Comparing the effectiveness of pattern differentiation treatment and fixed formula treatment for perimenopausal syndrome with Chinese herbal medicine:A study protocol

Objective:To further understand and compare the effectiveness of pattern differentiation treatment and fixed prescription treatment in perimenopausal syndrome.Methods:The study will be conducted in the Hong Kong Federation of Trade Unions Workers'Medical Clinics,Hong Kong Baptist University Chinese Medicine Clinic cum Training and Research Centre(Hong Kong,China).One hundred Chinese women,aged 45-55 years,will be recruited.The participants will be randomized into 2 groups.The intervention group will be administered medication,based on pattern differentiation,by qualified traditional Chinese medicine(TCM)practitioners.After each evaluation,TCM practitioners will evaluate and revise the prescription,based on the participants'patterns.The control group will be given the standard formula,i.e.,the Erxian decoction,which contains 6 herbs.The treatment period and the follow-up period will be 8 weeks each.The primary assessment outcome measure will be the Kupperman Index,and the secondary outcome measure will be the Menopause-specific Quality of Life Questionnaire score.Conclusion:Pattern-differentiated treatment is the basic principle of TCM to understand and treat diseases.The study will show the pattern-differentiated treatment is effectiveness than the fixed prescription.

NDVI spatial pattern and its differentiation on the Mongolian Plateau

GIMMS NDVI database and geo-statistics were used to depict the spatial distribution and temporal stability of NDVI on the Mongolian Plateau.The results demonstrated that:(1) Regions of interest with high NDVI indices were distributed primarily in forested mountainous regions of the east and the north,areas with low NDVI indices were primarily distributed in the Gobi desert regions of the west and the southwest,and areas with moderate NDVI values were mainly distributed in a middle steppe strap from northwest to southeast.(2) The maximum NDVI values maintained for the past 22 years showed little variation.The average NDVI variance coefficient for the 22-year period was 15.2%.(3) NDVI distribution and vegetation cover showed spatial autocorrelations on a global scale.NDVI patterns from the vegetation cover also demonstrated anisotropy;a higher positive spatial correlation was indicated in a NW-SE direction,which suggested that vegetation cover in a NW-SE direction maintained increased integrity,and vegetation assemblage was mainly distributed in the same specific direction.(4) The NDVI spatial distribution was mainly controlled by structural factors,88.7% of the total spatial variation was influenced by structural and 11.3% by random factors.And the global autocorrelation distance was 1178 km,and the average vegetation patch length(NW-SE) to width(NE-SW) ratio was approximately 2.4:1.0.

Control of paleogeographic pattern on sedimentary differentiation of evaporite-carbonate symbiotic system:A case study of the sixth sub-member of Ordovician Majiagou Formation M5 Member in central-eastern Ordos Basin,NW China

The relationship between paleogeographic pattern and sedimentary differentiation of evaporite-carbonate symbiotic system is examined based on logging,core and thin section data,by taking the sixth sub-member of fifth member of Ordovician Majiagou Formation(M56)in the central-eastern Ordos Basin as an example.(1)Seven sub-geomorphic units(Taolimiao west low,Taolimiao underwater high,Taolimiao east low,Hengshan high,East salt low,North slope and Southwest slope)developed in the study area.(2)The“three lows”from west to east developed dolomitic restricted lagoon,evaporite evaporative lagoon and salt evaporative lagoon sedimentary facies respectively,the"two highs"developed high-energy grain beach and microbial mound,and the north and south slopes developed dolomitic flats around land.(3)The paleogeographic pattern caused natural differentiation of replenishment seawater from the northwest Qilian sea,leading to the eccentric sedimentary differentiation of dolomite,evaporite and salt rock symbiotic system from west to east,which is different from the classic“bull's eye”and“tear drop”distribution patterns.(4)As the Middle Qilian block subducted and collided into the North China Plate,the far-end compression stress transferred,giving rise to the alternate highland and lowland in near north to south direction during the sedimentary period of M56 sub-member.(5)Taolimiao underwater high and Hengshan high developed favorable zones of microbial mounds and grain shoals in south to north strike in M56 sub-member,making them favorable exploration areas with great exploration potential in the future.

