Objective:This study mainly explores the clinical effect of Shashen Maidong Decoction in the treatment of advanced lung cancer.Methods:Twelve patients with advanced lung cancer from Inner Mongolia Baicaotang Qin's...Objective:This study mainly explores the clinical effect of Shashen Maidong Decoction in the treatment of advanced lung cancer.Methods:Twelve patients with advanced lung cancer from Inner Mongolia Baicaotang Qin's Zhong Meng Medical Hospital were randomly selected from February 2016 to February 2021.They were divided into two groups:the reference group and study group by the digital table method.The reference group was treated with conventional chemotherapy while the study group was treated with Shashen Maidong Decoction plus conventional chemotherapy.Results:The remission rate of the study group was higher than that of the reference group,and the incidence of adverse reactions was lower than that of the reference group,P<0.05.The levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the study group were higher than those in the reference group(P<0.05).After treatment,the quality of life score of the study group was higher than that of the reference group(P<0.05).Conclusion:Shashen Maidong Decoction can effectively reduce adverse reactions and improve the condition of patients in the treatment of advanced lung cancer.展开更多
目的:系统评价沙参麦冬汤加减方联合阿奇霉素治疗小儿支原体肺炎的临床疗效及安全性。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Embase、Web of Science等中英文数据库中沙参麦冬汤加减方联...目的:系统评价沙参麦冬汤加减方联合阿奇霉素治疗小儿支原体肺炎的临床疗效及安全性。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Embase、Web of Science等中英文数据库中沙参麦冬汤加减方联合阿奇霉素治疗小儿支原体肺炎的临床随机对照试验(观察组患者采用沙参麦冬汤加减方联合阿奇霉素治疗,对照组患者采用阿奇霉素治疗),时间为建库至2023年10月,筛选文献、提取数据后,对纳入的研究进行Meta分析。结果:共纳入13项研究,总病例数为1144例。Meta分析结果显示,相比对照组,沙参麦冬汤加减方联合阿奇霉素能够有效提高小儿支原体肺炎患者的临床总有效率(OR=5.65,95%CI=3.56~8.97,P<0.00001),缩短退热时间(MD=-2.88,95%CI=-5.11~-0.64,P=0.01)、咳嗽消失时间(MD=-2.78,95%CI=-4.63~-0.94,P=0.003)和肺部啰音消失时间(MD=-2.91,95%CI=-4.27~-1.54,P<0.0001),降低复发率(OR=0.21,95%CI=0.07~0.63,P=0.005),同时可降低不良反应发生率(OR=0.21,95%CI=0.12~0.37,P<0.00001),差异均有统计学意义。结论:中药沙参麦冬汤加减方联合阿奇霉素治疗小儿支原体肺炎具有一定的优势,可提高临床疗效,降低不良反应发生率,但仍需高质量、大样本、多中心的随机对照试验加以证实。展开更多
Objective: To evaluate the effect of Shashen Maidong Decoction (SSMDD) on gastric motility.Method: Effect of SSMDD on the gastric motility of mice and rats was observed in vivo by administration of SSMDD in various do...Objective: To evaluate the effect of Shashen Maidong Decoction (SSMDD) on gastric motility.Method: Effect of SSMDD on the gastric motility of mice and rats was observed in vivo by administration of SSMDD in various dosages and observation on gastric phenol red excretion rate, gastric emptying rate, frequency and amplitude of contraction of fundic longitudinal muscles, etc. Results: SSMDD could reduce markedly the gastric phenol red excretion rate of mice, antagonize the acceleration of gastric emptying induced by neostigmine, inhibit the frequency and amplitude of contraction of fundic longitudinal muscle, slow down the frequency and decrease the amplitude of gastric peristalsis, and reduce the gastric hypermotility induced by indomethacin significantly. Conclusion: SSMDD has evident inhibition action on motility of experimental animals in vivo, its mechanism might be related with adrenergic nerve and metabolism of prostaglandin E.展开更多
目的系统评估沙参麦冬汤联合化疗治疗非小细胞肺癌的临床疗效和安全性。方法检索时间设定为建库开始至2023年2月,计算机检索PubMed、Cochrane Library、Web of Science、Embase、中国知网、万方、维普和中国生物医学文献等数据库中关于...目的系统评估沙参麦冬汤联合化疗治疗非小细胞肺癌的临床疗效和安全性。方法检索时间设定为建库开始至2023年2月,计算机检索PubMed、Cochrane Library、Web of Science、Embase、中国知网、万方、维普和中国生物医学文献等数据库中关于沙参麦冬汤联合化疗治疗非小细胞肺癌的临床随机对照研究,并根据指定的纳入和排除条件进行文献筛选。在严格遵守Cochrane系统评价原则的条件下,由2名作者对文献质量进行合理分析评估以及再筛选,后使用Review manager 5.4软件对各研究中的疾病控制率(disease control rate,DCR)、卡氏评分(Karnofsky Performance Status,KPS)、免疫功能(CD4+/CD8+)和不良反应等评价指标进行Meta分析。结果共纳入14项研究,样本量为1116例。Meta分析结果提示,与对照组相比,观察组在提高DCR[RR=1.31,95%CI(1.21,1.43),P<0.00001]、提升KPS评分[MD=9.84,95%CI(8.34,11.34),P<0.00001]、改善免疫功能[MD=0.47,95%CI(0.41,0.54),P<0.00001]及减少不良反应[RR=0.28,95%CI(0.19,0.41),P<0.00001]上存在着优势。结论沙参麦冬汤能有效辅助化疗治疗非小细胞肺癌,可明显改善患者生存质量。展开更多
文摘Objective:This study mainly explores the clinical effect of Shashen Maidong Decoction in the treatment of advanced lung cancer.Methods:Twelve patients with advanced lung cancer from Inner Mongolia Baicaotang Qin's Zhong Meng Medical Hospital were randomly selected from February 2016 to February 2021.They were divided into two groups:the reference group and study group by the digital table method.The reference group was treated with conventional chemotherapy while the study group was treated with Shashen Maidong Decoction plus conventional chemotherapy.Results:The remission rate of the study group was higher than that of the reference group,and the incidence of adverse reactions was lower than that of the reference group,P<0.05.The levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)in the study group were higher than those in the reference group(P<0.05).After treatment,the quality of life score of the study group was higher than that of the reference group(P<0.05).Conclusion:Shashen Maidong Decoction can effectively reduce adverse reactions and improve the condition of patients in the treatment of advanced lung cancer.
