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A Meta-Analysis of the Prognostic and Clinicopathological Significance of circZFR in Human Gastrointestinal Cancers 被引量:1
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作者 Christian Cedric Bongolo Erick Thokerunga +1 位作者 Yu Zhang Jian-Cheng Tu 《International Journal of Clinical Medicine》 CAS 2024年第3期134-144,共11页
Background: Studies of gastrointestinal (GIT) cancers have shown that circZFR could be involved in the development and progression of various GIT cancers. However, small sample sizes limit the clinical significance of... Background: Studies of gastrointestinal (GIT) cancers have shown that circZFR could be involved in the development and progression of various GIT cancers. However, small sample sizes limit the clinical significance of these studies. Here, a meta-analysis was conducted to ascertain the actual involvement of circZFR in the development and prognosis of GIT cancers. Methods: PubMed, Embase, Web of Science, and the Cochrane Library were searched up to December 31, 2023. Hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to evaluate the association between circZFR expression and overall survival (OS). Publication bias was measured using the funnel plot and Egger’s test. Results: 10 studies having 659 participants were enrolled for meta-analysis. High circZFR expression was associated with poor OS (HR = 1.4, 95% CI: 1.20, 1.70). High circZFR expression also predicted larger tumor size (OR = 4.38, 95% CI 2.65, 7.25), advanced clinical stage (OR = 5.33, 95% CI 3.10, 9.16), and tendency for distant metastasis (OR = 2.89, 95% CI: 1.62, 5.11), but was not related to age, gender, and histological grade. Conclusions: In summary, high circZFR expression was associated with poor OS, larger tumor size, advanced stage cancer and tendency for distant metastasis. These findings suggested that circZFR could be a prognostic marker for GIT cancers. 展开更多
关键词 CircZFR GASTROINTESTINAL PROGNOSTIC significance META-ANALYSIS
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Flower morphology of Allium(Amaryllidaceae)and its systematic significance
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作者 Ju Eun Jang Shukherdorj Baasanmunkh +5 位作者 Nudkhuu Nyamgerel Seung-Yoon Oh Jun-Ho Song Ziyoviddin Yusupov Komijlon Tojibaev Hyeok Jae Choi 《Plant Diversity》 SCIE CAS CSCD 2024年第1期3-27,共25页
Allium is a complicated genus that includes approximately 1000 species.Although its morphology is well studied,the taxonomic importance of many morphological traits,including floral traits,are poorly understood.Here,w... Allium is a complicated genus that includes approximately 1000 species.Although its morphology is well studied,the taxonomic importance of many morphological traits,including floral traits,are poorly understood.Here,we examined and measured the floral characteristics of 87 accessions of 74 Allium taxa(belonging to 30 sections and nine subgenera)from Central to Eastern Asian countries.We then examined the taxonomic relationships between select flower characteristics and a phylogenetic tree based on ITS sequences.Our results confirm that floral morphology provides key taxonomic information to assess species delimitation in Allium.We found that perianth color is an important characteristic within the subg.Melanocrommyum,Polyprason,and Reticulatobulbosa.In subg.Allium,Cepa,and Rhizirideum,significant characteristics include ovary shape,perianth shape,and inner tepal apex.For species in subg.Angunium,the key taxonomic character is ovule number(only one ovule in per locule).In the subg.Allium,Cepa,Polyprason,and Reticulatobulbosa,which belong to the third evolutionary line of Allium,hood-like appendages occur in the ovary,although these do not occur in subg.Rhizirideum.Our results also indicated that the flower morphology of several species in some sections are not clearly distinguished,e.g.,sect.Sacculiferum(subg.Cepa)and sect.Tenuissima(subg.Rhizirideum).This study provides detailed photographs and descriptions of floral characteristics and information on general distributions,habitats,and phenology of the studied taxa. 展开更多
关键词 ALLIUM Flower morphology Pistil character Statistical analysis significant characteristic Species level
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Microscopic characteristics and geological significance of pyrite in shales of the Wufeng-Longmaxi formations,southeastern Chongqing,China
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作者 Xiao Cai Wei Xia +6 位作者 Yuxia Liu Shunzhou Liao Lei Zhang Weixue Hu Li Liu Wei Li Fanwu Zeng 《Energy Geoscience》 EI 2024年第3期203-211,共9页
