Objective:To investigate the effect of somatostatin combined with omeprazole on serum inflammatory factors and intestinal mucosal barrier function in severe acute pancreatitis. Methods: patients with severe acute panc...Objective:To investigate the effect of somatostatin combined with omeprazole on serum inflammatory factors and intestinal mucosal barrier function in severe acute pancreatitis. Methods: patients with severe acute pancreatitis who were treated in Zigong Third People's Hospital between August 2014 and December 2017 were chosen and divided into two groups by random number table method. Control group received conventional + omeprazole treatment, combined group received conventional + somatostatin + omeprazole treatment and the treatment lasted for 1 week. The differences in serum levels of inflammatory factors, chemokines and intestinal mucosal barrier function indexes were compared between the two groups immediately after admission and after 1 week of treatment.Results: After 1 week of treatment, serum IL-1β, IL-8, IL-18, hs-CRP, MCP-1, FKN, CINC, D-Lactate, DAO, Endotoxin and FABP levels of both groups significantly decreased and serum IL-1β, IL-8, IL-18, hs-CRP, MCP-1, FKN, CINC, D-Lactate, DAO, Endotoxin and FABP levels of combined group were significantly lower than those of control group.Conclusion: Somatostatin combined with omeprazole therapy for severe acute pancreatitis can effectively alleviate the inflammatory response and protect the intestinal mucosal barrier function.展开更多
Objective:To study the relationship between serums inflammatory factor levels and systemic target organ damage in patients with severe acute pancreatitis.Methods: A total of 85 patients who were diagnosed with severe ...Objective:To study the relationship between serums inflammatory factor levels and systemic target organ damage in patients with severe acute pancreatitis.Methods: A total of 85 patients who were diagnosed with severe acute pancreatitis in the Second Affiliated Hospital of Xi'an Jiaotong University between June 2013 and August 2016 were enrolled in SAP group, and 100 healthy volunteers who received physical examination during the same period were enrolled in control group. Then serum inflammatory factors, liver function injury indexes, renal function injury indexes and intestinal mucosal barrier function indexes as well as urine renal function injury indexes were determined.Results: Serum PCT, TNF-α, CRP, HMGB-1, ALT, AST, TBIL, BUN, Scr, CysC, DAO, D-lactate, Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels of SAP group were significantly higher than those of control group;serum PCT, TNF-α, CRP and HMGB-1 levels of patients with SAP were positively correlated with serum ALT, AST, TBIL, BUN, Scr, CysC, DAO, D-lactate, Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels.Conclusion:Abnormal release of inflammatory factors in serum of SAP patients can cause liver function, renal function and intestinal mucosal barrier function injury.展开更多
Objective: To study the relationship between serums inflammatory factor levels and systemic target organ damage in patients with severe acute pancreatitis. Methods: A total of 85 patients who were diagnosed with sever...Objective: To study the relationship between serums inflammatory factor levels and systemic target organ damage in patients with severe acute pancreatitis. Methods: A total of 85 patients who were diagnosed with severe acute pancreatitis in the Second Affiliated Hospital of Xi'an Jiaotong University between June 2013 and August 2016 were enrolled in SAP group, and 100 healthy volunteers who received physical examination during the same period were enrolled in control group. Then serum inflammatory factors, liver function injury indexes, renal function injury indexes and intestinal mucosal barrier function indexes as well as urine renal function injury indexes were determined. Results: Serum PCT, TNF-α, CRP, HMGB-1, ALT, AST, TBIL, BUN, Scr, CysC, DAO, D-lactate, Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels of SAP group were significantly higher than those of control group;serum PCT, TNF-α, CRP and HMGB-1 levels of patients with SAP were positively correlated with serum ALT, AST, TBIL, BUN, Scr, CysC, DAO, D-lactate, Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels. Conclusion: Abnormal release of inflammatory factors in serum of SAP patients can cause liver function, renal function and intestinal mucosal barrier function injury.展开更多
Objective:To explore the curative effect of Chaishao Chengqi Decoction on moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type and its effect on inflammatory reaction,and to provide new id...Objective:To explore the curative effect of Chaishao Chengqi Decoction on moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type and its effect on inflammatory reaction,and to provide new ideas for clinical treatment and prognosis evaluation.Methods:60 patients with moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type from June 2017 to June 2019 were randomly divided into control group treated with conventional therapy and treatment group treated with Chaishao Chengqi Decoction for 2 weeks.The differences of clinical efficacy and TCM syndromes between the two groups were compared.Ranson score,Balthazar CTSI score,SIRS score and modified Marshall score were recorded before and after treatment.The levels of inflammatory factors and oxidative stress-related molecules were compared before and after treatment.Result:After treatment,the total effective rates of the control group and the treatment group were 80.0%and 93.3%,respectively,with statistical difference(χ2=8.845,P=0.027);after treatment,the total effective rates of TCM syndromes evaluation of the control group and the treatment group were 76.7%and 93.3%,respectively,with statistical difference(χ2=10.024,P=0.012);after treatment,the Ranson score,Balthazar CTSI score,SIRS score and improved Marshall score were all significantly decreased(P<0.05),and the decrease was more significant in the treatment group(P<0.05);after treatment,the serum levels of TNF-α,IL-6 and MDA were significantly decreased in both groups,and superoxide dismutase(SOD)was significantly increased(P<0.05),and the treatment group improved more(P<0.05).Conclusion:Chaishao Chengqi Decoction has a good curative effect on moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type,and can effectively improve inflammatory response and oxidative stress,which has a high clinical significance.展开更多
文摘Objective:To investigate the effect of somatostatin combined with omeprazole on serum inflammatory factors and intestinal mucosal barrier function in severe acute pancreatitis. Methods: patients with severe acute pancreatitis who were treated in Zigong Third People's Hospital between August 2014 and December 2017 were chosen and divided into two groups by random number table method. Control group received conventional + omeprazole treatment, combined group received conventional + somatostatin + omeprazole treatment and the treatment lasted for 1 week. The differences in serum levels of inflammatory factors, chemokines and intestinal mucosal barrier function indexes were compared between the two groups immediately after admission and after 1 week of treatment.Results: After 1 week of treatment, serum IL-1β, IL-8, IL-18, hs-CRP, MCP-1, FKN, CINC, D-Lactate, DAO, Endotoxin and FABP levels of both groups significantly decreased and serum IL-1β, IL-8, IL-18, hs-CRP, MCP-1, FKN, CINC, D-Lactate, DAO, Endotoxin and FABP levels of combined group were significantly lower than those of control group.Conclusion: Somatostatin combined with omeprazole therapy for severe acute pancreatitis can effectively alleviate the inflammatory response and protect the intestinal mucosal barrier function.
