Background and Aims: On November 24, 2009, Huu S. TIEU and Golden Sunrise Pharmaceutical, Inc. (Golden Sunrise) applied for the Technology and Innovation to be reviewed and evaluated by the U.S. Food and Drug Administ...Background and Aims: On November 24, 2009, Huu S. TIEU and Golden Sunrise Pharmaceutical, Inc. (Golden Sunrise) applied for the Technology and Innovation to be reviewed and evaluated by the U.S. Food and Drug Administration (FDA). In the review and evaluation, it was requested by Golden Sunrise designated the new indications for this application under Serious or Life-threatening conditions or diseases. Discussions followed with the FDA, Huu S. TIEU, and Golden Sunrise for FDA approval on new products and new indications on existing new Medical Technology and Innovation. It was agreed in Year-2015 that the FDA would take the request for new indications to the United States Congress to establish into FDA regulation and law. At that time the following was the FDA Guidance—“Emergency Use of a Test Article” is exempt from prior Institutional Review Board or Advisory Committee evaluation and approval, provided that such emergency use is reported to the Institutional Review Board within five working days after use. Expedited Institutional Review Board or Advisory Committee approval is not permitted in emergency use. There has been no funding to the authors for the writing or publication of this article. Methods: It was requested by Huu S. TIEU and Golden Sunrise in documents given to the FDA to have Serious or Life-threatening conditions or diseases indication be recognized by law. On August 08, 2015, the FDA responding to this request took the documentation produced by Golden Sunrise to the United States Congress on behalf of Golden Sunrise and Huu S. TIEU. This article encompasses the FDA regulatory method as well as the discussion and results of the establishment of the FDA and the 21<sup>st</sup> Century Cures Act. Results: On December 13, 2016, H.R.34—114<sup>th</sup> United States Congress (2015-2016) 21<sup>st</sup> Century CURES Act was signed into law by President Barack H. Obama which included the Serious or Life-threatening indication to be written into the CURES Act. In summary, the 21<sup>st</sup> Century Cures Act is a landmark piece of legislation that enjoyed broad bipartisan support in United States Congress. The main goals of the Act are impactful and should transform future cancer, neurologic, and precision medicine or drug research as well as aid individuals with mental health is intended to facilitate the prompt approval of new agents and devices, clinicians should be aware of the types of data behind an approval and take this into consideration when developing illnesses and opioid dependence. However, some of the wording within the CURES Act regarding the drug and device approval process may bring pause to health care providers including pharmacists. Although this wording and implementing care plans and counseling patients. The 21<sup>st</sup> Century Cures Act was incorporated into laws and regulations by the FDA under § 3072 of the Act grants the Commissioner of Food and Drugs the authority to appoint and set the annual rate of pay for outstanding and qualified candidates to scientific, technical, or professional positions that support the development, review, and regulation of medical products.展开更多
In the present paper,the spatio-temporal evolution of vorticity in the first wake instability,i.e.,(pure)mode A,is investigated in order to understand the wake vortex dynamics and sign relationships among vorticity co...In the present paper,the spatio-temporal evolution of vorticity in the first wake instability,i.e.,(pure)mode A,is investigated in order to understand the wake vortex dynamics and sign relationships among vorticity components.Direct numerical simulation(DNS)for the flow past a circular cylinder is performed,typically at a Reynolds number of 200,in the three-dimensional(3-D)wake transition.According to characteristics of time histories of fluid forces,three different stages are identified as the computational transition,the initial stage and fully developed wake.In the second initial stage,the original two-dimensional spanwise vortices become obviously three-dimensional associated with the streamwise or vertical vorticity intensified up to about 0.1.As a matter of fact,these additional vorticities,caused by the intrinsic 3-D instability,are already generated firstly on cylinder surfaces early in the computational transition,indicating that the three-dimensionality appeared early near the cylinder.The evolution of additional components of vorticity with features the same as mode A shows that(pure)mode A can be already formed in the late computational transition.Through careful analysis of the vorticity field on the front surface,in the shear layers and near wake at typical times,two sign laws are obtained.They illustrate intrinsic relationships among three vorticity components,irrelevant to the wavelength or Fourier mode and Reynolds number in(pure)mode A.Most importantly,the origin of streamwise vortices is found and explained by a new physical mechanism based on the theory of vortex-induced vortex.As a result,the whole process of formation and shedding vortices with these vorticities is firstly and completely illustrated.Other characteristics are presented in detail.展开更多
