Effects of Shang Ke Jie Gu tablet on fracture healing in rabbits

Objective:To study the effects of Shang Ke Jie Gu tablet on fracture healing in rabbits.Methods:40 New Zealand rabbits,half male and half female,were randomly divided into two groups:normal saline group(N group)and Shang Ke Jie Gu tablet group(S group).Each group consisted of 20 rabbits.Left radial fracture models in upper and middle sections were made in rabbits and then intra-gastric administration was given.Five rabbits in each group were killed on the 10 th,20^(th),30^(th) and 40^(th) day after surgery,left radius was taken to get an X-ray.The degree of healing was assessed by the evaluation criteria of Shanghai Orthopaedics Institute.Results:The degree of fracture healing in S group was higher in the comparison with that in N group.Conclusions:Shang Ke Jie Gu tablet might affect endochondral ossification during fracture healing of rabbits,and promote porosis and fracture healing.

骨肽片和伤科接骨胶囊治疗桡骨远端骨折的疗效评价

目的:通过使用骨肽片治疗桡骨远端骨折,评价其在促进骨折早期愈合中的作用。方法:选择上肢新鲜闭合性骨折病人,将病人随机分为治疗组和对照组,其中治疗组又分为骨肽片组和伤科接骨胶囊组。三组均采用保守治疗方法,治疗组60例,30例在石膏固定的同时给予口服骨肽片,30例在石膏固定的同时服用伤科接骨胶囊;对照组30例,仅给予石膏固定。结果:治疗组骨肽片组中26例病人骨折愈合时间比同类骨折临床愈合时间提前1/4以上,总有效率86%;伤科接骨胶囊组中18例病人骨折愈合时间比同类骨折临床愈合标准时间提前1/4以上,总有效率60%。结论:骨肽片在促进Collies骨折早期愈合中效果明显。

伤科接骨片对家兔骨折愈合过程中血钙、磷和碱性磷酸酶的影响

目的:研究伤科接骨片对家兔骨折模型愈合过程中血钙、磷及碱性磷酸酶的影响。方法:将40只实验用家兔随机分为伤科接骨片组和空白组,用10%水合氯醛3ml/kg静脉麻醉,于左前肢桡骨中段造成3～5mm骨折缺损模型,术后按组分别给予伤科接骨片和蒸馏水灌胃,术后第2、3、4周分别检测血Ca、P和碱性磷酸酶。结果:伤科接骨片可调节血Ca、P和碱性磷酸酶水平,与空白组相比差异有统计学意义(P<0.05)。结论:伤科接骨片能够加速钙盐沉积,改善微循环,调节血Ca、P水平,调节血碱性磷酸酶水平,对骨折的愈合和修复有明显的促进作用。