With the rapid development of machine learning,the demand for high-efficient computing becomes more and more urgent.To break the bottleneck of the traditional Von Neumann architecture,computing-in-memory(CIM)has attra...With the rapid development of machine learning,the demand for high-efficient computing becomes more and more urgent.To break the bottleneck of the traditional Von Neumann architecture,computing-in-memory(CIM)has attracted increasing attention in recent years.In this work,to provide a feasible CIM solution for the large-scale neural networks(NN)requiring continuous weight updating in online training,a flash-based computing-in-memory with high endurance(10^(9) cycles)and ultrafast programming speed is investigated.On the one hand,the proposed programming scheme of channel hot electron injection(CHEI)and hot hole injection(HHI)demonstrate high linearity,symmetric potentiation,and a depression process,which help to improve the training speed and accuracy.On the other hand,the low-damage programming scheme and memory window(MW)optimizations can suppress cell degradation effectively with improved computing accuracy.Even after 109 cycles,the leakage current(I_(off))of cells remains sub-10pA,ensuring the large-scale computing ability of memory.Further characterizations are done on read disturb to demonstrate its robust reliabilities.By processing CIFAR-10 tasks,it is evident that~90%accuracy can be achieved after 109 cycles in both ResNet50 and VGG16 NN.Our results suggest that flash-based CIM has great potential to overcome the limitations of traditional Von Neumann architectures and enable high-performance NN online training,which pave the way for further development of artificial intelligence(AI)accelerators.展开更多
Objective:To clarify the effect of endurance training on the expression profile of circRNA-lncRNA-miRNA-mRNA in myocardial tissues of mice after exhaustive exercise.Methods:A total of 45 male C57BL/6 mice were randoml...Objective:To clarify the effect of endurance training on the expression profile of circRNA-lncRNA-miRNA-mRNA in myocardial tissues of mice after exhaustive exercise.Methods:A total of 45 male C57BL/6 mice were randomly divided into control(C),low-strength endurance training(LSET)and high-strength endurance training(HSET)groups(n=15).The mice in the control group were not conducted to platform training.The mice in the LSET and HSET groups were conducted to platform training at 30%and 60%of exhaustive exercise once a day for 5 days a week,respectively.The exhaustion exercise was performed after 5 weeks of platform training.Total RNA was extracted from myocardial tissues,and the expression profile of circRNA-lncRNA-miRNA-mRNA in myocardial tissues was analyzed using Illimina transcriptome sequencing.Results:The distance and time of exhaustive exercise were longer in the LSET and HSET groups than in the control group,and the distance and time of exhaustive exercise were longer in the HSET group than in the LSET group(P<0.05).A total of 54 differentially expressed circRNAs(28 down-regulated and 26 up-regulated),7 differentially expressed lncRNAs(all down-regulated),3 differentially expressed miRNAs(1 down-regulated and 2 up-regulated)and 99 differentially expressed mRNAs(81 down-regulated and 18 up-regulated)were identified by transcriptome sequencing(P<0.05).Interaction network analysis revealed that ENSMUSG00000113041,MSTRG.79740,mmu-miR-374c-5p,18 down-regulated mRNAs and 3 up-regulated mRNAs formed a regulatory network.GO functional analysis revealed that the differentially expressed mRNAs were mainly enriched in primary metabolic processes and macromolecular synthesis and metabolic processes.KEGG pathway analysis revealed that the differentially expressed mRNAs were mainly enriched in complement and coagulation cascade pathways,estrogen signaling pathway and glucagon signaling pathway.Conclusion:Endurance training could alter the expression profile of circRNA-lncRNA-miRNA-mRNA in myocardial tissues of mice after exhaustive exercise,and these differentially expressed RNAs form a regulatory network that affects cardiomyocyte synthesis and metabolism and thus participates in the regulation of myocardial injury.展开更多
Purpose-To optimize train operations,dispatchers currently rely on experience for quick adjustments when delays occur.However,delay predictions often involve imprecise shifts based on known delay times.Real-time and a...Purpose-To optimize train operations,dispatchers currently rely on experience for quick adjustments when delays occur.However,delay predictions often involve imprecise shifts based on known delay times.Real-time and accurate train delay predictions,facilitated by data-driven neural network models,can significantly reduce dispatcher stress and improve adjustment plans.Leveraging current train operation data,these models enable swift and precise predictions,addressing challenges posed by train delays in high-speed rail networks during unforeseen events.Design/methodology/approach-This paper proposes CBLA-net,a neural network architecture for predicting late arrival times.It combines CNN,Bi-LSTM,and attention mechanisms to extract features,handle time series data,and enhance information utilization.Trained on operational data from the Beijing-Tianjin line,it predicts the late arrival time of a target train at the next station using multidimensional input data from the target and preceding trains.Findings-This study evaluates our model’s predictive performance using two data approaches:one considering full data and another focusing only on late arrivals.Results show precise and rapid predictions.Training with full data achieves aMAEof approximately 0.54 minutes and a RMSEof 0.65 minutes,surpassing the model trained solely on delay data(MAE:is about 1.02 min,RMSE:is about 1.52 min).Despite superior overall performance with full data,the model excels at predicting delays exceeding 15 minutes when trained exclusively on late arrivals.For enhanced adaptability to real-world train operations,training with full data is recommended.Originality/value-This paper introduces a novel neural network model,CBLA-net,for predicting train delay times.It innovatively compares and analyzes the model’s performance using both full data and delay data formats.Additionally,the evaluation of the network’s predictive capabilities considers different scenarios,providing a comprehensive demonstration of the model’s predictive performance.展开更多
