Structural Characteristics and Evolution of a Weighted Sino-US Container Shipping Network

This study selected the Sino-US route data from the top 30 global container liner companies between December 1,2019,and December 29,2019,as the data source utilizing the complex network research methodology.It constructs a Sino-US container shipping network through voyage weighting and analyzes the essential structural characteristics to explore the network’s complex structural fea-tures.The network’s evolution is examined from three perspectives,namely,time,space,and event influence,aiming to comprehens-ively explore the network’s evolution mechanism.The results revealed that:1)the weighted Sino-US container shipping network exhib-its small-world and scale-free properties.Key hub ports in the United States include NEW YORK NY,SAVANNAH GA,LOS ANGELES CA,and OAKLAND CA,whereas SHANGHAI serving as the hub port in China.The geographical distribution of these hub ports is uneven.2)Concerning the evolution of the weighted Sino-US container shipping network,from a temporal perspective,the evolution of the regional structure of the entire Sino-US region and the Inland United States is in a stage of radiative expansion and de-velopment,with a need for further enhancement in competitiveness and development speed.The evolution of the regional structure of southern China and Europe is transitioning from the stage of radiative expansion and development to an advanced equilibrium stage.The shipping development in Northern China,the Western and Eastern United States,and Asia is undergoing significant changes but faces challenges of fierce competition and imbalances.From a spatial perspective,the rationality and effectiveness of the improved weighted Barrat-Barthelemy-Vespignani(BBV)model are confirmed through theoretical derivation.The applicability of the improved evolution model is verified by simulating the evolution of the weighted Sino-US container shipping network.From an event impact per-spective,the Corona Virus Disease 2019(COVID-19)pandemic has not fundamentally affected the spatial pattern of the weighted Sino-US container shipping network but has significantly impacted the network’s connectivity.The network lacks sufficient resilience and stability in emergency situations.3)Based on the analysis of the structural characteristics and evolution of the weighted Sino-US con-tainer shipping network,recommendations for network development are proposed from three aspects:emphasizing the development of hub ports,focusing on the balanced development of the network,and optimizing the layout of Chinese ports.

In Silico Investigation of Agonist Activity of a Structurally Diverse Set of Drugs to hPXR Using HM-BSM and HM-PNN

The human pregnane X receptor（hPXR） plays a critical role in the metabolism, transport and clearance of xenobiotics in the liver and intestine. The hPXR can be activated by a structurally diverse of drugs to initiate clinically relevant drug-drug interactions. In this article, in silico investigation was performed on a structurally diverse set of drugs to identify critical structural features greatly related to their agonist activity towards h PXR. Heuristic method（HM）-Best Subset Modeling（BSM） and HM-Polynomial Neural Networks（PNN） were utilized to develop the linear and non-linear quantitative structure-activity relationship models. The applicability domain（AD） of the models was assessed by Williams plot. Statistically reliable models with good predictive power and explain were achieved（for HM-BSM, r^2=0.881, q^2_（LOO）=0.797, q^2_（EXT）=0.674; for HM-PNN, r^2=0.882, q^2_（LOO）=0.856, q^2_（EXT）=0.655）. The developed models indicated that molecular aromatic and electric property, molecular weight and complexity may govern agonist activity of a structurally diverse set of drugs to h PXR.

A fine-grained perspective on the robustness of global cargo ship transportation networks

