Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

During the development of the nervous system,there is an overproduction of neurons and synapses.Hebbian competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or strengthening.We have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse consolidation.The purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this process.In particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental competition.The dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific endings.We describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon terminals.The downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary synapses.Finally,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to reduce transmitter release and promote withdrawal of the most unfavorable nerve terminals during elimination(the weakest in acetylcholine release and those that have already become silent).The main findings contribute to a better understanding of punishment-rewarding interactions between nerve endings during development.Identifying the molecular targets and signaling pathways that allow synapse consolidation or withdrawal of synapses in different situations is important for potential therapies in neurodegenerative diseases.

Discussion on the Application of Technical and Tactical Skills in Mixed Martial Arts Competitions

This article mainly analyzes the application of technical and tactical skills in mixed martial arts competitions,including mixed martial arts and its competition characteristics,the main application significance of technical and tactical skills in mixed martial arts competitions,and its primary application strategies.It is hoped that this analysis can provide some guidelines for the appropriate application of mixed martial arts athletes’technical and tactical skills to improve their winning rate in mixed martial arts competitions.

Research on the Role of Guiding Students to Participate in Skills Competitions on the Development of Young Teachers in Vocational Colleges

This paper explores the role of guiding students to participate in skills competitions on the development of young teachers in vocational colleges.We investigate the impact of skills competitions on the consolidation of professional knowledge,development of innovation capabilities,improvement of hands-on abilities,and enhancement of communication skills with students.The results of this research demonstrate that skills competitions have a positive influence on the professional growth of young teachers.The consolidation of professional knowledge,development of innovation capabilities,improvement of hands-on abilities,and enhancement of communication skills collectively contribute to the effectiveness of young teachers in vocational colleges.It is recommended that vocational colleges prioritize and support the participation of young teachers in skills competitions to foster their professional development.

Teaching Design and Implementation of the Electrical and Electronic Technology Course Based on Teaching Ability Competition

The teaching ability competition is a vital method for stimulating teachers’enthusiasm and enhancing their teaching skills.This approach has gained increasing attention from colleges and universities in recent years.The competition focuses on evaluating teachers’capabilities in designing and implementing lessons,encouraging the exchange of new educational ideas and high-quality teaching methods.Reforming the teaching of Electrical and Electronic Technology courses based on insights from teaching competitions can significantly improve teaching quality.This paper explores the teaching design and implementation of the Electrical and Electronic Technology course,drawing on the principles of teaching ability competitions.First,it analyzes the existing problems in teaching this course.Then,it highlights the significant benefits that teaching competitions bring to the course.Based on these insights,the paper proposes practical strategies aimed at enhancing students’interest and practical skills,thereby promoting innovative developments in teaching Electrical and Electronic Technology.

The Model of“Post,Course,Competition,Certificate”Integrated Education for Electronic Information Engineering Technology Major in Higher Vocational Colleges

The core education function of higher vocational colleges is to train technical talents with high quality,so as to meet the needs of talents in the development stage of our society.Under the guidance of talent training,higher vocational colleges need to pay attention to establishing an all-round and three-dimensional education model,and promote innovation of higher vocational education on the basis of this.It is also a way to promote the innovation of higher vocational education to vigorously promote the construction of“post,course,competition,certificate”mode in the construction of education mode.Through the construction of“post,course,competition,certificate”mode,the education mode of higher vocational colleges is gradually improved,so as to strengthen the effectiveness of talent training in higher vocational colleges.Therefore,in this paper,the author puts forward some suggestions to promote the construction of the integrated education mode of the electronic information engineering technology major in higher vocational colleges,so as to help improve the talent training level of higher vocational colleges.

Developing nonlinear additive tree crown width models based on decomposed competition index and tree variables

Crown development is closely related to the biomass and growth rate of the tree and its width(CW)is an important covariable in growth and yield models and in forest management.To date,various CW models have been proposed.However,limited studies have explicitly focused on additive and inherent correlation of crown components and total CW as well as the influence of competition on crown radius from the corresponding direction.In this study,two model systems were used,i.e.,aggregation method system(AMS)and disaggregation method system(DMS),to develop crown width additive model systems.For calculating spatially explicit competition index(CI),four neighbor tree selection methods were evaluated.CI was decomposed into four cardinal directions and added into the model systems.Results show that the power model form was more proper for our data to fit CW growth.For each crown radius and total CW,height to the diameter at breast height(HDR)and basal area of trees larger than the subject tree(BAL)significantly contributed to the increase of prediction accuracy.The 3-m fixed radius was optimal among the four neighborhoods selection ways.After adding decomposed competition Hegyi index into model systems AMS and DMS,the prediction accuracy improved.Of the model systems evaluated,AMS based on decomposed CI provided the best performance as well as the inherent correlation and additivity properties.Our study highlighted the importance of decomposed CI in tree CW modelling for additive model systems.This study focused on methodology and could be applied to other species or stands.