Shales of the Wufeng-Longmaxi formations in the basin-margin transition zone of southeastern Chongqing,China are characterized by high organic matter content and a significant presence of pyrite development.By examini... Shales of the Wufeng-Longmaxi formations in the basin-margin transition zone of southeastern Chongqing,China are characterized by high organic matter content and a significant presence of pyrite development.By examining numerous scanning electron microscope(SEM)images and considering the crystal and aggregate characteristics of minerals,we identified four types of pyrite in the study area:euhedral crystals,irregular aggregates,framboidal aggregates,and metasomatized organisms.Among these types,framboidal aggregates are the most prevalent.The formation mechanism of framboidal pyrite can be categorized into inorganic and organic origins.As inferred from the pyrite characteristics in the study area,the formation mechanism of the metasomatized organisms aligns with the biologically induced mineralization mode of organic origin,whereas the framboidal aggregates are more associated with the biologically controlled mineralization mode of organic origin.This underscores a close relationship between the pyrite formation and organic matter,which in turn indicates that an organic origin is more consistent with the pyrite characteristics observed in this study area.The pyrite morphology can reflect reactive iron concentration.Euhedral pyrite crystals tend to form under a low reactive iron concentration,whereas the formation of framboidal pyrite requires a high reactive iron concentration.Additionally,the type and grain size of pyrite aggregates can reflect variations in the redox conditions of the depositional environment.Pyrite produces positive effects on reservoir storage space,with intercrystalline organic pores,intercrystalline pores,and mold pores associated with pyrite contributing greatly to the storage spaces. 展开更多
关键词 Wufeng-Longmaxi formations SHALE PYRITE Microscopic characteristics Geological significance
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Nomogram to predict gas-related complications during transoral endoscopic resection of upper gastrointestinal submucosal lesions:Clinical significance
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作者 Xu-Peng Wen Qi-Quan Wan 《World Journal of Gastrointestinal Endoscopy》 2024年第1期5-10,共6页
Transoral endoscopic resections in treating upper gastrointestinal submucosal lesions have the advantages of maintaining the integrity of the gastrointestinal lumen,avoiding perforation and reducing gastrointestinal f... Transoral endoscopic resections in treating upper gastrointestinal submucosal lesions have the advantages of maintaining the integrity of the gastrointestinal lumen,avoiding perforation and reducing gastrointestinal fistulae.They are becoming more widely used in clinical practice,but,they may also present a variety of complications.Gas-related complications are one of the most common,which can be left untreated if the symptoms are mild,but in severe cases,they can lead to rapid changes in the respiratory and circulatory systems in a short period,which can be life-threatening.Therefore,it is important to predict the occurrence of gas-related complications early and take preventive measures actively.Based on the authors'results in the prepublication of the article“Nomogram to predict gas-related complications during transoral endoscopic resection of upper gastrointestinal submucosal lesions,”and in conjunction with our evaluation and additions to the relevant content,radiographs may help screen patients at high risk for gas-related complications.Controlling blood glucose levels,shortening the duration of surgery,and choosing the most appropriate surgical resection may positively impact the prognosis of patients at high risk for gas-related complications during transoral endoscopic resection of upper gastrointestinal submucosal lesions. 展开更多
关键词 COMPLICATIONS ENDOSCOPY Upper gastrointestinal tract NOMOGRAM Clinical significance
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Three-dimensional structural models,evolution and petroleum geological significances of transtensional faults in the Ziyang area,central Sichuan Basin,SW China
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作者 TIAN Fanglei GUO Tonglou +6 位作者 HE Dengfa GU Zhanyu MENG Xianwu WANG Renfu WANG Ying ZHANG Weikang LU Guo 《Petroleum Exploration and Development》 SCIE 2024年第3期604-620,共17页
