Glucocorticoids-based prodrug design:Current strategies and research progress

Attributing to their broad pharmacological effects encompassing anti-inflammation,antitoxin,and immunosuppression,glucocorticoids(GCs)are extensively utilized in the clinic for the treatment of diverse diseases such as lupus erythematosus,nephritis,arthritis,ulcerative colitis,asthma,keratitis,macular edema,and leukemia.However,longterm use often causes undesirable side effects,including metabolic disorders-induced Cushing's syndrome(buffalo back,full moon face,hyperglycemia,etc.),osteoporosis,aggravated infection,psychosis,glaucoma,and cataract.These notorious side effects seriously compromise patients'quality of life,especially in patients with chronic diseases.Therefore,glucocorticoid-based advanced drug delivery systems for reducing adverse effects have received extensive attention.Among them,prodrugs have the advantages of low investment,low risk,and high success rate,making them a promising strategy.In this review,we propose the strategies for the design and summarize current research progress of glucocorticoid-based prodrugs in recent decades,including polymer-based prodrugs,dendrimer-based prodrugs,antibody-drug conjugates,peptide-drug conjugates,carbohydrate-based prodrugs,aliphatic acid-based prodrugs and so on.Besides,we also raise issues that need to be focused on during the development of glucocorticoid-based prodrugs.This review is expected to be helpful for the research and development of novel GCs and prodrugs.

Research on the Course of Principles of Concrete Structure Design

Nowadays,education and teaching have become a hot topic,and teaching in colleges and universities is facing a brand-new development direction.Principles of Concrete Structure Design,as one of the main courses,transmits professional knowledge for students,enhances the students’professional ability,and further carries out in-depth research on the course to bring a better teaching effect for students.The article mainly focuses on the research of the principles of concrete structure design course,conducts an analysis of the teaching characteristics of the principles of concrete structure design course,and reasonably sets the teaching content from the optimization of the course teaching objectives;innovative course teaching methods can deepen the effect of knowledge understanding;reform of experimental practice teaching can lay down the effect of the internalization of knowledge,etc.The in-depth description and discussion of the relevant aspects of the research aim to provide guidelines for related research.

Curriculum Reform Practices in “Cosmetic Product Formulation Design and Preparation Technology” Under the Perspective of Integration of Industry, Education, and Research

With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Technology”serves as the foundation for cultivating students’abilities in cosmetic development and preparation.To foster high-quality skilled talents capable of adapting to the rapid growth of color cosmetics and to better promote the deep integration of scientific and technological industries with curriculum teaching,the teacher team embarked on active explorations and practical teaching research for curriculum teaching reform from four dimensions:strengthening top-level design,enriching teaching content,optimizing teaching design,and reforming assessment methods.These efforts have enhanced students’comprehensive vocational qualities and innovative consciousness,contributing to the teaching reform in higher vocational colleges under the integration of industry,education,and research.

从Design Research思潮看我国艺术设计工作室教学模式的改革

艺术设计教学改革一直是困扰我国艺术设计教育的一个重大课题,本文将国内当前各大院校流行的艺术设计工作室教学改革模式与欧美发达国家的艺术设计Design Research思潮进行对比,结合美国著名大学艺术设计研究生的实际设计课题,剖析中西方关于艺术设计教育教学模式中存在的较深层次的差异,目的是为完善我国设计工作室教学模式和整个艺术设计教育找出新的办法。

Neutronic design investigation of a liquid injection-based second shutdown system for a typical research reactor using MCNPX

Safety systems, built on state-of-the-art technology, are essential for achieving acceptable levels of plant safety to minimize hazards to the reactor and the general public. The second shutdown system(SSS) as an engineered safety feature and a part of the reactor protection system(RPS) is a means for rapidly shutting down a nuclear reactor, keeping it in a subcritical state and serving as a backup to the first shutdown system(FSS). In this research, one SSS with two types of optimum chamber designs is proposed that take into account the main current characteristic features of the Tehran research reactor with improvements over earlier designs. They are based on a liquid neutron absorber injection that is preferably different, diverse, and independent from the FSS based on the rod drop mechanism. The major design characteristics of this SSS with two different chambers were investigated using MCNPX 2.6.0 code. The performed calculations showed that the designed SSS is a reliable shutdown system, assuring an appropriate shutdown margin and injection time, with no significant effects on the effective delayed neutron fraction while causing minimal variations to the core structure. Further, the reasonable financial cost and the prolongation of the operation cycle are additional advantages of this design.

