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Management of Severely Malnourished Children Aged 6 - 59 Months Hospitalized in the Pediatric Ward of Kayanza Hospital/Burundi
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作者 Michel Baseka Jonathan Niyukuri +2 位作者 Alice Ndayishimiye Sedki Az-Eddine Vestine Ntakarutimana 《Open Journal of Pediatrics》 2024年第1期11-21,共11页
The implementation of WHO guidelines has significantly reduced hospital mortality due to severe malnutrition. Nevertheless, severe acute malnutrition in children under five remains a major public health problem in all... The implementation of WHO guidelines has significantly reduced hospital mortality due to severe malnutrition. Nevertheless, severe acute malnutrition in children under five remains a major public health problem in all low-income countries and is little studied. The study aimed to assess the nutritional status and quality of management of severe acute malnutrition in children aged 06 to 59 months hospitalized in the pediatric ward of Kayanza Hospital. This is a prospective study with descriptive and analytical aims over 6 months from February 10 to July 9, 2023. All children aged 6 to 59 months admitted for severe acute malnutrition are included in this study. The results show that the most affected age group is 12 to 23 months (42.55%). Marasmus is the most common clinical form, at 70.2%. Housewives and mothers from rural areas are the most affected, with rates ranging from 69.14% to 91.49%. The study shows that the reasons for consultation are respectively: edema (29.78%), diarrhea (26.59%), vomiting (19.14%), and fever (14.89%). Dehydration and hypothermia were the main complications observed in 45.74% and 22.34% respectively. Medical treatment was provided by antibiotics (44.68%), artesunate (31.91%), and resomal (21.27%). Nutritional treatment consisted of F75 100% milk and F100 100% milk. Pathologies observed were: anemia 38.29%, malaria 37.23%, urinary tract infection 12.7%, measles 11.7%. The national protocol for integrated management of acute malnutrition (PCIMA) was followed. This study shows that 72.3% of children were successfully treated, with 9.5% dropping out and dying, and 8.5% not responding. We found that malnutrition remains a public health problem, affecting mostly children aged 12 to 24 months. The main complications or pathologies associated with malnutrition are diarrhea, malaria, and fever, and the majority of children suffer from marasmus. 展开更多
关键词 severe Acute Malnutrition child BURUNDI
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Empirical Study on the Empowerment of Families Raising Children with Severe Motor and Intellectual Disabilities in Japan: The Association with Positive Feelings towards Child Rearing
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作者 Hiroshi Fujioka Rie Wakimizu +4 位作者 Ryuta Tanaka Tatsuyuki Ohto Atsushi Ieshima Akira Yoneyama Kiyoko Kamibeppu 《Health》 2015年第12期1725-1740,共16页
Background: “Children with severe motor and intellectual disabilities” refers to children with markedly limited activity due to severe overlapping of physical and intellectual disabilities. The physical and mental b... Background: “Children with severe motor and intellectual disabilities” refers to children with markedly limited activity due to severe overlapping of physical and intellectual disabilities. The physical and mental burden placed on families raising severely disabled children, particularly the primary caregivers, is great in home settings. For families to effectively utilize services and over-come child rearing problems, the families themselves need the “strength” to cooperate with others for the purpose of raising a severely disabled child. The ultimate goal of family support is to enable such families to achieve satisfaction and self-growth in child rearing. Methods: We used a questionnaire to survey 75 primary caregivers to empirically elucidate the empowerment and positive feelings towards child rearing of families raising children with severe motor and intellectual disabilities and the related factors. The t-test and Spearman’s rank correlation coefficient were used to examine the association with bivariates. A multiple regression analysis was conducted for empowerment and positive feelings. Results: Results revealed that life events, livelihood, awareness of social support and the child’s sleep problems were factors related to empowerment. Of these, awareness of social support from outside of the family was found to contribute the most to empowerment. Furthermore, improvement and maintenance of positive feelings towards child rearing reaffirmed the existence of empowerment in addition to reducing negative feelings towards child rearing and ensuring social support. Conclusions: Raising children with severe motor and intellectual disabilities requires specialist knowledge and skills. Support from professionals to empower the entire family is therefore important in order to strengthen positive feelings towards child rearing. 展开更多
