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Severe liver injury by heat stroke: analysis of 10 cases
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作者 Xiao-Fen Ye Sen-Ming Yu Shi Yuan The Department of Gastroenterology, Hangzhou Zhijiang Hospital, Hangzhou 310051, China 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2002年第4期629-629,共1页
Objective: To analyse the clinical features and prognosisof liver injury caused by heat stroke.Methods: The clinical data of 10 patients with severe liverinjury caused by heat stroke were analysed retrospective-ly.Res... Objective: To analyse the clinical features and prognosisof liver injury caused by heat stroke.Methods: The clinical data of 10 patients with severe liverinjury caused by heat stroke were analysed retrospective-ly.Results: In 4 patients the level of ALT was over 1000 U/L, in 3 patients ranged from 300 to 1000 U/L, and in 3patients 50-300 U/L. The level of TBIL in 2 patientswas over 400 μmol/L and in 5 varied from 20 to 75μmol/L. Two patients showed jaundice and petechia on 展开更多
关键词 HEAT severe liver injury by heat stroke analysis of 10 cases
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Impact of COVID-19 pandemic on liver,liver diseases,and liver transplantation programs in intensive care units 被引量:1
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作者 Amr Salah Omar Rasha Kaddoura +1 位作者 Bassant Orabi Samy Hanoura 《World Journal of Hepatology》 2021年第10期1215-1233,共19页
Emerging worldwide data have been suggesting that coronavirus disease 2019(COVID-19)pandemic consequences are not limited to the respiratory and cardiovascular systems but encompass adverse gastrointestinal manifestat... Emerging worldwide data have been suggesting that coronavirus disease 2019(COVID-19)pandemic consequences are not limited to the respiratory and cardiovascular systems but encompass adverse gastrointestinal manifestations including acute liver injury as well.Severe cases of liver injury associated with higher fatality rates were observed in critically ill patients with COVID-19.Intensive care units(ICU)have been the center of disposition of severe cases of COVID-19.This review discusses the pathogenesis of acute liver injury in ICU patients with COVID-19,and analyzes its prevalence,consequences,possible drug-induced liver injury,and the impact of the pandemic on liver diseases and transplantation programs. 展开更多
关键词 COVID-19 Critical care DRUGS liver liver transplantation OUTCOME severe liver injury
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Prednisolone therapy accelerates recovery of severe drug-induced liver injury: A prospective, randomized controlled study
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作者 Fang-Jiao Song Hong-Ling Liu +10 位作者 Ying Sun Tian-Jiao Xu Dong-Ze Li Hai-Bo Wang Shao-Jie Xin Yu-Dong Wang Gregory Cheng George Lau Sa Lv Shao-Li You Bing Zhu 《iLIVER》 2023年第3期156-162,共7页
Background and aims:Drug-induced liver injury(DILI)is one of the most serious adverse drug reactions and its incidence has been increasing rapidly.Accumulating evidence suggests that immune activation and systemic inf... Background and aims:Drug-induced liver injury(DILI)is one of the most serious adverse drug reactions and its incidence has been increasing rapidly.Accumulating evidence suggests that immune activation and systemic inflammatory responses are very important in the progression of DILI.Corticosteroids are often used in DILI,but their clinical usefulness remains controversial.We therefore conducted a prospective,randomized controlled study to investigate whether corticosteroid therapy can accelerate recovery and reduce mortality in severe DILI(SDILI).Methods:SDILI patients with total bilirubin?171μmol/L who presented to the Fifth Medical Center of Chinese PLA General Hospital,Beijing from 2016 to 2019 were randomly allocated to prednisolone and control groups.The endpoints were resolution of SDILI,defined as a decrease in total bilirubin of at least 35μmol/L to<171μmol/L,and overall survival at 6 months.Patients in the prednisolone group received prednisolone 60 mg/day therapy for the first 7 days.Patients with a decrease in total bilirubin of more than 35μmol/L on day 8 continued on tapering doses of prednisolone;otherwise,prednisolone was discontinued.Results:On day 8,50.75%(34/67)and 26.47%(18/68)of the participants in the prednisolone and control groups,respectively,achieved the primary endpoint(p¼0.002).However,there was no significant difference in overall survival at 6 months:95.52%(64/67)vs.91.18%(62/68)in the prednisolone and control groups,respectively(p¼0.3).All deaths in both groups occurred in patients who failed to achieve SDILI resolution on day 8.Conclusion:Prednisolone therapy may accelerate the recovery of SDILI. 展开更多
关键词 Randomized study severe drug-induced liver injury HEPATOTOXICITY PREDNISOLONE Efficacy Accelerated recovery
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