Objective To study the relationship between traditional Chinese medicine (TCM) syndrome and serum level of IGF 1 and IGFBP 3 in patients with acute cerebral infarction (ACI).Methods 75 patients of ACI were divided int...Objective To study the relationship between traditional Chinese medicine (TCM) syndrome and serum level of IGF 1 and IGFBP 3 in patients with acute cerebral infarction (ACI).Methods 75 patients of ACI were divided into two groups by TCM`s syndrome differentiation: apolexy involving the channels (AIC) and apolexy involving the viscera (AIV).Serum level of IGF 1 and IGFBP 3 was detected by ELISA di antibody clipping technique (DACT) and was compared with that of 30 normal controls.Results Serum level of IGF 1 and IGFBP 3 in AIC group and AIV group were significantly different from control groups;and differences between AIC group and AIV group were statistically significant.Serum level of IGF 1 and IGFBP 3 in all syndromes of AIC group and AIV group were remarkably lower than control group.Among them,syndrome of Yin deficiency of liver and kidney and sthenia liver yang and syndrome of blood stasis due to Qi deficiency had lower serum level of IGF 1 and IGFBP 3 than syndrome of empty and obstruction of channel.So did collapse syndrome and syndrome of mental disorder due to phlegm fire to syndrome of wind fire evil lucid orifices and block Yin syndrome.Conclusion There are to some extent correlation with TCM’s Syndrome and serum level of IGF 1 and IGFBP 3 in patients with ACI. Serum level of IGF 1 and IGFBP 3 might be microcosmic referent markers of the damage of Qi and Yin by TCM`s syndrome differentiation.展开更多
Objective:To establish a diagnostic system for heat toxin syndrome of acute cerebral infarction.Based on this toxin syndrome diagnostic system,the general principles of heat toxin development will be uncovered,and the...Objective:To establish a diagnostic system for heat toxin syndrome of acute cerebral infarction.Based on this toxin syndrome diagnostic system,the general principles of heat toxin development will be uncovered,and the critical turning point at which the heat toxin syndrome occurs will also be explored.Methods:In this study,a total of 271 hypertension patients with cerebral infarction within 72 h were recruited from the Affiliated Dongfang Hospital of the Beijing University of Chinese Medicine,the Affiliated Dongzhimen Hospital of Beijing University of Chinese Medicine,the Affiliated Renmin Hospital of Peking University,the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,the Affiliated Hospital of Changchun University of Traditional Chinese Medicine,the Affiliated Hospital of Hebei University of Traditional Chinese Medicine and China Meitan General Hospital from August,2008,to December,2009.The patients’Chinese medical information was recorded on days 1,3,5,7,and 14 during their hospitalizations.The medical records were recorded according to traditional Chinese medicine(TCM)theory and included the serum marker levels at the beginning and at the end of the trial.The time line was also analyzed.Results:The level of Hs-CRP,PAG,NSE,OX-LDL,and MMP-9 were abnormal and,were higher in CI patients compared to hypertension patients.In the study of the heat toxin diagnosis system,according to the entropy clustering results,30 combinations of the medical information can be sorted into the traditional syndromes,but 13 combinations cannot be sorted.To obtain more precise symptoms related to the heat toxins,a logistic regression equation was set up with the variables from the unsorted medical information;the dependent variables were fever and BP fluctuation.Weighted variables were obtained.MLP analysis demonstrated that the diagnosis model was stable and precise.The