关键词 childREN with severe Motor and Intellectual Disabilities Family EMPOWERMENT POSITIVE FEELINGS towards child REARING
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Severe Childhood Malaria in Two Health Districts of Cuvette-Congo
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作者 Moyen Engoba Prudencia Joachinelle Malouono Moukassa +3 位作者 Géril Sekangue Obili Lynda Tchidjo Ngamo Georges Marius Moyen Jean-Louis Nkoua 《Open Journal of Pediatrics》 CAS 2022年第3期582-593,共12页
Introduction: Malaria is a public health problem. Severe forms of malaria are linked to high mortality. Objective: To establish the cartography of severe malaria in two health districts in Cuvette-Congo. Methodology: ... Introduction: Malaria is a public health problem. Severe forms of malaria are linked to high mortality. Objective: To establish the cartography of severe malaria in two health districts in Cuvette-Congo. Methodology: An analytical and cross-sectional study was conducted from January to September 2019 in two health districts of Cuvette-Congo. Children aged three months to 17 years diagnosed with severe malaria were included. The epidemiological, clinical and paraclinical variables were analyzed. The statistical tests used were Pearson’s chi<sup>2</sup> and the corrected Yates test. Results: Out of 806 children hospitalized, 277 had severe malaria (34.4%). There were 144 boys and 133 girls, an average of 60.9 months old. Anemia n = 247 (89.2%), repeated seizures n = 66 (23.8%), were the signs of severity observed. The clinical forms were isolated (n = 237) in 85.6% and associated (n = 40) in 14.4%, including 210 (88.6%) anemic form and 27 (11.4%) neurological form. The death occurred in seven cases (2.5%). The predictors of death were coma, jaundice, hypoglycemia, thrombocytopenia, hepatomegaly, undernutrition, dehydration and delayed consultation. Conclusion: The large number of cases of severe malaria in Cuvette, often in children under five years old, requires that the national program for control of malaria be strengthened by insisting on a wide distribution of long-lasting insecticide-treated mosquito nets. 展开更多
关键词 severe Malaria child Cuvette-Congo
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不同证型慢性重型肝炎患者血浆内毒素水平与Child-Pugh评分的相关性分析 被引量:5
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作者 龙富立 徐刚 +5 位作者 王娜 王沙 谢丽 王明刚 张荣臻 毛德文 《中西医结合肝病杂志》 CAS 2017年第1期11-12,30,共3页
目的:探究不同证型CSH患者血浆内毒素水平与Child-Pugh评分之间的相关性。方法:选择在我院肝病科住院的CSH患者100例,按中医辨证分型标准分为5个组,另设一组健康成年人20例作为正常对照,计算患者Child-Pugh评分分值和检测各组患者血浆... 目的:探究不同证型CSH患者血浆内毒素水平与Child-Pugh评分之间的相关性。方法:选择在我院肝病科住院的CSH患者100例,按中医辨证分型标准分为5个组,另设一组健康成年人20例作为正常对照,计算患者Child-Pugh评分分值和检测各组患者血浆内毒素水平,并进行统计分析。结果:20例健康成年人未检出内毒素;5个证型中热毒入营(血)证相关系数最大,即相关系数r=0.751(P<0.01),其次是热毒炽盛证,相关系数r=0.481(P<0.01),其余3证型也存在一定的相关性,但相关系数要略低于前两证。结论:不同中医证型CSH患者内毒素水平与Child-Pugh评分分值之间存在正相关关系;内毒素水平越高者,其Child-Pugh评分越高、死亡率亦越高。 展开更多
关键词 肝炎 重型 慢性 内毒素 中医证型 child-PUGH评分 相关性分析
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Can ultrasound predict the severity of acute pancreatitis early by observing acute fluid collection? 被引量:8
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作者 Yan Luo1 Chao Xin Yuan1 +5 位作者 Yu Lan Peng1 Pei Lin Wei1 Zhao Da Zhang2 Jun Ming Jiang3 Lin Dai1 Yun Kai Hu1 1Ultrasound Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China2Surgery Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China3Tranditional Chinese Medicine, Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第2期293-295,共3页
INTRODUCTIONThe spectrum of acute pancreatitis (AP) ranges from a mild spontaneously resolved disorder to severe disease with mortality up to 20%-48.4%[1-3]. sAP is defined as the AP with organ failure and /or local... INTRODUCTIONThe spectrum of acute pancreatitis (AP) ranges from a mild spontaneously resolved disorder to severe disease with mortality up to 20%-48.4%[1-3]. sAP is defined as the AP with organ failure and /or local complications which developed form acute fluid collection (AFC) including necrosis ,abscess , pseudocyst formation into or around the pancreas [4]. 展开更多
关键词 Acute Disease ADOLESCENT Adult Aged Aged 80 and over child child Preschool Exudates and Transudates Female Humans Male Middle Aged PANCREATITIS Prognosis Research Support Non-U.S. Gov't Retrospective Studies severity of Illness Index
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Child-Pugh肝功能分级在老年心力衰竭患者严重程度和预后评估中的应用 被引量:3
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作者 谢娟 《中国现代医生》 2020年第11期34-37,46,共5页
