Background and objective Epidemiological studies have suggested that menstrual and reproductive factors may in uence lung cancer risk,but the results are controversial.We therefore carried out a meta-analysis aiming t...Background and objective Epidemiological studies have suggested that menstrual and reproductive factors may in uence lung cancer risk,but the results are controversial.We therefore carried out a meta-analysis aiming to examine the associations of lung cancer in women with menstrual and reproductive factors.Methods Relevant studies were searched from PubMed database,CNKI,WANFANG DATA and VIP INFORMATION up to January 2012,with no language restrictions.References listed from selected papers were also reviewed.We included studies that reported the estimates of relative risks(RRs) with 95% con dence intervals(CIs) for the association between menstrual and reproductive factors and lung cancer risk.e pooled RRs were calculated a er the heterogeneity test with the so ware Stata 11,and publication bias and sensitivity were evaluated at the same time.Results Twenty-ve articles,representing 24 independent studies,were included in this meta-analysis.Older age at menarche in North America women(RR=0.83;95%CI:0.73-0.94) was associated with a signi cant decreased risk of lung cancer.Longer length of menstrual cycle was also associated with decreased lung cancer risk(RR=0.72;95%CI:0.57-0.90).Other exposures were not signi cantly associated.Conclusions Our analysis provides evidence of the hypothesis that female sex hormones in uence the risk of lung cancer in women,yet additional studies are warranted to extend this nding and to clarify the underlying mechanisms.展开更多
基金supported by grants No.81102194 from National Natural Science Foundation of ChinaNo.LS2010168 from Liaoning Provincial Department of Educationgrant No.00726 from China Medical Board
文摘Background and objective Epidemiological studies have suggested that menstrual and reproductive factors may in uence lung cancer risk,but the results are controversial.We therefore carried out a meta-analysis aiming to examine the associations of lung cancer in women with menstrual and reproductive factors.Methods Relevant studies were searched from PubMed database,CNKI,WANFANG DATA and VIP INFORMATION up to January 2012,with no language restrictions.References listed from selected papers were also reviewed.We included studies that reported the estimates of relative risks(RRs) with 95% con dence intervals(CIs) for the association between menstrual and reproductive factors and lung cancer risk.e pooled RRs were calculated a er the heterogeneity test with the so ware Stata 11,and publication bias and sensitivity were evaluated at the same time.Results Twenty-ve articles,representing 24 independent studies,were included in this meta-analysis.Older age at menarche in North America women(RR=0.83;95%CI:0.73-0.94) was associated with a signi cant decreased risk of lung cancer.Longer length of menstrual cycle was also associated with decreased lung cancer risk(RR=0.72;95%CI:0.57-0.90).Other exposures were not signi cantly associated.Conclusions Our analysis provides evidence of the hypothesis that female sex hormones in uence the risk of lung cancer in women,yet additional studies are warranted to extend this nding and to clarify the underlying mechanisms.