An Research on the Model Design of the Academic Education's Credit Transfer in the Open University

Based on the analyses of the credit bank both at home and abroad, explore the effective way to construct the credit transfer model, find out the main problems in the process of transferring, design a much better model, formulate a new standard for credit transfer and carry out the research on the model design of the academic education's credit transfer in the open university.

Research and Design of Reconfigurable Matrix Multiplication over Finite Field in VLIW Processor

Matrix multiplication plays a pivotal role in the symmetric cipher algorithms, but it is one of the most complex and time consuming units, its performance directly affects the efficiency of cipher algorithms. Combined with the characteristics of VLIW processor and matrix multiplication of symmetric cipher algorithms, this paper extracted the reconfigurable elements and analyzed the principle of matrix multiplication, then designed the reconfigurable architecture of matrix multiplication of VLIW processor further, at last we put forward single instructions for matrix multiplication between 4×1 and 4×4 matrix or two 4×4 matrix over GF(2~8), through the instructions extension, the instructions could support larger dimension operations. The experiment shows that the instructions we designed supports different dimensions matrix multiplication and improves the processing speed of multiplication greatly.

Caregiving in Alzheimer’s Disease: Research Designs &Considerations

Alzheimer’s disease and related dementias have made a considerable impact on society, and can take a significant toll on familial caregivers. Recent successful caregiving interventions suggest a promising future, though informed research design, a priori, is paramount in ensuring quality results that the Government and public may use to make informed policy and personal healthcare decisions. Research designs including basic science, randomized controlled trials (RCTs), qualitative, and quasi-experimental designs serve as the primary basis for discussion with literary examples and caveats.

Engineering Intelligent Racing Concepts Using Design Research Methods

The automotive seat market is positioned to significantly grow over the next five years. Research into how sensor implementation in every day driver cars can enhance driver wellness is becoming increasingly popular and visible in the automotive seat industry. However, in the competitive race car industry,?drivers prioritize driving ability over wellness. To further examine this phenomenon, the Human-Machine Interaction?Lab at the Georgia Institute of Technology took a unique approach to developing strong use cases for implementing sensor technology to improve driving ability for race car drivers by combining qualitative and quantitative research data obtained through modern design research and planning methodology. Following a process relying heavily on user-centered design methods, the authors developed a business case concept?for?a sensor-based seat accessory that acts as a competitive racer’s?driving coach?that is able to identify the mechanics of braking, turning, and accelerating through pressure sensors in the driver’s seat pan surface. This technology allows drivers to precisely understand when and how hard to brake, turn, or accelerate out of turns, thus reducing heat times and financial burden for drivers.

Research on and Design of Mechanical System with Optimal Cutting Movement Trajectory of Energy-Saving Stone-Sawing Machine