With drilling and seismic data of Transtensional(strike-slip)Fault System in the Ziyang area of the central Sichuan Basin,SW China plane-section integrated structural interpretation,3-D fault framework model building,... With drilling and seismic data of Transtensional(strike-slip)Fault System in the Ziyang area of the central Sichuan Basin,SW China plane-section integrated structural interpretation,3-D fault framework model building,fault throw analyzing,and balanced profile restoration,it is pointed out that the transtensional fault system in the Ziyang 3-D seismic survey consists of the northeast-trending F_(I)19 and F_(I)20 fault zones dominated by extensional deformation,as well as 3 sets of northwest-trending en echelon normal faults experienced dextral shear deformation.Among them,the F_(I)19 and F_(I)20 fault zones cut through the Neoproterozoic to Lower Triassic Jialingjiang Formation,presenting a 3-D structure of an“S”-shaped ribbon.And before Permian and during the Early Triassic,the F_(I)19 and F_(I)20 fault zones underwent at least two periods of structural superimposition.Besides,the 3 sets of northwest-trending en echelon normal faults are composed of small normal faults arranged in pairs,with opposite dip directions and partially left-stepped arrangement.And before Permian,they had formed almost,restricting the eastward growth and propagation of the F_(I)19 fault zone.The F_(I)19 and F_(I)20 fault zones communicate multiple sets of source rocks and reservoirs from deep to shallow,and the timing of fault activity matches well with oil and gas generation peaks.If there were favorable Cambrian-Triassic sedimentary facies and reservoirs developing on the local anticlinal belts of both sides of the F_(I)19 and F_(I)20 fault zones,the major reservoirs in this area are expected to achieve breakthroughs in oil and gas exploration. 展开更多
关键词 transtensional(strike-slip)fault three-dimensional structural model structural evolution petroleum geological significance Ziyang area Sichuan Basin
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A Study on the Educational Significance Guidance Plan Value of the Jumong Myth Using STEAM
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作者 Lee Eun-min 《Cultural and Religious Studies》 2024年第6期338-355,共18页
Jumong is a legendary figure in Korean mythology.He is depicted as a genius archer,a brilliant mind with horses,a god who rules the rivers and the sky.Jumong is a mythical character who is believed to be of divine des... Jumong is a legendary figure in Korean mythology.He is depicted as a genius archer,a brilliant mind with horses,a god who rules the rivers and the sky.Jumong is a mythical character who is believed to be of divine descent and to possess superhuman abilities that humans cannot match.The myth of Jumong is a very competitive content that can compete on a global scale.However,in order for it to be successful,it is necessary to be able to reinterpret our mythology to suit the times and reproduce it culturally.To this end,the realistic globalization of Korean classical literature should commence with the genre of Korean mythology.This paper presents the educational significance of the Jumong myth as a teaching-learning model,via STEAM(science,technology,engineering,arts,and mathematics),on the theme of Korean mythology.As we enter the era of artificial intelligence(AI)through the 4th Industrial Revolution,the most appropriate teaching and learning method,the convergence class,will provide an opportunity for students living in modern times to discover the cultural archetypes that allow them to recognise themselves as individuals and us as a collective,and to find the roots of the myth to positively renew their identity.Furthermore,it is my hope that they will rediscover and appreciate the representative work of Korean mythology,Gojomong,the eponymous story of Goguryeo. 展开更多
关键词 Jumong STEAM educational significance personal and reflective assessments organic complexes evaluate a collaborative activity(rubric)
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Expression of CD151 in Gastric Cancer Tissues and Its Clinical Significance
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作者 Chunhua Liu Dekuan Song +3 位作者 Xiaoying Gong Xin Hao Baokun Chang Bin Deng 《Proceedings of Anticancer Research》 2024年第1期17-22,共6页