Competitive oxidation behavior of Ni-based superalloy GH4738 at extreme temperature

A high thrust-to-weight ratio poses challenges to the high-temperature performance of Ni-based superalloys. The oxidation behavior of GH4738 at extreme temperatures has been investigated by isothermal and non-isothermal experiments. As a result of the competitive diffusion of alloying elements, the oxide scale included an outermost porous oxide layer (OOL), an inner relatively dense oxide layer (IOL), and an internal oxide zone (IOZ), depending on the temperature and time. A high temperature led to the formation of large voids at the IOL/IOZ interface. At 1200℃, the continuity of the Cr-rich oxide layer in the IOL was destroyed, and thus, spallation occurred. Extension of oxidation time contributed to the size of Al-rich oxide particles with the increase in the IOZ. Based on this finding,the oxidation kinetics of GH4738 was discussed, and the corresponding oxidation behavior at 900-1100℃ was predicted.

ENTIRE SOLUTIONS OF LOTKA-VOLTERRA COMPETITION SYSTEMS WITH NONLOCAL DISPERSAL

This paper is mainly concerned with entire solutions of the following two-species Lotka-Volterra competition system with nonlocal(convolution)dispersals:{u_(t)=k*u-u+u(1-u-av),x∈R,t∈R,vt=d(k*v-v)+rv(1-v-bu),c∈R,t∈R.(0.1)Here a≠1,b≠1,d,and r are positive constants.By studying the eigenvalue problem of(0.1)linearized at(ϕc(ξ),0),we construct a pair of super-and sub-solutions for(0.1),and then establish the existence of entire solutions originating from(ϕc(ξ),0)as t→−∞,whereϕc denotes the traveling wave solution of the nonlocal Fisher-KPP equation ut=k*u−u+u(1−u).Moreover,we give a detailed description on the long-time behavior of such entire solutions as t→∞.Compared to the known works on the Lotka-Volterra competition system with classical diffusions,this paper overcomes many difficulties due to the appearance of nonlocal dispersal operators.

GPU parallel computation of dendrite growth competition in forced convection using the multi-phase-field-lattice Boltzmann model

A graphics-processing-unit(GPU)-parallel-based computational scheme is developed to realize the competitive growth process of converging bi-crystal in two-dimensional states in the presence of forced convection conditions by coupling a multi-phase field model and a lattice Boltzmann model.The elimination mechanism in the evolution process is analyzed for the three conformational schemes constituting converging bi-crystals under pure diffusion and forced convection conditions,respectively,expanding the research of the competitive growth of columnar dendrites under melt convection conditions.The results show that the elimination mechanism for the competitive growth of converging bi-crystals of all three configurations under pure diffusion conditions follows the conventional Walton-Chalmers model.When there is forced convection with lateral flow in the liquid phase,the anomalous elimination phenomenon of unfavorable dendrites eliminating favorable dendrites occurs in the grain boundaries.In particular,the anomalous elimination phenomenon is relatively strong in conformation 1 and conformation 2 when the orientation angle of unfavorable dendrites is small,and relatively weak in conformation 3.Moreover,the presence of convection increases the tip growth rate of both favorable and unfavorable dendrites in the grain boundary.In addition,the parallelization of the multi-phase-field-lattice Boltzmann model is achieved by designing the parallel computation of the model on the GPU platform concerning the computerunified-device-architecture parallel technique,and the results show that the parallel computation of this model based on the GPU has absolute advantages,and the parallel acceleration is more obvious as the computation area increases.

Competitive effect, but not competitive response, varies along a climatic gradient depending on tree species identity

Background: Understanding the role of species identity in interactions among individuals is crucial for assessing the productivity and stability of mixed forests over time. However, there is limited knowledge concerning the variation in competitive effect and response of different species along climatic gradients. In this study, we investigated the importance of climate, tree size, and competition on the growth of three tree species: spruce(Picea abies), fir(Abies alba), and beech(Fagus sylvatica), and examined their competitive response and effect along a climatic gradient.Methods: We selected 39 plots distributed across the European mountains with records of the position and growth of 5,759 individuals. For each target species, models relating tree growth to tree size, climate and competition were proposed. Competition was modelled using a neighbourhood competition index that considered the effects of inter-and intraspecific competition on target trees. Competitive responses and effects were related to climate.Likelihood methods and information theory were used to select the best model.Results: Our findings revealed that competition had a greater impact on target species growth than tree size or climate. Climate did influence the competitive effects of neighbouring species, but it did not affect the target species? response to competition. The strength of competitive effects varied along the gradient, contingent on the identity of the interacting species. When the target species exhibited an intermediate competitive effect relative to neighbouring species, both higher inter-than intraspecific competitive effects and competition reduction occurred along the gradient. Notably, species competitive effects were most pronounced when the target species' growth was at its peak and weakest when growing conditions were far from their maximum.Conclusions: Climate modulates the effects of competition from neighbouring trees on the target tree and not the susceptibility of the target tree to competition. The modelling approach should be useful in future research to expand our knowledge of how competition modulates forest communities across environmental gradients.