目的探讨Child-Pugh肝功能分级在老年心力衰竭患者严重程度和预后评估中的应用。方法纳入2017年1月~2018年9月于南充市中心医院老年病科已确诊为心力衰竭的患者132例,按照Child-Pugh肝功能的得分将患者分为3个等级:A级、B级、C级,观察... 目的探讨Child-Pugh肝功能分级在老年心力衰竭患者严重程度和预后评估中的应用。方法纳入2017年1月~2018年9月于南充市中心医院老年病科已确诊为心力衰竭的患者132例,按照Child-Pugh肝功能的得分将患者分为3个等级:A级、B级、C级,观察记录三组患者的临床特征、肝功能分级与心衰严重程度指标如NYHA分级、NT-proBNP、LVEF的关系,住院时间及患者出院后随访1年的全因死亡率。结果入院的心力衰竭患者中,Child-Pugh A级占比最多;病史特征上,Child-Pugh A、B级心力衰竭患者以合并冠心病病史居多,而Child-Pugh C级心力衰竭患者以合并扩心病病史居多(P<0.05)。Child-Pugh肝功能分级越高,其心衰的NYHA的分级及NT-proBNP的水平也越高,同时LVEF的水平越低(P<0.05)。Child-Pugh肝功能分级越高,心衰患者的住院时间越长,随访1年的全因死亡率越高(P<0.05)。结论肝功能损伤在老年心力衰竭患者中比较常见,Child-Pugh肝功能分级可用于判断老年心力衰竭患者的严重程度,在长期随访中对老年心力衰竭患者的预后有较好的预测价值。 展开更多
关键词 child-PUGH肝功能分级 老年 心力衰竭 严重程度 预后 全因死亡率
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Febrile Seizures in Children at the Departmental Teaching Hospital of OuéméPlateau: Etiologies and Risk Factors for Death
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作者 Caroline Padonou Gilles Bognon +3 位作者 Lutécia Zohoun Florence Alihonou Mauriella Edjrokinto Gratien Sagbo 《Open Journal of Pediatrics》 2022年第2期364-375,共12页
Background: Febrile seizures are the most frequent neurological disorder in pediatrics. They have multiple etiologies and require urgent management. The aim of this survey was to study febrile seizures in children at ... Background: Febrile seizures are the most frequent neurological disorder in pediatrics. They have multiple etiologies and require urgent management. The aim of this survey was to study febrile seizures in children at the Departmental Teaching Hospital of Ouémé Plateau (DTH/OP). Method: This was a cross-sectional survey, conducted from January 1, 2020, to December 31, 2020, in the pediatric department of the DTH/OP. Children aged 1 month to 18 years, hospitalized for febrile seizures recognized at the anamnesis and/or during the physical examination were included in this study. Results: The frequency of seizures was 17.08% (510/2986). The male to female ratio was equal to 1.4. The mean age was 44.27 ± 40.75 months. The seizure was generalized tonic-clonic in 77.9% of cases and localized in 11.6% of cases. The main etiologies were severe malaria (75.5%), sepsis (21.6%), enteric infections (14.9%) and pneumonia (10.2%). Diazepam was the anticonvulsant treatment used in the first intention (79.7%). Most of the children were hospitalized for 3 to 7 days. The recovery rate was 82.3% and the fatality rate was equal to 17.7%. Eight children presented sequelae. There was a statistically significant link between the children’s clinical outcome and age (p < 0.001);severe malaria (p < 0.001);sepsis (p < 0.001) and enteric infections (p = 0.003). Conclusion: Febrile seizures were frequent in the pediatric emergency department of the DTH/OP. There is a need to intensify sensitization on malaria prevention measures in the community and improve case management at the hospital. 展开更多
关键词 Febrile Seizures severe Malaria SEPSIS child
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Restraint Usage Characteristics and Other Factors Associated with Safety of Children Involved in Motor Vehicle Crashes
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作者 Sunanda Dissanayake Niranga Amarasingha 《Journal of Civil Engineering and Architecture》 2016年第1期81-95,共15页
Involvement in road traffic crashes as vehicle occupants is a leading cause of death and serious injury among children. The objective of this study was to investigate crash severity factors and child safety restraint ... Involvement in road traffic crashes as vehicle occupants is a leading cause of death and serious injury among children. The objective of this study was to investigate crash severity factors and child safety restraint use characteristics in order to identify effective countermeasures to increase children's highway safety. Characteristics and percentages of restraint use among child passengers aged 4-13 years were examined using highway crash data from Kansas. The association between restraint use, injury severity and characteristics of children involved in crashes were investigated using OR (odds ratios) and a logistic regression model, which was used to identify risk factors. Results showed that children, who were unrestrained, were seated in the front seat, traveling with drunk drivers and on rural roads, and traveling during nighttime was more vulnerable to severe injury in the case of motor vehicle crashes. The most frequent contributing causes related to crashes involving children included driver's inattention while driving, failure to yield right-of-way, driving too fast, wet roads and animals in the road. Based on identified critical factors, general countermeasure ideas to improve children's traffic safety were suggested, including age-appropriate and size-appropriate seat belt restraints and having children seated in the rear seat. Parents and children must gain better education regarding these safety measures in order to increase child safety on the road. 展开更多
关键词 child safety child restraint use severity model logistic regression model crash data analysis.
