Synthesis of the Core-Shell Structure Materials as the Controlled-Release Drug Carrier

We have developed a controlled-release drug carrier. Smartly controlled-release polymer nanoparticles were firstly synthesized through RAFT polymerization as the controlled-release core. The structural and particle properties of polymer nanoparticles were characterized by nuclear magnetic resonance spectroscopy (1H-NMR), scanning electron microscope (SEM) and X-ray spectroscopy (EDX). Mesoporous materials were selected as the shell materials to encapsulate the smart core as the stable shell. The mesoporous shell was characterized by transmission electron microscopy (TEM) and scanning electron microscope (SEM). All the results showed that a well-defined core-shell structure with mesoporous structure was obtained, and this controllable delivery system will have the great potential in nanomedicine.

Synthesis of mesoporous silica materials with ascorbic acid as template via sol-gel process

Mesoporous silica materials with pore diameters of 2–5 nm have been prepared using ascorbic add as a nonsurfactant template or pore-forming agent in HCl-catalyzed sol-gel reactions of tetraethylorthosilicate, followed by removing the ascorbic acid compound by extraction with ethanol. Characterization results from nitrogen sorption isotherm, powder X-ray diffraction and transmission electron microscopy indicate that me materials have large specific surface areas (e.g. 1000 m2/g) and pore volumes (e.g. 0.8 cm3/g). The mesoporosity is arisen from interconnecting disordered wormlike channels and pores with relatively broad size distributions. As the ascorbic acid concentration is increased, the pore diameters and pore volumes of the materials increase.

A Novel, Efficient and Facile Method for the Template Removal from Mesoporous Materials

A new catalytic-oxidation method was adopted to remove the templates from SBA-1 5 and MCM-4 1 me- soporous materials via Fenton-like techniques under microwave irradiation. The mesoporous silica materials were treated with different Fenton agents based on the template＇s property and textural property. The samples were cha- racterized by powder X-ray diffraction（XRD） measurement, N2 adsorption-desorption isotherms, infrared spectro- scopy, 29Si MAS NMR and thermo gravimetric analysis（TGA）. The results reveal that this is an efficient and facile approach to the thorough template-removal from mesoporous silica materials, as well as to offering products with more stable structures, higher BET surface areas, larger pore volumes and larger quantity of silanol groups.