Objective: This systematic review aimed to critically analyze the literature to determine how high-intensity intermittent training(HIIT) affects recreational endurance runners in the short-and long-term.Methods: Elect...Objective: This systematic review aimed to critically analyze the literature to determine how high-intensity intermittent training(HIIT) affects recreational endurance runners in the short-and long-term.Methods: Electronic databases were searched for literature dating from January 2000 to October 2015. The search was conducted using the key words "high-intensity intermittent training" or "high-intensity interval exercise" or "interval running" or "sprint interval training" and "endurance runners" or "long distance runners". A systematic approach was used to evaluate the 783 articles identified for initial review. Studies were included if they investigated HIIT in recreational endurance runners. The methodological quality of the studies was evaluated using the Physiotherapy Evidence Database(PEDro) scale(for intervention studies) and the modified Downs and Black Quality Index(for cross-sectional studies).Results: Twenty-three studies met the inclusionary criteria for review. The results are presented in 2 parts: cross-sectional(n = 15) and intervention studies(n = 8). In the 15 cross-sectional studies selected, endurance runners performed at least 1 HIIT protocol, and the acute impact on physiological, neuromuscular, metabolic and/or biomechanical variables was assessed. Intervention studies lasted a minimum of 4 weeks, with 10 weeks being the longest intervention period, and included 2 to 4 HIIT sessions per week. Most of these studies combined HIIT sessions with continuous run(CR) sessions; 2 studies' subjects performed HIIT exclusively.Conclusion: HIIT-based running plans(2 to 3 HIIT sessions per week, combining HIIT and CR runs) show athletic performance improvements in endurance runners by improving maximal oxygen uptake and running economy along with muscular and metabolic adaptations. To maximize the adaptations to training, both HIIT and CR must be part of training programs for endurance runners.展开更多
After intraperitoneal injection of 20 mg/kg lead acetate, rats received 8 weeks of treadmill exercise (15-22 m/min, 25-64 minutes) and/or treadmill exercise at 1.6 km/h until exhaustion. The markers related to neuro...After intraperitoneal injection of 20 mg/kg lead acetate, rats received 8 weeks of treadmill exercise (15-22 m/min, 25-64 minutes) and/or treadmill exercise at 1.6 km/h until exhaustion. The markers related to neurotoxicity were measured by enzyme-linked immunosorbent assay method. 8 weeks of treadmill exercise significantly increased brain-derived neurotrophic factor level in the hippocampus (P = 0.04) and plasma level of total antioxidant capacity of rats exposed to lead acetate (P 〈 0.001), and significantly decreased plasma level of malondialdehyde (P 〈 0.001). Acute exercise only decreased the hippocampal malondialdehyde level (P = 0.09) and increased brain-derived neurotrophic factor level in the hippocampus (P = 0.66). Acute exercise also enhanced the total antioxidant capacity in rats exposed to lead acetate, insignificantly (P = 0.99), These findings suggest that chronic treadmill exercise can significantly decrease neurotoxicity and alleviate oxidative stress in rats exposed to lead acetate. However, acute endurance exercise was not associated with these beneficial effects.展开更多
Purpose:The purpose of this study was to compare the effects of intermittent sprint training and plyometric training on endurance running performance.Methods:Fourteen moderately trained male endurance runners were all...Purpose:The purpose of this study was to compare the effects of intermittent sprint training and plyometric training on endurance running performance.Methods:Fourteen moderately trained male endurance runners were allocated into either the intermittent sprint training group(n = 7)or the plyometric training group(n = 7).The preliminary tests required subjects to perform a treadmill graded exercise test,a countermovement jump test for peak power measurement,and a 10-km time trial.Training included 12 sessions of either intermittent sprint or plyometric training carried out twice per week.On completion of the intervention,post-tests were conducted.Results:Both groups showed significant reduction in weekly training mileage from pre-intervention during the intervention period.There were significant improvements in the 10-km time trial performance and peak power.There was also significant improvement in relative peak power for both groups.The 10-km time trial performance and relative peak power showed a moderate inverse correlation.Conclusion:These findings showed that both intermittent sprint and plyometric training resulted in improved 10-km running performance despite reduction in training mileage.The improvement in running performance was accompanied by an improvement in peak power and showed an inverse relationship with relative peak power.展开更多
BACKGROUND: Exhaustive exercise can lead to apoptosis of skeletal muscle cells and myocardial cells as a result of pathological changes in the corresponding cellular ultrastructure. It is hypothesized that such chang...BACKGROUND: Exhaustive exercise can lead to apoptosis of skeletal muscle cells and myocardial cells as a result of pathological changes in the corresponding cellular ultrastructure. It is hypothesized that such changes could also occur in neurons. OBJECTIVE: To observe brain cell apoptosis and ultrastructural changes in hippocampal neurons in rats following endurance training and acute exhaustive exercise. DESIGN, TIME AND SETTING: A randomized, controlled, morphological analysis was performed at the Medical Laboratory Center of Zhengzhou University between July and November 2007. MATERIALS: Forty male, 8-week-old, Sprague Dawley rats were included in this study. METHODS: Endurance training consisted of treadmill running once a day, 6 days a week, for 4. weeks. For acute exhaustive exercise, graded treadmill running was conducted. Rats were exposed to exercise at an increasing speed (10 m/min, increasing to 20 and 36 m/min for moderate- and high-intensity exhaustive exercise, respectively, and then was continued until exhaustion). A total of 40 rats were evenly distributed into the following 4. groups: Group A rats were not exercised; Group B rats were not trained but sacrificed 24 hours after acute exhaustive treadmill running exercise; Group C-rats were subjected to endurance training and sacrificed immediately after acute exhaustive treadmill running exercise; Group D rats were subjected to endurance training and sacrificed 24 hours after acute exhaustive treadmill running exercise. MAIN OUTCOME MEASURES: Apoptotic cell death was detected by the TUNEL method and hippocampal neuronal ultrastructural change was observed through using transmission electron microscopy. RESULTS: All 40 rats were included in the final analysis. Subsequent to exhaustive exercise, rat cerebral cortex and hippocampal neurons appeared contracted and degenerated. In addition, high amount of lipofuscin was visible in the hippocampal region, Necrotic neurons encased by glial cells appeared in the cerebral cortex and hippocampus. Glial cells exhibited different degrees of swelling. Subsequent to exhaustive exercise, brain cell apoptosis rate significantly increased, and reached over 30% in some regions, compared with group A (P 〈 0.05). No significant difference in apoptosis rate existed between groups B, C, and D (P 〈 0.05). CONCLUSION: Endurance training and acute exhaustive exercise cause, to some degree, injuries to glial cells, resulting in apoptosis of numerous brain cells. Subsequent to exhaustive exercise, high amounts of lipofuscin appear in the hippocampus, indicating that exhaustive exercise possibly contributes to neural cell aging or dysmetabolism.展开更多
