Adolescent suicide risk factors and the integration of socialemotional skills in school-based prevention programs

Adolescents are considered one of the most vulnerable groups affected by suicide.Rapid changes in adolescents’physical and mental states,as well as in their lives,significantly and undeniably increase the risk of suicide.Psychological,social,family,individual,and environmental factors are important risk factors for suicidal behavior among teenagers and may contribute to suicide risk through various direct,indirect,or combined pathways.Social-emotional learning is considered a powerful intervention measure for addressing the crisis of adolescent suicide.When deliberately cultivated,fostered,and enhanced,selfawareness,self-management,social awareness,interpersonal skills,and responsible decision-making,as the five core competencies of social-emotional learning,can be used to effectively target various risk factors for adolescent suicide and provide necessary mental and interpersonal support.Among numerous suicide intervention methods,school-based interventions based on social-emotional competence have shown great potential in preventing and addressing suicide risk factors in adolescents.The characteristics of school-based interventions based on social-emotional competence,including their appropriateness,necessity,cost-effectiveness,comprehensiveness,and effectiveness,make these interventions an important means of addressing the crisis of adolescent suicide.To further determine the potential of school-based interventions based on social-emotional competence and better address the issue of adolescent suicide,additional financial support should be provided,the combination of socialemotional learning and other suicide prevention programs within schools should be fully leveraged,and cooperation between schools and families,society,and other environments should be maximized.These efforts should be considered future research directions.

High-risk factors for delirium in severely ill patients and the application of emotional nursing combined with pain nursing

BACKGROUND Delirium is a neuropsychiatric syndrome characterized by acute disturbances of consciousness with rapid onset,rapid progression,obvious fluctuations,and preventable,reversible,and other characteristics.Patients with delirium in the intensive care unit(ICU)are often missed or misdiagnosed and do not receive adequate attention.AIM To analyze the risk factors for delirium in ICU patients and explore the applica-tion of emotional nursing with pain nursing in the management of delirium.METHODS General data of 301 critically ill patients were retrospectively collected,including histories(cardiovascular and cerebrovascular diseases,hypertension,smoking,alcoholism,and diabetes),age,sex,diagnosis,whether surgery was performed,and patient origin(emergency/clinic).Additionally,the duration of sedation,Richmond Agitation Sedation Scale score,combined emotional and pain care,ven-tilator use duration,vasoactive drug use,drainage tube retention,ICU stay du-ration,C-reactive protein,procalcitonin,white blood cell count,body tempe-rature,Acute Physiology and Chronic Health Evaluation II(APACHE II)score,and Sequential Organ Failure Assessment score were recorded within 24 h after ICU admission.Patients were assessed for delirium according to confusion assessment method for the ICU,and univariate and multivariate logistic regre-ssion analyses were performed to identify the risk factors for delirium in the patients.RESULTS Univariate logistic regression analysis was performed on the 24 potential risk factors associated with delirium in ICU patients.The results showed that 16 risk factors were closely related to delirium,including combined emotional and pain care,history of diabetes,and patient origin.Multivariate logistic regression analysis revealed that no combined emotional and pain care,history of diabetes,emergency source,surgery,long stay in the ICU,smoking history,and high APACHE II score were independent risk factors for de-lirium in ICU patients.CONCLUSION Patients with diabetes and/or smoking history,postoperative patients,patients with a high APACHE II score,and those with emergency ICU admission need emotional and pain care,flexible visiting modes,and early intervention to reduce delirium incidence.

Effect of Lanthanum on Mycelium Growth and Some Pathogenic Factors

Three soil-transmitted pathogenic fungi including Rhizoctonia solani, Fusarium solani, and Pythium sp. were selected to investigate the effect of lanthanum on their growth and the pathogenic enzymes using liquid culture. Variance analysis shows significant differences among treatments with different concentrations of lanthanum （Rhizoctonia solani F = 6.75 〉 F0.01= 5.99; Fusarium solani F = 18.1 〉 F0.01 = 5.99, Pythium sp. F = 23.29 〉 F0.01 = 5.99）. The inhibitory effect of lanthanum on pathogenic fungi increased with an increase in La concentration. The activities of the three pathogenic enzymes per gram mycelium were promoted remarkably. However, the quantity or the activities of the total enzymes were inhibited because of the strong inhibition of mycelium growth by lanthanum. Meanwhile, the effect of lanthanum on toxins of pathogenic fungi were studied using the seed germination experiment. Toxins of pathogenic fungi are influenced by lanthanum and the virulence decreases significantly with the increase of lanthanum concentration.

