Effects of Shenmai Injection(参麦注射液)Combined with Meglumine Adenosine Cyclophosphate Injection on Cardiac Function and Peripheral Serum Levels of TNF-α,TGF-β1 and IFN-γ in Patients with Viral Myocarditis

Objective: To explore effects of Shenmai Injection(参麦注射液) combined with Meglumine Adenosine Cyclophosphate Injection on cardiac function and peripheral serum levels of tumor necrosis factor-α(TNF-α), transforming growth factor-β1(TGF-β1) and interferon-γ(IFN-γ) in patients with viral myocarditis.Methods: A total of 70 patients with viral myocarditis admitted in Cardiovascular Medicine Department of our hospital from June 2016 to June 2018 were selected and divided into a control group(treated with Meglumine Adenosine Cyclophosphate Injection) and an observation group(additionally treated with Shenmai Injection(参麦注射液) on the treatment basis of the control group) according to random number method, with 35 cases in each group.Before and after the treatment, cardiac functional indexes like cardiac index(CI), left ventricular ejection fraction(LVEF) and left ventricular shortening fraction(FS), serum levels of TNF-α, TGF-β1 and IFN-γ, clinical efficacy and adverse reactions occurred in the 2 groups were recorded and compared.Results: Therapeutic effective rate in the observation group was 88.57%, higher than 68.57% in the control group(P < 0.05).After the treatment, cardiac functional indexes like CI, LVEF and FS were higher than those in the control group(P < 0.05).After the treatment, the serum expression levels of TNF-α and TGF-β1 were lower than those in the control group(P < 0.05), while the serum expression level of IFN-γ was higher than that in the control group(P < 0.05).There was no statistically significant difference in the adverse reaction rates between the 2 groups(P > 0.05).Conclusion: The treatment of patients with viral myocarditis by Shenmai Injection(参麦注射液) combined with Meglumine Adenosine Cyclophosphate Injection is more effective, reducing inflammation and restoring cardiac function.

参麦注射液对大鼠离体胸主动脉血管环的作用及其机制

目的探讨参麦注射液对大鼠离体胸主动脉血管环的作用及其机制。方法采用离体血管灌流方法,观察参麦注射液对血管环的直接作用;对苯肾上腺素(PE)或氯化钾(KCl)所引发血管收缩作用的影响;对内钙释放和外钙内流所引发血管收缩作用的影响;对乙酰胆碱(ACh)所引发血管舒张作用的影响。结果参麦注射液对血管环无明显的直接作用;对PE和KCl引发的收缩均有明显的抑制(P<0.05或<0.01);对内钙释放和外钙内流所引发收缩作用均有明显的抑制(P<0.01);对ACh所引发的舒张作用有明显的抑制(P<0.05或<0.01)。结论参麦注射液既能抑制PE和KCl对血管环所引起的收缩作用,又能抑制ACh对血管环所引起的舒张作用,有双向调节血管张力的作用。

参麦注射液对离体大鼠胸主动脉血管环的实验研究

目的：探讨参麦注射液对离体大鼠胸主动脉血管环的作用及作用机制。方法：采用离体血管灌流方法,观察参麦注射液对血管环的直接作用、对肾上腺素和氯化钾所引发收缩作用的影响及对乙酰胆碱（Ach）所引发舒张作用的影响。结果：各浓度参麦注射液对完整内皮和无内皮血管环均有一定的收缩作用,且有一定的浓度依赖性;对KC1引发的收缩无明显的抑制,100200m l/L对NE引发的血管环收缩有抑制作用;对Ach所引发的舒张作用有明显的抑制作用。结论：参麦注射液既对离体血管环有直接收缩,抑制Ach所引发的舒张作用,又能抑制NE引发的无内皮血管环收缩作用。