Study on the effect of moxibustion at “Shénquè”(神阙 CV 8) on the immune system of rats taking long-term exhaustive exercise

Objective To explore the effect of moxibustion at ＂Shénquè＂（神阙 CV 8） on the immune system of rats taking long-term exhaustive exercise.Method Thirty male SD rats were randomly divided into blank group,model group and moxibustion group with 10 rats in each group.Except the rats in blank group,all the rats were established into long-term exhaustive models through swimming again and again.Mild moxibustion at CV 8 for 15 min was carried out in the rats in moxibustion group after modeling.The treatment was conducted once every other day,and treatment for 10 times was needed.The exhaustive duration for each time was recorded,the levels of serum Ig A,Ig G,Ig M and ACP were detected 24 h after the 10 th exhaustive exercise,and the histomorphological changes of spleen were observed.Immunoturbidimetry was adopted for detecting the Ig A level,and ELISA method was used for detecting the levels of Ig G,Ig M and ACP.Results The common exhaustive duration in moxibustion group was longer than that in model group,however,the time difference was statistically significant after the 5th exhaustive exercise（P0.01）.The levels of serum IgG and IgM in model group were lower than that in blank group（all P0.01）,and the serum ACP level in model group was higher than that in blank group（P0.01）,indicating that the splenic histomorphology was damaged.The levels of serum Ig G and Ig M in moxibustion group were higher than that in model group（all P0.01）,and the serum ACP level in moxibustion group was lower than that in model group,showing that the splenic histomorphology was repaired.Conclusion Moxibustion at CV 8 can improve the levels of immunoglobulin（Ig G,Ig A,Ig M） of tired body for a long time,decrease the ACP level,and repair the damaged spleen tissues.

大黄外敷神阙穴联合胃肠起搏在老年功能性便秘患者中的应用

目的探讨大黄外敷神阙穴联合胃肠起搏在老年功能性便秘(FC)患者中的应用效果。方法选取江苏省南通市中医院2018年9月—2020年3月收治60例老年FC患者为研究对象,采用随机数字表法将其分为对照组和试验组,每组各30例。对照组给予生活指导和胃肠起搏治疗,试验组在对照组的基础上加用大黄外敷神阙穴治疗。治疗4个疗程(连续治疗10 d为1个疗程)后评价两组疗效,分别于治疗前、治疗4个疗程后,比较两组患者肛管运动功能[肛管最大收缩压(MSP)、收缩持续时间(DSS)及肛管静息压(RP)水平]改善情况。结果治疗后,试验组疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组MSP及RP均较治疗前降低,且试验组均低于对照组;两组DSS均较治疗前缩短,且试验组短于对照组,差异有统计学意义(P<0.05)。结论大黄外敷神阙穴联合胃肠起搏治疗老年FC患者可有效提高肛管运动功能,临床疗效确切。

Difference in the anti-fatigue effect of moxibustion at different acupoints in one-off exhausted rats

Objective:To explore the difference in the anti-fatigue effect of moxibustion at different acupoints through observing the impacts of moxibustion at"Shènshù(肾俞BL23)","Zúsānlǐ(足三里ST36)","Guānyuán(关元CV4)"and"Shénquè(神阙CV8)"on energy metabolic indexes in the one-off exhausted rats.Methods:A total of 56 SPF male rats were randomized into 7 groups,named a blank group,a model group,a non-acupoint group,a"BL23"group,a"ST36"group,a"CV4"group and a"CV8"group,8 rats in each group.The one-off exhaustion model was established by weight-bearing swimming experiment.Right after the exhaustive swimming of rats in each intervention group,the mild moxibustion was applied at the corresponding acupoints for 15 min immediately.4 h after the exhaustive swimming,the blood was collected from the femoral artery and the quadriceps femoris of the left hindlimb was stripped.The levels of blood lactate(BLD),lactate dehydrogenase(LDH),creatine kinase(CK)and blood urea nitrogen(BUN),the expressions of adenosine triphosphatease(ATP),fructose-6-phosphofructokinase(PFK)and malomdialdehyde(MDA)in the quadriceps femoris and the activity of superoxide dismutase(SOD)and catalase(CAT)were detected.Results:Compared with the model group and the non-acupoint group,the levels of serum BLD,LDH,CK and BUN were all lower those in the"BL23"group,the"ST36"group,the"CV4"group and the"CV8"group,indicating a statistical significance(all P<0.05).Compared with the model group and the nonacupoint group,PFK was higher in the"BL23"group,indicating a statistical significance(both P<0.05).Compared with the model group and the non-acupoint group,PFK was higher in the"ST36"group and the"CV4"group,indicating a statistical significance(all P<0.05).Conclusion:It was found in the research that moxibustion at"BL23""ST36""CV4"and"CV8"regulated the energy metabolism in the one-off exhausted rats so as to bring the anti-fatigue effect into play and the effect was different among the acupoints.Moxibustion at"CV8"may work on the prevention of the protein decomposition in the skeletal muscle and moxibustion at"BL23"may be against the oxidation in the skeletal muscle.

Jiāwèi Wǔbèizǐsǎn(Supplemented Galla Chinensis Powder) application on the navel for different syndromes of profuse sweating after tumor chemotherapy

Objective To observe the clinical efficacy of Jiāwèi Wǔbèizǐ sǎn（加味五倍子散,Supplemented Galla Chinensis Powder） application on the different syndromes of profuse sweating after tumor chemotherapy.Methods One hundred and sixty patients with profuse sweating after tumor chemotherapy were randomly divided into a control group（n=80） and a treatment group（n=80）.Placebo application was carried out in the control group,and traditional Chinese medicine application was conducted in the treatment group.Treatment for 7 days was considered as 1 course of treatment.Results In treatment group,48 patients were cured,improvement was found in25 cases,and ineffectiveness was seen in 7 cases.For the patients with lungwei insecurity syndrome,19 cases were cured,improvement was found in10 cases,and ineffectiveness was seen in 1 case;for the patients with deficiency of both qi and yin,27 cases were cured,improvement was found in 9 cases,and ineffectiveness was seen in 2 cases;for the patients with vigorous fire due to yin deficiency,3 cases were cured,improvement was found in5 cases,and ineffectiveness was seen in 4 cases.According to statistical analysis,the total efficacy of treatment group was superior to that of control group（P0.05）.The efficacy on lung-wei insecurity and deficiency of both qi and yin of treatment group was superior to that of control group（both P0.05）,but there was no obvious difference between treatment group and control group in the efficacy on vigorous fire due to yin deficiency（P0.05）.Conclusion Supplemented Galla Chinensis Powder application on the navel can effectively improve the profuse sweating syndrome of patients in the types of lung-wei insecurity and deficiency of both qi and yin after tumor chemotherapy,but the efficacy is not so good for the patients in the type of vigorous fire due to yin deficiency.