Objective:To study the effects of Shensong Yangxin capsules and amiodarone on heart rate variability indexes and inflammatory factors in the treatment of patients with arrhythmia.Methods:The research subjects were sel...Objective:To study the effects of Shensong Yangxin capsules and amiodarone on heart rate variability indexes and inflammatory factors in the treatment of patients with arrhythmia.Methods:The research subjects were selected patients with arrhythmia admitted in our hospitaFs department from October 2018 to October 2019,and a total of 70 patients were divided into two groups.35 subjects in the control group were treated with amiodarone alone,and 35 subjects in the observation group were treated with Shensongyangxin capsule in combination with amiodarone for comparisons in treatment effects,heart rate variability indices,inflammatory factors,and adverse reactions.Results:After observation,the treatment efficiency in the observation group was higher than that in the control group(P<0.05).Before treatment,there was no difference in heart rate variability indices between the two groups(P>0.05),after treatment,the improvement in patients of the observation group was better than that of the control group(P<0.05).After treatment,the inflammatory factors of the two groups of patients decreased,and the indicators of the observation group were comparably lower than those of the control group(P<0.05).In the comparison of adverse reactions,the observation group showed a lower incidence of adverse reactions after treatment than the control group(P<0.05).Conclusion:In the treatment of patients with arrhythmia,the combined use of Shensong Yangxin capsules and amiodarone has more significant therapeutic effects,which can effectively improve the patient's heart rate variability indices,reduce the inflammatory factors,and relieve the symptoms in patients.The incidence of adverse reactions is low and the safety is quite high,therefore it has great value in clinical applications.展开更多
目的:系统评价参松养心胶囊治疗快速性心律失常的疗效及安全性。方法:计算机检索PubMed、Web of Science、the Cochrane library、Embase、CBM、中国知网、万方、维普数据库中参松养心胶囊治疗快速性心律失常的随机对照试验,时限为建库...目的:系统评价参松养心胶囊治疗快速性心律失常的疗效及安全性。方法:计算机检索PubMed、Web of Science、the Cochrane library、Embase、CBM、中国知网、万方、维普数据库中参松养心胶囊治疗快速性心律失常的随机对照试验,时限为建库至2022年9月。由2名研究员独立筛选文献、提取数据并根据Cochrane手册对纳入研究的偏倚风险进行评价。采用RevMan 5.3软件进行数据分析,并绘制漏斗图对纳入研究的发表偏倚进行评价。结果:共纳入42项随机对照试验,包含3867例受试患者,参松养心胶囊联合常规西药治疗患者1952例,单纯常规西药治疗患者1915例。Meta分析结果显示:与单纯常规西药治疗相比,联用参松养心胶囊可明显改善临床总有效率(RR=1.18,95%CI=[1.13,1.22],P<0.00001)、心率(MD=-8.29,95%CI=[-12.29,-4.29],P<0.0001)、左心室射血分数(MD=4.90,95%CI=[3.48,6.33],P<0.00001)、左心舒张末期内径(MD=-6.94,95%CI=[-8.50,-5.38],P<0.00001)、左心收缩末期内径(MD=-4.62,95%CI=[-4.93,-4.31],P<0.00001)、6分钟步行试验(MD=72.36,95%CI=[27.39,117.34],P=0.002)、不良反应发生率(RR=0.65,95%CI=[0.49,0.86],P=0.002)。结论:当前证据显示,参松养心胶囊联合常规西药治疗快速性心律失常在改善临床总有效率、心率、左心室射血分数、左心舒张末期内径、左心收缩末期内径、6分钟步行试验疗效显著,且不良反应发生率低。但受纳入研究质量及数量的限制,今后仍需要开展能体现中医病证结合、辨证论治诊疗特色的大样本、多中心、随机、双盲、安慰剂平行对照试验进一步验证结论。展开更多
Objective:To investigate the effect of Chinese compound Shensong Yangxin Capsule(参松养心胶囊,SSYX)on myocardial microcirculation in myocardial-infarcted rabbits.Methods:Myocardial infarction(MI)was established in rab...Objective:To investigate the effect of Chinese compound Shensong Yangxin Capsule(参松养心胶囊,SSYX)on myocardial microcirculation in myocardial-infarcted rabbits.Methods:Myocardial infarction(MI)was established in rabbits by ligation of the left circumflex coronary.Thirty rabbits were randomly divided into the control group,the MI group(model),and the MI treated with SSYX group(MI+SSYX)by a random number table method.After 4 weeks of administration,low-energy real-time myocardial contrast echocardiography(RT-MCE)was conducted to assess the microcirculatory perfusion.Immunofluorescence double staining was used to detect the capillary density.The endothelial ultrastructure was observed with a transmission electron microscope.The m RNA expression levels of vascular endothelial growth factor(VEGF),endothelin 1(ET-1),prostaglandin I2(PGI2)and endothelial nitric oxide synthase(e NOS)were measured by real-time quantitative polymerase chain reaction(Real-time PCR).The plasmic levels of ET-1,thromboxane A2(TXA2),nitric oxide(NO)and von willebrand factor(v WF)were examined with enzyme-linked immunosorbent assays(ELISA).Results:SSYX significantly improved the myocardial blood volume,myocardial micro bubble velocity,and myocardial inflow according to