Non-invasive assessment of esophageal varices:Status of today

With increasing burden of compensated cirrhosis,we desperately need noninvasive methods for assessment of clinically significant portal hypertension.The use of liver and spleen stiffness measurement helps in deferring unnecessary endoscopies for low risk esophageal varices.This would reduce cost and patient discomfort.However,these special techniques may not be feasible at remote areas where still we need only biochemical parameters.More prospective studies validating the non-invasive risk prediction models are definitely needed.

Simultaneous splenectomy improving the outcomes of patients with hepatocellular carcinoma,cirrhosis and portal hypertension treated with hepatectomy

Aims:Patients with cirrhosis and clinically significant portal hypertension(CSPH)usually have concomitant secondary hypersplenism,and splenectomy(Spx)is an option for treating these patients in the Asia‐Pacific region.CSPH is the most important risk factor for postoperative liver dysfunction(PLD)in patients with hepatocellular carcinoma(HCC)and cirrhosis undergoing liver resection.However,the impact of simultaneous Spx and hepatectomy in patients with HCC and CSPH remains unclear.In this study,we aimed to determine the impact of simultaneous Spx on the posthepatectomy outcomes in these patients.Methods:This study included 691 consecutive patients with hepatitis B virusrelated HCC,cirrhosis,and CSPH.These included 565 patients who underwent hepatectomy only(non‐Spx group)and 126 who underwent simultaneous hepatectomy and splenectomy(Spx group).We analyzed the effect of 25 preoperative and 5 intraoperative factors on postoperative outcomes using logistic regression.To overcome any possible selection bias,confounders were balanced by propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)analyses,and subgroup analyses were performed within the PSM‐matched groups.Results:Logistic regression analyses revealed that Spx was an independent protective factor for severe postoperative liver dysfunction(SPLD;odds ratio[OR]=0.22,95%confidence interval[CI]:0.11–0.43,p<0.001)and 90‐day SPLD‐related mortality(OR=0.21,95%CI:0.06–0.55,p=0.004),respectively.Spx was also independently associated with a higher overall survival rate(hazard ratio=0.63,95%CI=0.47–0.85,p=0.002)based on Cox regression analysis.PSM and IPTW models showed that the benefit of Spx was also consistent across the major and minor hepatectomy subgroups examined.Conclusion:Simultaneous Spx improved the outcomes of patients with HCC,cirrhosis,and CSPH treated with hepatectomy,including patients who underwent major and minor hepatectomies.