文摘目的:系统评价沙参麦冬汤加减方联合阿奇霉素治疗小儿支原体肺炎的临床疗效及安全性。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Embase、Web of Science等中英文数据库中沙参麦冬汤加减方联合阿奇霉素治疗小儿支原体肺炎的临床随机对照试验(观察组患者采用沙参麦冬汤加减方联合阿奇霉素治疗,对照组患者采用阿奇霉素治疗),时间为建库至2023年10月,筛选文献、提取数据后,对纳入的研究进行Meta分析。结果:共纳入13项研究,总病例数为1144例。Meta分析结果显示,相比对照组,沙参麦冬汤加减方联合阿奇霉素能够有效提高小儿支原体肺炎患者的临床总有效率(OR=5.65,95%CI=3.56~8.97,P<0.00001),缩短退热时间(MD=-2.88,95%CI=-5.11~-0.64,P=0.01)、咳嗽消失时间(MD=-2.78,95%CI=-4.63~-0.94,P=0.003)和肺部啰音消失时间(MD=-2.91,95%CI=-4.27~-1.54,P<0.0001),降低复发率(OR=0.21,95%CI=0.07~0.63,P=0.005),同时可降低不良反应发生率(OR=0.21,95%CI=0.12~0.37,P<0.00001),差异均有统计学意义。结论:中药沙参麦冬汤加减方联合阿奇霉素治疗小儿支原体肺炎具有一定的优势,可提高临床疗效,降低不良反应发生率,但仍需高质量、大样本、多中心的随机对照试验加以证实。
文摘Objective: To evaluate the effect of Shashen Maidong Decoction (SSMDD) on gastric motility.Method: Effect of SSMDD on the gastric motility of mice and rats was observed in vivo by administration of SSMDD in various dosages and observation on gastric phenol red excretion rate, gastric emptying rate, frequency and amplitude of contraction of fundic longitudinal muscles, etc. Results: SSMDD could reduce markedly the gastric phenol red excretion rate of mice, antagonize the acceleration of gastric emptying induced by neostigmine, inhibit the frequency and amplitude of contraction of fundic longitudinal muscle, slow down the frequency and decrease the amplitude of gastric peristalsis, and reduce the gastric hypermotility induced by indomethacin significantly. Conclusion: SSMDD has evident inhibition action on motility of experimental animals in vivo, its mechanism might be related with adrenergic nerve and metabolism of prostaglandin E.
文摘目的系统评估沙参麦冬汤联合化疗治疗非小细胞肺癌的临床疗效和安全性。方法检索时间设定为建库开始至2023年2月,计算机检索PubMed、Cochrane Library、Web of Science、Embase、中国知网、万方、维普和中国生物医学文献等数据库中关于沙参麦冬汤联合化疗治疗非小细胞肺癌的临床随机对照研究,并根据指定的纳入和排除条件进行文献筛选。在严格遵守Cochrane系统评价原则的条件下,由2名作者对文献质量进行合理分析评估以及再筛选,后使用Review manager 5.4软件对各研究中的疾病控制率(disease control rate,DCR)、卡氏评分(Karnofsky Performance Status,KPS)、免疫功能(CD4+/CD8+)和不良反应等评价指标进行Meta分析。结果共纳入14项研究,样本量为1116例。Meta分析结果提示,与对照组相比,观察组在提高DCR[RR=1.31,95%CI(1.21,1.43),P<0.00001]、提升KPS评分[MD=9.84,95%CI(8.34,11.34),P<0.00001]、改善免疫功能[MD=0.47,95%CI(0.41,0.54),P<0.00001]及减少不良反应[RR=0.28,95%CI(0.19,0.41),P<0.00001]上存在着优势。结论沙参麦冬汤能有效辅助化疗治疗非小细胞肺癌,可明显改善患者生存质量。
