Background:The Siddha system of traditional medicine has historically been utilized to treat a wide range of illnesses,including noncommunicable diseases.With more than 62 million people in India already living with d...Background:The Siddha system of traditional medicine has historically been utilized to treat a wide range of illnesses,including noncommunicable diseases.With more than 62 million people in India already living with diabetes,the disease is quickly gaining the status of a possible epidemic.It has been demonstrated that this medical theory contains anti-diabetic substances.The goal of this work is to assess in silico computational investigations of the phytoconstituents in the traditional Siddha polyherbal preparation ABC,which is frequently used to treat diabetes.Method:Alpha-Glucosidase was used as the target enzyme in docking calculations for recovered phytocomponents.With the help of Auto Dock tools,necessary hydrogen atoms,Kollman unified atom type charges,and solvation parameters were added.The Lamarckian genetic algorithm and the Solis and Wets local search approach were used to simulate docking.Results:A total of 13 bioactive lead compounds were identified from the Siddha Formulation ABC.According to the herb’s stated data,the target enzyme Alpha-Glucosidase can interact with the phytochemicals Beta-Sitosterol,Amyrin,Lupeol,Arjunic acid,Arjungenin,Tinosporide,and Tembetarine up to four or five times.The second-placed substances,which had a maximum of two to three interactions with the target enzyme Alpha-Glucosidase,were betulonic acid,kaempferol,gallic acid,and barbaloin.Conclusion:The implementation of these formulations in future preclinical and clinical studies could result in the effective management of Type II Diabetes Mellitus.展开更多
The Siddha system of medicine is one of the ancient systems of the world that is believed to be originated and found popular in the southern parts of India.The philosophical bases of this alternative system are also f...The Siddha system of medicine is one of the ancient systems of the world that is believed to be originated and found popular in the southern parts of India.The philosophical bases of this alternative system are also found comparable with the Ayurveda.The process of computing the Drug Efficacy Index Q(VPK)of various Ayurvedic formulations was reported earlier and supported by many research publications.In this modern era of medicine,the incorporation of artificial intelligence to various research fields is found common.In this paper,it is tried to incorporate artificial intelligence to predict the efficacy of certain unique powder formulations of the Siddha System of medicine that are frequently prescribed in the common parlance.We computes the Drug Efficacy Indices Q(VPK)of certain common simple curnas of Siddha System of Medicine,such as Amukkara kizzhangu Curnam,Arathai Curnam,Nannari Curnam,Nellivattral Curnam and Punaikali Curnam,using a previously reported method which was found successful for the computation of efficacies of various Ayurvedic formulations.The possible variations in the efficacies of these powder formulations with respective recommended adjuvants used in common parlance were also studied from the computed values and compared accordingly.The selected curnas are unique and common but simple/single powder formulations for the practice of Siddha system of medicine.展开更多
Background: Siddha system is one of the ancient medical systems which originated in Indiamore than 4000 years ago had given many formularies and treatment methods for variousdiseases especially skin diseases and autoi...Background: Siddha system is one of the ancient medical systems which originated in Indiamore than 4000 years ago had given many formularies and treatment methods for variousdiseases especially skin diseases and autoimmune diseases. One of the most well-knownmembers of the Fabaceae family and a popular medicinal plant is Athimathuram(Glycyrrhiza glabra). Glycyrrhiza glabra root powder (Athimathuram chooranam) fromSiddha herbal formulation mentioned in the texts to treat vitiligo. The study is aimed toexecute the In Silico computational studies of phytoconstituents of Siddha herbAthimathuram chooranam (Glycyrrhiza glabra) against Tyrosinase enzyme for the treatmentof vitiligo. Method: Making use of Auto Dock 4, docking calculations were performed.Gasteiger partial charges were applied to the ligand atoms. In order to simulate docking, theSolis & Wets local search approach and the Lamarckian genetic algorithm were employed.The ligand molecules’ initial locations, orientations, and torsion angles were determined atrandom. During docking, all rotatable torsions were freed. Results: By interacting withamino acids located on the active site of the tyrosinase enzyme, bioactive substances likeGlycyrrhizin, Liquirtin, Glabridin, Umbelliferone, and Glabrene included in the Siddhaformulation exhibit substantial binding activity against the target protein. Conclusion: Itwas concluded that these compounds might exert promising anti-vitiligo properties.展开更多