In this study, healthy young males were randomized into groups with moderate intensity training (n = 24), high intensity training (n = 24) and utmost intensity training (n = 24). At the end of 8-week training period, ...In this study, healthy young males were randomized into groups with moderate intensity training (n = 24), high intensity training (n = 24) and utmost intensity training (n = 24). At the end of 8-week training period, HRV measurements demonstrated a marked increase of RMSSD (P = 0.003), PNN50 (P = 0.002), HF (P = 0.002), SDNN (P = 0.002) and LF (P = 0.003) in the moderate intensity group and a decreasing tendency in LFn and LF/HF;however, in the utmost intensity group HFn (P = 0.012) decreased prominently while its LF (P = 0.032), LFn (P = 0.039) and LF/HF (P = 0.015) increased significantly. Nevertheless marked changes were not found in the above indexes of the high intensity group. While resting HR of the three groups declined significantly at the end of 8 weeks (P was 0.001, 0.0001 and 0.001 respectively);RMSSD, PNN50, HF, LF and SDNN were significantly higher in the moderate intensity group than in the other two groups (P P = 0.012) was significantly lower but its LFn and LF/HF were markedly higher (P was 0.025 and 0.015 respectively);LF/HF of both the high and utmost intensity group was significantly higher (P was 0.033 and 0.037 respectively). Despite a significant reduction of plasma NE in all the three groups at the end of 8-week training period (P was 0.016, 0, 0.031 respectively), plasma NE level of moderate and high intensity group was much lower than that of the utmost intensity group (P was 0.001, 0 respectively). Utmost and moderate endurance training results in altered sympathetic and parasympathetic balance towards sympathetic dominance and parasympathetic dominance respectively;whereas high intensity endurance training almost has no effect on ANS function. CPT and HUTT reveal the potential danger posed by utmost intensity endurance training.展开更多
Overseas three-month intra-university training program is rear in Yunnan,China.Using adult learning and social con-structivism as theoretical basis,the author,introduces the background of the program and the course de...Overseas three-month intra-university training program is rear in Yunnan,China.Using adult learning and social con-structivism as theoretical basis,the author,introduces the background of the program and the course design,highlighting the inten-tion for the program and similar programs.展开更多
Background Stable angina pectoris is a common subtype of coronary heart disease.Patients suffer from chest tightness,chest pain and crushing pain under the inducement of fatigue and emotional agitation.This study aims...Background Stable angina pectoris is a common subtype of coronary heart disease.Patients suffer from chest tightness,chest pain and crushing pain under the inducement of fatigue and emotional agitation.This study aims to investigate the effect of exercise training guidance based on action research on exercise endurance and readmission rate of patients with stable angina pectoris.Methods A retrospective study was conducted on 60 patients with stable angina pectoris due to coronary heart disease admitted to our hospital from February 2020 to November 2023.Patients were divided into a control group of 29 cases(receiving conventional exercise training guidance)and a guidance group of 31 cases(receiving action research-based exercise training guidance).Both groups received continuous training for one month.A comparison was made between the exercise endurance indicators[6-minute walk test distance(6MWT),peak oxygen consumption(peak VO2),anaerobic threshold(AT),exercise duration(ED)],quality of life,and readmission rate within 6 months after intervention in both groups.Results After 1 month of intervention,6MWT,peak VO2,AT and ED were increased in both groups,and those in the guidance group were higher than those in the conventional group(P<0.05).The score of quality of life(The 36-item shot-form health status survey,SF-36)in both groups was increased,and the guidance group scored higher than the conventional group(P<0.05).The readmission rate of patients in the guidance group was 6.45%,which was lower than that in the conventional group(27.59%)(P<0.05).Conclusions The application of action research-based exercise training guidance in patients with stable angina pectoris due to coronary heart disease has significant effects,improving exercise endurance,significantly improving quality of life,and reducing readmission rate,thus having practical value.[S Chin J Cardiol 2024;25(3):162-168]展开更多
Objective To evaluate the short-term effect of pelvic floor muscle rehabilitation training under the guidance of doctors on children with neuropathic acontractile sphincter incontinence ( NASI) . Methods Sixty-eighty ...Objective To evaluate the short-term effect of pelvic floor muscle rehabilitation training under the guidance of doctors on children with neuropathic acontractile sphincter incontinence ( NASI) . Methods Sixty-eighty children ( aged 4 - 12 mean,7) years with NASI展开更多