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儿童大环内酯类耐药重症肺炎支原体肺炎的临床特征及危险因素分析 被引量:6
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作者 陈梦雪 李京阳 +3 位作者 杨芬 田野 李菁 丁国栋 《临床儿科杂志》 CAS CSCD 北大核心 2024年第3期187-192,共6页
目的 探讨大环内酯类耐药重症肺炎支原体肺炎(SMPP)患儿临床特点及危险因素。方法 回顾性分析2023年3月至9月在儿呼吸内科住院治疗的大环内酯类耐药肺炎支原体肺炎(MPP)患儿的临床资料,根据病情严重程度分为耐药重症组和耐药非重症组,... 目的 探讨大环内酯类耐药重症肺炎支原体肺炎(SMPP)患儿临床特点及危险因素。方法 回顾性分析2023年3月至9月在儿呼吸内科住院治疗的大环内酯类耐药肺炎支原体肺炎(MPP)患儿的临床资料,根据病情严重程度分为耐药重症组和耐药非重症组,比较两组间临床特征,分析影响SMPP发生的危险因素。结果 纳入224例大环内酯类耐药MPP患儿,耐药重症组132例,男65例、女67例,中位年龄7.0(5.0~9.0)岁;耐药非重症组92例,男46例、女46例,中位年龄7.0(5.0~9.0)岁。二分类多因素logistic回归分析结果发现,发热时间延长,D-二聚体水平升高及肺实变是预测大环内酯类耐药SMPP发生的独立危险因素(P<0.05),而乳酸脱氢酶、IgE水平升高,可能与耐药SMPP发生相关(P<0.05)。ROC曲线分析显示,发热时间、乳酸脱氢酶、D-二聚体对于预测大环内酯类耐药SMPP的发生均有中等诊断价值(AUC>0.8,P<0.05)。所有耐药MPP患儿经治疗后痊愈出院。耐药重症组住院天数为7.0(6.0~9.0)天,显著长于耐药非重症组[6.0(5.0~7.0)天];耐药重症组住院费用12 283(10 836~15 012)元,明显高于耐药非重症组[9 769(8 756~11 642)元],差异均有统计学意义(P<0.01)。结论 大环内酯类耐药SMPP发热时间及住院天数长,炎症指标明显升高,肺部影像学改变重,给患儿家庭带来的经济负担更沉重。 展开更多
关键词 肺炎支原体 耐药 重症肺炎 危险因素 儿童
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大环内酯类耐药肺炎支原体肺炎患儿发展为重症肺炎支原体肺炎的危险因素分析及预测模型构建
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作者 施明杰 叶洪舟 袁琛 《中国现代医生》 2024年第33期70-73,共4页
目的探索早期预测大环内酯类耐药肺炎支原体肺炎(macrolide-resistant Mycoplasma pneumoniae pneumonia,MRMP)患儿发展为重症肺炎支原体肺炎(severe Mycoplasma pneumoniae pneumonia,SMPP)的方法。方法回顾性分析2023年1月至2024年1... 目的探索早期预测大环内酯类耐药肺炎支原体肺炎(macrolide-resistant Mycoplasma pneumoniae pneumonia,MRMP)患儿发展为重症肺炎支原体肺炎(severe Mycoplasma pneumoniae pneumonia,SMPP)的方法。方法回顾性分析2023年1月至2024年1月于湖州市第一人民医院住院治疗的117例MRMP患儿的临床资料。根据患儿病情严重程度分为重症组和轻症组,比较两组患儿的临床特征,进一步分析导致耐药患儿发展为SMPP的危险因素。结果117例MRMP患儿中重症组63例,轻症组54例。重症组患儿的发热持续时间、咳嗽持续时间、白细胞计数、C反应蛋白(C-reactive protein,CRP)、乳酸脱氢酶(lactatede hydrogenase,LDH)均高于轻症组(P<0.05)。Logistic回归分析显示发热持续时间、CRP、LDH是MRMP发展为SMPP的独立危险因素,3项联合检测的曲线下面积达0.963(95%CI:0.935~0.991,P<0.001)。结论根据患儿首次就诊时的发热持续时间、CRP、LDH水平可预测MRMP发展为SMPP的概率,进而实现早诊断、早治疗。 展开更多
关键词 肺炎支原体 重症肺炎 预测 儿童
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新型冠状病毒感染流行背景下的儿童多系统炎症综合征