Background:Aavarai Bhavanai Chooranam(ABC)is a Siddha polyherbal formulation containing ten medicinal plants that have been used in the Siddha system of medicine,practiced in the Southern part of Tamil Nadu,India for ...Background:Aavarai Bhavanai Chooranam(ABC)is a Siddha polyherbal formulation containing ten medicinal plants that have been used in the Siddha system of medicine,practiced in the Southern part of Tamil Nadu,India for the management of urolithiasis.Objective:The study is carried out to scientifically validate the traditional formulation and to study the mechanism of ABC.Methods:In the present study,the antiurolithiatic activity of ABC was evaluated in Wister albino rats by using ethylene glycol through drinking water.Group I acted as the standard control group and was given unlimited access to conventional rat food and water.Group II-V was given ethylene glycol(0.75%)in water to induce renal calculi for 28 days.Group III got the typical anti-urolithiatic medication,Cystone(750 mg/kg),from the 15th day to the 28th day,whereas Group II functioned as the lithiatic control group and received the vehicle.Aavarai Bhavanai Chooranam(200 mg/kg)was administered to Group IV from the 15th to the 28th day as a curative regimen.From the first day to the 28th day,Group V received Aavarai Bhavanai Chooranam(200 mg/kg),which was administered as a preventative regimen.All groups'urine samples were taken,and using accepted techniques,their calcium,magnesium,oxalate,inorganic phosphate,protein,and creatinine levels were determined.ABC treatment promotes diuresis which leads to flushing of the renal stones and maintains the alkaline condition in the urinary system which probably mediates the antilithiatic activity.Conclusion:ABC provides structural and functional protection to the kidneys by enhancing its physiological function against stone formation and validates its clinical use.展开更多
近年来,中印传统医药界间的学习互动日益增多,但对于印度五大传统医学中较小众的悉达医学,国内相关研究资料甚少。为此,本文通过翻译AYUSH in India 2010-2018,并结合相关参考文献、印度政府官网资料等,系统地介绍了悉达的起源与历史、...近年来,中印传统医药界间的学习互动日益增多,但对于印度五大传统医学中较小众的悉达医学,国内相关研究资料甚少。为此,本文通过翻译AYUSH in India 2010-2018,并结合相关参考文献、印度政府官网资料等,系统地介绍了悉达的起源与历史、基本理论、医药、现代发展等情况,为我国传统医药界了解悉达提供了第一手资料,对今后开展中印传统医药交流奠定了基础。展开更多
Healthcare is significant for a person’s comfort as well as the economic benefit of a country. Irrespective of ability, everyone should have access to health care while anyone is sick. This paper aims to compare Cana...Healthcare is significant for a person’s comfort as well as the economic benefit of a country. Irrespective of ability, everyone should have access to health care while anyone is sick. This paper aims to compare Canadian and Indian health care highlighting the financing system and people’s benefits. In Canada, universal health care means everyone, including citizens, permanent residents, and visitors, can have health care from the government. Canadian healthcare pays the doctors based on the services they provide the patients. In India, 80% of health financing comes from private sources through out-of-pocket and private insurance. In India, government-paid doctors can do private practice beyond their office hours;any patient can go to any doctor without the general practitioner’s (GP) referral as the GP system does not exist there. The healthcare agents are aggressively eager to make money, forgetting quality service to the patients. On the other hand, in Canada, the insurance system plays a supportive role in making payments and ensuring quality healthcare.展开更多