BACKGROUND The prevalence of chronic obstructive pulmonary disease(COPD)is increasing worldwide,and at the same time it is associated with increased mortality and reduced quality of life.Efforts to build sustainable r...BACKGROUND The prevalence of chronic obstructive pulmonary disease(COPD)is increasing worldwide,and at the same time it is associated with increased mortality and reduced quality of life.Efforts to build sustainable rehabilitation approaches to COPD treatment and prevention are crucial.The system of long-term pulmonary rehabilitation care is insufficient.The main reasons for the absence of these outpatient programs are the lack of experience,the lack of interest of insurance companies in secondary prevention programs,and the lack of healthcare facilities in large geographical areas.The possibility of at-home pulmonary rehabilitation models(telemonitoring and telecoaching)could solve this problem.CASE SUMMARY A 71-year-old man with severe COPD,Global Initiative for Obstructive Lung Diseases stage 3 underwent an 8-wk remotely monitored inspiratory muscle training with a device based on the test of incremental respiratory endurance method.Spirometry,body plethysmography,test of incremental respiratory endurance examination,6-min walking test,body mass index,airflow obstruction,dyspnea,exercise capacity index,and subjective perception of dyspnea were performed as part of the initial and final examination.The patient performed training at home,and the physiotherapist monitored the patient remotely through a web application that allowed the physiotherapist to evaluate all training parameters in real-time and respond to any problems.After 8 wk of home training,there was a significant increase in all monitored values:maximal inspiratory pressure,a novel parameter sustained maximal inspiratory pressure,forced expiratory volume in 1 s,total lung capacity,forced vital capacity,peak expiratory flow,and inspiratory capacity.There was also an improvement in the perception of dyspnea according to the COPD Assessment Test and a modified Medical Research Council Breathlessness Scale,an increase in exercise tolerance according to the 6-min walking test,and a decrease in the exercise capacity index as a predictor of prognosis.CONCLUSION Respiratory telerehabilitation was greatly beneficial in a cooperative patient with COPD and may represent an alternative therapeutic approach to the increasing incidence of all lung diseases.展开更多
BACKGROUND: Plyometric training has been shown to improve performance in distance running events up to 5-km, but little research has been done on this type of training for marathon (42.195-km) runners. The purpose ...BACKGROUND: Plyometric training has been shown to improve performance in distance running events up to 5-km, but little research has been done on this type of training for marathon (42.195-km) runners. The purpose of this study was to examine the effects of plyometric and explosive speed training (PLYO) on recreational marathoners. METHODS: Twenty-two subjects (ages 18-23), were randomized to either PLYO or core training (CORE) for a weekly session performed for 12 weeks, in addition to marathon training. Sprint, jump, and distance running performance variables were measured pre- and post-intervention. RESULTS: In the sprint tests, the PLYO group improved in both the 200-m run (P ≤ 0.001) and 60-m run (P = 0.004), and trended toward improvement in the 30-m fly (P = 0.051). The difference from CORE was significant only in the 200-m (P = 0.002). The CORE group did not change in any of the sprint or jump variables. The PLYO group was significantly different from the CORE group in the standing long jump (P = 0.024). There were no differences between groups in distance running performance. Both improved in 2-mile (3.219-km) time trial (p 〈 0.001), VO2MAX (P = 0.026 for CORE; P = 0.002 for PLYO), and running economy (P = 0.01). CONCLUSION: Weekly PLYO training improves sprint speed and maintains jumping ability in recreational marathoners, but does not augment improvements in distance running performance.展开更多
Objective:To explore the clinical effect of long-term aerobic exercise combined with resistance training in patients with myocardial ischemia caused by coronary heart disease and its influence on cardiac function, exe...Objective:To explore the clinical effect of long-term aerobic exercise combined with resistance training in patients with myocardial ischemia caused by coronary heart disease and its influence on cardiac function, exercise endurance and quality of life. Methods:100 patients with myocardial ischemia caused by coronary heart disease from January 2017 to January 2019 were randomly divided into control group (n = 50 cases) and observation group (n = 50 cases). The control group was given resistance training, while the observation group was combined with long-term aerobic exercise on the basis of the control group. The two groups were treated for 3 months. The cardiac function, exercise endurance and quality of life were compared between the two groups. Results:The levels of IVST (8.20+1.32) mm, LVDD (46.43+4.13) mm and LVSD (32.59+3.15) mm in the observation group were lower than those in the control group at 3 months after treatment. The level of LVEF (67.49+5.77)% in the observation group was higher than that in the control group at 3 months after treatment. The difference between the two groups was significant (P<0.05). The ET (55.42+2.9) in the observation group was higher than that in the control group (P<0.05). 2) The levels of ng/L and TXB2 (93.23 + 6.26) ng/L were significantly lower than those of the control group, and the difference between the two groups was statistically significant (P<0.05). The 6-minute walking distance (561.25 +43.64) m and the quality of life score (95.31 +6.39) in the observation group were higher than those in the control group 3 months after treatment, and the difference between the two groups was statistically significant (P<0.05). Conclusions:Long-term aerobic exercise combined with resistance training can improve cardiac function, exercise tolerance and quality of life in patients with myocardial ischemia caused by coronary heart disease, which is worthy of popularization and application.展开更多
目的探讨呼吸训练对痉挛型四肢瘫(spastic quadriplegia,SP)患儿步行耐力及平衡能力的影响。方法选取2021年11月至2023年11月中国康复研究中心北京博爱医院SP患儿60例,随机分为对照组(n=30)与试验组(n=30)。对照组接受常规康复训练(60 m...目的探讨呼吸训练对痉挛型四肢瘫(spastic quadriplegia,SP)患儿步行耐力及平衡能力的影响。方法选取2021年11月至2023年11月中国康复研究中心北京博爱医院SP患儿60例,随机分为对照组(n=30)与试验组(n=30)。对照组接受常规康复训练(60 min/次),试验组接受常规康复训练(40 min/次)和呼吸训练(20 min/次);两组训练频率为1次/d,5 d/周,连续4周。分别采用10米步行测试(10-meter work test,10MWT)速度、6分钟步行测试(6-minute walk test,6MWT)距离、Berg平衡量表(Berg balance scale,BBS)评分和肺活量(vital capacity,VC)、用力肺活量(forced vital capacity,FVC)、1秒用力呼气量(forced expiratory volume in first second,FEV1)、呼气峰值流速(peak expiratory flow,PEF)评估患儿训练前后步行耐力、平衡能力和肺功能。结果60例患儿中,男31例、女29例,年龄6~12岁,平均(9.0±1.7)岁。两组性别、年龄、粗大运动功能分级系统(gross motor function classification system,GMFCS)的比较,差异均无统计学意义(P>0.05)。训练4周后,两组患儿的6MWT距离、BBS评分、10MWT速度、FVC、FEV1、PEF均高于训练前,且试验组均高于对照组,差异有统计学意义(P<0.05)。结论呼吸训练能有效改善SP患儿的步行耐力、平衡能力,提高肺功能,增强有氧运动的耐力,降低跌倒风险,提高日常生活质量。展开更多
基金This work was supported by the National Natural Science Foundation of China(Nos.62034006,92264201,and 91964105)the Natural Science Foundation of Shandong Province(Nos.ZR2020JQ28 and ZR2020KF016)the Program of Qilu Young Scholars of Shandong University.
