Organophosphorus flame retardants(OPFRs) are gradually replacing brominated flame retardants(BFRs), which are widely used in the world. The increasing output of OPFRs and the increasing detection of OPFRs in environme...Organophosphorus flame retardants(OPFRs) are gradually replacing brominated flame retardants(BFRs), which are widely used in the world. The increasing output of OPFRs and the increasing detection of OPFRs in environmental media have attracted wide attention of scholars at home and abroad. OPFRs are generally semi-volatile, easy to enter the environment and accumulate in organisms,causing potential hazards to the environment and human health. In this paper, the pollution status and toxic effects of OPFRs in aquatic environment were introduced,and the research progress of human health risk caused by them was summarized.The existing problems were pointed out, and the future research was prospected. In the future, the analytical methods of various environmental and biological media should be improved, and comprehensive and in-depth environmental investigation and ecological and health risk assessment should be carried out. Attention should be paid to the effects of combined pollution on organisms and the study of biological acceptability.展开更多
Alterations in the respiratory epithelium of gills of a catfish, Heteropneustes fossilis by the sublethal and lethal concentrations of HgCl2 have been observcd using scanning electron microscope. Fish exposed to 0.1 ...Alterations in the respiratory epithelium of gills of a catfish, Heteropneustes fossilis by the sublethal and lethal concentrations of HgCl2 have been observcd using scanning electron microscope. Fish exposed to 0.1 ppm shows a thin coat ot mucus, but the continuous layer of mucus is not retained in 0.3 ppm after 24 h of exposure. Epithelial cells of the gill filament are hyperplastic. Other changcs in the respiratory epithelium are contraction of epithelium, formation of interlamellar bridge and diminishing number of microridges. Massive destruction of the respiratory epithelium by deep lesions and sloughing of epithelial layer in 0.5 and 1.0 ppm solutions after 6-12 h of exposure apparently causes death to the fish. SEM observations are well in conformity with the findings made at light microscopic level展开更多
Histopathological effects of sublethal (0.1, 0.2, 0.3 ppm) and lethal (0.5, 1.0 ppm)solutions of mercuric chloride (HgCl2) have been studied on the gills of the air breathing catfish, Heteropneustes fossilis at the in...Histopathological effects of sublethal (0.1, 0.2, 0.3 ppm) and lethal (0.5, 1.0 ppm)solutions of mercuric chloride (HgCl2) have been studied on the gills of the air breathing catfish, Heteropneustes fossilis at the intervals ranging from 6h to 15 days. Thickening of the epithelium, swelling and hyperplasia of the mucous cells, fusion of secondary lamellae, formation of interlamellar bridge and deposition of mucous over the entire surface are some noteworthy features of mercury poisoning in sublethal concentrations. Acute pathological manifestations are formation of subepithelial space, sloughing of the epithelial layer, hemorrhage and hypertrophy of the mucous cells. Causes and impact of these cellular alterations affecting survival of the fish have been discussed展开更多
Benzophenone ultraviolet light filters(BPs)are high-production-volume chemicals extensively used in personal care products,leading to widespread human exposure.Given their estrogenic properties,the potential health ri...Benzophenone ultraviolet light filters(BPs)are high-production-volume chemicals extensively used in personal care products,leading to widespread human exposure.Given their estrogenic properties,the potential health risks associated with exposure to BPs have become a public health concern.This review aims to summarize sources and pathways of exposure to BPs and associated health risks.Dermal exposure,primarily through the use of sunscreens,constitutes a major pathway for BP exposure.At a recommended application rate,dermal exposure of BP-3 via the application of sunscreens may reach or exceed the suggested reference dose.Other exposure pathways to BPs,such as drinking water,seafood,and packaged foods,contribute minimal to the overall dose.Inhalation is a minor pathway of exposure;however,its contribution cannot be ignored.Human exposure to BPs is an order of magnitude higher in North America than in Asia and Europe.Studies conducted on laboratory animals and cells have consistently demonstrated the toxic effects of BP exposure.BPs are estrogenic and elicit reproductive and developmental toxicities.Furthermore,neurotoxicity,hepatotoxicity,nephrotoxicity,and carcinogenicity have been reported from chronic BP exposure.In addition to animal and cell studies,epidemiological investigations have identified associations between BPs and couples'fecundity and other reproductive disorders,as well as adverse birth outcomes.Further studies are urgently needed to understand the risks posed by BPs on human health.展开更多