文摘Background and Aims: On November 24, 2009, Huu S. TIEU and Golden Sunrise Pharmaceutical, Inc. (Golden Sunrise) applied for the Technology and Innovation to be reviewed and evaluated by the U.S. Food and Drug Administration (FDA). In the review and evaluation, it was requested by Golden Sunrise designated the new indications for this application under Serious or Life-threatening conditions or diseases. Discussions followed with the FDA, Huu S. TIEU, and Golden Sunrise for FDA approval on new products and new indications on existing new Medical Technology and Innovation. It was agreed in Year-2015 that the FDA would take the request for new indications to the United States Congress to establish into FDA regulation and law. At that time the following was the FDA Guidance—“Emergency Use of a Test Article” is exempt from prior Institutional Review Board or Advisory Committee evaluation and approval, provided that such emergency use is reported to the Institutional Review Board within five working days after use. Expedited Institutional Review Board or Advisory Committee approval is not permitted in emergency use. There has been no funding to the authors for the writing or publication of this article. Methods: It was requested by Huu S. TIEU and Golden Sunrise in documents given to the FDA to have Serious or Life-threatening conditions or diseases indication be recognized by law. On August 08, 2015, the FDA responding to this request took the documentation produced by Golden Sunrise to the United States Congress on behalf of Golden Sunrise and Huu S. TIEU. This article encompasses the FDA regulatory method as well as the discussion and results of the establishment of the FDA and the 21<sup>st</sup> Century Cures Act. Results: On December 13, 2016, H.R.34—114<sup>th</sup> United States Congress (2015-2016) 21<sup>st</sup> Century CURES Act was signed into law by President Barack H. Obama which included the Serious or Life-threatening indication to be written into the CURES Act. In summary, the 21<sup>st</sup> Century Cures Act is a landmark piece of legislation that enjoyed broad bipartisan support in United States Congress. The main goals of the Act are impactful and should transform future cancer, neurologic, and precision medicine or drug research as well as aid individuals with mental health is intended to facilitate the prompt approval of new agents and devices, clinicians should be aware of the types of data behind an approval and take this into consideration when developing illnesses and opioid dependence. However, some of the wording within the CURES Act regarding the drug and device approval process may bring pause to health care providers including pharmacists. Although this wording and implementing care plans and counseling patients. The 21<sup>st</sup> Century Cures Act was incorporated into laws and regulations by the FDA under § 3072 of the Act grants the Commissioner of Food and Drugs the authority to appoint and set the annual rate of pay for outstanding and qualified candidates to scientific, technical, or professional positions that support the development, review, and regulation of medical products.
文摘In the present paper,the spatio-temporal evolution of vorticity in the first wake instability,i.e.,(pure)mode A,is investigated in order to understand the wake vortex dynamics and sign relationships among vorticity components.Direct numerical simulation(DNS)for the flow past a circular cylinder is performed,typically at a Reynolds number of 200,in the three-dimensional(3-D)wake transition.According to characteristics of time histories of fluid forces,three different stages are identified as the computational transition,the initial stage and fully developed wake.In the second initial stage,the original two-dimensional spanwise vortices become obviously three-dimensional associated with the streamwise or vertical vorticity intensified up to about 0.1.As a matter of fact,these additional vorticities,caused by the intrinsic 3-D instability,are already generated firstly on cylinder surfaces early in the computational transition,indicating that the three-dimensionality appeared early near the cylinder.The evolution of additional components of vorticity with features the same as mode A shows that(pure)mode A can be already formed in the late computational transition.Through careful analysis of the vorticity field on the front surface,in the shear layers and near wake at typical times,two sign laws are obtained.They illustrate intrinsic relationships among three vorticity components,irrelevant to the wavelength or Fourier mode and Reynolds number in(pure)mode A.Most importantly,the origin of streamwise vortices is found and explained by a new physical mechanism based on the theory of vortex-induced vortex.As a result,the whole process of formation and shedding vortices with these vorticities is firstly and completely illustrated.Other characteristics are presented in detail.
