with a reduced risk of certain health conditions like pre-eclampsia, gestational diabetes, and postpartum depression. Brittle bones, osteoporosis in the elderly, and osteomalacia in young children are all symptoms of vitamin D insufficiency. Additionally, it contributes to problems linked to gum disease, including an increase in dental cavities, alveolar bone loss around the teeth, and other problems. It could lead to depression, tiredness, and a loss of appetite. In this study, urban children and adolescents in Dhaka city, Bangladesh are examined for vitamin D deficiency, insufficiency, and sufficiency. Methods: The Study was a cross-sectional study conducted under Dhaka National Medical College and Hospital, Dhaka and additionally included two other health centers Medinova Medical Services and Monoara General Hospital Service Golap bag, Dhaka from October 2020 to November 2021. The study location was at the 3 (Three) different hospitals which was located in Dhaka City. In this cross-sectional study, Participants will be selected purposively and conveniently based on the age categories from 0 - 19 years of age at the outdoor department of the hospital. The study included the secondary dataset of ambulatory individuals who came to the 3 (three) hospitals, randomly to evaluate serum vitamin D levels on referral from a general out-patient-department (OPD). They were examined for laboratory findings of serum 25 hydroxyvitamin D levels to determine vitamin D deficiency, insufficiency, and sufficiency among children and adolescent groups of both male and female Sex. Results: A total of 6394 individuals with a diverse age group were statistically examined for laboratory findings of serum vitamin D levels. Vitamin D deficiency was observed in 40.58% of individuals with a mean log of 1.01 ± 0.18 ng/ml serum vitamin D levels, vitamin D insufficiency in 30.93% of individuals with a mean log of 1.38 ± 0.05 ng/ml serum vitamin D levels and vitamin D sufficiency in 19.49% individuals with a mean log of 1.63 ± 0.12 ng/ml serum vitamin D levels. The highest percentage of individuals deficient in vitamin D were children and adolescents of age ranging between 15 to 19 years. Conclusion: The findings of vitamin D deficiency in children and adolescents direct higher authorities in the public health sector to take immediate steps to screen, intervene and educate high-risk populations incorporating vitamin D supplements to establish preventive and therapeutic measures.
文摘Background: Recent studies suggested that vitamin D deficiency among children is widespread worldwide. Most of the Asian countries are suffering from high prevalence of vitamin D deficiency, especially in children. However, the vitamin D deficiency of Bangladeshi children has not been investigated yet. The objective of the study was to assess the prevalence of vitamin D deficiency among children in Dhaka city, Bangladesh. Methods: A cross-sectional study was designed. Children aged 0 month to 16 years attended Pediatrics’ clinics with minor illness were conveniently recruited. After obtaining informed written consent, venous blood was taken and serum 25(OH)D levels were determined by direct enzyme-linked immunosorbent assay. Descriptive statistics were performed for age, sex, biochemical parameters. Socio-economic status (SES) was estimated using a wealth index, producing a weighted score. Scores were categorized into quintiles, with category 1 representing the poorest and category 5 the richest. Serum 25(OH)D was categorized: deficient as Results: 31.88% children of 0 - 1 year had deficient serum 25(OH)D level and 52.17% children had insufficient level. Among 2 - 5 years’ group, 38.16% were deficient and 50% were insufficient. Among the 6 - 11 years group, 41.02% were deficient and 52.56% were insufficient. Among 12 - 16 years group, 46.75% were deficient and 51.95% were insufficient. That means, serum 25-hydroxyvitamin D deficiency and insufficiency rate is found very high among Bangladeshi children. Conclusions: The prevalence of vitamin D deficiency and insufficiency among children in Bangladesh is high. The study recommended that vitamin D supplementation in Bangladeshi children should be formally launched from first day of birth up to adolescence.
文摘目的探讨过敏性鼻炎患者血清辅助性T细胞17(Th17)/调节性T细胞(Treg)值与血清甲壳质酶蛋白-40(YKL-40)水平及维生素D水平的相关性。方法选择过敏性鼻炎患者99例(观察组)及同期体检健康者99例(对照组),采集空腹外周静脉血9 m L,采用酶联免疫吸附试验检测外周血25(OH)D_(3),采用流式细胞术检测外周血CD4^(+)IL-17+Th17细胞、CD4^(+)CD25^(+)Foxp3^(+)Treg细胞占CD4^(+)T细胞的百分比,采用双抗体夹心酶联免疫吸附法测定血清YKL-40,比较两组CD4^(+)IL-17+Th17细胞、CD4^(+)CD25^(+)Foxp3^(+)Treg细胞占CD4^(+)T细胞的百分比、YKL-40及维生素D水平。结果观察组血清25(OH)D_(3)水平和CD4^(+)CD25^(+)Foxp3^(+)Treg细胞占CD4^(+)T细胞的百分比低于对照组(P均<0.05),CD4^(+)IL-17+Th17细胞占CD4^(+)T细胞的百分比、Th17/Treg值及血清YKL-40水平高于对照组(P均<0.05)。观察组血清Th17/Treg值与YKL-40水平呈正相关(r=0.429,P<0.05),与血清25(OH)D_(3)水平呈负相关(r=-0.735,P<0.05);血清YKL-40与25(OH)D_(3)水平呈负相关(r=-0.450,P<0.05)。结论过敏性鼻炎患者血清25(OH)D_(3)水平降低,YKL-40水平升高,二者异常表达可能与Th17/Treg值失调有关,共同参与过敏性鼻炎的发生发展。