Occurrence Factors and Efficient Green Prevention and Control Technology of Peanut Stem Rot Caused by Sclerotium rolfsii in Southern Mountainous Area of Shandong Province

Peanut stem rot caused by Sclerotium rolfsii is a soil-borne disease,and it has become the main disease of peanut in Yimeng mountainous area.S.rolfsii survives the winter as mycelia and sclerotia in soil and debris,becoming the primary source of infection in the following year.The disease resistance of peanut varieties,high temperature and humidity,and cultivation measures are the pathogenic factors affecting the occurrence of peanut stem rot.The disease can be effectively controlled by screening disease-resistant varieties and seed chemical treatment,improving soil by deep tillage and crop rotation,carrying out flowing water management of affected field,cutting off transmission routes,and strengthening seed dressing and triple spraying control.

Analysis of factors related to postpartum depression in pregnancyinduced hypertension syndrome patients and construction and evaluation of nomograms

BACKGROUND It is positive to integrate and evaluate the risk factors for postpartum depression in patients with pregnancy-induced hypertension syndrome and to detect highrisk patients as early as possible,which has application value for the clinical development of personalized prevention programs and prognosis of patients.AIM To analyze factors related to postpartum depression in patients with pregnancyinduced hypertension and construct and evaluate a nomogram model.METHODS The clinical data of 276 patients with pregnancy-induced hypertension admitted to Huzhou Maternity and Child Health Care Hospital between January 2017 and April 2022 were retrospectively analyzed.We evaluated the depression incidence at 6 wk postpartum.The depression group included patients with postpartum depression,and the remainder were in the non-depression group.Multivariate logistic regression analysis and the LASSO regression model were applied to analyze the factors related to postpartum depression in patients with pregnancyinduced hypertension.After that,a risk prediction model nomogram was constructed and evaluated.RESULTS Multivariate logistic regression analysis showed that vitamin A deficiency(VAD)during pregnancy and puerperium,family history of hypertension,maternal intestinal flora imbalance,eicosapentaenoic acid(EPA),and docosahexaenoic acid(DHA)were independent risk factors for postpartum depression in patients with pregnancy-induced hypertension(P<0.05).We constructed the nomogram model based on these five risk factors.The area under the curve,specificity,and sensitivity of the model in predicting postpartum depression in patients with pregnancy-induced hypertension was 0.867(95%confidence interval:0.828–0.935),0.676,and 0.889,respectively.The average absolute error was 0.037(Hosmer-Lemeshow testχ2=10.739,P=0.217).CONCLUSION VAD during pregnancy and puerperium,family history of hypertension,maternal intestinal flora imbalance,EPA,and DHA affect postpartum depression in patients with pregnancy-induced hypertension.

<i>cagA</i>and <i>vacA</i><i>Helicobacter pylori</i>Pathogenicity Factors in Brazzaville, Congo