Objective:To explore the expression of CD151 in gastric cancer tissues and its clinical significance.Methods:Immunohistochemistry was employed to detect the expression of CD151 in gastric cancer tissues and adjacent n... Objective:To explore the expression of CD151 in gastric cancer tissues and its clinical significance.Methods:Immunohistochemistry was employed to detect the expression of CD151 in gastric cancer tissues and adjacent normal tissues.The relationship between CD151 expression and the clinicopathological characteristics of gastric cancer was analyzed.Results:The expression of CD151 in gastric cancer tissues was significantly higher than in adjacent normal tissues(P<0.05).It was associated with the degree of differentiation,depth of invasion,lymph node metastasis,and TNM staging of gastric cancer.The survival time of patients with high CD151 expression was significantly shorter than that of those with low expression(P<0.05).Conclusion:High expression of CD151 in gastric cancer tissues is correlated with the malignant biological behavior of gastric cancer and can serve as an indicator for evaluating the prognosis of gastric cancer. 展开更多
关键词 Gastric cancer CD151 IMMUNOHISTOCHEMISTRY Clinical significance
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Exploring the Significance and Implementation Strategies of Mental Health Education for College Students
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作者 Chang Xu Xiaoyi Qu +1 位作者 Bining Yang Kaidi Wang 《Journal of Contemporary Educational Research》 2024年第2期1-7,共7页
College students are influenced by diverse cultures in the new era,thus their inner world is rich and changing rapidly.The acceleration of social rhythm can easily lead to different kinds of psychological problems.Men... College students are influenced by diverse cultures in the new era,thus their inner world is rich and changing rapidly.The acceleration of social rhythm can easily lead to different kinds of psychological problems.Mental health education is people-oriented,using scientific methods and means to train high-quality talents with all-round development across the world.A healthy psychological state can promote the sound development of students,make them establish correct core social values,and realize self-value.At present,there are some problems in university mental health education,such as single form and imperfect system.At the same time,college education plays an important role in the formation of ideas for college students’ideological values.As a front-line student worker,college counselors should cooperate with the school’s psychological departments to improve the college psychological education system,rationally plan the psychological teaching program,and pay attention to the college students’mental health education.The government should also take into account the need to ensure that the education system is not undermined by the lack of a comprehensive and effective education system. 展开更多
关键词 significance Mental health education DEVELOPMENT VALUES COUNSELORS
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Analysis of the Significance of Key Points of Patient Interventional Psychological Care and Pain Care
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作者 Xiaoping Dai Chu Luo Jiawei Dai 《Journal of Clinical and Nursing Research》 2024年第3期66-71,共6页
Interventional therapy has become increasingly popular in clinical practice due to advancements in medical technology.However,patients often experience psychological and physiological pressure due to its invasive natu... Interventional therapy has become increasingly popular in clinical practice due to advancements in medical technology.However,patients often experience psychological and physiological pressure due to its invasive nature.The management of patient discomfort and tension is crucial to ensure effective treatment.Psychological and pain management are essential components of interventional therapy,as they significantly impact patient recovery and prognosis.This article discussed the importance of interventional psychological and pain care for patients,starting with the development and spread of interventional therapy.The significance of providing high-quality nursing services to patients and improving their quality of life was also discussed. 展开更多
关键词 Interventional treatment Psychological nursing Pain care Key points significance analysis
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Unveiling clinical significance and tumor immune landscape of CXCL12 in bladder cancer: Insights from multiple omics analysis 被引量:1
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作者 Zhouting Tuo Dechao Feng +3 位作者 Zhiwei Jiang Liangkuan Bi Chao Yang Qi Wang 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2023年第6期686-701,共16页