accuracy reached 83.82%.The ROC test showed that seven points of the diagnosis system was the best cutting point,with a sensitivity of 0.857 and a specificity of 0.955.Progressing stroke was related to heat toxin syndrome.When the turning point appeared,the combination of symptoms,such as coma,aphasia,gummy eyes,and halitosis,predicted the deterioration or recovery of CI.The heat toxin syndrome existed in every subtype of CI;however,the observed heat toxin levels were highest in PACI and lowest in LACI.Meanwhile,blood and sputum stasis syndromes transformed into heat toxicity were one source of heat toxin syndrome.Conclusion:Heat toxin syndrome,as well as qi/blood/sputum stasis,co-existed in the CI patients,and the transformation frequently appeared during the process.Three to five days after the onset of CI was the turning point,at which time several combinations of medical indicators make it possible to predict the development of CI.展开更多
目的:观察半夏白术天麻汤加减联合康复训练对风痰瘀阻型急性脑梗死合并H型高血压患者神经功能及生活质量的影响。方法:将182例风痰瘀血型急性脑梗死合并H型高血压患者按照随机数字表法分为对照组和观察组,每组各91例。两组均接受西医基...目的:观察半夏白术天麻汤加减联合康复训练对风痰瘀阻型急性脑梗死合并H型高血压患者神经功能及生活质量的影响。方法:将182例风痰瘀血型急性脑梗死合并H型高血压患者按照随机数字表法分为对照组和观察组,每组各91例。两组均接受西医基础治疗,对照组给予康复训练治疗,观察组在对照组治疗的基础上联合半夏白术天麻汤加减。比较两组患者的临床疗效及治疗前后中医证候积分、美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分、世界卫生组织生活质量评定简表(world health organization quality of life-bref,WHOQOL-BREF)评分、收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)、同型半胱氨酸(homocysteine,Hcy)水平变化情况。结果:观察组有效率为94.51%,明显高于对照组的75.82%,差异具有统计学意义(P<0.05)。两组患者治疗后中医证候积分、NIHSS评分低于本组治疗前,WHOQOL-BREF评分高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后HCY、SBP、DBP水平低于本组治疗前,且观察组治疗后低于对照组(P<0.05)。结论:半夏白术天麻汤加减结合康复训练治疗风痰瘀阻型急性脑梗死合并H型高血压,临床疗效确切,可促进患者神经功能的恢复,提高患者的生活质量。展开更多
目的 探讨扶阳急救汤加减治疗急性脑梗死患者的疗效及对患者中医证候评分、卒中量表评分和凝血功能的影响。方法 将2020年6月—2022年6月安徽中医药大学附属太和中医院收治的120例急性脑梗死患者随机等分为观察组和对照组。对照组给予...目的 探讨扶阳急救汤加减治疗急性脑梗死患者的疗效及对患者中医证候评分、卒中量表评分和凝血功能的影响。方法 将2020年6月—2022年6月安徽中医药大学附属太和中医院收治的120例急性脑梗死患者随机等分为观察组和对照组。对照组给予抗血小板聚集等治疗措施,观察组在此基础上联合扶阳急救汤加减治疗。两组均持续治疗2周。比较两组患者的临床疗效、中医证候评分、美国国立卫生研究院卒中量表(National Institute of Health stroke scale, NIHSS)评分、凝血功能及3个月后改良RANKIN量表(Modified Rankin Scale, mRS)评分。结果 治疗后,观察组总有效率较高(P<0.05)。治疗1周、2周后,两组中医证候主证、次证、总积分和NIHSS评分逐渐明显降低(P<0.05),且观察组显著低于对照组(P<0.05)。治疗2周后,对照组凝血酶原时间(Prothrombin time, PT)、活化的部分凝血活酶时间(Activated partial thromboplastin time, APTT)、纤维蛋白原(Fibrinogen, FIB)、凝血酶时间(Thrombin time, TT)水平较治疗前差异无统计学意义(P>0.05),观察组PT、TT水平较治疗前差异无统计学意义(P>0.05),APTT及FIB水平则明显降低(P<0.05),且显著低于对照组(P<0.05)。治疗后3个月,观察组mRS评分显著低于对照组(P<0.05)。结论 扶阳急救汤加减治疗可以更好地促进痰瘀阻络证型急性脑梗死患者神经功能及中医证候的恢复,提高患者近期疗效及长期生活质量,且并未影响凝血功能,有较好的安全性,值得临床应用。展开更多
目的:观察中医辨证护理结合思维导图对急性脑梗死伴吞咽障碍患者康复效果的影响。方法:将60例急性脑梗死伴吞咽障碍患者随机分为A组(常规护理)和B组(常规护理加中医辨证护理及思维导图干预)各30例,干预1个月后比较两组患者美国国立卫生...目的:观察中医辨证护理结合思维导图对急性脑梗死伴吞咽障碍患者康复效果的影响。方法:将60例急性脑梗死伴吞咽障碍患者随机分为A组(常规护理)和B组(常规护理加中医辨证护理及思维导图干预)各30例,干预1个月后比较两组患者美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)、Barthel指数及并发症发生情况。结果:B组患者干预后NIHSS评分低于干预前及A组干预后(P<0.05),B组Barthel指数优于干预前及A组干预后(P<0.05);B组误吸及吸入性肺炎发生率低于A组(P<0.05)。结论:中医辨证护理结合思维导图干预有助于改善急性脑梗死伴吞咽障碍患者的神经功能,提高患者生活运动能力,降低相关并发症发生率。展开更多
文摘Objective To study the relationship between traditional Chinese medicine (TCM) syndrome and serum level of IGF 1 and IGFBP 3 in patients with acute cerebral infarction (ACI).Methods 75 patients of ACI were divided into two groups by TCM`s syndrome differentiation: apolexy involving the channels (AIC) and apolexy involving the viscera (AIV).Serum level of IGF 1 and IGFBP 3 was detected by ELISA di antibody clipping technique (DACT) and was compared with that of 30 normal controls.Results Serum level of IGF 1 and IGFBP 3 in AIC group and AIV group were significantly different from control groups;and differences between AIC group and AIV group were statistically significant.Serum level of IGF 1 