Obesity is recognized as a social problem, associated with serious health risks and increased mortality. Numerous trials have been conducted to find and devetop new anti-obesity drugs through herbal sources to minimiz...Obesity is recognized as a social problem, associated with serious health risks and increased mortality. Numerous trials have been conducted to find and devetop new anti-obesity drugs through herbal sources to minimize adverse reactions associated with the present anti-obesity drugs. The use of natural products as medicine has been documented for hundreds of years in various traditional systems of medicines throughout the world. This review focuses on the medicinal plants such as Achyranthus aspera, Camellia sinensis, Emblica officinalis, Garcinia cambogia, Terminalia arjuna, etc., being used traditionally in Ayurvedic, Unani, Siddha and Chinese, etc., systems of medicine. The review also highlights recent reported phytechemicals such as escins, perennisosides, dioscin, gracillin, etc., and the various extracts of the plants like Nelumbo nucifera, Panax japonicas, Cichorium intybus, Cyperus rotunclus, Paeonia suffruticosa, etc., which have been successfully identified for the treatment of obesity.展开更多
Objective： To assess the knowledge, attitude, perception and practice of Ayurveda, yoga, Unani, Siddha, homeopathy and naturopathy （AYUSH） among allopathic doctors and interns and determine their opin- ion regardin...Objective： To assess the knowledge, attitude, perception and practice of Ayurveda, yoga, Unani, Siddha, homeopathy and naturopathy （AYUSH） among allopathic doctors and interns and determine their opin- ion regarding integration of AYUSH education within the allopathic curriculum. Methods： This prospective, cross sectional study was conducted in a tertiary care teaching Hospital, New Delhi, India, from March 2016 to March 2017. A survey of 500 aUopathic doctors and 150 interns was performed using a structured questionnaire. Results： A majority of doctors （95.2%） were aware of the term AYUSH and had knowledge of yoga （70.6%）, homeopathy （55.6%）, Ayurveda （50.3%）, Siddha （47.8%）, naturopathy （32.9%） and Unani （28.9%）. Most of the participants （63.0%） felt that therapies under AYUSH are effective. A majority （84.0%） of the doctors were of the view that more research is required in the field of AYUSH. While homeopathy （44.0%） was the most common system used by doctors for themselves, yoga was the therapy most commonly （60.0%） recommended to patients. Nearly half of the doctors （46.7%） recommended AYUSH to their patients, mainly for chronic illness （74.0%）. A majority （77.5%） of the respondents agreed that students of allopathic med- icine should be familiarized with AYUSH. The modes of incorporation of AYUSH into the medical curriculum most commonly suggested by respondents were optional courses （54.5%） and introductory lectures （42.3%）. Conclusion： Doctors and interns ofallopathic medicine are aware of AYUSH systems. They use it for them- selves and recommend it to patients. They believe that familiarization of Bachelor of Medicine and Bachelor of Surgery students with AYUSH therapies and their integration with allopathic medicine may help in improving patient care.展开更多
文摘Background:The Siddha system of traditional medicine has historically been utilized to treat a wide range of illnesses,including noncommunicable diseases.With more than 62 million people in India already living with diabetes,the disease is quickly gaining the status of a possible epidemic.It has been demonstrated that this medical theory contains anti-diabetic substances.The goal of this work is to assess in silico computational investigations of the phytoconstituents in the traditional Siddha polyherbal preparation ABC,which is frequently used to treat diabetes.Method:Alpha-Glucosidase was used as the target enzyme in docking calculations for recovered phytocomponents.With the help of Auto Dock tools,necessary hydrogen atoms,Kollman unified atom type charges,and solvation parameters were added.The Lamarckian genetic algorithm and the Solis and Wets local search approach were used to simulate docking.Results:A total of 13 bioactive lead compounds were identified from the Siddha Formulation ABC.According to the herb’s stated data,the target enzyme Alpha-Glucosidase can interact with the phytochemicals Beta-Sitosterol,Amyrin,Lupeol,Arjunic acid,Arjungenin,Tinosporide,and Tembetarine up to four or five times.The second-placed substances,which had a maximum of two to three interactions with the target enzyme Alpha-Glucosidase,were betulonic acid,kaempferol,gallic acid,and barbaloin.Conclusion:The implementation of these formulations in future preclinical and clinical studies could result in the effective management of Type II Diabetes Mellitus.