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作者 周彬 黄育坤 +2 位作者 洪少贤(综述) 焦富勇 谢凯生(审校) 《中国当代儿科杂志》 CSCD 北大核心 2024年第1期98-102,共5页
儿童多系统炎症综合征(multisystem inflammatory syndrome in children,MIS-C)是在严重急性呼吸综合征冠状病毒-2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)暴发流行的背景下出现的一种多系统受累综合征。MIS-C的... 儿童多系统炎症综合征(multisystem inflammatory syndrome in children,MIS-C)是在严重急性呼吸综合征冠状病毒-2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)暴发流行的背景下出现的一种多系统受累综合征。MIS-C的临床表现与川崎病类似,但以发热及胃肠道症状为主要表现,严重者可出现中毒性休克和心功能不全。流行病学调查结果表明,大多数MIS-C患儿SARS-CoV-2抗体检测呈阳性。关于MIS-C的发病机制及病理生理过程尚不明确,SARS-CoV-2感染后的免疫失调被认为是主要原因。目前对于MIS-C的治疗以免疫球蛋白及对症支持治疗为主。该文对MIS-C的定义、流行病学、发病机制、临床表现、诊断、治疗及预后等进行了综述。 展开更多
关键词 儿童多系统炎症综合征 新型冠状病毒感染 严重急性呼吸综合征冠状病毒2 儿童
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MP合并hMPV和SP感染的重症肺炎患儿1例药学监护
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作者 段小菊 毕文超 +4 位作者 侯静静 王岩 谷雨 刘宪勇 郑俊青 《国际医药卫生导报》 2024年第10期1716-1719,共4页
临床药师全程参与1例肺炎支原体(MP)合并偏肺病毒(hMPV)和肺炎链球菌(SP)感染的重症肺炎患儿药学监护,在患儿病情复杂、医师忽略MP感染、超说明书用药和违反传统理论联合用药的情况下,查阅资料,结合病情深入剖析,及时提供安全有效的治... 临床药师全程参与1例肺炎支原体(MP)合并偏肺病毒(hMPV)和肺炎链球菌(SP)感染的重症肺炎患儿药学监护,在患儿病情复杂、医师忽略MP感染、超说明书用药和违反传统理论联合用药的情况下,查阅资料,结合病情深入剖析,及时提供安全有效的治疗方案分析和建议,监测疗效和不良反应,进行用药指导;较好地保障了患儿用药的安全性和有效性,提供了有效的药学服务,同时为此类患儿的药物治疗和监护提供参考。 展开更多
关键词 肺炎支原体 偏肺病毒 肺炎链球菌 重症肺炎 患儿 药学监护
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双歧杆菌四联活菌片联合阿奇霉素治疗小儿重症肺炎的效果及对肺部超声评分、肠道菌群的影响 被引量:1
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作者 杨帆 《河南医学研究》 CAS 2024年第5期897-901,共5页
目的探讨双歧杆菌四联活菌片联合阿奇霉素治疗小儿重症肺炎的效果及对肺部超声评分、肠道菌群的影响。方法选取2021年2月至2023年2月信阳市中心医院收治的98例重症肺炎患儿作为研究对象,按随机数字表法分为观察组、对照组,各49例。对照... 目的探讨双歧杆菌四联活菌片联合阿奇霉素治疗小儿重症肺炎的效果及对肺部超声评分、肠道菌群的影响。方法选取2021年2月至2023年2月信阳市中心医院收治的98例重症肺炎患儿作为研究对象,按随机数字表法分为观察组、对照组,各49例。对照组接受阿奇霉素治疗,观察组接受双歧杆菌四联活菌片联合阿奇霉素治疗。比较两组临床疗效、临床症状恢复情况、肺部超声评分、炎症反应指标[白细胞介素-17(IL-17)、可溶性髓系细胞触发受体-1(sTREM-1)、超敏C反应蛋白(hs-CRP)]、肠道菌群指标[肠杆菌、双歧杆菌、拟杆菌]。结果观察组总有效率(95.92%)高于对照组(71.43%)(P<0.05);治疗8 d后观察组心率恢复、肺部啰音消失、呼吸困难缓解、体温恢复、肺部阴影消失、咳嗽缓解时间均短于对照组(P<0.05);治疗1、3、8 d后观察组肺部超声评分低于对照组(P<0.05);治疗8 d后观察组IL-17、sTREM-1、hs-CRP水平均低于对照组(P<0.05);治疗8 d后观察组肠杆菌菌落数少于对照组,双歧杆菌、拟杆菌菌落数多于对照组(P<0.05)。结论双歧杆菌四联活菌片、阿奇霉素联合应用于小儿重症肺炎的治疗中效果显著,能有效改善机体炎症状态,维持肠道菌群平衡,降低肺部超声评分,利于促进预后恢复。 展开更多