Introduction: CagA and VacA are the most important and well-studied virulence factors found in Helicobacter pylori. The aim of this work was to identify genes corresponding to H. pylori pathogenicity factors in Brazzaville, Congo. Material & Methods: A cross-sectional study was carried out from October 2013 to December 2016. Biopsy specimens were obtained from patients scheduled for upper gastrointestinal endoscopy in Brazzaville, Congo and were sent to the French National Reference Center for Campylobacters and Helicobacters in Bordeaux, France. H. pylori detection was conducted by real-time PCR using a fuorescence resonance energy transfer-melting curve analysis protocol. The identification of the genes encoding pathogenicity factors was carried out by conventional PCR using the appropriate primers for determination of CagA phosphorylation motifs 1, 2, 3;and vacAs, I and m regions: vacAi1, vacAi2, vacAs1a, vacAs1b. Results: A high prevalence of H. pylori infection was reported (108/143;75.5%). In 92.2% (n = 71/77), the presence of P1, P2 and P3 CagA phosphorylation motifs was noted. Concerning vacA, vacAs1m1 was observed in 82% of the strains (n = 59/72). vacAi1 was present in all strains (n = 76). With regard to the distribution according to the vacAs1 subtype, the majority of the strains (59/71;83%) were vacAs1b positive, as compared to vacAs1c (17/34, 33%). The vacAs1a gene was absent in all of these patients. Conclusion: The presence of genes associated with severe gastric diseases indicates the importance of H. pylori eradication in the prevention of these diseases in Congo.

Investigation on Pathogenic Factors of Tobacco Root-Knot Nematode Disease in Gengma County,Yunnan Province

Tobacco root-knot nematode disease has caused severe damage in Geng- ma County, Yunnan Province. In order to identify the pathogenic factors of the tobac- co root-knot nematode disease in this county, the pathogenic nematodes, hosts and environment of tobacco fields in Mengsa, Hepai and Sipaishan 3 main tobacco-grow- ing towns in Gengma County were investigated and analyzed based on the local re- lated field survey on tobacco root-knot nematode disease in this county in 2012. The results showed the incidence and severity of the tobacco root-knot nematode disease were all higher than those of previous years. dominant pathogens of the tobacco root-knot The species identification showed the nematode disease were Meloidogyne arenaria and M. javanica in Gengma County. The lacking of disease-resistant culti- vars, poor management and climatic anomaly were the main causes of the tobacco root-knot nematode disease in Gengma. According to the occurrence characteristics of the disease, the agricultural prevention-based control measures were proposed.

New insights of Helicobacter pylori host-pathogen interactions: The triangle of virulence factors, epigenetic modifications and non-coding RNAs

Helicobacter pylori(H. pylori) is a model organism for understanding host-pathogen interactions and infection-mediated carcinogenesis. Gastric cancer and H. pylori colonization indicates the strong correlation. The progression and exacerbation of H. pylori infection are influenced by some factors of pathogen and host. Several virulence factors involved in the proper adherence and attenuation of immune defense to contribute the risk of emerging gastric cancer, therefore analysis of them is very important. H. pylori also modulates inflammatory and autophagy process to intensify its pathogenicity. From the host regard, different genetic factors particularly affect the development of gastric cancer. Indeed, epigenetic modifications, Micro RNA and long non-coding RNA received more attention. Generally, various factors related to pathogen and host that modulate gastric cancer development in response to H. pylori need more attention due to develop an efficacious therapeutic intervention. Therefore, this paper will present a brief overview of host-pathogen interaction especially emphases on bacterial virulence factors, interruption of host cellular signaling, the role of epigenetic modifications and non-coding RNAs.

Role of the Arabidopsis thafiana NAC transcription factors ANAC019 and ANAC055 in regulating jasmonic acid-signaled defense responses

Jasmonic acid （JA） is an important phytohormone that regulates plant defense responses against herbivore attack, pathogen infection and mechanical wounding. In this report, we provided biochemical and genetic evidence to show that the Arabidopsis thaliana NAC family proteins ANAC019 and ANAC055 might function as transcription activators to regulate JA-induced expression of defense genes. The role of the two NAC genes in JA signaling was examined with the anacO19 anac055 double mutant and with transgenic plants overexpressing ANACO19 or ANAC055. The anacO19 anac055 double mutant plants showed attenuated JA-induced VEGETATIVE STORAGE PROTEIN1 （VSP1） and LIPOXYGENASE2 （LOX2） expression, whereas transgenic plants overexpressing the two NAC genes showed enhanced JA-induced VSP1 and LOX2 expression. That the JA-induced expression of the two NAC genes depends on the function of COIl and AtMYC2, together with the finding that overexpression of ANACO19 partially rescued the JA-related phenotype of the atmyc2-2 mutant, has led us to a hypothesis that the two NAC proteins act downstream of AtMYC2 to regulate JA-signaled defense responses. Further evidence to substantiate this idea comes from the observation that the response of the anacO19 anac055 double mutant to a necrotrophic fungus showed high similarity to that of the atmyc2-2 mutant.