Objective To verify the health advisory for short-term exposure to phenol.Methods The method of this validation experiment was the same as the US Environmental Protection Agency(EPA)methodology for toxicology experime...Objective To verify the health advisory for short-term exposure to phenol.Methods The method of this validation experiment was the same as the US Environmental Protection Agency(EPA)methodology for toxicology experiments used to determine phenol drinking water equivalent level(DWEL).Pregnant female Sprague-Dawley rats were administered phenol in distilled water by gavage at daily doses of 15,30,60,120,and 240 mg/kg body weight(b.w.)from implantation(the 6 th day post-mating)to the day prior to the scheduled caesarean section(the 20th day of pregnancy).The following information was recorded:general behavior;body weight;number of corpus luteum,live birth,fetus,stillbirth,and implantation;fetal gender;body weight;body length;tail length;and abnormalities and pathomorphological changes in the dams.Results In the 60 mg/kg b.w.dose group,the mortality of pregnant rats increased with increasing doses,suggesting maternal toxicity.Fetal and placental weights decreased as phenol dose increased from30 mg/kg b.w.,and were significantly different compared those in the vehicle control group,which suggested developmental toxicity in the fetuses.However,the phenol-exposed groups showed no significant change in other parameters compared with the vehicle control group(P>0.05).Conclusion Despite using the same method as the US EPA,a different NOEAL of 15 mg/(kg·d)was obtained in this study.展开更多
In May 2018,the primetime news casted a shocking report saying that radon concentration on a certain model of bed mattress found to be as high as 2200 Bq/m3.After a humble,the Nuclear Safety and Security Commission(NS...In May 2018,the primetime news casted a shocking report saying that radon concentration on a certain model of bed mattress found to be as high as 2200 Bq/m3.After a humble,the Nuclear Safety and Security Commission(NSSC)of Korea confirmed that significant amount of thoron gas is emanated from several mattress models marketed by a company claiming beneficial health effects of negative ions.Laboratory analysis showed that some internal fabric sheets of those mattresses contain high concentration of Th-232.It was revealed that the manufacture treated the material with so-called‘negative ion powder’procured from the market and NSSC found that its radioactive content is the monazite powder.Although measurements with reliable instruments resulted in somewhat lower values,the tentative but conservative estimates of doses to the users are still remarkable,ranging from a few to 14 mSv a year.Most of the affected models have been marketed from 2010 but earlier models,with lower thorium content,were supplied from 2006.As many as 88,000 mattresses have been produced.The manufacturer with help of the government,recalled all the affected models and separated the radioactive internals.A large amount of waste is waiting for the government decision on disposal method.Similar problems were identified in other consumer products including latex mattresses and pillows imported,hot pads,and several models of sanitary or health-aid goods.These episodes called for revisiting NORM control strategy in Korea.展开更多
Air pollution, both indoor and outdoor, has been found to be related to serious adverse health effects. Accurate estimation of air pollution exposure has become very important to suggest proper air pollution control p...Air pollution, both indoor and outdoor, has been found to be related to serious adverse health effects. Accurate estimation of air pollution exposure has become very important to suggest proper air pollution control policies and to further assess the effectiveness of these policies. In many instances, personal exposures have been found to be greater than concentrations measured at fixed site monitoring stations. As people spend most of their time indoors particularly during harsh weather conditions, it is necessary to consider indoor air quality in exposure assessment studies. The current paper focuses on the importance of personal exposure assessment based on spatial and temporal activity patters both indoors and outdoors.展开更多
In indoor environment, emission factor of the cooking fuel plays a vital role in determining correlation between exposure assessment and health effects. Both indoor and outdoor air pollution exposures are widely influ...In indoor environment, emission factor of the cooking fuel plays a vital role in determining correlation between exposure assessment and health effects. Both indoor and outdoor air pollution exposures are widely influenced by the ventilation status. An optimum control of the air change rate has also significant impact on the exposure pattern. A number of studies revealed that the indoor particulates and gaseous exposures, resulting from the combustion of various cooking fuels, are associated with significant adverse health effects on pregnant mothers and new born babies. The impacts of ventilation status on air pollution exposure in households’ kitchens or living rooms have not been explored enough. Except a few studies with concrete rooms, especially in industries, no other studies have been established on the correlation between the ventilation index and air pollution exposure. The intent of this review is to discuss reported findings focused on the ventilation and exposure to air pollution. This will obviously help better understanding to modulate exposure profile in household condition using simple tool of ventilation measurement.展开更多