and IGFBP 3 in all syndromes of AIC group and AIV group were remarkably lower than control group.Among them,syndrome of Yin deficiency of liver and kidney and sthenia liver yang and syndrome of blood stasis due to Qi deficiency had lower serum level of IGF 1 and IGFBP 3 than syndrome of empty and obstruction of channel.So did collapse syndrome and syndrome of mental disorder due to phlegm fire to syndrome of wind fire evil lucid orifices and block Yin syndrome.Conclusion There are to some extent correlation with TCM’s Syndrome and serum level of IGF 1 and IGFBP 3 in patients with ACI. Serum level of IGF 1 and IGFBP 3 might be microcosmic referent markers of the damage of Qi and Yin by TCM`s syndrome differentiation.
基金This work was supported by the National Basic Research Program of China(973 Program)under Grants No.2012CB518406 and 2006CB504805the National Science Foundation of China(Grant No.81173463).
文摘Objective:To establish a diagnostic system for heat toxin syndrome of acute cerebral infarction.Based on this toxin syndrome diagnostic system,the general principles of heat toxin development will be uncovered,and the critical turning point at which the heat toxin syndrome occurs will also be explored.Methods:In this study,a total of 271 hypertension patients with cerebral infarction within 72 h were recruited from the Affiliated Dongfang Hospital of the Beijing University of Chinese Medicine,the Affiliated Dongzhimen Hospital of Beijing University of Chinese Medicine,the Affiliated Renmin Hospital of Peking University,the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,the Affiliated Hospital of Changchun University of Traditional Chinese Medicine,the Affiliated Hospital of Hebei University of Traditional Chinese Medicine and China Meitan General Hospital from August,2008,to December,2009.The patients’Chinese medical information was recorded on days 1,3,5,7,and 14 during their hospitalizations.The medical records were recorded according to traditional Chinese medicine(TCM)theory and included the serum marker levels at the beginning and at the end of the trial.The time line was also analyzed.Results:The level of Hs-CRP,PAG,NSE,OX-LDL,and MMP-9 were abnormal and,were higher in CI patients compared to hypertension patients.In the study of the heat toxin diagnosis system,according to the entropy clustering results,30 combinations of the medical information can be sorted into the traditional syndromes,but 13 combinations cannot be sorted.To obtain more precise symptoms related to the heat toxins,a logistic regression equation was set up with the variables from the unsorted medical information;the dependent variables were fever and BP fluctuation.Weighted variables were obtained.MLP analysis demonstrated that the diagnosis model was stable and precise.The accuracy reached 83.82%.The ROC test showed that seven points of the diagnosis system was the best cutting point,with a sensitivity of 0.857 and a specificity of 0.955.Progressing stroke was related to heat toxin syndrome.When the turning point appeared,the combination of symptoms,such as coma,aphasia,gummy eyes,and halitosis,predicted the deterioration or recovery of CI.The heat toxin syndrome existed in every subtype of CI;however,the observed heat toxin levels were highest in PACI and lowest in LACI.Meanwhile,blood and sputum stasis syndromes transformed into heat toxicity were one source of heat toxin syndrome.Conclusion:Heat toxin syndrome,as well as qi/blood/sputum stasis,co-existed in the CI patients,and the transformation frequently appeared during the process.Three to five days after the onset of CI was the turning point,at which time several combinations of medical indicators make it possible to predict the development of CI.
