Clinical Observastion on 30 Cases of Chronic Renal Failure Trested with Shentekang Capsule(肾特康胶囊)and Peritoneal Dialysis

Objective: To evaluate the effect of Shentekang Capsule (STKC) combined with peritonealdialysis (PD) in treating chronic renal failure (CRF). Methods: With single-blind, parallel control and random method, 60 cases of CRF patients were equally divided into 2 groups: (1 ) STKC group treated with combined therapy of STKC and PD; (2 ) control group treated with PD alone. The course of treatment were 1~ 2 months for both groups. Clinical manifestations, blood urea nitrogen, serum creatinine, total protein and hemoglobin were observed before and after the treatment. Results: Blood urea nitrogen decreased in both groups after treat ment as compared with that before treatment significantly (P< 0. 05), but no obvious difference was found be tween blood urea nitrogen levels of the two groups (P > 0. 05 ). However, levels of serum total protein and hemoglobin of the STKC group after treatment were higher than those of the control group (P < 0. 01 ). Clinical manifestation in STKC group also showed more improvement after treatment than that in the control group.Conclusion: STKC could improve nutritional state and quality of CRF patient's life treated with PD.

薄层扫描法测定肾特康胶囊中黄芪甲苷含量

目的建立测定肾特康胶囊中黄芪甲苷含量的薄层扫描法。方法采用薄层扫描法测定黄芪甲苷含量,硅胶G板,氯仿-乙酸乙酯-甲醇-水(15∶40∶22∶10)10℃以下放置过夜的下层溶液为展开剂,测定波长510nm,参比波长700nm。结果黄芪甲苷点样量在0.4～2μg之间和吸收度积分值呈良好的线性关系,平均回收率为98.3%,RSD=1.20%。结论薄层扫描法便捷、灵敏、准确,可作为肾特康胶囊的质量控制方法。

用高效液相法测定肾特康胶囊中盐酸小檗碱的含量

目的：研究肾特康胶囊所含盐酸小檗碱的HPLC测定方法。方法：采用ThermoHypersilC18色谱柱（4.6mm×25mm,5μm）;流动相：乙腈-0.33mol/L磷酸二氢钾溶液（0.5%三乙胺,磷酸调pH值至3.0）30：70;检测波长：265nm;流速：1.0mL/min。结果：盐酸小檗碱在0.2336~1.752μg范围呈良好的线性关系,r=0.9997（n=6）,平均回收率98.67%,RSD=3.1%（n=5）。结论：该方法简便、准确、重现性好,可用于肾特康胶囊中盐酸小檗碱含量测定。