文摘The Siddha system of medicine is one of the ancient systems of the world that is believed to be originated and found popular in the southern parts of India.The philosophical bases of this alternative system are also found comparable with the Ayurveda.The process of computing the Drug Efficacy Index Q(VPK)of various Ayurvedic formulations was reported earlier and supported by many research publications.In this modern era of medicine,the incorporation of artificial intelligence to various research fields is found common.In this paper,it is tried to incorporate artificial intelligence to predict the efficacy of certain unique powder formulations of the Siddha System of medicine that are frequently prescribed in the common parlance.We computes the Drug Efficacy Indices Q(VPK)of certain common simple curnas of Siddha System of Medicine,such as Amukkara kizzhangu Curnam,Arathai Curnam,Nannari Curnam,Nellivattral Curnam and Punaikali Curnam,using a previously reported method which was found successful for the computation of efficacies of various Ayurvedic formulations.The possible variations in the efficacies of these powder formulations with respective recommended adjuvants used in common parlance were also studied from the computed values and compared accordingly.The selected curnas are unique and common but simple/single powder formulations for the practice of Siddha system of medicine.
文摘Background: Siddha system is one of the ancient medical systems which originated in Indiamore than 4000 years ago had given many formularies and treatment methods for variousdiseases especially skin diseases and autoimmune diseases. One of the most well-knownmembers of the Fabaceae family and a popular medicinal plant is Athimathuram(Glycyrrhiza glabra). Glycyrrhiza glabra root powder (Athimathuram chooranam) fromSiddha herbal formulation mentioned in the texts to treat vitiligo. The study is aimed toexecute the In Silico computational studies of phytoconstituents of Siddha herbAthimathuram chooranam (Glycyrrhiza glabra) against Tyrosinase enzyme for the treatmentof vitiligo. Method: Making use of Auto Dock 4, docking calculations were performed.Gasteiger partial charges were applied to the ligand atoms. In order to simulate docking, theSolis & Wets local search approach and the Lamarckian genetic algorithm were employed.The ligand molecules’ initial locations, orientations, and torsion angles were determined atrandom. During docking, all rotatable torsions were freed. Results: By interacting withamino acids located on the active site of the tyrosinase enzyme, bioactive substances likeGlycyrrhizin, Liquirtin, Glabridin, Umbelliferone, and Glabrene included in the Siddhaformulation exhibit substantial binding activity against the target protein. Conclusion: Itwas concluded that these compounds might exert promising anti-vitiligo properties.
文摘Background:Aavarai Bhavanai Chooranam(ABC)is a Siddha polyherbal formulation containing ten medicinal plants that have been used in the Siddha system of medicine,practiced in the Southern part of Tamil Nadu,India for the management of urolithiasis.Objective:The study is carried out to scientifically validate the traditional formulation and to study the mechanism of ABC.Methods:In the present study,the antiurolithiatic activity of ABC was evaluated in Wister albino rats by using ethylene glycol through drinking water.Group I acted as the standard control group and was given unlimited access to conventional rat food and water.Group II-V was given ethylene glycol(0.75%)in water to induce renal calculi for 28 days.Group III got the typical anti-urolithiatic medication,Cystone(750 mg/kg),from the 15th day to the 28th day,whereas Group II functioned as the lithiatic control group and received the vehicle.Aavarai Bhavanai Chooranam(200 mg/kg)was administered to Group IV from the 15th to the 28th day as a curative regimen.From the first day to the 28th day,Group V received Aavarai Bhavanai Chooranam(200 mg/kg),which was administered as a preventative regimen.All groups'urine samples were taken,and using accepted techniques,their calcium,magnesium,oxalate,inorganic phosphate,protein,and creatinine levels were determined.ABC treatment promotes diuresis which leads to flushing of the renal stones and maintains the alkaline condition in the urinary system which probably mediates the antilithiatic activity.Conclusion:ABC provides structural and functional protection to the kidneys by enhancing its physiological function against stone formation and validates its clinical use.