文摘With the rapid development of machine learning,the demand for high-efficient computing becomes more and more urgent.To break the bottleneck of the traditional Von Neumann architecture,computing-in-memory(CIM)has attracted increasing attention in recent years.In this work,to provide a feasible CIM solution for the large-scale neural networks(NN)requiring continuous weight updating in online training,a flash-based computing-in-memory with high endurance(10^(9) cycles)and ultrafast programming speed is investigated.On the one hand,the proposed programming scheme of channel hot electron injection(CHEI)and hot hole injection(HHI)demonstrate high linearity,symmetric potentiation,and a depression process,which help to improve the training speed and accuracy.On the other hand,the low-damage programming scheme and memory window(MW)optimizations can suppress cell degradation effectively with improved computing accuracy.Even after 109 cycles,the leakage current(I_(off))of cells remains sub-10pA,ensuring the large-scale computing ability of memory.Further characterizations are done on read disturb to demonstrate its robust reliabilities.By processing CIFAR-10 tasks,it is evident that~90%accuracy can be achieved after 109 cycles in both ResNet50 and VGG16 NN.Our results suggest that flash-based CIM has great potential to overcome the limitations of traditional Von Neumann architectures and enable high-performance NN online training,which pave the way for further development of artificial intelligence(AI)accelerators.
基金The Medical and Health Science and Technology Development Planning Project of Shandong Province(202103011061)。
文摘Objective:To clarify the effect of endurance training on the expression profile of circRNA-lncRNA-miRNA-mRNA in myocardial tissues of mice after exhaustive exercise.Methods:A total of 45 male C57BL/6 mice were randomly divided into control(C),low-strength endurance training(LSET)and high-strength endurance training(HSET)groups(n=15).The mice in the control group were not conducted to platform training.The mice in the LSET and HSET groups were conducted to platform training at 30%and 60%of exhaustive exercise once a day for 5 days a week,respectively.The exhaustion exercise was performed after 5 weeks of platform training.Total RNA was extracted from myocardial tissues,and the expression profile of circRNA-lncRNA-miRNA-mRNA in myocardial tissues was analyzed using Illimina transcriptome sequencing.Results:The distance and time of exhaustive exercise were longer in the LSET and HSET groups than in the control group,and the distance and time of exhaustive exercise were longer in the HSET group than in the LSET group(P<0.05).A total of 54 differentially expressed circRNAs(28 down-regulated and 26 up-regulated),7 differentially expressed lncRNAs(all down-regulated),3 differentially expressed miRNAs(1 down-regulated and 2 up-regulated)and 99 differentially expressed mRNAs(81 down-regulated and 18 up-regulated)were identified by transcriptome sequencing(P<0.05).Interaction network analysis revealed that ENSMUSG00000113041,MSTRG.79740,mmu-miR-374c-5p,18 down-regulated mRNAs and 3 up-regulated mRNAs formed a regulatory network.GO functional analysis revealed that the differentially expressed mRNAs were mainly enriched in primary metabolic processes and macromolecular synthesis and metabolic processes.KEGG pathway analysis revealed that the differentially expressed mRNAs were mainly enriched in complement and coagulation cascade pathways,estrogen signaling pathway and glucagon signaling pathway.Conclusion:Endurance training could alter the expression profile of circRNA-lncRNA-miRNA-mRNA in myocardial tissues of mice after exhaustive exercise,and these differentially expressed RNAs form a regulatory network that affects cardiomyocyte synthesis and metabolism and thus participates in the regulation of myocardial injury.
基金supported in part by the National Natural Science Foundation of China under Grant 62203468in part by the Technological Research and Development Program of China State Railway Group Co.,Ltd.under Grant Q2023X011+1 种基金in part by the Young Elite Scientist Sponsorship Program by China Association for Science and Technology(CAST)under Grant 2022QNRC001in part by the Youth Talent Program Supported by China Railway Society,and in part by the Research Program of China Academy of Railway Sciences Corporation Limited under Grant 2023YJ112.