Objective: The interplay between chemokine C-X-C motif ligand 12(CXCL12) and its specific receptors is known to trigger various signaling pathways, contributing to tumor proliferation and metastasis. Consequently,targ... Objective: The interplay between chemokine C-X-C motif ligand 12(CXCL12) and its specific receptors is known to trigger various signaling pathways, contributing to tumor proliferation and metastasis. Consequently,targeting this signaling axis has emerged as a potential strategy in cancer therapy. However, the precise role of CXCL12 in clinical therapy, especially in immunotherapy for bladder cancer(BCa), remains poorly elucidated.Methods: We gathered multiple omics data from public databases to unveil the clinical relevance and tumor immune landscape associated with CXCL12 in BCa patients. Univariate and multivariate Cox regression analyses were employed to assess the independent prognostic significance of CXCL12 expression and formulate a nomogram. The expression of CXCL12 in BCa cell lines and clinical tissue samples was validated using enzymelinked immunosorbent assays(ELISA) and immunohistochemistry(IHC).Results: While transcriptional expression of CXCL12 exhibited a decrease in nearly all tumor tissues, CXCL12 methylation expression was notably increased in BCa tissues. Single-cell RNA analysis highlighted tissue stem cells and endothelial cells as the primary sources expressing CXCL12. Abnormal CXCL12 expression, based on transcriptional and methylation levels, correlated with various clinical characteristics in BCa patients. Functional analysis indicated enrichment of CXCL12 and its co-expression genes in immune regulation and cell adhesion. The immune landscape analysis unveiled a significant association between CXCL12 expression and M2 macrophages(CD163~+ cells) in BCa tissues. Notably, CXCL12 expression emerged as a potential predictor of immunotherapy response and chemotherapy drug sensitivity in BCa patients.Conclusions: Taken together, these findings suggest aberrant production of CXCL12 in BCa tissues,potentially influencing the treatment responses of affected individuals. 展开更多
关键词 C-X-C motif ligand 12 bladder cancer tumor immune landscape clinical significance
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Environmental significance and hydrochemical characteristics of rivers in the western region of the Altay Mountains,China 被引量:1
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作者 LIU Shuangshuang WANG Feiteng +2 位作者 XU Chunhai WANG Lin LI Huilin 《Journal of Arid Land》 SCIE CSCD 2023年第9期1052-1066,共15页
Analysis of environmental significance and hydrochemical characteristics of river water in mountainous regions is vital for ensuring water security.In this study,we collected a total of 164 water samples in the wester... Analysis of environmental significance and hydrochemical characteristics of river water in mountainous regions is vital for ensuring water security.In this study,we collected a total of 164 water samples in the western region of the Altay Mountains,China,in 2021.We used principal component analysis and enrichment factor analysis to examine the chemical properties and spatiotemporal variations of major ions(including F-,Cl-,NO_(3)-,SO_(4)^(2-),Li+,Na+,NH4+,K+,Mg^(2+),and Ca^(2+))present in river water,as well as to identify the factors influencing these variations.Additionally,we assessed the suitability of river water for drinking and irrigation purposes based on the total dissolved solids,soluble sodium percentage,sodium adsorption ratio,and total hardness.Results revealed that river water had an alkaline aquatic environment with a mean pH value of 8.00.The mean ion concentration was ranked as follows:Ca^(2+)>SO_(4)^(2-)>Na+>NO_(3)->Mg^(2+)>K+>Cl->F->NH_(4)+>Li+.Ca^(2+),SO_(4)^(2-),Na+,and NO_(3)-occupied 83%of the total ion concentration.In addition,compared with other seasons,the spatial variation of the ion concentration in spring was obvious.An analysis of the sources of major ions revealed that these ions originated mainly from carbonate dissolution and silicate weathering.The recharge impact of precipitation and snowmelt merely influenced the concentration of Cl-,NO_(3)-,SO_(4)^(2-),Ca^(2+),and Na+.Overall,river water was in pristine condition in terms of quality and was suitable for both irrigation and drinking.This study provides a scientific basis for sustainable management of water quality in rivers of the Altay Mountains. 展开更多
关键词 environmental significance hydrochemical characteristics water quality soluble sodium percentage(SSP) ion concentration Altay Mountains