Micro-and nano-plastics(MNPs)pollution has become a pressing global environmental issue,with growing concerns regarding its impact on human health.However,evidence on the effects of MNPs on human health remains limite...Micro-and nano-plastics(MNPs)pollution has become a pressing global environmental issue,with growing concerns regarding its impact on human health.However,evidence on the effects of MNPs on human health remains limited.This paper reviews the three routes of human exposure to MNPs,which include ingestion,inhalation,and dermal contact.It further discusses the potential routes of translocation of MNPs in human lungs,intestines,and skin,analyses the potential impact of MNPs on the homeostasis of human organ systems,and provides an outlook on future research priorities for MNPs in human health.There is growing evidence that MNPs are present in human tissues or fluids.Lab studies,including in vivo animal models and in vitro human-derived cell cultures,revealed that MNPs exposure could negatively affect human health.MNPs exposure could cause oxidative stress,cytotoxicity,disruption of internal barriers like the intestinal,the air–blood and the placental barrier,tissue damage,as well as immune homeostasis imbalance,endocrine disruption,and reproductive and developmental toxicity.Limitedly available epidemiological studies suggest that disorders like lung nodules,asthma,and blood thrombus might be caused or exacerbated by MNPs exposure.However,direct evidence for the effects of MNPs on human health is still scarce,and future research in this area is needed to provide quantitative support for assessing the risk of MNPs to human health.展开更多
Objective To investigate the effect of occupational exposure to coal tar pitch on workers’health and metabolism.Methods 805 workers exposed to coal tar pitch were selected as exposure group from the factory.Other peo...Objective To investigate the effect of occupational exposure to coal tar pitch on workers’health and metabolism.Methods 805 workers exposed to coal tar pitch were selected as exposure group from the factory.Other people handle administrative and logistical affairs who not exposed to coal tar pitch were selected as control group.展开更多
Recent research indicates that the human infertility rate is increasing. Although various reasons have been hypothesized for the growing infertility rate, environmental contaminants are potentially important causal ag...Recent research indicates that the human infertility rate is increasing. Although various reasons have been hypothesized for the growing infertility rate, environmental contaminants are potentially important causal agents associated with this change.Chemical contaminants are widespread throughout our environment and human exposure is virtually unavoidable. The overall contribution of environmental exposure to infertility is unknown, but studies involving occupational exposure, together with results from animal experiments, suggest that environmental contaminants may adversely affect fertility. We reviewed the adverse effects of environmental exposure on fertility and related reproductive outcomes. Environmental contaminants covered in this review include heavy metals, organic solvents, pesticides and endocrine disrupting chemicals. It is hoped that this review will highlight the need for further research in this area.展开更多
基金Supported by National Science and Technology Major Project of China(2017ZX07202004)~~
文摘Organophosphorus flame retardants(OPFRs) are gradually replacing brominated flame retardants(BFRs), which are widely used in the world. The increasing output of OPFRs and the increasing detection of OPFRs in environmental media have attracted wide attention of scholars at home and abroad. OPFRs are generally semi-volatile, easy to enter the environment and accumulate in organisms,causing potential hazards to the environment and human health. In this paper, the pollution status and toxic effects of OPFRs in aquatic environment were introduced,and the research progress of human health risk caused by them was summarized.The existing problems were pointed out, and the future research was prospected. In the future, the analytical methods of various environmental and biological media should be improved, and comprehensive and in-depth environmental investigation and ecological and health risk assessment should be carried out. Attention should be paid to the effects of combined pollution on organisms and the study of biological acceptability.
