A total of 315 women who had Sino implant Ⅱ implantation and 302 healthy women were recruited and followed up for 3 years in order to observe the effect of Sino implant Ⅱ on myoma of uterus and ovarian cysts. The...A total of 315 women who had Sino implant Ⅱ implantation and 302 healthy women were recruited and followed up for 3 years in order to observe the effect of Sino implant Ⅱ on myoma of uterus and ovarian cysts. The blood pressure, body weight, vaginal ultrasonic examination and smear of cervix were measured once a year. The results show that Sino implant Ⅱ does not influence the blood pressure and body weight obviously. There are more ovarian cysts in Sino implant group than in the control group, but they are all found to disappear when reexamined after menstruation. These ovarian cysts may be follicular cysts. There are fewer myomas of uterus in Sino implant group than in the control group, and these myomas develop slowly. The results suggest that Sino implant is a safe contraceptive method.展开更多
A multicentre comparative clinical study of CLa implant and Sino-implant was carried out at 100 subcentres in 11 provinces, and α total of 19673 subjects were recruited. Two-year follow-up has been finished. The foll...A multicentre comparative clinical study of CLa implant and Sino-implant was carried out at 100 subcentres in 11 provinces, and α total of 19673 subjects were recruited. Two-year follow-up has been finished. The follow-up rate at the end of two years was 94.29%. Two-year cumulative continuation rate per 100 women for Sino-implant(89.93) was significantly higher than that for CLa implant (88.89). Two-year cumulative pregnancy rates per 100 women were 0.0462(CLa implant) and 0.281(Sino-implant) respectively, there was statistically significant difference between them. No ectopic pregnancy was recorded among CLa implant users and three ectopic pregnancies were reported among Sino-implant users,resulting in an ectopic pregnancy rate of 0.163 per 1000 women-years. The incidence of side effects appeared to diminish with time. The major side-effects were the menstrual disturbances, which accounted for more than 90% of the total sideeffects, and the incidence of frequent menstruation, irregular bleeding and spotting was higher than that of infrequent/scanty menstruation and amenorrhea. Use of CLa implant had higher incidence of amenorrhea and infrequent/scanty menstruation than that of Sino-implant. During two-year follow-up, the number of discontinuation due to menstrual problems contributed 78% of the total number of discontinuation; two year menstrual-related cumulative discontinuation rates were 8.96 per 100 women for CLa implant and 7.84 for Sino-implant, there wasAddress coryespoll(lol,c'c toe D]' Fang ac juan, Shanghai Institute of Planned Pal.cnthood Research, 2140 Xit, 'I'u BOilal. Shanghai. 200032, China. Tel/F..f 86--021 64171432 E ..ill SIPPRms. STN. sh. C Nstatistically significant difference(P< 0.01). Two year study shows that the two types of implant are similar to Norplant in the incidence of side-effects and contraceptive efficacy as well as two year continuation rates.展开更多
The effects of the domestically manufactured contraceptive, Sino implant containing LNG on various lipids, lipoproteins, apolipoproteins and the HDL 2 C levels were evaluated in 20 healthy reproductive aged volu...The effects of the domestically manufactured contraceptive, Sino implant containing LNG on various lipids, lipoproteins, apolipoproteins and the HDL 2 C levels were evaluated in 20 healthy reproductive aged volunteers, during cycles after implantation. Results show that the levels of lipids, lipoproteins and apolipoproteins were reduced to different degrees during the 12 treatment cycles. A significant decrease was observed in the serum levels of triglycerides (TG, P<0.05) and apolipoprotein AⅠ (apo AⅠ , P<0.05) during treatment cycles. However these values increased again at the end of the 12th cycle. High density lipoprotein 2 cholesterel (HDL 2) decreased significantly (P< 0.05), only during the 3rd and 12th cycle. These results indicate that Sino implants containing LNG exerts an influence on reducing the levels of TG, apo AⅠ and HDL 2, but those values could return gradually as the released drug dose decreased and then became unchanged. On the other hand, the mechanism of the low HDL 2 C level induced by Sino implant is different from that of low HDL 2 C level in patients with coronary heart disease. The conclusion is: there is no obvious side effect on lipid metabolism during treatment with the Sino implant.展开更多
基金Shanghai Science &Technology Commission and Shanghai Family Planning Commission
文摘A total of 315 women who had Sino implant Ⅱ implantation and 302 healthy women were recruited and followed up for 3 years in order to observe the effect of Sino implant Ⅱ on myoma of uterus and ovarian cysts. The blood pressure, body weight, vaginal ultrasonic examination and smear of cervix were measured once a year. The results show that Sino implant Ⅱ does not influence the blood pressure and body weight obviously. There are more ovarian cysts in Sino implant group than in the control group, but they are all found to disappear when reexamined after menstruation. These ovarian cysts may be follicular cysts. There are fewer myomas of uterus in Sino implant group than in the control group, and these myomas develop slowly. The results suggest that Sino implant is a safe contraceptive method.
