Objective To study the pathological characteristics of severe acute respiratory syndrome (SARS) and its relationship to clinical manifestation Methods Tissue specimens from 3 autopsies of probable SARS cases wer...Objective To study the pathological characteristics of severe acute respiratory syndrome (SARS) and its relationship to clinical manifestation Methods Tissue specimens from 3 autopsies of probable SARS cases were studied by microscope, and the clinical data was reviewed Results The typical pathological changes of lungs were diffuse hemorrhaging on the surface A combination of serous, fibrinous and hemorrhagic inflammation was seen in most of the pulmonary alveoli with the engorgement of capillaries and detection of micro thrombosis in some of these capillaries Pulmonary alveoli thickened with interstitial mononuclear inflammatory infiltrates, suffered diffuse alveolar damage, experienced desquamation of pneumocytes and had hyaline membrane formation, fibrinoid materials, and erythrocytes in alveolar spaces There were thromboembolisms in some bronchial arteries Furthermore, hemorrhagic necrosis was also evident in lymph nodes and spleen with the attenuation of lymphocytes Other atypical pathological changes, such as hydropic degeneration, fatty degeneration, interstitial cell proliferation and lesions having existed before hospitalization were observed in the liver, heart, kidney and pancreas Conclusion Severe damage to the pulmonary and immunological systems is responsible for the clinical features of SARS and may lead to the death of patients展开更多
The outbreak of severe pneumonia at the end of 2019 was proved to be caused by the SARS-CoV-2 virus spreading out the world.And COVID-19 spread rapidly through a terrible transmission way by human-to-human,which led t...The outbreak of severe pneumonia at the end of 2019 was proved to be caused by the SARS-CoV-2 virus spreading out the world.And COVID-19 spread rapidly through a terrible transmission way by human-to-human,which led to many suspected cases waiting to be diagnosed and huge daily samples needed to be tested by an eff ective and rapid detection method.With an increasing number of COVID-19 infections,medical pressure is severe.Therefore,more e fficient and accurate diagnosis methods were keen urgently established.In this review,we summarized several methods that can rapidly and sensitively identify COVID-19;some of them are widely used as the diagnostic techniques for SARS-CoV-2 in various countries,some diagnostic technologies refer to SARS(Severe Acute Respiratory Syndrome)or/and MERS(Middle East Respiratory Syndrome)detection,which may provide potential diagnosis ideas.展开更多
文摘Objective To study the pathological characteristics of severe acute respiratory syndrome (SARS) and its relationship to clinical manifestation Methods Tissue specimens from 3 autopsies of probable SARS cases were studied by microscope, and the clinical data was reviewed Results The typical pathological changes of lungs were diffuse hemorrhaging on the surface A combination of serous, fibrinous and hemorrhagic inflammation was seen in most of the pulmonary alveoli with the engorgement of capillaries and detection of micro thrombosis in some of these capillaries Pulmonary alveoli thickened with interstitial mononuclear inflammatory infiltrates, suffered diffuse alveolar damage, experienced desquamation of pneumocytes and had hyaline membrane formation, fibrinoid materials, and erythrocytes in alveolar spaces There were thromboembolisms in some bronchial arteries Furthermore, hemorrhagic necrosis was also evident in lymph nodes and spleen with the attenuation of lymphocytes Other atypical pathological changes, such as hydropic degeneration, fatty degeneration, interstitial cell proliferation and lesions having existed before hospitalization were observed in the liver, heart, kidney and pancreas Conclusion Severe damage to the pulmonary and immunological systems is responsible for the clinical features of SARS and may lead to the death of patients
基金The Shandong Natural Science Foundation(ZR2018ZC0233)the Taishan Scholar Program at Shandong Province。
文摘The outbreak of severe pneumonia at the end of 2019 was proved to be caused by the SARS-CoV-2 virus spreading out the world.And COVID-19 spread rapidly through a terrible transmission way by human-to-human,which led to many suspected cases waiting to be diagnosed and huge daily samples needed to be tested by an eff ective and rapid detection method.With an increasing number of COVID-19 infections,medical pressure is severe.Therefore,more e fficient and accurate diagnosis methods were keen urgently established.In this review,we summarized several methods that can rapidly and sensitively identify COVID-19;some of them are widely used as the diagnostic techniques for SARS-CoV-2 in various countries,some diagnostic technologies refer to SARS(Severe Acute Respiratory Syndrome)or/and MERS(Middle East Respiratory Syndrome)detection,which may provide potential diagnosis ideas.