文摘Purpose-To optimize train operations,dispatchers currently rely on experience for quick adjustments when delays occur.However,delay predictions often involve imprecise shifts based on known delay times.Real-time and accurate train delay predictions,facilitated by data-driven neural network models,can significantly reduce dispatcher stress and improve adjustment plans.Leveraging current train operation data,these models enable swift and precise predictions,addressing challenges posed by train delays in high-speed rail networks during unforeseen events.Design/methodology/approach-This paper proposes CBLA-net,a neural network architecture for predicting late arrival times.It combines CNN,Bi-LSTM,and attention mechanisms to extract features,handle time series data,and enhance information utilization.Trained on operational data from the Beijing-Tianjin line,it predicts the late arrival time of a target train at the next station using multidimensional input data from the target and preceding trains.Findings-This study evaluates our model’s predictive performance using two data approaches:one considering full data and another focusing only on late arrivals.Results show precise and rapid predictions.Training with full data achieves aMAEof approximately 0.54 minutes and a RMSEof 0.65 minutes,surpassing the model trained solely on delay data(MAE:is about 1.02 min,RMSE:is about 1.52 min).Despite superior overall performance with full data,the model excels at predicting delays exceeding 15 minutes when trained exclusively on late arrivals.For enhanced adaptability to real-world train operations,training with full data is recommended.Originality/value-This paper introduces a novel neural network model,CBLA-net,for predicting train delay times.It innovatively compares and analyzes the model’s performance using both full data and delay data formats.Additionally,the evaluation of the network’s predictive capabilities considers different scenarios,providing a comprehensive demonstration of the model’s predictive performance.
基金the University of Jaén for its support to the present study
文摘Objective: This systematic review aimed to critically analyze the literature to determine how high-intensity intermittent training(HIIT) affects recreational endurance runners in the short-and long-term.Methods: Electronic databases were searched for literature dating from January 2000 to October 2015. The search was conducted using the key words "high-intensity intermittent training" or "high-intensity interval exercise" or "interval running" or "sprint interval training" and "endurance runners" or "long distance runners". A systematic approach was used to evaluate the 783 articles identified for initial review. Studies were included if they investigated HIIT in recreational endurance runners. The methodological quality of the studies was evaluated using the Physiotherapy Evidence Database(PEDro) scale(for intervention studies) and the modified Downs and Black Quality Index(for cross-sectional studies).Results: Twenty-three studies met the inclusionary criteria for review. The results are presented in 2 parts: cross-sectional(n = 15) and intervention studies(n = 8). In the 15 cross-sectional studies selected, endurance runners performed at least 1 HIIT protocol, and the acute impact on physiological, neuromuscular, metabolic and/or biomechanical variables was assessed. Intervention studies lasted a minimum of 4 weeks, with 10 weeks being the longest intervention period, and included 2 to 4 HIIT sessions per week. Most of these studies combined HIIT sessions with continuous run(CR) sessions; 2 studies' subjects performed HIIT exclusively.Conclusion: HIIT-based running plans(2 to 3 HIIT sessions per week, combining HIIT and CR runs) show athletic performance improvements in endurance runners by improving maximal oxygen uptake and running economy along with muscular and metabolic adaptations. To maximize the adaptations to training, both HIIT and CR must be part of training programs for endurance runners.
文摘After intraperitoneal injection of 20 mg/kg lead acetate, rats received 8 weeks of treadmill exercise (15-22 m/min, 25-64 minutes) and/or treadmill exercise at 1.6 km/h until exhaustion. The markers related to neurotoxicity were measured by enzyme-linked immunosorbent assay method. 8 weeks of treadmill exercise significantly increased brain-derived neurotrophic factor level in the hippocampus (P = 0.04) and plasma level of total antioxidant capacity of rats exposed to lead acetate (P 〈 0.001), and significantly decreased plasma level of malondialdehyde (P 〈 0.001). Acute exercise only decreased the hippocampal malondialdehyde level (P = 0.09) and increased brain-derived neurotrophic factor level in the hippocampus (P = 0.66). Acute exercise also enhanced the total antioxidant capacity in rats exposed to lead acetate, insignificantly (P = 0.99), These findings suggest that chronic treadmill exercise can significantly decrease neurotoxicity and alleviate oxidative stress in rats exposed to lead acetate. However, acute endurance exercise was not associated with these beneficial effects.
文摘Purpose:The purpose of this study was to compare the effects of intermittent sprint training and plyometric training on endurance running performance.Methods:Fourteen moderately trained male endurance runners were allocated into either the intermittent sprint training group(n = 7)or the plyometric training group(n = 7).The preliminary tests required subjects to perform a treadmill graded exercise test,a countermovement jump test for peak power measurement,and a 10-km time trial.Training included 12 sessions of either intermittent sprint or plyometric training carried out twice per week.On completion of the intervention,post-tests were conducted.Results:Both groups showed significant reduction in weekly training mileage from pre-intervention during the intervention period.There were significant improvements in the 10-km time trial performance and peak power.There was also significant improvement in relative peak power for both groups.The 10-km time trial performance and relative peak power showed a moderate inverse correlation.Conclusion:These findings showed that both intermittent sprint and plyometric training resulted in improved 10-km running performance despite reduction in training mileage.The improvement in running performance was accompanied by an improvement in peak power and showed an inverse relationship with relative peak power.