文摘目的:观察半夏白术天麻汤加减联合康复训练对风痰瘀阻型急性脑梗死合并H型高血压患者神经功能及生活质量的影响。方法:将182例风痰瘀血型急性脑梗死合并H型高血压患者按照随机数字表法分为对照组和观察组,每组各91例。两组均接受西医基础治疗,对照组给予康复训练治疗,观察组在对照组治疗的基础上联合半夏白术天麻汤加减。比较两组患者的临床疗效及治疗前后中医证候积分、美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分、世界卫生组织生活质量评定简表(world health organization quality of life-bref,WHOQOL-BREF)评分、收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)、同型半胱氨酸(homocysteine,Hcy)水平变化情况。结果:观察组有效率为94.51%,明显高于对照组的75.82%,差异具有统计学意义(P<0.05)。两组患者治疗后中医证候积分、NIHSS评分低于本组治疗前,WHOQOL-BREF评分高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后HCY、SBP、DBP水平低于本组治疗前,且观察组治疗后低于对照组(P<0.05)。结论:半夏白术天麻汤加减结合康复训练治疗风痰瘀阻型急性脑梗死合并H型高血压,临床疗效确切,可促进患者神经功能的恢复,提高患者的生活质量。
文摘目的 探讨扶阳急救汤加减治疗急性脑梗死患者的疗效及对患者中医证候评分、卒中量表评分和凝血功能的影响。方法 将2020年6月—2022年6月安徽中医药大学附属太和中医院收治的120例急性脑梗死患者随机等分为观察组和对照组。对照组给予抗血小板聚集等治疗措施,观察组在此基础上联合扶阳急救汤加减治疗。两组均持续治疗2周。比较两组患者的临床疗效、中医证候评分、美国国立卫生研究院卒中量表(National Institute of Health stroke scale, NIHSS)评分、凝血功能及3个月后改良RANKIN量表(Modified Rankin Scale, mRS)评分。结果 治疗后,观察组总有效率较高(P<0.05)。治疗1周、2周后,两组中医证候主证、次证、总积分和NIHSS评分逐渐明显降低(P<0.05),且观察组显著低于对照组(P<0.05)。治疗2周后,对照组凝血酶原时间(Prothrombin time, PT)、活化的部分凝血活酶时间(Activated partial thromboplastin time, APTT)、纤维蛋白原(Fibrinogen, FIB)、凝血酶时间(Thrombin time, TT)水平较治疗前差异无统计学意义(P>0.05),观察组PT、TT水平较治疗前差异无统计学意义(P>0.05),APTT及FIB水平则明显降低(P<0.05),且显著低于对照组(P<0.05)。治疗后3个月,观察组mRS评分显著低于对照组(P<0.05)。结论 扶阳急救汤加减治疗可以更好地促进痰瘀阻络证型急性脑梗死患者神经功能及中医证候的恢复,提高患者近期疗效及长期生活质量,且并未影响凝血功能,有较好的安全性,值得临床应用。
文摘目的:观察中医辨证护理结合思维导图对急性脑梗死伴吞咽障碍患者康复效果的影响。方法:将60例急性脑梗死伴吞咽障碍患者随机分为A组(常规护理)和B组(常规护理加中医辨证护理及思维导图干预)各30例,干预1个月后比较两组患者美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)、Barthel指数及并发症发生情况。结果:B组患者干预后NIHSS评分低于干预前及A组干预后(P<0.05),B组Barthel指数优于干预前及A组干预后(P<0.05);B组误吸及吸入性肺炎发生率低于A组(P<0.05)。结论:中医辨证护理结合思维导图干预有助于改善急性脑梗死伴吞咽障碍患者的神经功能,提高患者生活运动能力,降低相关并发症发生率。
