Objective: To explore the therapeutic mechanism of Shuguan Granule (舒关冲剂, SGG) in treating mid late stage rheumatoid arthritis (RA). Methods: Based on the principle of reinforcing Kidney to treat arthritis, removi...Objective: To explore the therapeutic mechanism of Shuguan Granule (舒关冲剂, SGG) in treating mid late stage rheumatoid arthritis (RA). Methods: Based on the principle of reinforcing Kidney to treat arthritis, removing phlegm to relieve stasis, two SGG, Shuguan Wenjing (SW) and Shuguan Qingluo (SQ) were prepared and used to treat 44 and 43 mid late stage patients of RA respectively. The clinical results were compared with those of Wangbi Granule. Animal experiments on the effect of these two SGG were conducted. Results: The total effective rate of the SW, SQ and control group was 88.64%, 93.02% and 73.17% respectively. Results of experimental studies in rats with adjuvant induced arthritis showed that the two SGG obviously raise the level of serum superoxide dismutase, and lowered the levels of serum interleukin 1, plasma prostaglandin E 2 and thromboxane B 2, as compared with the model group, the difference was significant ( P <0.05, P <0.01). Conclusion: The two SGG have a comprehensive function of anti inflammatory, analgesic, antioxidatory, antihypercoagulatory and immunoregulatory effect.展开更多
Objective： To investigate the effects of Corocalm （Shuguan Capsule, 疏冠胶囊） on acute myocardial ischemia in anesthetized dogs and its possible therapeutic mechanism. Methods： The acute ischemia model was establi...Objective： To investigate the effects of Corocalm （Shuguan Capsule, 疏冠胶囊） on acute myocardial ischemia in anesthetized dogs and its possible therapeutic mechanism. Methods： The acute ischemia model was established by ligating the left anterior descending （LAD） artery. Twenty- five dogs were randomly divided into 5 groups （5 dogs in each group）： the control group （treated with normal saline 3 mL/kg）, the refined Guanxin Capsule group （精制冠心胶囊, GXC 200 mg/kg）, high and low dose Corocalm groups （48.5 mg/kg for low dose group and 194.0 mg/kg for high dose group） and the Diltiazem group （5 mg/kg）. The animals were treated via a single duodenal administration after the model was established. The experiments used epicardial electrocardiogram （EECG） to measure the scope and degree of myocardial ischemia. Simultaneously, the coronary blood flow （CBF） and serum activity levels of creatine phosphokinase （CK） and lactate dehydrogenase （LDH） were measured by electromagnetic flow meter and automatic biochemical analyzer respectively. The plasma endothelin （ET） content was quantified by radioimmunoassay. Results： Corocalm （48.5 mg/kg and 194.0 mg/kg） significantly decreased the degree and scope of myocardial ischemia, reduced the infarct area, markedly increased the CBF, and inhibited the increase of CK and LDH activities and ET levels induced by myocardial ischemia/infarction. Conclusion： Corocalm could improve the state of acute myocardial ischemia and infarction in dogs. The mechanism of action might be correlated to increasing CBF, inhibiting CK and LDH activities and preventing ET release.展开更多
文摘Objective: To explore the therapeutic mechanism of Shuguan Granule (舒关冲剂, SGG) in treating mid late stage rheumatoid arthritis (RA). Methods: Based on the principle of reinforcing Kidney to treat arthritis, removing phlegm to relieve stasis, two SGG, Shuguan Wenjing (SW) and Shuguan Qingluo (SQ) were prepared and used to treat 44 and 43 mid late stage patients of RA respectively. The clinical results were compared with those of Wangbi Granule. Animal experiments on the effect of these two SGG were conducted. Results: The total effective rate of the SW, SQ and control group was 88.64%, 93.02% and 73.17% respectively. Results of experimental studies in rats with adjuvant induced arthritis showed that the two SGG obviously raise the level of serum superoxide dismutase, and lowered the levels of serum interleukin 1, plasma prostaglandin E 2 and thromboxane B 2, as compared with the model group, the difference was significant ( P <0.05, P <0.01). Conclusion: The two SGG have a comprehensive function of anti inflammatory, analgesic, antioxidatory, antihypercoagulatory and immunoregulatory effect.
基金Supported by the National Key Technology Program Foundation during the 9th Five-Year Plan Period (No.96-903-01-02)
文摘Objective： To investigate the effects of Corocalm （Shuguan Capsule, 疏冠胶囊） on acute myocardial ischemia in anesthetized dogs and its possible therapeutic mechanism. Methods： The acute ischemia model was established by ligating the left anterior descending （LAD） artery. Twenty- five dogs were randomly divided into 5 groups （5 dogs in each group）： the control group （treated with normal saline 3 mL/kg）, the refined Guanxin Capsule group （精制冠心胶囊, GXC 200 mg/kg）, high and low dose Corocalm groups （48.5 mg/kg for low dose group and 194.0 mg/kg for high dose group） and the Diltiazem group （5 mg/kg）. The animals were treated via a single duodenal administration after the model was established. The experiments used epicardial electrocardiogram （EECG） to measure the scope and degree of myocardial ischemia. Simultaneously, the coronary blood flow （CBF） and serum activity levels of creatine phosphokinase （CK） and lactate dehydrogenase （LDH） were measured by electromagnetic flow meter and automatic biochemical analyzer respectively. The plasma endothelin （ET） content was quantified by radioimmunoassay. Results： Corocalm （48.5 mg/kg and 194.0 mg/kg） significantly decreased the degree and scope of myocardial ischemia, reduced the infarct area, markedly increased the CBF, and inhibited the increase of CK and LDH activities and ET levels induced by myocardial ischemia/infarction. Conclusion： Corocalm could improve the state of acute myocardial ischemia and infarction in dogs. The mechanism of action might be correlated to increasing CBF, inhibiting CK and LDH activities and preventing ET release.