the examination of RT-MCE,and it visibly ameliorated the capillary endothelial structure.Furthermore,compared with the MI group,the plasma levels of TXA2,ET-1 and v WF contents significantly decreased in the MI+SSYX group,and the ET-1 mRNA expression levels of myocardium in the border zone significantly decreased,and the VEGF,PGI2 and e NOS m RNA expression levels significantly increased(all P<0.05).Conclusions:SSYX has favorable advantages in ameliorating the impaired myocardial microcirculation following MI.The mechanisms of the effect are related to the ability of SSYX in balancing the endothelial-derived vasodilators and vasoconstrictors,and up-regulating the expression of VEGF and e NOS.展开更多
目的:系统评价参松养心胶囊联合西药对阵发性房颤P波离散度的影响及安全性。方法:通过计算机检索Pubmed、Cochrane Library、Web of Science、中国知网、万方、维普数据库内自建库至2022年7月1日有关参松养心胶囊联合西药治疗阵发性房...目的:系统评价参松养心胶囊联合西药对阵发性房颤P波离散度的影响及安全性。方法:通过计算机检索Pubmed、Cochrane Library、Web of Science、中国知网、万方、维普数据库内自建库至2022年7月1日有关参松养心胶囊联合西药治疗阵发性房颤临床随机对照试验(randomized controlled trials,RCTs)。由2名研究员根据纳入及排除标准独立的对文献进行筛选,提取相关数据。采用RevMan5.4进行Meta分析。结果:共纳入11个临床随机对照试验,共1052例患者。Meta分析结果:实验组的P波离散度<对照组[MD=-7.12,95%CI(-9.21,-5.03),Z=6.69,P<0.00001];实验组的P波最大时限<对照组[MD=-7.88,95%CI(-10.12,-5.65),Z=6.91,P<0.00001];实验组的房颤发作次数<对照组[MD=-2.30,95%CI(-2.71,-1.85),Z=11.08,P<0.00001];实验组的左心房内径<对照组[MD=-2.59,95%CI(-3.83,-1.36),Z=4.11,P<0.00001];实验组的不良反应发生情况低于对照组。结论:参松养心胶囊联合西药可降低P波离散度,减少房颤复发,延缓左房内径扩大且具有良好的安全性。展开更多
Objective To develop a ultra performance liquid chromatography (UPLC) method for the quality evaluation of Shensong Yangxin Capsule (SYC). Methods The Waters Acquity UPLC HSS T3 column (100 mm × 2.1 mm, 1.8 μm...Objective To develop a ultra performance liquid chromatography (UPLC) method for the quality evaluation of Shensong Yangxin Capsule (SYC). Methods The Waters Acquity UPLC HSS T3 column (100 mm × 2.1 mm, 1.8 μm) was used. Acetonitrile and water containing 0.1% phosphoric acid were used as mobile phases of UPLC with gradient elution. The detection wavelength was set at 203 (ginsenoside Rb1), 286 (salvianolic acid B), 230 (paeoniflorin), 221 (schisantherin A), 280 (sodium danshensu), 327 (chlorognenic acid), 335 (spinosin), and 345 nm (berberine hydrochloride). Flow rate was set at 0.4 mL/min and column temperature was 35 ℃. Results The contents of paeoniflorin, salvianolic acid B, schisantherin A, sodium danshensu, chlorognenic acid, spinosin, berberine hydrochloride, and ginsenoside Rb1 were determined from 10 batches SYC. Conclusion The method of the quality evaluation of SYC has acceptable precision, reproducibility, and stability, which can be used as a new method for the quality control of SYC.展开更多
文摘Objective:To study the effects of Shensong Yangxin capsules and amiodarone on heart rate variability indexes and inflammatory factors in the treatment of patients with arrhythmia.Methods:The research subjects were selected patients with arrhythmia admitted in our hospitaFs department from October 2018 to October 2019,and a total of 70 patients were divided into two groups.35 subjects in the control group were treated with amiodarone alone,and 35 subjects in the observation group were treated with Shensongyangxin capsule in combination with amiodarone for comparisons in treatment effects,heart rate variability indices,inflammatory factors,and adverse reactions.Results:After observation,the treatment efficiency in the observation group was higher than that in the control group(P<0.05).Before treatment,there was no difference in heart rate variability indices between the two groups(P>0.05),after treatment,the improvement in patients of the observation group was better than that of the control group(P<0.05).After treatment,the inflammatory factors of the two groups of patients decreased,and the indicators of the observation group were comparably lower than those of the control group(P<0.05).In the comparison of adverse reactions,the observation group showed a lower incidence of adverse reactions after treatment than the control group(P<0.05).Conclusion:In the treatment of patients with arrhythmia,the combined use of Shensong Yangxin capsules and amiodarone has more significant therapeutic effects,which can effectively improve the patient's heart rate variability indices,reduce the inflammatory factors,and relieve the symptoms in patients.The incidence of adverse reactions is low and the safety is quite high,therefore it has great value in clinical applications.
