Effects of fumigation and washing with Shujin Huoluo decoction combined with Duhuo Parasitic decoction on TIMP-1 and PON1 levels in KOA patients

Objective:To study the effect of fumigation and washing with Shujin Huoluo Decoction combined with Duhuo Parasitic Decoction on Metalloproteinase inhibitor-1(TIMP-1)and Oxyphosphatase 1,PON1)level.Methods:A total of 100 KOA patients,59 males and 41 females,were selected for diagnosis and treatment in our hospital from November 2018 to November 2019.The patients were divided into the control group and the combined group with 50 patients each according to a completely random method.The control group was treated with Duhuo Parasitic Decoction and the combined group was treated with Duhuo Parasitic Decoction and Shujinhuoluo decoction.Detection of TIMP-1,PON1,Matrix metalloproteinase-3(MMP-3),C-reactive protease(CRP),Tumor necrosis factor-alpha(TNF-α)and Superoxide dismutase(SOD)levels.WOMAC score,Lysholm score,and VAS score were evaluated.Results:The levels of TIMP-1 and PON1 in the combined group were higher than those in the control group after treatment,and the levels of MMP-3 were lower than those in control group(P<0.05).The WOMAC score and VAS score of the combined group were lower than those of the control group,and the Lysholm score was higher than that of control group(P<0.05).The levels of CRP and TNF-αin the combined group were lower than those in the control group,and the SOD levels were higher than those in control group(P<0.05).The total effective rate of the combined group was higher than the total effective rate of control group(P<0.05).Conclusion:The combination of fumigation and washing with Shujin Huoluo Decoction and Duhuo Parasitic Decoction has a significant effect on the treatment of KOA patients.It improves the levels of TIMP-1 and PON1,improves the knee function of patients and pain.

舒筋活络汤熏洗联合独活寄生汤加减对KOA患者TIMP-1、PON1水平的影响

目的:研究舒筋活络汤熏洗联合独活寄生汤加减对膝骨性关节炎(knee osteoarthritis,KOA)患者金属蛋白酶抑制剂-1(metalloproteinase inhibitor-1,TIMP-1)、氧磷酶1(oxyphosphatase 1,PON1)水平的影响。方法:选取2018年11月~2019年11月在本院进行诊治的KOA患者100例,男性59例,女性41例,随机分为对照组和联合组各50例。对照组实施独活寄生汤加减治疗,联合组实施独活寄生汤加减联合舒筋活络汤熏洗治疗。检测TIMP-1、PON1、基质金属蛋白酶-3(matrix metalloproteinase-3,MMP-3)、C反应蛋白(C-reactive protease,CRP)、肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)及超氧化物歧化酶(superoxide dismutase,SOD)水平,进行WOMAC评分、Lysholm评分及VAS评分评估。结果:联合组治疗后TIMP-1、PON1水平高于对照组,MMP-3水平低于对照组(P<0.05),联合组治疗后WOMAC评分、VAS评分低于对照组,Lysholm评分高于对照组(P<0.05),联合组治疗后CRP、TNF-α水平低于对照组,SOD水平高于对照组(P<0.05),联合组总有效率高于对照组(P<0.05)。结论:舒筋活络汤熏洗联合独活寄生汤加减对KOA患者治疗效果明显,可提高TIMP-1、PON1水平,改善患者膝关节功能和疼痛。

舒筋健骨汤熏洗联合康复训练对股骨颈骨折患者术后康复的影响

目的探讨康复训练指导联合舒筋健骨汤熏洗对股骨颈骨折患者术后康复效果的影响。方法选择2016年5月—2018年12月收治的100例股骨颈骨折患者作为研究对象,随机分为2组。对照组给予常规护理,观察组在此基础上给予康复指导联合舒筋健骨汤熏洗,比较2组患者术后疼痛情况及髋关节功能恢复情况。结果治疗前2组患者VAS评分、Harris评分比较,差异无统计学意义(P> 0. 05);治疗1周、2个月后,观察组VAS评分均低于对照组,Harris评分均高于对照组,差异有统计学意义(P <0. 05)。结论股骨颈骨折患者实施康复训练指导联合舒筋健骨汤熏洗,能够有效促进患者术后髋关节功能恢复,改善患者术后疼痛情况,值得临床推广应用。

舒筋汤熏洗辅助治疗老年人远端桡骨折45例分析

目的观察舒筋汤熏洗辅助治疗老年人桡骨远端骨折的临床效果。方法选择台州市中西医结合医院2016年1月至2018年1月收治的老年桡骨远端骨折患者90例为观察对象,采用随机数字表法分为对照组45例和观察组45例,对照组给予锁定钢板内固定治疗,观察组在对照组的基础上于术后给予自拟舒筋汤熏洗,连续治疗8周。记录肿胀消退时间、骨折愈合时间及住院时间,采用视觉模拟评分法(VAS)评估术后4、8周疼痛情况,术后6个月进行Gartland-Werley及McBride腕关节功能恢复效果评估,记录术后并发症发生情况,结果对照组肿胀消退、骨折愈合及住院时间分别为(8.02±2.45)d、(42.50 ±4.20)d、(14.86 士2.48)d,均明显长于观察组的(5.85±1.64)d、(34.30 ±5.60)d、(10.28 ±2.44)d(t =5.036、9.531、4.372,均P<0.05)。对照组术后4周、8周VAS评分分别为(6.50 ±1.45)分、(4.55 ± 1.74)分,均明显高于观察组的(5.26±1.16)分、(3.02 ± 1.02)分(t = 3.653、3.436,均 P <0.05 )。对照组 Gartland-Werley 腕关节功能恢复优良率为53%(24/45),明显低于观察组的78%(35/45)(x^2 =9.202,P<0.05);对照组的McBride腕关节功能恢复优良率为51%(23/45),明显低于观察组76%(34/45)(X^2=9.011 ,P <0.05)。对照组并发症发生率为18%(8/45),明显高于观察组的2%(l/45)(x^2 =6.049.P <0.05)。结论自拟舒筋汤熏洗辅助治疗老年桡骨远端骨折效果较好,能促进术后肿胀消退和骨折愈合,改善腕关节功能.降低并发症发生率,提高临床效果。