关键词 双歧杆菌四联活菌片 阿奇霉素 重症肺炎 儿童 肠道菌群
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盐酸氨溴索联合乙酰半胱氨酸在儿童重症肺炎治疗中的应用效果分析
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作者 王梦楠 刘莹 黄冬冬 《中国处方药》 2024年第11期120-123,共4页
目的 分析盐酸氨溴索联合乙酰半胱氨酸在儿童重症肺炎治疗中的应用效果。方法 选取2023年1月~12月收治的75例重症肺炎患儿,按照随机数字法分为对照组(n=37)和观察组(n=38),所有患儿均进行退热、止咳、抗炎、维持水电解质平衡等常规基础... 目的 分析盐酸氨溴索联合乙酰半胱氨酸在儿童重症肺炎治疗中的应用效果。方法 选取2023年1月~12月收治的75例重症肺炎患儿,按照随机数字法分为对照组(n=37)和观察组(n=38),所有患儿均进行退热、止咳、抗炎、维持水电解质平衡等常规基础治疗。对照组进行盐酸氨溴索治疗,观察组进行盐酸氨溴索联合乙酰半胱氨酸治疗。对两组临床疗效、肺功能、免疫功能、症状消失时间、炎症因子和不良反应进行评估。结果 治疗后,观察组的总有效率为94.74%,对照组的总有效率为75.68%,观察组高于对照组(P<0.05)。治疗后,观察组的第1秒用力呼气容积占用力肺活量的比值(FEV_(1)/FVC)、第1秒用力呼气容积占预计值百分比(FEV_(1)%)、最大呼气流速(PEF)指标均高于对照组(P <0.05)。治疗后,观察组的免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)及补体C3指标均高于对照组(P <0.05)。治疗后,观察组的高热、气促、肺部湿啰音、咳嗽咯痰、肺部X线阴影等症状消失时间均低于对照组(P <0.05)。治疗后,观察组的超敏-C反应蛋白(hs-CRP)、γ-干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)水平均低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P> 0.05)。结论 儿童重症肺炎采用盐酸氨溴索联合乙酰半胱氨酸治疗效果显著,可以加快患儿的症状消失时间,提高患儿的肺功能和免疫功能,降低患儿的炎症因子水平,且具有良好的安全性。 展开更多
关键词 重症肺炎 儿童 盐酸氨溴索 乙酰半胱氨酸 肺功能
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重症肺炎患儿气管插管拔管后吞咽功能障碍康复训练的效果研究
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作者 莫海丽 廖婵 +1 位作者 梁新婷 蒙美琴 《中国中西医结合儿科学》 2024年第4期320-323,共4页
目的探讨吞咽功能训练联合安慰奶嘴吸吮在重症肺炎气管插管拔管后获得性吞咽障碍患儿中的临床应用效果,为促进深入开展重症肺炎患儿气管插管拔管后吞咽障碍的康复训练提供指导及参考依据。方法回顾性分析2019年7月至2023年9月收治于我... 目的探讨吞咽功能训练联合安慰奶嘴吸吮在重症肺炎气管插管拔管后获得性吞咽障碍患儿中的临床应用效果,为促进深入开展重症肺炎患儿气管插管拔管后吞咽障碍的康复训练提供指导及参考依据。方法回顾性分析2019年7月至2023年9月收治于我院重症医学科的重症肺炎气管插管(插管时间≥5 d),且发生拔管后吞咽功能障碍的患儿120例作为研究对象,以2021年7月开展吞咽功能训练联合安慰奶嘴研究为界,将未开展该研究前的病例设为对照组,开展并实施该研究的病例设为观察组,每组60例。其中对照组拔管后实施常规护理,观察组实施吞咽功能训练联合安慰奶嘴吸吮。干预后通过评估患儿吞咽功能恢复的效果、误吸率、吸入性肺炎发生率、再插管率、ICU重返率等指标。结果观察组在拔管后4 h、24 h、48 h、72 h及出院时标准吞咽功能评定量表(SSA)评分均明显低于对照组,差异有统计学意义(P<0.01)。观察组患儿吞咽功能改善总有效率为100.0%(60/60),高于对照组86.7%(52/60),差异有统计学意义(P<0.01)。观察组并发症总发生率为16.7%(10/60),低于对照组73.3%(44/60),其中误吸率、吸入性肺炎发生率、再插管率和ICU重返率均低于对照组,差异有统计学意义(P<0.05)。结论吞咽功能训练联合安慰奶嘴吸吮能有效改善重症肺炎气管插管拔管后吞咽障碍患儿的吞咽功能,减少相关并发症的发生。 展开更多