The technique of cutting slabstone with stone-sawi ng machine is analyzed completely. A new kind of cutting movement trajectory is gi ven whose actual cutting efficiency is near to 100%. It can reduce the energy w earing greatly, and the surface quality of the product is improved to the utmost extent. The design mechanism of the optimal cutting movement trajectory system structure is analyzed incisively. At the same time, the principle of the complex movement of horizontal movement and swing is researched. The optimal design scheme of th e cutting movement trajectory system structure is set up. The choice method to g et the superior value of the movement system structure is found. The mathematics function formula is established which exhibits the relationship between the par ameter of the complex movement structure and that of the system movement structu re. By the formula, the precision value of the offset can be figured out. The r ule is adapted to different types of energy-saving stone-sawing machines. The complex movement structure of horizontal movement and swing is designed to f ulfill the cutting movement. It can make the saw frame move up with the hanging pod deviating from the vertical direction. At the same time, the saw frame have a down-movement. Then the sum of the two movements is near to zero, and the saw blade and the stone can keep in touch during the whole horizontal cutting. The result is that the actual cutting efficiency is 100%. Also, when the hanging pod moves to the limited position, the saw frame can keep the original inertia, and continue to swing up. It makes the back-cutting have high energy-storing. The optimal design of the eccentricity balance wheel is done. The mathematics fo rmula for expressing the movement system structure is deduced. The calculation m ethod and formula is set up which is used to get the value of important componen ts such as offset. The choice method and formula of elasticity distortion coeffi cient is set up when the saw frame moves smoothly. It is concluded that the offs et is the key dimension to actualize the optimal cutting movement trajectory. The resolving of the technical problems discussed above offers a theoretic and technical basis for optimal design of energy-saving stone-sawing machines.

Global Urban Design Research from 2007 to 2017: A Systematic Research Review

Urban design research in the last decade was reported by conducting a bibliometric analysis of the literature published worldwide between 2007 and 2017. The exploratory study aimed to show the origins and frontiers for researchers. The document co-occurrence analysis of keywords and co-citation analysis of references were made in CiteS pace III to explore research basements and research trajectories, emerging trends and new development, together with Bibexcel tools. Physical activities and thermal comfort are two main topics of urban design research that are indirectly connected in some way, and sociological and computer-based research is likely to be strengthened.

Research and Design of IPv6 Network Management and Operations Support System

IPv6 is the foundation of the development of Next Generation Internet (NGI). An IPv6 network management and operations support system is necessary for real operable NGI. Presently there are no approved standards yet and relevant equipment interfaces are not perfect. A Network Management System (NMS) at the network layer helps implement the integrated management of a network with equipment from multiple vendors, including the network resources and topology, end-to-end network performance, network failures and customer Service Level Agreement (SLA) management. Though the NMS will finally realize pure IPv6 network management, it must be accommodated to the management of relevant IPv4 equipment. Therefore, modularized and layered structure is adopted for the NMS in order to implement its smooth transition.

Conceptual Proposal of a Facility Design for Accommodating Minipigs for Pharmaceutical and Radiopharmaceutical Research

The use of Animal House Facilities of IPEN-CNEN/SP （Nuclear and Energetic Research Institute-National Nuclear Energy Commission/SP, Brazil） has provided rats and mice with controlled sanitary quality for research and quality control in the production of radiopharmaceuticals lots, produced at IPEN, following rules of CONCEA-Brazilian National Council for Animal Experimentation Control and approved in CEUA （Ethics Committee on the Use of Animals）, before they are sent to hospitals and clinics spread out in Brazil, for use in nuclear medicine. The production and the supply of high quality laboratory animals have fundamental importance for the accomplishment of vanguard scientific research, with reproducibility and universality. The quality of those animals depends, largely, on the available facilities for their production and lodging, to assure the demanded sanitary control and animal＇s welfare, in agreement with the ethical principles that control the activity. Therefore, the facilities design is of vital importance so that the mentioned requirements can be reached. Nevertheless, pigs and miniature pigs have gained importance as large animal models in medicine. With their size, organ capacity, and physiology resembling in several aspects that of humans, pigs are well suited for preclinical experiments and long-term safety studies. Minipigs will be used for preclinical testing of radiopharmaceuticals and assays radioactive materials for cardiac tests. This paper describes the premises and preliminary activities that have been performed at IPEN for the design of new Animal House Facilities dedicated to keeping minipigs taking into account fundamental aspects such as： animal＇s welfare, sanitation, genetic, in agreement with the ethical principles that control the activity and environmental concerns.