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AE81镁合金轧制变形显微组织演变的研究
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作者 武红飞 胡文鑫 +4 位作者 马少博 杨正华 王玮 刘峰 何伟 《热加工工艺》 北大核心 2024年第11期129-133,共5页
通过重力铸造法制备了AE81稀土镁合金,并对固溶处理后的合金在300℃和350℃进行压下量分别为15%、20%、25%和30%的轧制变形。结果表明:稀土元素Ce的加入导致铸态组织中Mg_(17)Al_(12)相不连续分布,镁基体上分布的Al4Ce相以块状形貌、中... 通过重力铸造法制备了AE81稀土镁合金,并对固溶处理后的合金在300℃和350℃进行压下量分别为15%、20%、25%和30%的轧制变形。结果表明:稀土元素Ce的加入导致铸态组织中Mg_(17)Al_(12)相不连续分布,镁基体上分布的Al4Ce相以块状形貌、中空管状形貌和针状形貌存在。轧制变形后,AE81合金所产生的变形组织的体积分数随着压下量的增大而增大,当压下量增大到25%时出现了明显的动态再结晶现象,再结晶晶粒的平均尺寸主要分布在200~400nm之间,且动态再结晶区域主要分布在Al_(4)Ce相周围。同时,Mg_(17)Al_(12)析出相的体积分数随着轧制温度和压下量的增大而增大,Mg_(17)Al_(12)相在基体上的分布得到改善。 展开更多
关键词 AE81镁合金 轧制 显微组织
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羊痘病毒81基因原核表达载体构建及蛋白表达
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作者 葛志毅 赵微 +3 位作者 程思危 肖婼婷 周娇洋 李有文 《塔里木大学学报》 2024年第3期36-42,共7页
为研究羊痘病毒81基因的生物学功能,构建羊痘病毒81基因的原核表达载体并表达其蛋白。利用在线软件对羊痘病毒81基因进行生物信息学分析,通过PCR技术扩增羊痘病毒81基因,与原核表达载体PET-42b构建重组质粒,大肠感受态细胞表达其蛋白。... 为研究羊痘病毒81基因的生物学功能,构建羊痘病毒81基因的原核表达载体并表达其蛋白。利用在线软件对羊痘病毒81基因进行生物信息学分析,通过PCR技术扩增羊痘病毒81基因,与原核表达载体PET-42b构建重组质粒,大肠感受态细胞表达其蛋白。结果表明:羊痘病毒81基因蛋白无信号肽,无跨膜区,有19个抗原决定簇,二、三级结构预测表明其以无规则卷曲为主,表现出疏水性;PCR成功扩增羊痘病毒81基因(492 bp),PET-42b-81原核表达载体构建成功,成功表达18.35 kDa大小81基因蛋白。本研究为深入探究羊痘病毒中间基因提供基础。 展开更多
关键词 羊痘病毒81基因 原核表达 生物信息学分析 81基因蛋白
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Distribution and geochemical significance of trace elements in kerogens from Ediacaran–Lower Cambrian strata in South China
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作者 Qian Deng Guanyu Zhao +2 位作者 Haozhe Wang Bin Cheng Zewen Liao 《Acta Geochimica》 EI CAS CSCD 2023年第1期50-62,共13页
Some trace elements(TEs),both bio-essential and redox-sensitive,are promising tracers of Earth’s surface processes.As an essential sedimentary organic matter,kerogen may have inherited and retained the key TEs from o... Some trace elements(TEs),both bio-essential and redox-sensitive,are promising tracers of Earth’s surface processes.As an essential sedimentary organic matter,kerogen may have inherited and retained the key TEs from organisms.In this study,the distribution of TEs in kerogens from two sections(Dongkanshang and Fengtan) in South China was analyzed to explore its biogeochemical significance during Ediacaran-Lower Cambrian.Compared with V and Zn,the relative concentrations of Co,Ni,Cu,and Mo were generally higher in kerogens than in the whole rocks.Enrichment of TEs in the kerogen was involved in the selective utilization of TEs by different organic precursors and the competition of sulfide in the depositional environment.The significant content of TEs in the kerogens from deep-water facies corresponded to a more negative δ^(13) Ckeras a result of the dominant taxa of chemo autotrophs with tremendous bioaccumulation potential for trace metals and the reduction conditions favorable for organic matter preservation.Furthermore,the content variations of trace elements in the kerogens coincided with the rise and fall of the Ediacaran biota,implying that the trace elements might have played an important role in early life evolution. 展开更多
关键词 Trace elements KEROGEN Ediacaran-Early Cambrian Biogeochemical significance South China
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国审中早熟高油大豆新品种合农81的选育及高产栽培技术
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作者 王象然 郭泰 +7 位作者 王志新 郑伟 李灿东 张振宇 徐杰飞 赵星棋 郭美玲 赵建有 《农业科技通讯》 2024年第4期192-194,200,共4页
合农81是黑龙江省农业科学院佳木斯分院以合丰55为母本、合农97为父本经有性杂交,利用系谱法选择育成的北方春大豆中早熟高油型大豆品种,适宜在黑龙江省第二积温带和第三积温带上限区域种植,2023年通过国审。本文作者介绍了该品种的品... 合农81是黑龙江省农业科学院佳木斯分院以合丰55为母本、合农97为父本经有性杂交,利用系谱法选择育成的北方春大豆中早熟高油型大豆品种,适宜在黑龙江省第二积温带和第三积温带上限区域种植,2023年通过国审。本文作者介绍了该品种的品种来源和选育经过、特征特性、产量表现,并对其栽培技术要点做了简要概述。 展开更多
关键词 高油大豆 中早熟 合农81 选育 栽培技术
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Changes and significance of serum ubiquitin carboxyl-terminal hydrolase L1 and glial fibrillary acidic protein in patients with glioma
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作者 Qing-Hua Zhu Jing-Kun Wu Gao-Lei Hou 《World Journal of Clinical Cases》 SCIE 2023年第14期3158-3166,共9页
