In order to explore the exact nature of deformation defects previously observed in nanostructured Al-Mg alloys subjected to severe plastic deformation, a more thorough examination of the radiation effect on the format...In order to explore the exact nature of deformation defects previously observed in nanostructured Al-Mg alloys subjected to severe plastic deformation, a more thorough examination of the radiation effect on the formation of the planar defects in the high pressure torsion （HPT） alloys was conducted using high-resolution transmission electron microscopy （HRTEM）. The results show that high density defects in the HRTEM images disappear completely when these images are exposed under the electron beam for some duration of time. At the same time, lattice defects are never observed within no-defect areas even when the beam-exposure increases to the degree that holes appear in the areas. Therefore, it is confirmed that the planar defects observed in the HPT alloys mainly result from the significant plastic deformation and are not due to the radiation effect during HRTEM observation.展开更多
A novel reconstructive prosthesis was designed with topological optimization(TO)and a lattice structure to enhance biomechanical and biological properties in the proximal tibia.The biomechanical performance was valida...A novel reconstructive prosthesis was designed with topological optimization(TO)and a lattice structure to enhance biomechanical and biological properties in the proximal tibia.The biomechanical performance was validated through finite element analysis(FEA)and biomechanical tests.The tibia with inhomogeneous material properties was reconstructed according to computed tomography images,and different components were designed to simulate the operation.Minimum compliance TO subject to a volume fraction constraint combined with a graded lattice structure was utilized to redesign the prosthesis.FEA was performed to evaluate the mechanical performances of the tibia and implants after optimization,including stress,micromotion,and strain energy.The results were analyzed by paired-samples t tests,and p<0.05 was considered significant.Biomechanical testing was used to verify the tibial stresses.Compared to the original group(OG),the TO group(TOG)exhibited lower stress on the stem,and the maximum von Mises stresses were 87.2 and 53.1 MPa,respectively,a 39.1%reduction(p<0.05).Conversely,the stress and strain energy on the tibia increased in the TOG.The maximum von Mises stress values were 16.4 MPa in the OG and 22.9 MPa in the TOG with a 39.6%increase(p<0.05),and the maximum SED value was 0.026 MPa in the OG and 0.042 MPa in the TOG,corresponding to an increase of 61.5%(p<0.05).The maximum micromotions in the distal end of the stem were 135μm in the OG and 68μm in the TOG,almost a 50%reduction.The stress curves of the biomechanical test coincided well with the FEA results.The TO approach can effectively reduce the whole weight of the prosthesis and improve the biomechanical environment of the tibia.It could also pave the way for next-generation applications in orthopedics surgery.展开更多
充足的骨量是保证种植体植入和维持长期稳定的关键因素,因而对牙槽骨重度骨缺损的修复重建有着重要的临床意义。随着引导骨再生(guided bone regeneration,GBR)的不断发展,各种GBR术式应用于临床,以解决牙槽骨修复与再生问题。作者基于...充足的骨量是保证种植体植入和维持长期稳定的关键因素,因而对牙槽骨重度骨缺损的修复重建有着重要的临床意义。随着引导骨再生(guided bone regeneration,GBR)的不断发展,各种GBR术式应用于临床,以解决牙槽骨修复与再生问题。作者基于“以稳定性为核心”的牙槽骨修复与再生理念,研发了帐篷钉系列产品,取得了口腔类Ⅲ类医疗器械注册证,并完成了新型帐篷钉技术的构建。该技术能够在不使用自体骨的情况下实现牙槽骨重度缺损的修复与重建,为牙槽骨重度缺损的功能和美学修复提供了新的解决方案。新型帐篷钉技术已在临床上获得了成功验证,并且由于其具有“三低”(技术敏感性低、失败率低及成本低)和“三易”(易操作、易推广及易普及)的特点,使该技术备受口腔医师和患者的青睐。为了进一步提升广大临床医生对新型帐篷钉技术的认识,本文就帐篷钉系列医疗产品的创新性及新型帐篷钉技术的优势作详细介绍,并通过临床病例进行展示,以期该项技术能够在临床上得到规范化应用。展开更多