基金Supported by the National Key Basic Research Development Program of China(The"973"Program,No.2012CB518604)。
文摘Objective:To investigate the effect of Chinese compound Shensong Yangxin Capsule(参松养心胶囊,SSYX)on myocardial microcirculation in myocardial-infarcted rabbits.Methods:Myocardial infarction(MI)was established in rabbits by ligation of the left circumflex coronary.Thirty rabbits were randomly divided into the control group,the MI group(model),and the MI treated with SSYX group(MI+SSYX)by a random number table method.After 4 weeks of administration,low-energy real-time myocardial contrast echocardiography(RT-MCE)was conducted to assess the microcirculatory perfusion.Immunofluorescence double staining was used to detect the capillary density.The endothelial ultrastructure was observed with a transmission electron microscope.The m RNA expression levels of vascular endothelial growth factor(VEGF),endothelin 1(ET-1),prostaglandin I2(PGI2)and endothelial nitric oxide synthase(e NOS)were measured by real-time quantitative polymerase chain reaction(Real-time PCR).The plasmic levels of ET-1,thromboxane A2(TXA2),nitric oxide(NO)and von willebrand factor(v WF)were examined with enzyme-linked immunosorbent assays(ELISA).Results:SSYX significantly improved the myocardial blood volume,myocardial micro bubble velocity,and myocardial inflow according to the examination of RT-MCE,and it visibly ameliorated the capillary endothelial structure.Furthermore,compared with the MI group,the plasma levels of TXA2,ET-1 and v WF contents significantly decreased in the MI+SSYX group,and the ET-1 mRNA expression levels of myocardium in the border zone significantly decreased,and the VEGF,PGI2 and e NOS m RNA expression levels significantly increased(all P<0.05).Conclusions:SSYX has favorable advantages in ameliorating the impaired myocardial microcirculation following MI.The mechanisms of the effect are related to the ability of SSYX in balancing the endothelial-derived vasodilators and vasoconstrictors,and up-regulating the expression of VEGF and e NOS.
基金the National Technology Research Program for Creating New Drugs(2011ZX09401-020)
National Basic Research Program of China(973 Program 2012CB518606)
文摘Objective To develop a ultra performance liquid chromatography (UPLC) method for the quality evaluation of Shensong Yangxin Capsule (SYC). Methods The Waters Acquity UPLC HSS T3 column (100 mm × 2.1 mm, 1.8 μm) was used. Acetonitrile and water containing 0.1% phosphoric acid were used as mobile phases of UPLC with gradient elution. The detection wavelength was set at 203 (ginsenoside Rb1), 286 (salvianolic acid B), 230 (paeoniflorin), 221 (schisantherin A), 280 (sodium danshensu), 327 (chlorognenic acid), 335 (spinosin), and 345 nm (berberine hydrochloride). Flow rate was set at 0.4 mL/min and column temperature was 35 ℃. Results The contents of paeoniflorin, salvianolic acid B, schisantherin A, sodium danshensu, chlorognenic acid, spinosin, berberine hydrochloride, and ginsenoside Rb1 were determined from 10 batches SYC. Conclusion The method of the quality evaluation of SYC has acceptable precision, reproducibility, and stability, which can be used as a new method for the quality control of SYC.