BACKGROUND Brain gliomas are malignant tumors with high postoperative recurrence rates.Early prediction of prognosis using specific indicators is of great significance.AIM To assess changes in ubiquitin carboxy-termin... BACKGROUND Brain gliomas are malignant tumors with high postoperative recurrence rates.Early prediction of prognosis using specific indicators is of great significance.AIM To assess changes in ubiquitin carboxy-terminal hydrolase L1(UCH-L1)and glial fibrillary acidic protein(GFAP)levels in patients with glioma pre-and postoperatively.METHODS Between June 2018 and June 2021,91 patients with gliomas who underwent surgery at our hospital were enrolled in the glioma group.Sixty healthy volunteers were included in the control group.Serum UCH-L1 and GFAP levels were measured in peripheral blood collected from patients with glioma before and 3 d after surgery.UCH-L1 and GFAP levels in patients with glioma with different clinicopathological characteristics were compared before and after surgery.The patients were followed-up until February 2022.Postoperative glioma recurrence was recorded to determine the serum UCH-L1 and GFAP levels,which could assist in predicting postoperative glioma recurrence.RESULTS UCH-L1 and GFAP levels in patients with glioma decreased significantly 3 d after surgery compared to those before therapy(P<0.05).However,UCH-L1 and GFAP levels in the glioma group were significantly higher than those in the control group before and after surgery(P<0.05).There were no statistically significant differences in preoperative serum UCH-L1 and GFAP levels among patients with glioma according to sex,age,pathological type,tumor location,or number of lesions(P>0.05).Serum UCH-L1 and GFAP levels were significantly lower in the patients with WHO grade I-II tumors than in those with gradeⅢ-IV tumors(P<0.05).Serum UCH-L1 and GFAP levels were lower in the patients with tumor diameter≤5 cm than in those with diameter>5 cm,in which the differences were statistically significant(P<0.05).Glioma recurred in 22 patients.The preoperative and 3-d postoperative serum UCH-L1 and GFAP levels were significantly higher in the recurrence group than these in the non-recurrence group(P<0.05).Receiver operating characteristic curves were plotted.The areas under the curves of preoperative serum UCH-L1 and GFAP levels for predicting postoperative glioma recurrence were 0.785 and 0.775,respectively.However,the efficacy of serum UCH-L1 and GFAP levels 3 d after surgery in predicting postoperative glioma recurrence was slightly lower compared with their preoperative levels.CONCLUSION UCH-L1 and GFAP efficiently reflected the development and recurrence of gliomas and could be used as potential indicators for the recurrence and prognosis of glioma. 展开更多
关键词 GLIOMA Ubiquitin carboxy-terminal hydrolase L1 Glial fibrillary acidic protein Surgery Prognosis Clinical significance
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基于E81T8-Ni2填充盖面的L415M管线钢的焊接工艺评定 被引量:1
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作者 郭勇 吴红伟 +2 位作者 朱丽华 孙玉领 刘善民 《化工设备与管道》 CAS 北大核心 2024年第1期107-111,共5页
L415M管线钢环向焊接接头焊接工艺填充盖面焊丝采用E81T8-Ni2代替E71T8-Ni1,替代原则不符合GB/T 31032—2014《钢质管道焊接及验收》的覆盖原则,需要重新进行焊接工艺评定。基于施工单位焊接工艺需求,为了验证E81T8-Ni2能否用于L415M对... L415M管线钢环向焊接接头焊接工艺填充盖面焊丝采用E81T8-Ni2代替E71T8-Ni1,替代原则不符合GB/T 31032—2014《钢质管道焊接及验收》的覆盖原则,需要重新进行焊接工艺评定。基于施工单位焊接工艺需求,为了验证E81T8-Ni2能否用于L415M对接焊缝的填充盖面焊接,采用焊条电弧焊打底,自保护药芯焊丝半自动焊填充盖面组合焊接方法,根焊焊接材料为E6010,填充盖面为E81T8-Ni2,依据GB/T31032—2014进行焊接工艺评定。对评定试样进行外观检查、无损检测、拉伸试验、弯曲试验、刻槽锤断试验以及冲击试验。试验结果表明,L415M管线钢环向焊接接头各项指标合格,拉伸试样断在母材上,焊接接头满足高强匹配要求。焊接工艺评定试验研究成果可为长输管道用L415M管线钢焊接工艺以及焊材选择提供参考。 展开更多
关键词 长输管道 L415M FCAW E81T8-Ni2 焊接工艺评定
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Selection of Surgical Approach and Clinical Significance of Lower Cervical Spine Injuries Guided by SLIC Scoring System
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作者 Xinming Yang Xuyang Zhang +5 位作者 Yongli Jia Yanlin Yin Peinan Zhang Xingchong Du Yeming Wang Chen Chen 《Surgical Science》 2023年第12期695-704,共10页
Objective: To explore the feasibility and clinical significance of surgical approach selection for cervical spine injury guided by SLIC scoring system. Methods: The clinical data of 75 patients with lower cervical inj... Objective: To explore the feasibility and clinical significance of surgical approach selection for cervical spine injury guided by SLIC scoring system. Methods: The clinical data of 75 patients with lower cervical injury surgery from January 2020 to November 2022 were retrospectively analyzed, including 48 males and 27 females. Age: 28 - 65 years old. Causes of injury: 39 cases of traffic accidents, 15 cases of ice and snow sports, 12 cases of falling from high places, 9 cases of heavy objects. There were 12 cases of C3-4, 33 cases of C4-5, 21 cases of C5-6, and 9 cases of C6-7. Time from injury to medical treatment: 4 h - 2 d. Cervical spine X-ray, MRI, MDCT examination and preoperative SLIC score were performed on admission. Anterior approach was performed by subtotal cervical vertebrae resection or discectomy, titanium Cage or cage supported bone grafting and anterior titanium plate