文摘Objective:To study the relationship between serums inflammatory factor levels and systemic target organ damage in patients with severe acute pancreatitis.Methods: A total of 85 patients who were diagnosed with severe acute pancreatitis in the Second Affiliated Hospital of Xi'an Jiaotong University between June 2013 and August 2016 were enrolled in SAP group, and 100 healthy volunteers who received physical examination during the same period were enrolled in control group. Then serum inflammatory factors, liver function injury indexes, renal function injury indexes and intestinal mucosal barrier function indexes as well as urine renal function injury indexes were determined.Results: Serum PCT, TNF-α, CRP, HMGB-1, ALT, AST, TBIL, BUN, Scr, CysC, DAO, D-lactate, Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels of SAP group were significantly higher than those of control group;serum PCT, TNF-α, CRP and HMGB-1 levels of patients with SAP were positively correlated with serum ALT, AST, TBIL, BUN, Scr, CysC, DAO, D-lactate, Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels.Conclusion:Abnormal release of inflammatory factors in serum of SAP patients can cause liver function, renal function and intestinal mucosal barrier function injury.
文摘Objective: To study the relationship between serums inflammatory factor levels and systemic target organ damage in patients with severe acute pancreatitis. Methods: A total of 85 patients who were diagnosed with severe acute pancreatitis in the Second Affiliated Hospital of Xi'an Jiaotong University between June 2013 and August 2016 were enrolled in SAP group, and 100 healthy volunteers who received physical examination during the same period were enrolled in control group. Then serum inflammatory factors, liver function injury indexes, renal function injury indexes and intestinal mucosal barrier function indexes as well as urine renal function injury indexes were determined. Results: Serum PCT, TNF-α, CRP, HMGB-1, ALT, AST, TBIL, BUN, Scr, CysC, DAO, D-lactate, Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels of SAP group were significantly higher than those of control group;serum PCT, TNF-α, CRP and HMGB-1 levels of patients with SAP were positively correlated with serum ALT, AST, TBIL, BUN, Scr, CysC, DAO, D-lactate, Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels. Conclusion: Abnormal release of inflammatory factors in serum of SAP patients can cause liver function, renal function and intestinal mucosal barrier function injury.
基金Zhangjiagang municipal commission of health and family planning system youth science and technology project in 2018(ZJGQNLKJ201813).
文摘Objective:To explore the curative effect of Chaishao Chengqi Decoction on moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type and its effect on inflammatory reaction,and to provide new ideas for clinical treatment and prognosis evaluation.Methods:60 patients with moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type from June 2017 to June 2019 were randomly divided into control group treated with conventional therapy and treatment group treated with Chaishao Chengqi Decoction for 2 weeks.The differences of clinical efficacy and TCM syndromes between the two groups were compared.Ranson score,Balthazar CTSI score,SIRS score and modified Marshall score were recorded before and after treatment.The levels of inflammatory factors and oxidative stress-related molecules were compared before and after treatment.Result:After treatment,the total effective rates of the control group and the treatment group were 80.0%and 93.3%,respectively,with statistical difference(χ2=8.845,P=0.027);after treatment,the total effective rates of TCM syndromes evaluation of the control group and the treatment group were 76.7%and 93.3%,respectively,with statistical difference(χ2=10.024,P=0.012);after treatment,the Ranson score,Balthazar CTSI score,SIRS score and improved Marshall score were all significantly decreased(P<0.05),and the decrease was more significant in the treatment group(P<0.05);after treatment,the serum levels of TNF-α,IL-6 and MDA were significantly decreased in both groups,and superoxide dismutase(SOD)was significantly increased(P<0.05),and the treatment group improved more(P<0.05).Conclusion:Chaishao Chengqi Decoction has a good curative effect on moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type,and can effectively improve inflammatory response and oxidative stress,which has a high clinical significance.