With the population aging and an increasing desire for a high quality of life,millions of patients who suffered knee arthropathy have undergone total knee arthroplasty （TKA）.Although the success rate for primary TKA...With the population aging and an increasing desire for a high quality of life,millions of patients who suffered knee arthropathy have undergone total knee arthroplasty （TKA）.Although the success rate for primary TKA has been quite high,the number of revision surgeries can not be ignored.Bone loss is one of the challenges confronting surgeons who perform revision TKAs as it can impair alignment accuracy and the long-term stability of the implant.Although several options are available for bone loss after TKA--cement,bone grafting,standard augments,and hinged implants--there is no single ideal option available for all patients with a severe bone defect because of the variety and severity of the defects.1 The burgeoning rapid prototyping （RP） technique,which has been used to fabricate components with complex and unique structures,may offer a novel option in these cases.Keywords：rapid prototyping; severe bone defects; knee展开更多
针对软件缺陷报告严重性预测中现有模型分类精度较低、深层次的语义特征不够丰富等问题,本文提出了一种基于BERT句子级别与词级别特征融合的SWF-BERT(Sentence-level and Word-level features Fusion-BERT)软件缺陷报告严重性预测模型....针对软件缺陷报告严重性预测中现有模型分类精度较低、深层次的语义特征不够丰富等问题,本文提出了一种基于BERT句子级别与词级别特征融合的SWF-BERT(Sentence-level and Word-level features Fusion-BERT)软件缺陷报告严重性预测模型.首先,对缺陷报告中的文本进行了数据预处理.其次,为了加强嵌入层中融合后的特征语义信息,提取词频最高的前100个单词,筛选出与缺陷严重性相关的特征词对其进行关键词嵌入操作,并融合嵌入层中的其他向量进行词嵌入.最后,将BERT模型输出层得到的特征(除[CLS]token外)送入多尺度卷积神经网络结合长短期记忆网络(MC-LSTM)模型中,加强了不同特征间远距离的时序信息.采用BERT模型输出得到的[CLS]句向量经过线性变换的结果与MC-LSTM模型输出经过线性变换得到的结果做可学习的自适应加权融合,实现了对软件缺陷报告严重性的有效预测.实验结果表明,使用SWF-BERT模型的平均准确率、召回率和F1值在Mozilla数据集中分别达到了68.41%、64.60%和64.86%,在Eclipse数据集中分别达到了61.32%、62.62%和59.31%,与其他分类算法相比,该方法在性能上得到了较大的提升.展开更多
目的探究[牙合]垫式可摘局部义齿(RPD)修复治疗牙齿重度磨耗(SOA)伴牙列缺损(DD)患者的效果。方法回顾性收集我院60例牙齿SOA伴DD患者(2019年12月至2022年12月),按治疗方案不同分成A组(30例)、B组(30例)。B组接受传统RPD修复,A组接受垫...目的探究[牙合]垫式可摘局部义齿(RPD)修复治疗牙齿重度磨耗(SOA)伴牙列缺损(DD)患者的效果。方法回顾性收集我院60例牙齿SOA伴DD患者(2019年12月至2022年12月),按治疗方案不同分成A组(30例)、B组(30例)。B组接受传统RPD修复,A组接受垫式RPD修复。对比2组咀嚼功能[咬合力(BF)与咀嚼效率(ME)]、咀嚼肌功能肌电图[双侧颞肌前束(TA)、咬肌(MM)均值及牙尖交错位(ICP)最大紧咬平均峰值电位]、临床症状发生率、炎性因子指标[白细胞介素-6(IL-6)、IL-10、肿瘤坏死因子-α(TNF-α)]、并发症发生率。结果修复3个月A组ME、BF较B组高(P<0.05);修复3个月A组ICP最大紧咬平均峰值电位TA、MM值较B组高,息止位肌电图TA、MM值较B组低(P<0.05);修复3个月A组食物嵌塞、颞下颌关节疼痛发生率较B组低(P<0.05);修复3 d A组龈沟液TNF-α、IL-6含量较B组低,IL-10含量较B组高(P<0.05);2组并发症发生率相比差异无统计学意义(P>0.05)。结论与传统RPD修复治疗牙齿SOA伴DD患者相比,应用[牙合]垫式RPD修复治疗于改善临床症状、提高咀嚼肌功能及咬合功能方面更具优势,且对机体炎性应激反应影响更小。展开更多
基金Project (50971087) supported by the National Natural Science Foundation of ChinaProject (BK2012715) supported by the Basic Research Program (Natural Science Foundation) of Jiangsu Province, China+1 种基金Project (10371800) supported by the Research Council of Norway under the NEW Light (NEWLIGHT) Metals of the Strategic Area (SA) MaterialsProject (11JDG070) supported by the Senior Talent Research Foundation of Jiangsu University, China
文摘In order to explore the exact nature of deformation defects previously observed in nanostructured Al-Mg alloys subjected to severe plastic deformation, a more thorough examination of the radiation effect on the formation of the planar defects in the high pressure torsion （HPT） alloys was conducted using high-resolution transmission electron microscopy （HRTEM）. The results show that high density defects in the HRTEM images disappear completely when these images are exposed under the electron beam for some duration of time. At the same time, lattice defects are never observed within no-defect areas even when the beam-exposure increases to the degree that holes appear in the areas. Therefore, it is confirmed that the planar defects observed in the HPT alloys mainly result from the significant plastic deformation and are not due to the radiation effect during HRTEM observation.