关键词 重症肺炎 气管插管 吞咽障碍 吞咽功能 康复训练 儿童
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小儿重症肺炎的临床特征及预后影响因素 被引量:1
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作者 何婷婷 阎靓 张园园 《四川解剖学杂志》 2024年第1期57-59,72,共4页
目的:探讨小儿重症肺炎的临床特征及影响预后因素.方法:选取2018年1月至2022年12月本院收治的120例小儿重症肺炎患儿作为研究对象.采用回顾性分析临床方法,收集、整理其临床病例资料,根据预后结果将其分为预后良好组(n=102)和预后不良组... 目的:探讨小儿重症肺炎的临床特征及影响预后因素.方法:选取2018年1月至2022年12月本院收治的120例小儿重症肺炎患儿作为研究对象.采用回顾性分析临床方法,收集、整理其临床病例资料,根据预后结果将其分为预后良好组(n=102)和预后不良组(n=18).统计学分析两组临床资料;采取多元Logistic回归分析法对小儿重症肺炎预后影响因素进行分析.结果:120例患儿重症肺炎发病时间以冬季为主,年龄以≤2岁婴幼儿为主.年龄、发病至就诊时间、存在呼吸道反复感染、降钙素原(PCT)水平,均是患儿预后不良的独立危险因素.结论:小儿重症肺炎多发于冬季,尤其是≤2岁婴幼儿,其预后不良的独立危险因素包括年龄、发病至就诊时间、存在呼吸道反复感染、PCT水平. 展开更多
关键词 重症肺炎 临床特征 影响因素 儿童 预后
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儿童新型冠状病毒感染相关严重神经系统病变的研究进展
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作者 王璨 谈林华 《医药前沿》 2024年第3期44-47,共4页
自2019年新型冠状病毒感染在世界范围内流行,儿童新型冠状病毒感染重症突显,神经系统受累患儿数量持续增加。儿童新型冠状病毒感染相关严重神经系统病变,尤其急性坏死性脑病具有进展快、病死率高、预后差等特点。本文对儿童新冠感染合... 自2019年新型冠状病毒感染在世界范围内流行,儿童新型冠状病毒感染重症突显,神经系统受累患儿数量持续增加。儿童新型冠状病毒感染相关严重神经系统病变,尤其急性坏死性脑病具有进展快、病死率高、预后差等特点。本文对儿童新冠感染合并严重神经系统并发症的危险因素、发病机制、临床症状以及治疗方法等进行综述,以为临床的诊治提供参考,并建议儿科医生应加强对新型冠状病毒感染相关严重神经系统并发症的早期识别。 展开更多
关键词 儿童 新型冠状病毒 神经系统重症
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某妇幼保健院352例新的/严重的药品不良反应报告分析
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作者 丁燕 崔爱瑛 《海峡药学》 2024年第9期109-112,共4页
目的对妇幼保健院2019年至2023年所发生的352例新的/严重的药品不良反应(ADR)进行分析,以弥补说明书的滞后,为患者安全用药提供参考。方法通过国家药品不良反应监测系统回顾性调取某妇幼保健院2019年1月1日至2023年09月30日的352例新的... 目的对妇幼保健院2019年至2023年所发生的352例新的/严重的药品不良反应(ADR)进行分析,以弥补说明书的滞后,为患者安全用药提供参考。方法通过国家药品不良反应监测系统回顾性调取某妇幼保健院2019年1月1日至2023年09月30日的352例新的/严重的不良反应报告,使用Excel软件分析其详细情况并总结。结果上报成功的新的/严重的ADR报告共352例,患者年龄为(31.80±15.95)岁,女性为主(310例,88.07%),给药途径以口服为主(138例,39.20%),累及器官-系统以消化系统为主(27.02%);多数表现为恶心、呕吐、嗳气、腹泻、胀气和腹痛等,其次为皮肤及皮下组织类,表现为皮疹、瘙痒和皮肤潮红等。结论临床医师和药师用药期间应密切关注新的/严重的ADR,做好应对措施,保障用药安全。 展开更多
关键词 新的药品不良反应 严重的药品不良反应 用药安全 妇幼保健院