Putative Phosphatase UvPsr1 Is Required for Mycelial Growth, Conidiation, Stress Response and Pathogenicity in Ustilaginonidea virens

Ustilaginoidea virens is the causal agent of rice false smut,which can be a highly destructive disease of rice.The plasma membrane phosphatase Psr1 proteins,which act as a regulator of the salinity stress response in yeast,are widely distributed across fungi,but their functional characterization is sketchy.In this study,we characterized the functions of Psr1 protein,UvPsr1,in U.virens.Analyses of the AUvpsr1 and its complementation strain showed that UvPsr1 is required for normal mycelial growth,conidiation and tolerance to oxidative,osmotic and cell wall stresses.When rice panicles were inoculated with the AUvpsr1 strains,no symptoms of false smut disease developed,showing that UvPSR1 also contributes to the pathogenicity of the fungus.The deletion mutant of UvPSR1 also appeared to produce a smaller titer of toxic compounds able to inhibit elongation of the germinated seeds.In conclusion,our results indicated that UvPsr1 is a new pathogenic factor of U.virens.

Genome-Wide Identification of Zn_(2)Cys_(6 ) Class Fungal-Specific Transcription Factors(ZnFTFs)and Functional Analysis of UvZnFTFI in Ustilaginoidea virens

Transcription factors(TFs)orchestrate the regulation of cellular gene expression and thereby determine cell functionality.In this study,we analyzed the distribution of TFs containing domains,which named as ZnFTFs,both in ascomycete and basidiomycete fungi.We found that ZnFTFs were widely distributed in these fungal species,but there was more expansion of the ZnFTF class in Ascomycota than Basidiomycota.We identified 40 ZnFTFs in Ustilaginoidea virens,and demonstrated the involvement of UvZnFTF1 in vegetative growth,conidiation,pigment biosynthesis and pathogenicity.RNA-Seq analysis suggested that UvZnFTF1 may regulate different nutrient metabolism pathways,the production of secondary metabolites,and the expression of pathogen-host interaction genes and secreted protein-encodi ng genes.Analysis of the distributi on of differe nt fungal TFs in U.virens further dem on strated that UvZnFTFs make up a large TF family and may play essential biological roles in U.virens.

Towards Innovative Research Approaches to Investigating the Role of Emotional Variables in Promoting Language Teachers’ and Learners’ Mental Health

The adequacy of language education largely depends on the favorable and unfavorable emotions that teachers and students experience throughout the education process.Simply said,emotional factors play a key role in improving the quality of language teaching and learning.Furthermore,these emotional factors also promote the well-being of language teachers and learners and place them in a suitable mental condition.In view of the favorable impact of emotional factors on the mental health of language teachers and learners,many educational scholars around the world have studied these factors,their background,and their pedagogical consequences.Nonetheless,the majority of previous studies have employed traditional research methods in assessing these variables and their influences on language teachers’and learners’mental health.Because of the complex and dynamic quality of emotional factors,traditional research approaches often fail to evaluate these factors and their dynamic,non-linear connections with teachers’and learners’mental health and well-being.Accordingly,some novel research approaches are required to measure the dynamicity and complexity of emotional factors in language education settings.To address this call,the current state-of-the-art conceptual article seeks to provide new insights for investigating emotional factors and their potential impact on language teachers’and learners’mental states.This study also intends to offer a comprehensive list of emerging methods that take into account the complex and dynamic nature of emotional variables.Finally,the study outlines the potential implications of this review for educational researchers.