The robustness of cargo ship transportation networks is essential to the stability of the world trade system. The current research mainly focuses on the coarse-grained, holistic cargo ship transportation network while ignoring the structural diversity of different sub-networks. In this paper, we evaluate the robustness of the global cargo ship transportation network based on the most recent Automatic Identification System（AIS） data available. First, we subdivide three typical cargo ship transportation networks（i.e., oil tanker, container ship and bulk carrier） from the original cargo ship transportation network. Then, we design statistical indices based on complex network theory and employ four attack strategies, including random attack and three intentional attacks（i.e., degree-based attack, betweenness-based attack and flux-based attack） to evaluate the robustness of the three typical cargo ship transportation networks. Finally, we compare the integrity of the remaining ports of the network when a small proportion of ports lose their function. The results show that 1） compared with the holistic cargo ship transportation network, the fine-grain-based cargo ship transportation networks can fully reflect the pattern and process of global cargo transportation; 2） different cargo ship networks behave heterogeneously in terms of their robustness, with the container network being the weakest and the bulk carrier network being the strongest; and 3） small-scale intentional attacks may have significant influence on the integrity of the container network but a minor impact on the bulk carrier and oil tanker transportation networks. These conclusions can help improve the decision support capabilities in maritime transportation planning and emergency response and facilitate the establishment of a more reliable maritime transportation system.Abstract： The robustness of cargo ship transportation networks is essential to the stability of the world trade system. The current research mainly focuses on the coarse-grained, holistic cargo ship transportation network while ignoring the structural diversity of different sub-networks. In this paper, we evaluate the robustness of the global cargo ship transporta- tion network based on the most recent Automatic Identification System （AIS） data available. First, we subdivide three typical cargo ship transportation networks （i.e., oil tanker, container ship and bulk carrier） from the original cargo ship transportation network. Then, we design statistical indices based on complex network theory and employ four attack strategies, in- cluding random attack and three intentional attacks （i.e., degree-based attack, between- ness-based attack and flux-based attack） to evaluate the robustness of the three typical cargo ship transportation networks. Finally, we compare the integrity of the remaining ports of the network when a small proportion of ports lose their function. The results show that 1） com- pared with the holistic cargo ship transportation network, the fine-grain-based cargo ship transportation networks can fully reflect the pattern and process of global cargo transportation 2） different cargo ship networks behave heterogeneously in terms of their robustness, with the container network being the weakest and the bulk carrier network being the strongest; and 3） small-scale intentional attacks may have significant influence on the integrity of the con- tainer network but a minor impact on the bulk carrier and oil tanker transportation networks.These conclusions can help improve the decision support capabilities in maritime transportation planning and emergency response and facilitate the establishment of a more reliable maritime transportation system.

Spatial pattern of location advantages of ports along the Maritime Silk Road

Location advantages of ports refer to the current developments of ports based on their conditions, such as geographic location, traffic accessibility and hinterland economy, etc., and the spatial pattern of ports’ location advantages reflects the spatial distributions, the regularities and the correlations among their conditions for development. A good understanding of the spatial patterns of ports’ location advantages can help to better identify the relative advantages of ports, position ports’ functions and make strategic plans for development. This paper selected 1259 ports from 63 countries along the Maritime Silk Road as research objects and builds an accessing model to analyze their location advantages on the bases of six factors: the influence of strategic shipping pivot, the competitiveness of port location potential, port network status, the influence of city, the influence of traffic trunk, and road network density in hinterland. The study has the following three findings. Firstly, the location advantages of ports show a 'high-low-high' distribution pattern from the west to the east, displaying an obvious 'core-periphery' regionalized distribution. Secondly, most ports have high location advantages, mainly located in Strait of Malacca, the United Arab Emirates, northern Mediterranean coastal region and China-Japan region, the top 10 ports are mainly located in Singapore, China, Malaysia and Japan, indicating that the shipping industry in Asia-Pacific region has stepped to the far front of the global competition;slow economic growths, wars, far away from the Belt and Road countries or bad climate have low location advantages, mainly located in African coastal areas, Oceania, Northeast Europe and Russia. Thirdly, compared with the landward location advantages, the seaward location advantages have a higher influence, and different indicators of location advantages have different influences on the evaluation results, the competitiveness of port location potential being the core indicator.

A recursive model for static empty container allocation

Backlogged empty containers have gradually turned into a serious burden to shipping networks. Empty container allocation has become an urgent settlement issue for the container shipping industry on a global scale. Therefore, this paper proposes an improved immune algorithm based recursive model for optimizing static empty container allocation which integrates with the global maritime container shipping network. This model minimizes the operating and capital costs during container shipping considering 0-1 mixed-integer programming. So an immune algorithm procedure based on a special two- dimensional chromosome encoding is proposed. Finally, computational experiments are performed to optimize a 10-port static empty container shipping system. The results indicate that the proposed recursive model for static empty container allocation is effective in making an optimal strategy for empty container allocation.