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可弯曲支气管镜术对小儿重症支原体肺炎的治疗作用
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作者 巴荷霞 李静 +2 位作者 余永生 江国荣 王俊超 《中南医学科学杂志》 CAS 2024年第4期635-637,共3页
目的分析可弯曲支气管镜术对小儿重症支原体肺炎的治疗作用。方法选择重症支原体肺炎患儿100例,按照治疗方式均分为观察组(行可弯曲支气管镜术)和对照组(常规治疗)。比较两组患儿的临床疗效、动脉血气指标和炎症因子水平。结果观察组总... 目的分析可弯曲支气管镜术对小儿重症支原体肺炎的治疗作用。方法选择重症支原体肺炎患儿100例,按照治疗方式均分为观察组(行可弯曲支气管镜术)和对照组(常规治疗)。比较两组患儿的临床疗效、动脉血气指标和炎症因子水平。结果观察组总有效率高于对照组(P<0.05)。观察组湿啰音消失时间、发热减退时间、住院时间均较对照组短(P<0.05)。与术前比较,术后2周两组血氧饱和度、血氧分压、二氧化碳分压均显著改善;且观察组改善较对照组更为显著(P<0.05)。与术前比较,术后2周两组白细胞介素-6、C反应蛋白、降钙素原水平显著降低;且观察组低于对照组(P<0.05)。两组术后并发症发生率差异无显著性(P>0.05)。结论可弯曲支气管镜术可显著改善重症支原体肺炎患儿的动脉血气指标和炎症因子水平,有较好的临床疗效。 展开更多
关键词 可弯曲支气管镜术 小儿重症肺炎 支原体肺炎
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白细胞衍生性指标在儿童肺炎严重程度及预后评估中的应用观察
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作者 朱小健 万浩 余倩 《实用医技杂志》 2024年第5期360-365,共6页
目的 分析白细胞衍生性指标在儿童肺炎严重程度及预后评估中的应用价值。方法 选取2022年1月至2023年1月本院收治的60例肺炎患儿,根据肺炎严重指数(PSI)评分将其分为低危组(25例)、中危组(21例)和高危组(14例)。采集患儿静脉血,检测3组... 目的 分析白细胞衍生性指标在儿童肺炎严重程度及预后评估中的应用价值。方法 选取2022年1月至2023年1月本院收治的60例肺炎患儿,根据肺炎严重指数(PSI)评分将其分为低危组(25例)、中危组(21例)和高危组(14例)。采集患儿静脉血,检测3组患儿外周血乳酸脱氢酶(LDH)、降钙素原(PCT)、白细胞介素-6(IL-6)水平、C-反应蛋白(CRP)及血常规,计算中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、淋巴细胞与单核细胞比值(LMR)。采用Pearson相关系数分析上述指标与临床肺部感染评分(CPIS)之间的相关性。于出院时评估患儿预后效果,并根据评估结果将患儿分为预后良好组(47例)和预后不良组(13例),比较2组上述指标差异;采用多因素回归分析上述指标与儿童肺炎严重程度相关性;并应用受试者工作特征(ROC)曲线分析LDH、IL-6、CRP、NLR、PLR在儿童肺炎预后评估中的价值。结果 中、高危组LDH、PCT、IL-6、CRP、NLR、PLR、MLR及CPIS评分均高于低危组(P<0.05),高危组LDH、PCT、IL-6、CRP、NLR、PLR、MLR及CPIS评分均高于中危组(P<0.05);肺炎患儿血清LDH、PCT、IL-6、CRP、NLR、PLR、MLR水平与CPIS评分均呈正相关(r=0.625、0.429、0.358、0.413、0.676、0.465、0.645,P<0.05);预后良好组LDH、PCT、IL-6、CRP、NLR、PLR、MLR水平均低于预后不良组(P<0.01);多因素回归分析显示,LDH、IL-6、CRP、NLR以及PLR水平升高是影响儿童肺炎预后的独立危险因素(P<0.05);LDH、IL-6、CRP、NLR、PLR及联合检测在预测肺炎患儿预后方面效能较高,其中LDH预测效能最高。结论 LDH、PCT、IL-6、CRP、NLR、PLR、MLR水平与肺炎患儿病情严重程度呈正相关,LDH、IL-6、CRP、NLR、PLR水平升高是影响肺炎患儿预后的独立危险因素,应早期监测上述指标,以改善患儿预后。 展开更多
关键词 肺炎 儿童 白细胞衍生性指标 肺炎严重指数 严重程度 预后
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