Risk Factors and Distribution of Pathogens for Pulmonary Infection in Patients with Severe Acute Pancreatitis

Objective:To investigate risk factors and distribution of pathogens for pulmonary infection in patients with severe acute pancreatitis.Methods:The clinical data of 285 patients with severe acute pancreatitis were retrospectively analyzed.Sputum specimens of patients with lung infections were studied.Univariate analysis and logistic regression were performed to screening the factors correlating to lung infections.Results:Gram-negative bacilli were the principal microorganisms isolated from those lung infections,and these bacterial pathogens demonstrated a marked pattern of antibiotic resistance.It was identified that age(OR 1.05,95%CI 1.01-1.09,p=0.01),Ranson scores(OR 3.01,95%CI 1.13-8.03,p=0.03)and surgical treatment(OR4.27,95%CI 1.03-17.65,p=0.04)were independent risk factors of lung infections in patients with severe acute pancreatitis.Conclusion:Analysis of pathogen spectrum and drug sensitivity will contribute to choosing antibiotics empirically.And preventive measures aimed at risk factors could help reduce the incidence of lung infections in patients with severe acute pancreatitis.

Pathogenesis and drug resistance mechanism of Burkholderia pseudomallei

Burkholderia pseudomallei is the pathogen that causes melioidosis.Melioidosis has a long duration of chronic infection,atypical clinical manifestations at acute onset,and is prone to life-threatening complications and poor prognosis.Understanding the pathogenesis and drug resistance mechanism of Burkholderia pseudomallei will effectively help the diagnosis and treatment of the disease and improve the prognosis.This review focuses on the extracellular movement of Burkholderia pseudomallei in host cells,the way of infecting host cells,virulence factors,and drug resistance mechanisms(efflux pumps,changes in target sites,etc.).This study provides a possible direction for the early diagnosis,treatment and control of melioidosis caused by this bacterium.

Multi-label Emotion Classification of COVID–19 Tweets with Deep Learning and Topic Modelling

The COVID-19 pandemic has become one of the severe diseases in recent years.As it majorly affects the common livelihood of people across the universe,it is essential for administrators and healthcare professionals to be aware of the views of the community so as to monitor the severity of the spread of the outbreak.The public opinions are been shared enormously in microblogging med-ia like twitter and is considered as one of the popular sources to collect public opinions in any topic like politics,sports,entertainment etc.,This work presents a combination of Intensity Based Emotion Classification Convolution Neural Net-work(IBEC-CNN)model and Non-negative Matrix Factorization(NMF)for detecting and analyzing the different topics discussed in the COVID-19 tweets as well the intensity of the emotional content of those tweets.The topics were identified using NMF and the emotions are classified using pretrained IBEC-CNN,based on predefined intensity scores.The research aimed at identifying the emotions in the Indian tweets related to COVID-19 and producing a list of topics discussed by the users during the COVID-19 pandemic.Using the Twitter Application Programming Interface(Twitter API),huge numbers of COVID-19 tweets are retrieved during January and July 2020.The extracted tweets are ana-lyzed for emotions fear,joy,sadness and trust with proposed Intensity Based Emotion Classification Convolution Neural Network(IBEC-CNN)model which is pretrained.The classified tweets are given an intensity score varies from 1 to 3,with 1 being low intensity for the emotion,2 being the moderate and 3 being the high intensity.To identify the topics in the tweets and the themes of those topics,Non-negative Matrix Factorization(NMF)has been employed.Analysis of emotions of COVID-19 tweets has identified,that the count of positive tweets is more than that of count of negative tweets during the period considered and the negative tweets related to COVID-19 is less than 5%.Also,more than 75%nega-tive tweets expressed sadness,fear are of low intensity.A qualitative analysis has also been conducted and the topics detected are grouped into themes such as eco-nomic impacts,case reports,treatments,entertainment and vaccination.The results of analysis show that the issues related to the pandemic are expressed dif-ferent emotions in twitter which helps in interpreting the public insights during the pandemic and these results are beneficial for planning the dissemination of factual health statistics to build the trust of the people.The performance comparison shows that the proposed IBEC-CNN model outperforms the conventional models and achieved 83.71%accuracy.The%of COVID-19 tweets that discussed the different topics vary from 7.45%to 26.43%on topics economy,Statistics on cases,Government/Politics,Entertainment,Lockdown,Treatments and Virtual Events.The least number of tweets discussed on politics/government on the other hand the tweets discussed most about treatments.

