Many future directions of scientific endeavors depend on quantum theory and the precise interpretation and significance of the entanglement of quantum-particles. This interpretation depends in turn on the physical mea...Many future directions of scientific endeavors depend on quantum theory and the precise interpretation and significance of the entanglement of quantum-particles. This interpretation depends in turn on the physical meaning of so called Bell-tests that are mostly performed using entangled photons and randomly switched polarizers to measure their polarization at distant locations. This paper presents a detailed critique of the well known theory of Bell tests given by Clauser-Horne-Shimony-Holt (CHSH). It is demonstrated that several important steps of the CHSH derivations contain serious inaccuracies of the underlying physics and probability theory and even a calculus error. As a consequence, the Bell-CHSH theory cannot be used to demonstrate extreme and opposite interpretations of entanglement such as super-luminal influences or alternatively super-determinism that cast aspersions on Einstein’s concepts of locality and separability.展开更多
Scurs is a horn phenotype that exhibits as small corneous structures on the skull due to the deformed development of horn tissues. Previous genome-wide association analysis of scurs in Soay sheep showed a significant ...Scurs is a horn phenotype that exhibits as small corneous structures on the skull due to the deformed development of horn tissues. Previous genome-wide association analysis of scurs in Soay sheep showed a significant association to the polled locus, relaxin-like receptor 2(RXFP2). However, the molecular mechanism underlying the development of scurs remains largely unknown. In the present study, we performed an i TRAQ-based quantitative proteomic analysis of horn tissues from both scurs and normal two-horned and four-horned individuals among Altay sheep to identify the differentially expressed proteins(DEPs) responsible for the scurs phenotype. In total, 232 proteins showed significant differential expression, and the most significant Gene ontology categories were the adhesion processes(biological adhesion(P=4.07×10–17) and cell adhesion(P=3.7×10–16)), multicellular organismal process(single-multicellular organism process(P=2.06×10–11) and multicellular organismal process(P=2.29×10–11)) and extracellular processes(extracellular matrix organization(P=4.77×10–16) and extracellular structure organization(P=4.93×10–16)). Kyoto encyclopedia of genes and genomes(KEGG) analysis showed that extracellular matrix(ECM)-receptor interactions and focal adhesion pathways were the most significant pathways. This finding is consistent with the reduced formation of extracellular matrix in scurs and the development of deformed horn tissues. Our study helps to elucidate the inheritance pattern of sheep horn traits from the perspectives of downstream expressed proteins.展开更多
文摘Many future directions of scientific endeavors depend on quantum theory and the precise interpretation and significance of the entanglement of quantum-particles. This interpretation depends in turn on the physical meaning of so called Bell-tests that are mostly performed using entangled photons and randomly switched polarizers to measure their polarization at distant locations. This paper presents a detailed critique of the well known theory of Bell tests given by Clauser-Horne-Shimony-Holt (CHSH). It is demonstrated that several important steps of the CHSH derivations contain serious inaccuracies of the underlying physics and probability theory and even a calculus error. As a consequence, the Bell-CHSH theory cannot be used to demonstrate extreme and opposite interpretations of entanglement such as super-luminal influences or alternatively super-determinism that cast aspersions on Einstein’s concepts of locality and separability.
基金supported by the National Natural Science Foundations of China (31402033, U1603232)the Special Fund for Basic Scientific Research of Institute of Animal Sciences,the Chinese Academy of Agricultural Sciences (2017ywf-zd-11, Y2017JC03)the Agricultural Science and Technology Innovation Program of China (ASTIPIAS01)
文摘Scurs is a horn phenotype that exhibits as small corneous structures on the skull due to the deformed development of horn tissues. Previous genome-wide association analysis of scurs in Soay sheep showed a significant association to the polled locus, relaxin-like receptor 2(RXFP2). However, the molecular mechanism underlying the development of scurs remains largely unknown. In the present study, we performed an i TRAQ-based quantitative proteomic analysis of horn tissues from both scurs and normal two-horned and four-horned individuals among Altay sheep to identify the differentially expressed proteins(DEPs) responsible for the scurs phenotype. In total, 232 proteins showed significant differential expression, and the most significant Gene ontology categories were the adhesion processes(biological adhesion(P=4.07×10–17) and cell adhesion(P=3.7×10–16)), multicellular organismal process(single-multicellular organism process(P=2.06×10–11) and multicellular organismal process(P=2.29×10–11)) and extracellular processes(extracellular matrix organization(P=4.77×10–16) and extracellular structure organization(P=4.93×10–16)). Kyoto encyclopedia of genes and genomes(KEGG) analysis showed that extracellular matrix(ECM)-receptor interactions and focal adhesion pathways were the most significant pathways. This finding is consistent with the reduced formation of extracellular matrix in scurs and the development of deformed horn tissues. Our study helps to elucidate the inheritance pattern of sheep horn traits from the perspectives of downstream expressed proteins.