基金National Natural Science Foundation of China[Grant Numbers 81802174,81900726&82072456]Department of Science and Technology of Jilin Province,P.R.C[Grant Numbers 20200404202YY,20200403086SF&20200201453JC]+8 种基金Jilin Province Development and Reform Commission,P.R.C[Grant Number 2018C010]Education Department of Jilin Province,P.R.C[GrantNumber JJKH20180106KJ]Administration of Traditional Chinese Medicine of Jilin Province P.R.C[Grant Number 2018115]10th Youth Project of the First Hospital of Jilin University[Grant Number JDYY102019025]Department of Finance in Jilin Province[Grant Number 2019SCZT046]Undergraduate Teaching Reform Research Project of Jilin University[Grant Number 4Z2000610852]Key training plan for outstanding young teachers of Jilin University[Grant Number 419080520253]Bethune plan of Jilin University[Grant Number 470110000692]The major participant is Qing Han.
文摘A novel reconstructive prosthesis was designed with topological optimization(TO)and a lattice structure to enhance biomechanical and biological properties in the proximal tibia.The biomechanical performance was validated through finite element analysis(FEA)and biomechanical tests.The tibia with inhomogeneous material properties was reconstructed according to computed tomography images,and different components were designed to simulate the operation.Minimum compliance TO subject to a volume fraction constraint combined with a graded lattice structure was utilized to redesign the prosthesis.FEA was performed to evaluate the mechanical performances of the tibia and implants after optimization,including stress,micromotion,and strain energy.The results were analyzed by paired-samples t tests,and p<0.05 was considered significant.Biomechanical testing was used to verify the tibial stresses.Compared to the original group(OG),the TO group(TOG)exhibited lower stress on the stem,and the maximum von Mises stresses were 87.2 and 53.1 MPa,respectively,a 39.1%reduction(p<0.05).Conversely,the stress and strain energy on the tibia increased in the TOG.The maximum von Mises stress values were 16.4 MPa in the OG and 22.9 MPa in the TOG with a 39.6%increase(p<0.05),and the maximum SED value was 0.026 MPa in the OG and 0.042 MPa in the TOG,corresponding to an increase of 61.5%(p<0.05).The maximum micromotions in the distal end of the stem were 135μm in the OG and 68μm in the TOG,almost a 50%reduction.The stress curves of the biomechanical test coincided well with the FEA results.The TO approach can effectively reduce the whole weight of the prosthesis and improve the biomechanical environment of the tibia.It could also pave the way for next-generation applications in orthopedics surgery.