文摘近年来,中印传统医药界间的学习互动日益增多,但对于印度五大传统医学中较小众的悉达医学,国内相关研究资料甚少。为此,本文通过翻译AYUSH in India 2010-2018,并结合相关参考文献、印度政府官网资料等,系统地介绍了悉达的起源与历史、基本理论、医药、现代发展等情况,为我国传统医药界了解悉达提供了第一手资料,对今后开展中印传统医药交流奠定了基础。
文摘Healthcare is significant for a person’s comfort as well as the economic benefit of a country. Irrespective of ability, everyone should have access to health care while anyone is sick. This paper aims to compare Canadian and Indian health care highlighting the financing system and people’s benefits. In Canada, universal health care means everyone, including citizens, permanent residents, and visitors, can have health care from the government. Canadian healthcare pays the doctors based on the services they provide the patients. In India, 80% of health financing comes from private sources through out-of-pocket and private insurance. In India, government-paid doctors can do private practice beyond their office hours;any patient can go to any doctor without the general practitioner’s (GP) referral as the GP system does not exist there. The healthcare agents are aggressively eager to make money, forgetting quality service to the patients. On the other hand, in Canada, the insurance system plays a supportive role in making payments and ensuring quality healthcare.
文摘Obesity is recognized as a social problem, associated with serious health risks and increased mortality. Numerous trials have been conducted to find and devetop new anti-obesity drugs through herbal sources to minimize adverse reactions associated with the present anti-obesity drugs. The use of natural products as medicine has been documented for hundreds of years in various traditional systems of medicines throughout the world. This review focuses on the medicinal plants such as Achyranthus aspera, Camellia sinensis, Emblica officinalis, Garcinia cambogia, Terminalia arjuna, etc., being used traditionally in Ayurvedic, Unani, Siddha and Chinese, etc., systems of medicine. The review also highlights recent reported phytechemicals such as escins, perennisosides, dioscin, gracillin, etc., and the various extracts of the plants like Nelumbo nucifera, Panax japonicas, Cichorium intybus, Cyperus rotunclus, Paeonia suffruticosa, etc., which have been successfully identified for the treatment of obesity.
文摘Objective： To assess the knowledge, attitude, perception and practice of Ayurveda, yoga, Unani, Siddha, homeopathy and naturopathy （AYUSH） among allopathic doctors and interns and determine their opin- ion regarding integration of AYUSH education within the allopathic curriculum. Methods： This prospective, cross sectional study was conducted in a tertiary care teaching Hospital, New Delhi, India, from March 2016 to March 2017. A survey of 500 aUopathic doctors and 150 interns was performed using a structured questionnaire. Results： A majority of doctors （95.2%） were aware of the term AYUSH and had knowledge of yoga （70.6%）, homeopathy （55.6%）, Ayurveda （50.3%）, Siddha （47.8%）, naturopathy （32.9%） and Unani （28.9%）. Most of the participants （63.0%） felt that therapies under AYUSH are effective. A majority （84.0%） of the doctors were of the view that more research is required in the field of AYUSH. While homeopathy （44.0%） was the most common system used by doctors for themselves, yoga was the therapy most commonly （60.0%） recommended to patients. Nearly half of the doctors （46.7%） recommended AYUSH to their patients, mainly for chronic illness （74.0%）. A majority （77.5%） of the respondents agreed that students of allopathic med- icine should be familiarized with AYUSH. The modes of incorporation of AYUSH into the medical curriculum most commonly suggested by respondents were optional courses （54.5%） and introductory lectures （42.3%）. Conclusion： Doctors and interns ofallopathic medicine are aware of AYUSH systems. They use it for them- selves and recommend it to patients. They believe that familiarization of Bachelor of Medicine and Bachelor of Surgery students with AYUSH therapies and their integration with allopathic medicine may help in improving patient care.
