Founded on September 13,1956,the Shanghai People’s Association for Friendship with Foreign Countries(SPAFFC)is one of the first local branches of the Chinese People’s Association for Friendship with Foreign Countrie...Founded on September 13,1956,the Shanghai People’s Association for Friendship with Foreign Countries(SPAFFC)is one of the first local branches of the Chinese People’s Association for Friendship with Foreign Countries.In its 60-year history,it has been committed to people-to-people exchanges with foreign countries and regions.It is proud to say that up展开更多
Ⅰ.Introduction1) The People’s Park Square isShanghai’s best known land-mark and is the traditionalcenter of its cultural andrecreational facilities as wellas an extension of Shanghai’sprime commercial area.Thearea...Ⅰ.Introduction1) The People’s Park Square isShanghai’s best known land-mark and is the traditionalcenter of its cultural andrecreational facilities as wellas an extension of Shanghai’sprime commercial area.Thearea contains of Shanghai’sprime commercial area.Thearea contains a number ofbuildings of significant archi-tectural and heritage merit.展开更多
Objective To investigate whether or not the intestinal fatty acid binding protein gene (FABP2) Ala54Thr variation is related to non insulin dependent diabetes mellitus (NIDDM), obesity, dyslipidemia and glucose sti...Objective To investigate whether or not the intestinal fatty acid binding protein gene (FABP2) Ala54Thr variation is related to non insulin dependent diabetes mellitus (NIDDM), obesity, dyslipidemia and glucose stimulated insulin secretion (GSIS) in Chinese.Methods The FABP2 Ala54Thr variation was detected by PCR/HhaI digestion in 231 Chinese subjects (116 with normal glucose tolerance (NGT), 54 with impaired glucose tolerance (IGT) and 61 with NIDDM). Plasma glucose, insulin and C peptide levels before and after 75 g glucose load as well as fasting lipid profile were determined.Results (1) The Ala54 and Thr54 allele frequencies in Chinese were 0.71 and 0.29 respectively; (2) The FABP2 Ala54Thr variation was neither associated with fasting and post challenged plasma glucose levels nor with NIDDM; (3) This variation was neither associated with fasting lipid profile nor with obesity; (4) The IGT subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had lower fasting, 2 hour and total C peptide levels and smaller AUC representing lesser C peptide secretion after glucose challenge than those with genotype Thr54( ) (Ala54 homozygotes) (P= 0.04 , 0.03, 0.01 and 0.01 respectively). The serum insulin levels changed in the same tendency.Conclusions The glucose stimulated insulin secretion (GSIS) reserve of islet beta cells is more limited in subjects with FABP2 Thr54(+) genotype than in those with FABP2 Thr54(-) genotype. It suggests that FABP2 codon 54 variation might contribute to the insufficient insulin secretion in the development of NIDDM in Chinese.展开更多
文摘Founded on September 13,1956,the Shanghai People’s Association for Friendship with Foreign Countries(SPAFFC)is one of the first local branches of the Chinese People’s Association for Friendship with Foreign Countries.In its 60-year history,it has been committed to people-to-people exchanges with foreign countries and regions.It is proud to say that up
文摘Ⅰ.Introduction1) The People’s Park Square isShanghai’s best known land-mark and is the traditionalcenter of its cultural andrecreational facilities as wellas an extension of Shanghai’sprime commercial area.Thearea contains of Shanghai’sprime commercial area.Thearea contains a number ofbuildings of significant archi-tectural and heritage merit.
文摘Objective To investigate whether or not the intestinal fatty acid binding protein gene (FABP2) Ala54Thr variation is related to non insulin dependent diabetes mellitus (NIDDM), obesity, dyslipidemia and glucose stimulated insulin secretion (GSIS) in Chinese.Methods The FABP2 Ala54Thr variation was detected by PCR/HhaI digestion in 231 Chinese subjects (116 with normal glucose tolerance (NGT), 54 with impaired glucose tolerance (IGT) and 61 with NIDDM). Plasma glucose, insulin and C peptide levels before and after 75 g glucose load as well as fasting lipid profile were determined.Results (1) The Ala54 and Thr54 allele frequencies in Chinese were 0.71 and 0.29 respectively; (2) The FABP2 Ala54Thr variation was neither associated with fasting and post challenged plasma glucose levels nor with NIDDM; (3) This variation was neither associated with fasting lipid profile nor with obesity; (4) The IGT subjects with genotype Thr54(+) (Thr54 homozygotes and heterozygotes) had lower fasting, 2 hour and total C peptide levels and smaller AUC representing lesser C peptide secretion after glucose challenge than those with genotype Thr54( ) (Ala54 homozygotes) (P= 0.04 , 0.03, 0.01 and 0.01 respectively). The serum insulin levels changed in the same tendency.Conclusions The glucose stimulated insulin secretion (GSIS) reserve of islet beta cells is more limited in subjects with FABP2 Thr54(+) genotype than in those with FABP2 Thr54(-) genotype. It suggests that FABP2 codon 54 variation might contribute to the insufficient insulin secretion in the development of NIDDM in Chinese.
