Silk fibroin nanoparticles(SFN)are interesting drug delivery systems due to their high load capacity and low toxicity.The aim of this study was to reveal how SFN load red wine polyphenols(RWP),and to assess their prot...Silk fibroin nanoparticles(SFN)are interesting drug delivery systems due to their high load capacity and low toxicity.The aim of this study was to reveal how SFN load red wine polyphenols(RWP),and to assess their protective effect during the early stages of digestion by using the dynamic gastrointestinal simulator(simgi^(R))under physiological conditions.RWP-SFN were prepared by incubation of SFN in red wine and recovered by centrifugation.The obtained nanoparticles(particle size of 194.4±2.1 nm and a Zeta potential of22.7±0.1 mV)showed a significant polyphenol loading content(7386.59±1018.28μg/g)with a high encapsulation efficiency(66.66±2.58%).They were highly stable during their passage through the digestive tract,being the activity of RWP highly preserved.This data paves the way for future developments of SFN as stabilizers with a wide range of applications in the field of food additives.展开更多
基金This work was partially supported(80%)from the European Commission,European Regional Development Funds FEDER Operational Programme‘Murcia’CCINº2007ES161PO001(Project No.1420-20)as well as Grants PID2019-108851RB-C21(Spanish Ministry of Science and Innovation),and ALIBIRD-CM 2020 P2018/BAA-4343(Comunidad de Madrid,Spain).
文摘Silk fibroin nanoparticles(SFN)are interesting drug delivery systems due to their high load capacity and low toxicity.The aim of this study was to reveal how SFN load red wine polyphenols(RWP),and to assess their protective effect during the early stages of digestion by using the dynamic gastrointestinal simulator(simgi^(R))under physiological conditions.RWP-SFN were prepared by incubation of SFN in red wine and recovered by centrifugation.The obtained nanoparticles(particle size of 194.4±2.1 nm and a Zeta potential of22.7±0.1 mV)showed a significant polyphenol loading content(7386.59±1018.28μg/g)with a high encapsulation efficiency(66.66±2.58%).They were highly stable during their passage through the digestive tract,being the activity of RWP highly preserved.This data paves the way for future developments of SFN as stabilizers with a wide range of applications in the field of food additives.