Research on the Reform of the Course“Reading of Concrete Structure Plan and Construction Drawings”Under the Background of“Promoting Teaching and Learning Through Competitions”

The inherent teaching approach can no longer meet the demands of society.In this paper,current issues within the teaching landscape of architectural engineering technology in higher vocational colleges as well as the policies and teaching demands that formed the basis of this model were analyzed.The study shows the importance of the implementation of the teaching model“promoting teaching and learning through competitions.”This model puts emphasis on the curriculum and teaching resources,while also integrating the teaching process and evaluation with competition.These efforts aim to drive education reform in order to better align with the objectives of vocational education personnel training,while also acting as a reference for similar courses.

Empowering Vocational Students to Excel in Skills Competitions:Challenges and Recommendations

This paper analyzes the key challenges faced by vocational college students when participating in national skills competitions.It identifies problems such as limited resources,insufficient training,lack of mentorship,academic workload constraints,and inadequate equipment.Targeted solutions are proposed,including improving resource access,providing structured skill training,implementing expert mentorship programs,offering flexible schedules,and upgrading experimental equipment.Implementing these recommendations through a collaborative effort among stakeholders can significantly empower vocational students to excel in skills competitions by enabling access to resources,building practical skills,obtaining guidance,managing time effectively,and gaining hands-on experience.

Enhancing Vocational Education through Innovative Skills Competitions: Challenges and Solutions

This study investigates the challenges encountered by vocational colleges when preparing for innovative skills competitions and proposes effective countermeasures.It highlights issues concerning students’motivation,limited financial resources and hardware,teacher capacity limitations,inadequate reward systems,and curriculum misalignment.Through meticulous research and analysis,this paper presents practical recommendations to mitigate these challenges.Suggestions encompass strategies to enhance students’motivation,increase financial support,provide professional development opportunities for teachers,revamp the reward system,and align the curriculum with competition requirements.By implementing these measures,vocational colleges can cultivate active student participation,elevate teaching quality,bridge the gap between education and industry demands,and equip students for success in innovative skills competitions.

Research on the Cultivation Path of Craftsmanship Spirit in Vocational Colleges: from the Perspective of Skills Competition

The spirit of craftsmanship is gaining increasing attention from both society and the education community.Along with professional knowledge,continuous research,and innovation have become decisive factors in determining the quality of products.In this context,vocational colleges strive to cultivate high-quality skilled talents,making the cultivation of craftsmanship spirit a crucial component of vocational education.This study explores the cultivation path of craftsmanship spirit through the lens of skills competitions,with a special emphasis on developing students’perseverance.The research conclusions of this article hold significant reference value for the implementation of vocational education policies.

The Role of Skills Competitions in Improving the Practical Ability of Vocational College Students

Vocational education and general education are two different types of education that are equally important.The orientation of talent training in vocational education is to nurture skilled talents to serve the society.The practical ability of students is both the focus of teaching in vocational colleges and the requirement of enterprise posts.The various types of skills competitions provide a“stage”for students to showcase their abilities.First,this paper explores students’problem-solving ability while preparing for these competitions,expounding the importance of vocational education and skills competitions.Second,this paper summarizes the views of different scholars.Third,based on a specific case,this paper describes the improvement in students’ability while preparing for these competitions.Fourth,this paper analyzes the results of the questionnaire survey conducted to investigate the improvement in students’ability.Lastly,this paper puts forward several suggestions that appeal for vocational colleges to pay more attention to skills competitions.

Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma

BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in neoplasia.However,the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma(HCC)remain dismal.AIM To establish a cyclin dependent kinase inhibitor 2A(CDKN2A)-related ceRNA network and recognize potential prognostic indicators for HCC.METHODS The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal database.Differential expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC samples.The targeted microRNAs were predicted by lncBasev3.0,and the targeted mRNAs were predicted by miRDB,and Targetscan database.The univariate and multivariate analysis were utilized to identify independent prognostic indicators.RESULTS CDKN2A was frequently mutated and deleted in HCC.The single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle pathways.The CDKN2A-related ceRNA network-growth arrest specific 5(GAS5)/miR-25-3p/SRY-box transcription factor 11(SOX11)was successfully established.GAS5 was recognized as an independent prognostic biomarker,whose overexpression was correlated with a poor prognosis in HCC patients.The association between GAS5 expression and methylation,immune infilt-ration was explored.Besides,traditional Chinese medicine effective components targeting GAS5 were obtained.CONCLUSION This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and progression.Moreover,GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.