VSD治疗对胫骨骨折术后继发骨感染患者手术指标、炎性因子及功能恢复的影响

目的探讨负压封闭引流技术(VSD)治疗对胫骨骨折术后继发骨感染患者手术指标、炎性因子、功能恢复的影响。方法选取2020年12月至2022年6月河北医科大学第三医院收治的87例胫骨骨折内固定术后继发骨感染患者,均为胫骨干骨折;其中原开放骨折55例,一期均缝合伤口;32例在外伤发生时一期清创后行内固定手术;对患者采用手术清创、去除内固定物,行外固定架固定,经清创后局部均存在创面不能完全闭合,合并骨外露,随机选用VSD覆盖治疗(研究组,n=46)或骨水泥覆盖治疗(对照组,n=41),分析患者病原菌构成分布、比较两组手术指标、炎症因子[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、C反应蛋白(CRP)水平]、功能恢复情况[膝关节、踝关节功能以及肢体功能恢复情况]以及并发症情况。结果87例患者共87株病原菌,其中革兰阳性菌43株(49.42%),革兰阴性菌32株(36.78%),真菌12株(13.80%)。研究组换药次数少于对照组,控制感染时间、创面无菌时长、住院时间、行皮瓣转移手术时间均短于对照组,差异均有统计学意义(P<0.05);治疗后两组TNF-α、IL-6、CRP水平均下降,其中研究组变化最为显著,差异有统计学意义(P<0.05);治疗后两组HSS、Baird-Jackson评分均上升,其中研究组变化最为显著,差异有统计学意义(P<0.05)。研究组优良率为(95.65%)高于对照组优良率(80.49%),差异有统计学意义(P<0.05)。结论在创面不能闭合情况下,VSD治疗胫骨骨折内固定术后继发骨感染患者,可改善患者手术指标、炎性因子水平,促进患者肢体功能恢复,值得临床推广应用。

无隧道和涤纶套的透析导管相关性血流感染临床特点及危险因素分析

目的:探讨采用无隧道和涤纶套的透析导管(non-cuffed catheter, NCC)行血液透析患者发生导管相关性血流感染(catheter-related bloodstream infection, CRBSI)的临床特点及危险因素。方法:选择2019年1月至2021年12月在江苏大学附属医院血液净化中心通过超声引导下经皮中心静脉置入NCC行血液透析治疗的患者169例进行回顾性分析,统计不同置管部位的CRBSI发生率,分析CRBSI患者的感染特点及病原菌分布。依据是否发生CRBSI分为感染组(n=22)和非感染组(n=147),比较两组临床病理参数;进一步采用二元Logistic回归分析NCC患者发生CRBSI的影响因素,绘制受试者工作特征(ROC)曲线,评估预测效果。结果:颈内静脉置管和股静脉置管CRBSI发生率比较,差异无统计学意义(χ^(2)=0.221,P=0.638);22例CRBSI患者共检出病原菌21株,其中革兰阳性球菌16株,以金黄色葡萄球菌为主(10株),革兰阴性杆菌5株。感染组血清白蛋白、高密度脂蛋白和血清铁水平明显低于非感染组(P均<0.05);Logistic回归分析显示,血清白蛋白、高密度脂蛋白是血液透析患者发生CRBSI的影响因素(P=0.006,0.007)。ROC曲线显示,白蛋白AUC为0.726,高密度脂蛋白AUC为0.704。结论:NCC透析患者发生CRBSI的病原菌以革兰阳性球菌为主,多见于金黄色葡萄球菌;低水平血清白蛋白、高密度脂蛋白是CRBSI的危险因素。