文摘Alterations in the respiratory epithelium of gills of a catfish, Heteropneustes fossilis by the sublethal and lethal concentrations of HgCl2 have been observcd using scanning electron microscope. Fish exposed to 0.1 ppm shows a thin coat ot mucus, but the continuous layer of mucus is not retained in 0.3 ppm after 24 h of exposure. Epithelial cells of the gill filament are hyperplastic. Other changcs in the respiratory epithelium are contraction of epithelium, formation of interlamellar bridge and diminishing number of microridges. Massive destruction of the respiratory epithelium by deep lesions and sloughing of epithelial layer in 0.5 and 1.0 ppm solutions after 6-12 h of exposure apparently causes death to the fish. SEM observations are well in conformity with the findings made at light microscopic level
文摘Histopathological effects of sublethal (0.1, 0.2, 0.3 ppm) and lethal (0.5, 1.0 ppm)solutions of mercuric chloride (HgCl2) have been studied on the gills of the air breathing catfish, Heteropneustes fossilis at the intervals ranging from 6h to 15 days. Thickening of the epithelium, swelling and hyperplasia of the mucous cells, fusion of secondary lamellae, formation of interlamellar bridge and deposition of mucous over the entire surface are some noteworthy features of mercury poisoning in sublethal concentrations. Acute pathological manifestations are formation of subepithelial space, sloughing of the epithelial layer, hemorrhage and hypertrophy of the mucous cells. Causes and impact of these cellular alterations affecting survival of the fish have been discussed
基金supported by the Natural Science Foundation of China(No.22022612,and No.21677184)Natural Science Foundation of Guangdong Province,China(No.2020A0104006 and No.2021A1515010243)+1 种基金the Fundamental Research Funds for the Central Universitiessupported,in part,by the National Institute of Environmental Health Sciences(NIEHS)under award number U2CES026542(KK).
文摘Benzophenone ultraviolet light filters(BPs)are high-production-volume chemicals extensively used in personal care products,leading to widespread human exposure.Given their estrogenic properties,the potential health risks associated with exposure to BPs have become a public health concern.This review aims to summarize sources and pathways of exposure to BPs and associated health risks.Dermal exposure,primarily through the use of sunscreens,constitutes a major pathway for BP exposure.At a recommended application rate,dermal exposure of BP-3 via the application of sunscreens may reach or exceed the suggested reference dose.Other exposure pathways to BPs,such as drinking water,seafood,and packaged foods,contribute minimal to the overall dose.Inhalation is a minor pathway of exposure;however,its contribution cannot be ignored.Human exposure to BPs is an order of magnitude higher in North America than in Asia and Europe.Studies conducted on laboratory animals and cells have consistently demonstrated the toxic effects of BP exposure.BPs are estrogenic and elicit reproductive and developmental toxicities.Furthermore,neurotoxicity,hepatotoxicity,nephrotoxicity,and carcinogenicity have been reported from chronic BP exposure.In addition to animal and cell studies,epidemiological investigations have identified associations between BPs and couples'fecundity and other reproductive disorders,as well as adverse birth outcomes.Further studies are urgently needed to understand the risks posed by BPs on human health.
基金supported by the National Natural Science Foundation of China No.21806157National Water Pollution Control and Management Technology Major Projects No.2015ZX07402002。
文摘Objective To verify the health advisory for short-term exposure to phenol.Methods The method of this validation experiment was the same as the US Environmental Protection Agency(EPA)methodology for toxicology experiments used to determine phenol drinking water equivalent level(DWEL).Pregnant female Sprague-Dawley rats were administered phenol in distilled water by gavage at daily doses of 15,30,60,120,and 240 mg/kg body weight(b.w.)from implantation(the 6 th day post-mating)to the day prior to the scheduled caesarean section(the 20th day of pregnancy).The following information was recorded:general behavior;body weight;number of corpus luteum,live birth,fetus,stillbirth,and implantation;fetal gender;body weight;body length;tail length;and abnormalities and pathomorphological changes in the dams.Results In the 60 mg/kg b.w.dose group,the mortality of pregnant rats increased with increasing doses,suggesting maternal toxicity.Fetal and placental weights decreased as phenol dose increased from30 mg/kg b.w.,and were significantly different compared those in the vehicle control group,which suggested developmental toxicity in the fetuses.However,the phenol-exposed groups showed no significant change in other parameters compared with the vehicle control group(P>0.05).Conclusion Despite using the same method as the US EPA,a different NOEAL of 15 mg/(kg·d)was obtained in this study.
文摘In May 2018,the primetime news casted a shocking report saying that radon concentration on a certain model of bed mattress found to be as high as 2200 Bq/m3.After a humble,the Nuclear Safety and Security Commission(NSSC)of Korea confirmed that significant amount of thoron gas is emanated from several mattress models marketed by a company claiming beneficial health effects of negative ions.Laboratory analysis showed that some internal fabric sheets of those mattresses contain high concentration of Th-232.It was revealed that the manufacture treated the material with so-called‘negative ion powder’procured from the market and NSSC found that its radioactive content is the monazite powder.Although measurements with reliable instruments resulted in somewhat lower values,the tentative but conservative estimates of doses to the users are still remarkable,ranging from a few to 14 mSv a year.Most of the affected models have been marketed from 2010 but earlier models,with lower thorium content,were supplied from 2006.As many as 88,000 mattresses have been produced.The manufacturer with help of the government,recalled all the affected models and separated the radioactive internals.A large amount of waste is waiting for the government decision on disposal method.Similar problems were identified in other consumer products including latex mattresses and pillows imported,hot pads,and several models of sanitary or health-aid goods.These episodes called for revisiting NORM control strategy in Korea.