fixation. Posterior approach was performed with cervical laminoplasty, lateral mass or pedicle screw fixation and fusion. The combined anterior-posterior operation was performed by the anterior methods+ posterior methods. The time from injury to surgery is 12 h to 3 d. The function before and after operation was evaluated by JOA efficacy evaluation criteria. The correlation between the three surgical approaches and postoperative efficacy and SLIC score was compared. SPSS 22.0 software was used for statistical analysis of the data. Results: In this group of 75 patients, 32 cases of anterior operation, 22 cases of posterior operation and 21 cases of combined operation were followed up for no less than 12 months. There was no significant difference in age, gender, injury cause, injury segment, time from injury to treatment, and time from injury to operation among the three surgical approaches, which were comparable. The SLIC scores of mild, moderate and severe injuries of anterior surgery, posterior surgery and combined anterior and posterior surgery, They were (5.26 ± 1.24, 5.86 ± 1.67, 8.25 ± 0.21), (5.57 ± 1.43, 5.99 ± 1.85, 9.00 ± 0.25), (0, 5.98 ± 0.33, 9.44 ± 0.34), respectively. By comparing the SLIC scores and JOA scores of anterior surgery and posterior surgery, there was no difference in SLIC scores and JOA scores between the two groups for mild and moderate injuries (P > 0.05). However, the JOA scores at 3 months, 6 months and 12 months after surgery were different from those before surgery, and the postoperative efficacy and JOA scores were significantly improved (P & lt;0.05), indicating that the two surgical methods had the same therapeutic effect, that is, anterior or posterior surgery could be used to treat mild or moderate injuries (P > 0.05). There were differences in SLIC scores among the three surgical approaches for severe injury (P 0.05). The postoperative efficacy and JOA score of combined anterior-posterior approach were significantly improved compared with those before operation (P Conclusion: SLIC score not only provides accurate judgment for conservative treatment or surgical treatment of cervical spine injury, but also provides evidence-based medical basis and reference value for the selection of surgical approach and surgical method. According to the SLIC score, the surgical approach is safe and feasible. When the SLIC score is 4 - 7, anterior surgery is selected for type A injury, and posterior surgery is selected for type B injury. When the SLIC score is ≥8, combined anterior-posterior surgery should be selected. It is of great significance for clinical formulation of precision treatment strategy. 展开更多
关键词 Cervical Spine Injury Lower Cervical Injury Classification Score Surgical Route Selection Clinical significance
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The Significance and Application of the Introduction of Western Culture in College English Teaching
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作者 QIAO Xiaohong 《Sino-US English Teaching》 2023年第11期439-442,共4页
With the development and reform of China’s education,it is important for college English teachers to introduce western culture in the daily teaching process,and to improve the humanistic quality of college students.T... With the development and reform of China’s education,it is important for college English teachers to introduce western culture in the daily teaching process,and to improve the humanistic quality of college students.This paper discusses the significance of introducing western culture,and puts forward some countermeasures based on teaching experience,in order to provide some references for the application of the introduction of western culture in college English teaching. 展开更多
关键词 college English teaching western culture significance APPLICATION
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环剥处理对早熟核桃品种‘新温81’枝条发育及代谢相关酶活性的影响
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作者 王智宸 于军 +3 位作者 张锐 路琦 刘国庆 丁洋洋 《现代园艺》 2024年第5期14-17,共4页
核桃环剥处理可显著提升花芽分化比例以及果实中碳水化合物的积累。在核桃主枝部位进行环剥处理,测定枝条生长,叶片光合特征、氧化酶及代谢合成相关酶活性,综合分析不同环剥处理对叶片光合产物累计和代谢的影响。结果表明,环剥处理节间... 核桃环剥处理可显著提升花芽分化比例以及果实中碳水化合物的积累。在核桃主枝部位进行环剥处理,测定枝条生长,叶片光合特征、氧化酶及代谢合成相关酶活性,综合分析不同环剥处理对叶片光合产物累计和代谢的影响。结果表明,环剥处理节间长明显缩短,粗度明显增大,且营养枝节数显著增多,总花芽数增多。不同环剥处理花芽总数较对照分别增加27.1%、31.6%、33.1%;油脂转化期经过间隔环剥2圈(第1次环剥后30d环剥第2圈)处理,核桃叶片净光合速率和叶绿素含量分别显著升高了18.49%和18.79%;环剥处理后的叶片相较于对照组均促进了超氧化物歧化酶(SOD)、过氧化物酶(POD)、过氧化氢酶(CAT)、蔗糖合成酶(SS)、中性转化酶(NI)的酶活性。综合分析,生产上间隔环剥2圈处理能够提高叶片光合特性和代谢相关酶活性,促进光合产物的固定和蔗糖在枝条中的积累。 展开更多
关键词 新温81 环剥 光合作用 酶活性
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