文摘充足的骨量是保证种植体植入和维持长期稳定的关键因素,因而对牙槽骨重度骨缺损的修复重建有着重要的临床意义。随着引导骨再生(guided bone regeneration,GBR)的不断发展,各种GBR术式应用于临床,以解决牙槽骨修复与再生问题。作者基于“以稳定性为核心”的牙槽骨修复与再生理念,研发了帐篷钉系列产品,取得了口腔类Ⅲ类医疗器械注册证,并完成了新型帐篷钉技术的构建。该技术能够在不使用自体骨的情况下实现牙槽骨重度缺损的修复与重建,为牙槽骨重度缺损的功能和美学修复提供了新的解决方案。新型帐篷钉技术已在临床上获得了成功验证,并且由于其具有“三低”(技术敏感性低、失败率低及成本低)和“三易”(易操作、易推广及易普及)的特点,使该技术备受口腔医师和患者的青睐。为了进一步提升广大临床医生对新型帐篷钉技术的认识,本文就帐篷钉系列医疗产品的创新性及新型帐篷钉技术的优势作详细介绍,并通过临床病例进行展示,以期该项技术能够在临床上得到规范化应用。
文摘With the population aging and an increasing desire for a high quality of life,millions of patients who suffered knee arthropathy have undergone total knee arthroplasty （TKA）.Although the success rate for primary TKA has been quite high,the number of revision surgeries can not be ignored.Bone loss is one of the challenges confronting surgeons who perform revision TKAs as it can impair alignment accuracy and the long-term stability of the implant.Although several options are available for bone loss after TKA--cement,bone grafting,standard augments,and hinged implants--there is no single ideal option available for all patients with a severe bone defect because of the variety and severity of the defects.1 The burgeoning rapid prototyping （RP） technique,which has been used to fabricate components with complex and unique structures,may offer a novel option in these cases.Keywords：rapid prototyping; severe bone defects; knee
文摘针对软件缺陷报告严重性预测中现有模型分类精度较低、深层次的语义特征不够丰富等问题,本文提出了一种基于BERT句子级别与词级别特征融合的SWF-BERT(Sentence-level and Word-level features Fusion-BERT)软件缺陷报告严重性预测模型.首先,对缺陷报告中的文本进行了数据预处理.其次,为了加强嵌入层中融合后的特征语义信息,提取词频最高的前100个单词,筛选出与缺陷严重性相关的特征词对其进行关键词嵌入操作,并融合嵌入层中的其他向量进行词嵌入.最后,将BERT模型输出层得到的特征(除[CLS]token外)送入多尺度卷积神经网络结合长短期记忆网络(MC-LSTM)模型中,加强了不同特征间远距离的时序信息.采用BERT模型输出得到的[CLS]句向量经过线性变换的结果与MC-LSTM模型输出经过线性变换得到的结果做可学习的自适应加权融合,实现了对软件缺陷报告严重性的有效预测.实验结果表明,使用SWF-BERT模型的平均准确率、召回率和F1值在Mozilla数据集中分别达到了68.41%、64.60%和64.86%,在Eclipse数据集中分别达到了61.32%、62.62%和59.31%,与其他分类算法相比,该方法在性能上得到了较大的提升.
文摘目的探究[牙合]垫式可摘局部义齿(RPD)修复治疗牙齿重度磨耗(SOA)伴牙列缺损(DD)患者的效果。方法回顾性收集我院60例牙齿SOA伴DD患者(2019年12月至2022年12月),按治疗方案不同分成A组(30例)、B组(30例)。B组接受传统RPD修复,A组接受垫式RPD修复。对比2组咀嚼功能[咬合力(BF)与咀嚼效率(ME)]、咀嚼肌功能肌电图[双侧颞肌前束(TA)、咬肌(MM)均值及牙尖交错位(ICP)最大紧咬平均峰值电位]、临床症状发生率、炎性因子指标[白细胞介素-6(IL-6)、IL-10、肿瘤坏死因子-α(TNF-α)]、并发症发生率。结果修复3个月A组ME、BF较B组高(P<0.05);修复3个月A组ICP最大紧咬平均峰值电位TA、MM值较B组高,息止位肌电图TA、MM值较B组低(P<0.05);修复3个月A组食物嵌塞、颞下颌关节疼痛发生率较B组低(P<0.05);修复3 d A组龈沟液TNF-α、IL-6含量较B组低,IL-10含量较B组高(P<0.05);2组并发症发生率相比差异无统计学意义(P>0.05)。结论与传统RPD修复治疗牙齿SOA伴DD患者相比,应用[牙合]垫式RPD修复治疗于改善临床症状、提高咀嚼肌功能及咬合功能方面更具优势,且对机体炎性应激反应影响更小。