文摘Air pollution, both indoor and outdoor, has been found to be related to serious adverse health effects. Accurate estimation of air pollution exposure has become very important to suggest proper air pollution control policies and to further assess the effectiveness of these policies. In many instances, personal exposures have been found to be greater than concentrations measured at fixed site monitoring stations. As people spend most of their time indoors particularly during harsh weather conditions, it is necessary to consider indoor air quality in exposure assessment studies. The current paper focuses on the importance of personal exposure assessment based on spatial and temporal activity patters both indoors and outdoors.
文摘In indoor environment, emission factor of the cooking fuel plays a vital role in determining correlation between exposure assessment and health effects. Both indoor and outdoor air pollution exposures are widely influenced by the ventilation status. An optimum control of the air change rate has also significant impact on the exposure pattern. A number of studies revealed that the indoor particulates and gaseous exposures, resulting from the combustion of various cooking fuels, are associated with significant adverse health effects on pregnant mothers and new born babies. The impacts of ventilation status on air pollution exposure in households’ kitchens or living rooms have not been explored enough. Except a few studies with concrete rooms, especially in industries, no other studies have been established on the correlation between the ventilation index and air pollution exposure. The intent of this review is to discuss reported findings focused on the ventilation and exposure to air pollution. This will obviously help better understanding to modulate exposure profile in household condition using simple tool of ventilation measurement.
基金This research was funded by the National Natural Science Foundation of China(22241602,41991330,and 42177039)Funding by the European Commission within the Horizon Europe funded project Plasticsfate(grant agreement number 965367)is kindly acknowledged.
文摘Micro-and nano-plastics(MNPs)pollution has become a pressing global environmental issue,with growing concerns regarding its impact on human health.However,evidence on the effects of MNPs on human health remains limited.This paper reviews the three routes of human exposure to MNPs,which include ingestion,inhalation,and dermal contact.It further discusses the potential routes of translocation of MNPs in human lungs,intestines,and skin,analyses the potential impact of MNPs on the homeostasis of human organ systems,and provides an outlook on future research priorities for MNPs in human health.There is growing evidence that MNPs are present in human tissues or fluids.Lab studies,including in vivo animal models and in vitro human-derived cell cultures,revealed that MNPs exposure could negatively affect human health.MNPs exposure could cause oxidative stress,cytotoxicity,disruption of internal barriers like the intestinal,the air–blood and the placental barrier,tissue damage,as well as immune homeostasis imbalance,endocrine disruption,and reproductive and developmental toxicity.Limitedly available epidemiological studies suggest that disorders like lung nodules,asthma,and blood thrombus might be caused or exacerbated by MNPs exposure.However,direct evidence for the effects of MNPs on human health is still scarce,and future research in this area is needed to provide quantitative support for assessing the risk of MNPs to human health.
文摘Objective To investigate the effect of occupational exposure to coal tar pitch on workers’health and metabolism.Methods 805 workers exposed to coal tar pitch were selected as exposure group from the factory.Other people handle administrative and logistical affairs who not exposed to coal tar pitch were selected as control group.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB14010300)the Beijing Municipal Science and Technology Commission(No.Z151100004015167)+1 种基金the Beijing Municipal Health Technology High-level Talent Project(No.2014-3-076)the Open fund of State Key Laboratory of Environmental Chemistry and Ecotoxicology(No.KF-2017-13)
文摘Recent research indicates that the human infertility rate is increasing. Although various reasons have been hypothesized for the growing infertility rate, environmental contaminants are potentially important causal agents associated with this change.Chemical contaminants are widespread throughout our environment and human exposure is virtually unavoidable. The overall contribution of environmental exposure to infertility is unknown, but studies involving occupational exposure, together with results from animal experiments, suggest that environmental contaminants may adversely affect fertility. We reviewed the adverse effects of environmental exposure on fertility and related reproductive outcomes. Environmental contaminants covered in this review include heavy metals, organic solvents, pesticides and endocrine disrupting chemicals. It is hoped that this review will highlight the need for further research in this area.
