An efficient synthesis of bis(indolyl)methanes and N,N'-alkylidene bisamides by Silzic under solvent free conditions

An operationally simple and green method for the synthesis of a wide range of bis（indolyl）methanes,and N,N＇-alkylidene bisamides under mild conditions,with excellent yields using Silzic,has been developed.This improved method furnishes in good yields bis（indolyl）methanes derivatives starting from indole and aldehydes,or ketones,and N,N＇-alkylidene bisamides derivatives starting from acetamide and aldehydes.The catalytic system was reused up to three times with the same efficiency.

固载化ZnCl_2催化合成3-甲基-3-丁烯-1-醇

采用碾磨-活化法制备了SiO2-ZnCl2(Silzic)催化剂,并将其用于异丁烯与甲醛Prins缩合合成3-甲基-3-丁烯-1-醇(MBOH)。系统研究了温度、物料比、时间和催化剂的组成及用量对该反应的影响。结果表明,在不同的条件下,甲醛都保持着99%以上的高转化率;然而,不同的条件对MBOH的选择性和收率的影响程度不同,其中,反应温度、催化剂的酸量是影响该反应的关键因素;物料比和反应时间对MBOH的选择性和收率的影响相对较小。实验得到最佳的反应条件为,反应温度210℃、二氧六环8 g、三聚甲醛1.5 g、n(异丁烯)/n(三聚甲醛)=7∶1、30 mg 1 mmol/g Silzic和反应时间2 h,在此条件下MBOH的选择性和收率可分别达到93.8%和93.4%。当催化剂循环使用五次时,MBOH的收率降为85.2%,表明该催化剂具有一定的重复使用性。