文摘BACKGROUND: Exhaustive exercise can lead to apoptosis of skeletal muscle cells and myocardial cells as a result of pathological changes in the corresponding cellular ultrastructure. It is hypothesized that such changes could also occur in neurons. OBJECTIVE: To observe brain cell apoptosis and ultrastructural changes in hippocampal neurons in rats following endurance training and acute exhaustive exercise. DESIGN, TIME AND SETTING: A randomized, controlled, morphological analysis was performed at the Medical Laboratory Center of Zhengzhou University between July and November 2007. MATERIALS: Forty male, 8-week-old, Sprague Dawley rats were included in this study. METHODS: Endurance training consisted of treadmill running once a day, 6 days a week, for 4. weeks. For acute exhaustive exercise, graded treadmill running was conducted. Rats were exposed to exercise at an increasing speed (10 m/min, increasing to 20 and 36 m/min for moderate- and high-intensity exhaustive exercise, respectively, and then was continued until exhaustion). A total of 40 rats were evenly distributed into the following 4. groups: Group A rats were not exercised; Group B rats were not trained but sacrificed 24 hours after acute exhaustive treadmill running exercise; Group C-rats were subjected to endurance training and sacrificed immediately after acute exhaustive treadmill running exercise; Group D rats were subjected to endurance training and sacrificed 24 hours after acute exhaustive treadmill running exercise. MAIN OUTCOME MEASURES: Apoptotic cell death was detected by the TUNEL method and hippocampal neuronal ultrastructural change was observed through using transmission electron microscopy. RESULTS: All 40 rats were included in the final analysis. Subsequent to exhaustive exercise, rat cerebral cortex and hippocampal neurons appeared contracted and degenerated. In addition, high amount of lipofuscin was visible in the hippocampal region, Necrotic neurons encased by glial cells appeared in the cerebral cortex and hippocampus. Glial cells exhibited different degrees of swelling. Subsequent to exhaustive exercise, brain cell apoptosis rate significantly increased, and reached over 30% in some regions, compared with group A (P 〈 0.05). No significant difference in apoptosis rate existed between groups B, C, and D (P 〈 0.05). CONCLUSION: Endurance training and acute exhaustive exercise cause, to some degree, injuries to glial cells, resulting in apoptosis of numerous brain cells. Subsequent to exhaustive exercise, high amounts of lipofuscin appear in the hippocampus, indicating that exhaustive exercise possibly contributes to neural cell aging or dysmetabolism.
文摘In this study, healthy young males were randomized into groups with moderate intensity training (n = 24), high intensity training (n = 24) and utmost intensity training (n = 24). At the end of 8-week training period, HRV measurements demonstrated a marked increase of RMSSD (P = 0.003), PNN50 (P = 0.002), HF (P = 0.002), SDNN (P = 0.002) and LF (P = 0.003) in the moderate intensity group and a decreasing tendency in LFn and LF/HF;however, in the utmost intensity group HFn (P = 0.012) decreased prominently while its LF (P = 0.032), LFn (P = 0.039) and LF/HF (P = 0.015) increased significantly. Nevertheless marked changes were not found in the above indexes of the high intensity group. While resting HR of the three groups declined significantly at the end of 8 weeks (P was 0.001, 0.0001 and 0.001 respectively);RMSSD, PNN50, HF, LF and SDNN were significantly higher in the moderate intensity group than in the other two groups (P P = 0.012) was significantly lower but its LFn and LF/HF were markedly higher (P was 0.025 and 0.015 respectively);LF/HF of both the high and utmost intensity group was significantly higher (P was 0.033 and 0.037 respectively). Despite a significant reduction of plasma NE in all the three groups at the end of 8-week training period (P was 0.016, 0, 0.031 respectively), plasma NE level of moderate and high intensity group was much lower than that of the utmost intensity group (P was 0.001, 0 respectively). Utmost and moderate endurance training results in altered sympathetic and parasympathetic balance towards sympathetic dominance and parasympathetic dominance respectively;whereas high intensity endurance training almost has no effect on ANS function. CPT and HUTT reveal the potential danger posed by utmost intensity endurance training.
文摘Overseas three-month intra-university training program is rear in Yunnan,China.Using adult learning and social con-structivism as theoretical basis,the author,introduces the background of the program and the course design,highlighting the inten-tion for the program and similar programs.
文摘Background Stable angina pectoris is a common subtype of coronary heart disease.Patients suffer from chest tightness,chest pain and crushing pain under the inducement of fatigue and emotional agitation.This study aims to investigate the effect of exercise training guidance based on action research on exercise endurance and readmission rate of patients with stable angina pectoris.Methods A retrospective study was conducted on 60 patients with stable angina pectoris due to coronary heart disease admitted to our hospital from February 2020 to November 2023.Patients were divided into a control group of 29 cases(receiving conventional exercise training guidance)and a guidance group of 31 cases(receiving action research-based exercise training guidance).Both groups received continuous training for one month.A comparison was made between the exercise endurance indicators[6-minute walk test distance(6MWT),peak oxygen consumption(peak VO2),anaerobic threshold(AT),exercise duration(ED)],quality of life,and readmission rate within 6 months after intervention in both groups.Results After 1 month of intervention,6MWT,peak VO2,AT and ED were increased in both groups,and those in the guidance group were higher than those in the conventional group(P<0.05).The score of quality of life(The 36-item shot-form health status survey,SF-36)in both groups was increased,and the guidance group scored higher than the conventional group(P<0.05).The readmission rate of patients in the guidance group was 6.45%,which was lower than that in the conventional group(27.59%)(P<0.05).Conclusions The application of action research-based exercise training guidance in patients with stable angina pectoris due to coronary heart disease has significant effects,improving exercise endurance,significantly improving quality of life,and reducing readmission rate,thus having practical value.[S Chin J Cardiol 2024;25(3):162-168]
文摘Objective To evaluate the short-term effect of pelvic floor muscle rehabilitation training under the guidance of doctors on children with neuropathic acontractile sphincter incontinence ( NASI) . Methods Sixty-eighty children ( aged 4 - 12 mean,7) years with NASI
基金Ministry of Health of the Czech Republic(University Hospital Brno,65269705),No.NU21J-09-00004.
