目的:研究厚朴排气合剂联合腹腔镜下阑尾切除术治疗急性阑尾炎(AA)患者的效果。方法:选取2022年12月—2023年7月平和县医院收治的62例AA患者作为研究对象,按照随机抽签法将患者分为对照组与观察组,各31例。两组均接受腹腔镜下阑尾切除术...目的:研究厚朴排气合剂联合腹腔镜下阑尾切除术治疗急性阑尾炎(AA)患者的效果。方法:选取2022年12月—2023年7月平和县医院收治的62例AA患者作为研究对象,按照随机抽签法将患者分为对照组与观察组,各31例。两组均接受腹腔镜下阑尾切除术,对照组术后给予常规治疗,观察组在对照组基础上给予厚朴排气合剂,统计对比两组治疗效果、胃肠功能恢复时间及炎症指标。结果:观察组治疗总有效率为96.77%,高于对照组的80.65%,差异有统计学意义(P<0.05);观察组肠鸣音恢复、肛门排气、首次排便、首次进食时间早于对照组,差异有统计学意义(P<0.05);观察组治疗7 d C反应蛋白(CRP)、白细胞介素-6(IL-6)水平低于对照组,差异有统计学意义(P<0.05)。结论:厚朴排气合剂联合腹腔镜下阑尾切除术治疗AA患者效果更显著,能缩胃肠功能恢复时间,减轻炎症反应。展开更多
Objective: To evaluate the scientific basis for the use of Kang 601 heji(K-601) as an anti-in flammatory and antipyretic agent using appropriate animal models.Methods: Carrageenan-induced rat paw and xylene-induced ea...Objective: To evaluate the scientific basis for the use of Kang 601 heji(K-601) as an anti-in flammatory and antipyretic agent using appropriate animal models.Methods: Carrageenan-induced rat paw and xylene-induced ear oedemas were models used to investigate anti-in flammatory actions of K-601. Lipopolysaccharide-induced pyrexia model was used to evaluate antipyretic activity in Wistar rats. The antiin flammatory and antipyretic mechanisms were evaluated by detecting prostaglandins E2, nitric oxide, interleukin-1b and tumour necrosis factora levels using appropriate reagents and ELISA kits.Results: The results revealed that K-601 reduced the level of in flammations in both antiin flammatory models in a dose-dependent manner. The same was true for the antipyretic model. The possible mechanisms of actions were through the inhibition of prostaglandins E2, interleukin-1b, tumour necrosis factora and nitric oxide.Conclusions: K-601 has proven anti-in flammatory and antipyretic actions. The findings provide a scientific basis for the use of K-601 as anti-in flammatory and antipyretic agent in traditional Chinese medicinal practice.展开更多
文摘目的:研究厚朴排气合剂联合腹腔镜下阑尾切除术治疗急性阑尾炎(AA)患者的效果。方法:选取2022年12月—2023年7月平和县医院收治的62例AA患者作为研究对象,按照随机抽签法将患者分为对照组与观察组,各31例。两组均接受腹腔镜下阑尾切除术,对照组术后给予常规治疗,观察组在对照组基础上给予厚朴排气合剂,统计对比两组治疗效果、胃肠功能恢复时间及炎症指标。结果:观察组治疗总有效率为96.77%,高于对照组的80.65%,差异有统计学意义(P<0.05);观察组肠鸣音恢复、肛门排气、首次排便、首次进食时间早于对照组,差异有统计学意义(P<0.05);观察组治疗7 d C反应蛋白(CRP)、白细胞介素-6(IL-6)水平低于对照组,差异有统计学意义(P<0.05)。结论:厚朴排气合剂联合腹腔镜下阑尾切除术治疗AA患者效果更显著,能缩胃肠功能恢复时间,减轻炎症反应。
基金Supported in part by the National Natural Science Foundation of China(Nos.81222052 and 81421005)Jiangsu Province Science Fund for Distinguished Young Scholars(BK20130025)
文摘Objective: To evaluate the scientific basis for the use of Kang 601 heji(K-601) as an anti-in flammatory and antipyretic agent using appropriate animal models.Methods: Carrageenan-induced rat paw and xylene-induced ear oedemas were models used to investigate anti-in flammatory actions of K-601. Lipopolysaccharide-induced pyrexia model was used to evaluate antipyretic activity in Wistar rats. The antiin flammatory and antipyretic mechanisms were evaluated by detecting prostaglandins E2, nitric oxide, interleukin-1b and tumour necrosis factora levels using appropriate reagents and ELISA kits.Results: The results revealed that K-601 reduced the level of in flammations in both antiin flammatory models in a dose-dependent manner. The same was true for the antipyretic model. The possible mechanisms of actions were through the inhibition of prostaglandins E2, interleukin-1b, tumour necrosis factora and nitric oxide.Conclusions: K-601 has proven anti-in flammatory and antipyretic actions. The findings provide a scientific basis for the use of K-601 as anti-in flammatory and antipyretic agent in traditional Chinese medicinal practice.