川藏南线自驾游客情感体验的特征与影响机制

以流动性体验为核心的旅游形式在全球化背景下日益流行。作为大尺度流动型旅游形式典型代表的长途自驾游,因冒险、追逐自由、私密、个性化、高不确定性等特征,赋予了游客独特且复杂的情感体验。目前,学界尚缺乏从更为系统的视角关注大尺度流动情境下游客情感体验的特征、前因与影响机制的实证研究。文章基于景观感知理论,采用定量研究与定性研究相结合的方法,以川藏南线(318国道成都至拉萨段)的自驾游客为研究对象,分析游客在大尺度流动情境下的情感体验特征与影响机制。文章发现:1)自驾游客的积极情感体验未达强烈水平,情感体验(尤其是积极情感体验)伴随着自驾这一流动性实践呈现出动态变化的波动特征,且涉及多个维度;2)基于自我需要满足与否、满足程度如何这一标准,自驾游客与环境的互动(包含两组类型、6类特征)促进了他们上述情感体验的产生,并通过动态反馈机制持续影响了情感体验。上述研究发现不仅完善了有关游客情感体验前因和影响机制以及自驾入藏旅游体验的实证研究体系,还为目的地的管理与营销提供了思路。

重症患者导管相关性血流感染的病原菌分布与影响因素分析

目的探讨重症患者导管相关性血流感染(catheter-related bloodstream infection,CRBSI)的病原菌分布及影响因素。方法回顾性分析2019年7月1日至2022年7月2日期间在简阳市人民医院重症医学科接受中心静脉置管患者的临床资料,依据患者是否发生中心静脉CRBSI分为CRBSI组与非CRBSI组。对CRBSI组患者行病原菌种类分析,同时比较两组临床资料信息,并将有统计学意义的变量纳入多因素Logistic回归分析,明确接受中心静脉置管患者发生CRBSI的危险因素,通过受试者工作特征曲线(ROC)构建重症患者发生CRBSI的预测模型。结果共纳入接受中心静脉置管患者293例,其中CRBSI组38例、非CRBSI组255例。38例CRBSI患者共检出病原菌52珠,其中革兰氏阳性菌占比50.00%(26/52),以金黄色葡萄球菌19.23%(10/52)、表皮葡萄球菌7.69%(4/52)为主;革兰氏阴性菌占比44.23%(23/52),以大肠埃希菌17.31%(9/52)、肺炎克雷伯杆菌13.46%(7/52)为主;真菌占比5.77%(3/52),均为白色念珠菌。CRBSI组年龄≥60岁、合并糖尿病、置管部位为股静脉或颈内静脉、静脉营养液输液、置管前应用抗菌药物者占比显著高于非CRBSI组;CRBSI组BMI、入院时APACHEⅡ评分显著高于非CRBSI组,置管时间显著长于非CRBSI组,P值均<0.05。多因素Logistic回归分析结果显示,年龄≥60岁、高BMI、合并糖尿病、入院时高APACHEⅡ评分、置管部位为股静脉或颈内静脉、置管时间长、输液类型为静脉营养液、置管前应用抗菌药物为重症患者发生CRBSI的危险因素。ROC分析表明,BMI、入院时APACHEⅡ评分、置管时间均能用于重症患者发生CRBSI的预测,曲线下面积分别为0.778、0.919、0.975(P<0.05)。结论重症患者中心静脉置管后CRBSI的病原菌以金黄色葡萄球菌、大肠埃希菌较为多见,同时CRBSI的发生与年龄、BMI、置管天数、置管部位等因素关系密切,临床治疗过程中应当予以关注。

中国青少年社会与情感能力第二轮测评技术报告

本技术报告基于中国济南参加2023年社会与情感能力(Survey on Social and Emotional Skills,SSES)的测评数据,对第二轮测评工具在中国文化下的心理测量学特征进行分析。本报告简要介绍了学生问卷的开发和实施过程、社会与情感能力指标体系、问卷主要组成部分、数据集的主要内容,并对数据质量进行了分析。分析结果表明,济南参试学生参试态度认真积极,参试率和有效应答率高,但是10岁组产生了高分翘尾现象;采用ω系数和α系数来衡量分量表的信度,结果表明绝大多数分量表信度良好;运用验证性因子分析逐一检验社会与情感能力各个分量表的效度,发现拟合度较为满意;多组验证性因子分析表明,这些分量表跨性别测量等值性好于跨年龄组等值性,故在考察青少年社会与情感子能力的年龄差异时,对于等值性较差的分量表数据应慎重使用。