文摘BACKGROUND The prevalence of chronic obstructive pulmonary disease(COPD)is increasing worldwide,and at the same time it is associated with increased mortality and reduced quality of life.Efforts to build sustainable rehabilitation approaches to COPD treatment and prevention are crucial.The system of long-term pulmonary rehabilitation care is insufficient.The main reasons for the absence of these outpatient programs are the lack of experience,the lack of interest of insurance companies in secondary prevention programs,and the lack of healthcare facilities in large geographical areas.The possibility of at-home pulmonary rehabilitation models(telemonitoring and telecoaching)could solve this problem.CASE SUMMARY A 71-year-old man with severe COPD,Global Initiative for Obstructive Lung Diseases stage 3 underwent an 8-wk remotely monitored inspiratory muscle training with a device based on the test of incremental respiratory endurance method.Spirometry,body plethysmography,test of incremental respiratory endurance examination,6-min walking test,body mass index,airflow obstruction,dyspnea,exercise capacity index,and subjective perception of dyspnea were performed as part of the initial and final examination.The patient performed training at home,and the physiotherapist monitored the patient remotely through a web application that allowed the physiotherapist to evaluate all training parameters in real-time and respond to any problems.After 8 wk of home training,there was a significant increase in all monitored values:maximal inspiratory pressure,a novel parameter sustained maximal inspiratory pressure,forced expiratory volume in 1 s,total lung capacity,forced vital capacity,peak expiratory flow,and inspiratory capacity.There was also an improvement in the perception of dyspnea according to the COPD Assessment Test and a modified Medical Research Council Breathlessness Scale,an increase in exercise tolerance according to the 6-min walking test,and a decrease in the exercise capacity index as a predictor of prognosis.CONCLUSION Respiratory telerehabilitation was greatly beneficial in a cooperative patient with COPD and may represent an alternative therapeutic approach to the increasing incidence of all lung diseases.
文摘BACKGROUND: Plyometric training has been shown to improve performance in distance running events up to 5-km, but little research has been done on this type of training for marathon (42.195-km) runners. The purpose of this study was to examine the effects of plyometric and explosive speed training (PLYO) on recreational marathoners. METHODS: Twenty-two subjects (ages 18-23), were randomized to either PLYO or core training (CORE) for a weekly session performed for 12 weeks, in addition to marathon training. Sprint, jump, and distance running performance variables were measured pre- and post-intervention. RESULTS: In the sprint tests, the PLYO group improved in both the 200-m run (P ≤ 0.001) and 60-m run (P = 0.004), and trended toward improvement in the 30-m fly (P = 0.051). The difference from CORE was significant only in the 200-m (P = 0.002). The CORE group did not change in any of the sprint or jump variables. The PLYO group was significantly different from the CORE group in the standing long jump (P = 0.024). There were no differences between groups in distance running performance. Both improved in 2-mile (3.219-km) time trial (p 〈 0.001), VO2MAX (P = 0.026 for CORE; P = 0.002 for PLYO), and running economy (P = 0.01). CONCLUSION: Weekly PLYO training improves sprint speed and maintains jumping ability in recreational marathoners, but does not augment improvements in distance running performance.
基金Natural Science Fund Project of Shaanxi Provincial Education Department(No.12JK0707)regular project of Shaanxi Provincial Sports Bureau(No.2019029).
文摘Objective:To explore the clinical effect of long-term aerobic exercise combined with resistance training in patients with myocardial ischemia caused by coronary heart disease and its influence on cardiac function, exercise endurance and quality of life. Methods:100 patients with myocardial ischemia caused by coronary heart disease from January 2017 to January 2019 were randomly divided into control group (n = 50 cases) and observation group (n = 50 cases). The control group was given resistance training, while the observation group was combined with long-term aerobic exercise on the basis of the control group. The two groups were treated for 3 months. The cardiac function, exercise endurance and quality of life were compared between the two groups. Results:The levels of IVST (8.20+1.32) mm, LVDD (46.43+4.13) mm and LVSD (32.59+3.15) mm in the observation group were lower than those in the control group at 3 months after treatment. The level of LVEF (67.49+5.77)% in the observation group was higher than that in the control group at 3 months after treatment. The difference between the two groups was significant (P<0.05). The ET (55.42+2.9) in the observation group was higher than that in the control group (P<0.05). 2) The levels of ng/L and TXB2 (93.23 + 6.26) ng/L were significantly lower than those of the control group, and the difference between the two groups was statistically significant (P<0.05). The 6-minute walking distance (561.25 +43.64) m and the quality of life score (95.31 +6.39) in the observation group were higher than those in the control group 3 months after treatment, and the difference between the two groups was statistically significant (P<0.05). Conclusions:Long-term aerobic exercise combined with resistance training can improve cardiac function, exercise tolerance and quality of life in patients with myocardial ischemia caused by coronary heart disease, which is worthy of popularization and application.
文摘目的探讨呼吸训练对痉挛型四肢瘫(spastic quadriplegia,SP)患儿步行耐力及平衡能力的影响。方法选取2021年11月至2023年11月中国康复研究中心北京博爱医院SP患儿60例,随机分为对照组(n=30)与试验组(n=30)。对照组接受常规康复训练(60 min/次),试验组接受常规康复训练(40 min/次)和呼吸训练(20 min/次);两组训练频率为1次/d,5 d/周,连续4周。分别采用10米步行测试(10-meter work test,10MWT)速度、6分钟步行测试(6-minute walk test,6MWT)距离、Berg平衡量表(Berg balance scale,BBS)评分和肺活量(vital capacity,VC)、用力肺活量(forced vital capacity,FVC)、1秒用力呼气量(forced expiratory volume in first second,FEV1)、呼气峰值流速(peak expiratory flow,PEF)评估患儿训练前后步行耐力、平衡能力和肺功能。结果60例患儿中,男31例、女29例,年龄6~12岁,平均(9.0±1.7)岁。两组性别、年龄、粗大运动功能分级系统(gross motor function classification system,GMFCS)的比较,差异均无统计学意义(P>0.05)。训练4周后,两组患儿的6MWT距离、BBS评分、10MWT速度、FVC、FEV1、PEF均高于训练前,且试验组均高于对照组,差异有统计学意义(P<0.05)。结论呼吸训练能有效改善SP患儿的步行耐力、平衡能力,提高肺功能,增强有氧运动的耐力,降低跌倒风险,提高日常生活质量。