The Industrial Heritage and the New Architecture： Teaching, Researching, Designing the Place Identity

The new architecture may provide unusual opportunities for the abandoned areas involved by former industrial processes, both in the city centers and in the landscape. In fact, it may create new centralities and give new collective function for deprived areas. The case study of the architectural and educational project for a new museum park devoted to the technique and the science in the Apennine＇ s landscape near Parma （Italy） may give an interesting point of view about the role of the teaching and the research of the architecture in the former industrial heritage, and to avoid the abandonment and the pauperization of the territory around.

A Design Philosophy From the View of Creation:Design vs.Research

Mankind holds creation as a special human property contributing knowledge and culture.Both design and research belong to creative activities.While research focuses on new findings following the rule of truth,design pays more attention to new designed works following the rule of beauty.Three philosophical principles for design are suggested as ABC principles:A.Design approaches beauty;B.Design balances science and art;C.Design concerns culture.Three types of design are practically discussed,including 2D art or symbol design,3D engineering or product design,and nD program or form design.

A Research Design on Reading Strategies

Students' reading time is limited in class in high school English teaching, but the scores take up a big proportion in college entrance examination. In addition, parts of Reading Practice are added in the elective books of New Standard English for Senior High and have the features of long passages and many new words, increasing students' reading difficulties, As an English teacher in high school, the author deeply understands the students' confusion and thus conducts this research.

Under "Integration of Doing, Learning and Teaching", Research on the Project-Based Teaching Innovation of "Landscape Planning and Design"

Based on the research on the project course theory of "integration of theory and practice" in higher vocational education and the analysis of practical teaching in colleges and universities at home and abroad, combined with literature research, case analysis, system theory and other research methods, the project-based teaching goal, model, content and means of "integration of doing, learning and teaching" in higher vocational education is explored, and the project-based teaching model of "Landscape Planning and Design" is discussed combined with the application of information-based teaching methods. So as to provide references for carrying out the project-based teaching in similar courses in higher vocational colleges and really achieve docking the actual post requirements with the course to provide the basis for achieving the purpose of cultivating skilled talents in higher vocational education.

Research on the Design of the Innovative Teaching Platform for College English Linguistics Based on Network Technologies

As a compulsory course for English majors in colleges and universities, English linguistics is of great significance to English majors in colleges and universities. However, as the English linguistics curriculum itself belongs to theoretical teaching, the teaching process requires the two-way interaction between teachers and students, so the teaching effect is not good. College English linguistics takes the cultivation of students' comprehensive abilities to use English as the premise, and emphasizes the cultivation of students' listening and speaking abilities to help students transmit the accurate written and oral information in the process of the social work and communication, thus improving students' English levels and preparing for their future international communication.

Research on Teaching Design of TESOL

TESOL is the abbreviation of Teaching English to Speakers of Other Languages. The basic meaning is international English teacher qualification certificate, and the teaching objects are the students which uses English as the second language. The theme of TESOL is to observe the methods and theory of English teaching, which makes the teachers＇ level of English teaching improve. On the basis of course learning experience of TESOL, the paper observes the disadvantages and advantages of TESOL from teaching design and teaching ideas. And the paper discuses the enlightenment of it for domestic English teaching.

Ink Applied Research of Element Graphic Design Teaching in Intangible Cultural Context

With spreading and deepening of intangible cultural heritage protection movement in this century, Chinese ink art is among the Masterpieces of the Oral and Intangible Heritage of Humanity. Institutions of higher education is an academic heritage, culture, communication, personnel training platform and carrier, we assume an important role in the protection of heritage and ink art. Modem design teaching is in order to better local cultural heritage, but also to change their design education, more and more traditional elements are used in the classroom student design works. This paper aims to cultural connotations of traditional Chinese ink painting itself carrying elements and aesthetic charm of the excavation, analysis and sorting, which will be teaching in their designs into modem art. The contemporary art and design are to make cultural connotation and aesthetic meaning, making a good combination of tradition and art.