Objective: To evaluate the effects of thyorotropin-releasing hormone (TRH ) on severe head injury.Methods: Eighty--seven severely head injured patients with a Glasgow Coma Scale (GCS ) score of & or less wererando...Objective: To evaluate the effects of thyorotropin-releasing hormone (TRH ) on severe head injury.Methods: Eighty--seven severely head injured patients with a Glasgow Coma Scale (GCS ) score of & or less wererandomized into TRH--treated and saline control groups. In TRH treated group. the treatment was started with abolus injection of 0. 2 mg/kg followed by continuous infusion for 2 hours at 0. 2 mg/kg/h. Such treatment wasgiven once a day for 4 times. The patients in control group were given the equivalent normal saline with the samemethod. Results: TRH, administered intravenously after head injury. promoted the recovery of consciousness andGCS score, alleviated the traumatic brain edema, controlled and lowered the intracranial pressure. decreased thelevel of lipid superoxides, decreased the mortality rate. and improved the life quality of the survivals. Nocomplications or adverse and toxic effects were noted during the course of TRH treatment. Conclusion: TRH hasbeneficial effects on patients with severe head injury.展开更多
目的探讨围术期平衡针对重型颅脑损伤术后昏迷患者的促苏醒治疗的可行性。方法采用非随机对照临床观察研究方法。重型颅脑损伤术后昏迷患者30例分为治疗组(n=15)和对照组(n=15),对照组采用常规治疗,治疗组在常规治疗基础上加用平衡针治...目的探讨围术期平衡针对重型颅脑损伤术后昏迷患者的促苏醒治疗的可行性。方法采用非随机对照临床观察研究方法。重型颅脑损伤术后昏迷患者30例分为治疗组(n=15)和对照组(n=15),对照组采用常规治疗,治疗组在常规治疗基础上加用平衡针治疗。两组患者分别于治疗前,治疗后1疗程、2疗程、3疗程进行格拉斯哥昏迷量表(Glasgow Coma Scale,GCS)评分。结果两组患者在术后治疗1个疗程,GCS评分治疗组与治疗前比较差异有统计学意义(P<0.05),对照组与治疗前比较差异无统计学意义(P>0.05);术后治疗3个疗程,GCS评分治疗组与对照组比较差异有统计学意义(P<0.05)。结论提示平衡针治疗对重型颅脑损伤术后昏迷患者可能有促苏醒作用,从而缩短患者昏迷时间。展开更多
文摘Objective: To evaluate the effects of thyorotropin-releasing hormone (TRH ) on severe head injury.Methods: Eighty--seven severely head injured patients with a Glasgow Coma Scale (GCS ) score of & or less wererandomized into TRH--treated and saline control groups. In TRH treated group. the treatment was started with abolus injection of 0. 2 mg/kg followed by continuous infusion for 2 hours at 0. 2 mg/kg/h. Such treatment wasgiven once a day for 4 times. The patients in control group were given the equivalent normal saline with the samemethod. Results: TRH, administered intravenously after head injury. promoted the recovery of consciousness andGCS score, alleviated the traumatic brain edema, controlled and lowered the intracranial pressure. decreased thelevel of lipid superoxides, decreased the mortality rate. and improved the life quality of the survivals. Nocomplications or adverse and toxic effects were noted during the course of TRH treatment. Conclusion: TRH hasbeneficial effects on patients with severe head injury.
文摘目的探讨围术期平衡针对重型颅脑损伤术后昏迷患者的促苏醒治疗的可行性。方法采用非随机对照临床观察研究方法。重型颅脑损伤术后昏迷患者30例分为治疗组(n=15)和对照组(n=15),对照组采用常规治疗,治疗组在常规治疗基础上加用平衡针治疗。两组患者分别于治疗前,治疗后1疗程、2疗程、3疗程进行格拉斯哥昏迷量表(Glasgow Coma Scale,GCS)评分。结果两组患者在术后治疗1个疗程,GCS评分治疗组与治疗前比较差异有统计学意义(P<0.05),对照组与治疗前比较差异无统计学意义(P>0.05);术后治疗3个疗程,GCS评分治疗组与对照组比较差异有统计学意义(P<0.05)。结论提示平衡针治疗对重型颅脑损伤术后昏迷患者可能有促苏醒作用,从而缩短患者昏迷时间。