文摘A multicentre comparative clinical study of CLa implant and Sino-implant was carried out at 100 subcentres in 11 provinces, and α total of 19673 subjects were recruited. Two-year follow-up has been finished. The follow-up rate at the end of two years was 94.29%. Two-year cumulative continuation rate per 100 women for Sino-implant(89.93) was significantly higher than that for CLa implant (88.89). Two-year cumulative pregnancy rates per 100 women were 0.0462(CLa implant) and 0.281(Sino-implant) respectively, there was statistically significant difference between them. No ectopic pregnancy was recorded among CLa implant users and three ectopic pregnancies were reported among Sino-implant users,resulting in an ectopic pregnancy rate of 0.163 per 1000 women-years. The incidence of side effects appeared to diminish with time. The major side-effects were the menstrual disturbances, which accounted for more than 90% of the total sideeffects, and the incidence of frequent menstruation, irregular bleeding and spotting was higher than that of infrequent/scanty menstruation and amenorrhea. Use of CLa implant had higher incidence of amenorrhea and infrequent/scanty menstruation than that of Sino-implant. During two-year follow-up, the number of discontinuation due to menstrual problems contributed 78% of the total number of discontinuation; two year menstrual-related cumulative discontinuation rates were 8.96 per 100 women for CLa implant and 7.84 for Sino-implant, there wasAddress coryespoll(lol,c'c toe D]' Fang ac juan, Shanghai Institute of Planned Pal.cnthood Research, 2140 Xit, 'I'u BOilal. Shanghai. 200032, China. Tel/F..f 86--021 64171432 E ..ill SIPPRms. STN. sh. C Nstatistically significant difference(P< 0.01). Two year study shows that the two types of implant are similar to Norplant in the incidence of side-effects and contraceptive efficacy as well as two year continuation rates.
文摘The effects of the domestically manufactured contraceptive, Sino implant containing LNG on various lipids, lipoproteins, apolipoproteins and the HDL 2 C levels were evaluated in 20 healthy reproductive aged volunteers, during cycles after implantation. Results show that the levels of lipids, lipoproteins and apolipoproteins were reduced to different degrees during the 12 treatment cycles. A significant decrease was observed in the serum levels of triglycerides (TG, P<0.05) and apolipoprotein AⅠ (apo AⅠ , P<0.05) during treatment cycles. However these values increased again at the end of the 12th cycle. High density lipoprotein 2 cholesterel (HDL 2) decreased significantly (P< 0.05), only during the 3rd and 12th cycle. These results indicate that Sino implants containing LNG exerts an influence on reducing the levels of TG, apo AⅠ and HDL 2, but those values could return gradually as the released drug dose decreased and then became unchanged. On the other hand, the mechanism of the low HDL 2 C level induced by Sino implant is different from that of low HDL 2 C level in patients with coronary heart disease. The conclusion is: there is no obvious side effect on lipid metabolism during treatment with the Sino implant.