Reform and Practice of Talent Training of Architectural Interior Design Professionals in Higher Vocational Skills Competition: Taking Chongqing Energy Vocational College as an Example

For higher vocational colleges,skills competition is an important indicator of professional personnel training quality.In this paper,the architectural interior design professional skills competition in Chongqing Energy Vocational College is taken as an example,the many years of teaching and competition experience are taken into account,the problems existing in the cultivation of architectural interior design professionals in higher vocational colleges are analyzed,and corresponding solutions are proposed.

Treatment of Helicobacter pylori with potassium competitive acid blockers:A systematic review and meta-analysis

BACKGROUND Helicobacter pylori(H.pylori)infects over half the global population,causing gastrointestinal diseases like dyspepsia,gastritis,duodenitis,peptic ulcers,GMALT lymphoma,and gastric adenocarcinoma.Eradicating H.pylori is crucial for treating and preventing these conditions.While conventional proton pump inhibitor(PPI)-based triple therapy is effective,there’s growing interest in longer acid suppression therapies.Potassium competitive acid blocker(P-CAB)triple and dual therapy are new regimens for H.pylori eradication.Initially used in Asian populations,vonoprazan(VPZ)has been recently Food and Drug Administration-approved for H.pylori eradication.AIM To assess the efficacy of regimens containing P-CABs in eradicating H.pylori infection.METHODS This study,following PRISMA 2020 guidelines,conducted a systematic review and meta-analysis by searching MEDLINE and Scopus libraries for randomized clinical trials(RCTs)or observational studies with the following command:[("Helicobacter pylori"OR"H pylori")AND("Treatment"OR"Therapy"OR"Eradication")AND("Vonaprazan"OR"Potassium-Competitive Acid Blocker"OR"P-CAB"OR"PCAB"OR"Revaprazan"OR"Linaprazan"OR"Soraprazan"OR"Tegoprazan")].Studies comparing the efficacy of P-CABs-based treatment to classical PPIs in eradicating H.pylori were included.Exclusion criteria included case reports,case series,unpublished trials,or conference abstracts.Data variables encompassed age,diagnosis method,sample sizes,study duration,intervention and control,and H.pylori eradication method were gathered by two independent reviewers.Meta-analysis was performed in R software,and forest plots were generated.RESULTS A total of 256 references were initially retrieved through the search command.Ultimately,fifteen studies(7 RCTs,7 retrospective observational studies,and 1 comparative unique study)were included,comparing P-CAB triple therapy to PPI triple therapy.The intention-to-treat analysis involved 8049 patients,with 4471 in the P-CAB intervention group and 3578 in the PPI control group across these studies.The analysis revealed a significant difference in H.pylori eradication between VPZ triple therapy and PPI triple therapy in both RCTs and observational studies[risk ratio(RR)=1.17,95%confidence interval(CI):1.11-1.22,P<0.0001]and(RR=1.13,95%CI:1.09-1.17,P<0.0001],respectively.However,no significant difference was found between tegoprazan(TPZ)triple therapy and PPI triple therapy in both RCTs and observational studies(RR=1.04,95%CI:0.93-1.16,P=0.5)and(RR=1.03,95%CI:0.97-1.10,P=0.3),respectively.CONCLUSION VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H.pylori,positioning it as a highly effective first-line regimen.Additionally,TPZ-based triple therapy was non-inferior to classical PPI triple therapy.

Countermeasures of“Post-Course Competition Certificate”Mode to Promote Innovation and Reform of BIM Course in Vocational Colleges

The model of“post-course competition certificate”can be the basic model of Building Information Modeling(BIM)course teaching in vocational colleges in the new era,and many vocational colleges have also made attempts to construct and apply this model in BIM courses and other professional courses.Based on the application of methods such as literature review and observation,it can be found that it is highly feasible in theory and practice to promote the innovation and reform of BIM curriculum based on this model.However,there are more influencing factors at the practical level,which can easily lead to some problems.In this paper,we will analyze the corresponding problems and put forward a more effective reform strategy of BIM course education innovation in combination with reality.

The Construction of Architectural CAD Course Competition Integration Teaching Mode

Architectural Computer-Aided Design(CAD)is a basic course for architectural engineering majors in vocational colleges.The integration of competition into teaching will not only help stimulate the students’enthusiasm,but also help them improve their professional skills.However,there are still some problems in the teaching of Architectural CAD.Therefore,teachers must continuously optimize the integration of competition content into Architectural CAD classes through various strategies,so as to give full play to the value of competition content in classes.We explored and analyzed the problems in the integration of competition content into Architectural CAD classes,and proposed specific strategies,in hopes of improving the quality of Architectural CAD teaching.