Spatial differentiation pattern of interregional migration in ethnic minority areas of Yunnan Province, China

Interregional migration has broad and far-reaching impacts on regional urbanization process in ethnic minority areas of Southwest China.The previous literature of interregional migration paid less attention on the ethnic minority areas with fragile geographical feature and marginal socio-economic context in the developing world due to the dearth of reliable data.Based on the 2015 national 1%population sampling survey at the village/community scale,taking Yulong Naxi Autonomous County,Yunnan Province,China as the case study,this paper analyzed the spatial differentiation pattern.The results showed that:(1)migration in Yulong Naxi Autonomous County exhibited obvious spatial differentiation characteristics in terms of population aggregation,population loss,migration direction,and migration activity;(2)the overall spatial differentiation of migration exhibited a"layer+sector"pattern in Yulong Naxi Autonomous County:the first layer was active areas with net inflows(<20 km from the seat of the county government),the second layer was inactive areas(within 20–60 km of the seat of the county government),and the third layer was a mixed"layer+sector"zone(>60 km to the seat of the county government),comprised of inactive areas and active areas with net outflows;(3)the spatial differentiation pattern of migration was highly correlated with the regional contexts including the regional economic development,regional transportation accessibility and regional social development,while regional physical geographical factors had insignificant relationships with the migration pattern.

Patterns, processes, and differentiation mechanisms of China's transition from old to new economic drivers

Transition from old to new economic drivers(TONED) is of great significance for optimizing economic structures. Using a combination of methods including entropy weight technique for order preference by similarity to ideal solution, geospatial analysis, and optimal parameter geodetector, this study investigates the patterns and mechanisms of China's TONED in the prefecture-level cities from 2011 to 2020. The findings reveal that(1) the TONED exhibited a spatial distribution characterized by higher levels in the east and lower levels in the west, along with a pyramidal hierarchy of levels. The distribution of hot and cold spots roughly followed the Heihe-Yulin line.(2) The informatization levels, openness to the outside world, and urbanization played a dominant role in the TONED. The types of dual-factor interactions exhibited both dual-factor enhancement and non-linear enhancement effects.(3) The eastern and central regions were more likely to promote the TONED through enhanced informatization levels, whereas the western region relied more on increasing openness. This study finds that the TONED results from the combined effects of three geographical natures, each playing a distinct role. The recommendations provided can serve as a reference for China and other developing countries to implement the TONED in the context of deglobalization.

Compressed ghost imaging based on differential speckle patterns

We propose a compressed ghost imaging scheme based on differential speckle patterns,named CGI-DSP.In the scheme,a series of bucket detector signals are acquired when a series of random speckle patterns are employed to illuminate an unknown object.Then the differential speckle patterns(differential bucket detector signals)are obtained by taking the difference between present random speckle patterns(present bucket detector signals)and previous random speckle patterns(previous bucket detector signals).Finally,the image of object can be obtained directly by performing the compressed sensing algorithm on the differential speckle patterns and differential bucket detector signals.The experimental and simulated results reveal that CGI-DSP can improve the imaging quality and reduce the number of measurements comparing with the traditional compressed ghost imaging schemes because our scheme can remove the environmental illuminations efficiently.

Characteristics of Regional Differentiation of Urbanization Development in Anhui Province

On the basis of connotation of urbanization,by using SPSS factor analysis and cluster analysis,we establish index system of urbanization development level and conduct quantitative analysis on development level of urbanization in 17 prefecture-level city of Anhui Province,in order to find out the differentiation pattern of regional space of urbanization development in Anhui Province based on these.The results show that Anhui's difference of urbanization gradient is prominent.Classification of three clusters shows that the pattern of status quo of urbanization development in Anhui Province is "dual-nucleus" and "two-stretches";classification of five clusters show that the pattern of status quo of urbanization development in Anhui Province is "one-core","one-strip" and "three-region".From five aspects,namely natural geography,transportation location,resources distribution,economic development and administrative system,we analyze the reason and influencing factors of differentiation of urbanization development in the region.The results of three clusters and five clusters show that there is great possibility that "dual-nucleus" changes into "individual-nucleus";"one-core" and "one-strip" may evolve into "one-group".We should foster the urban agglomeration in central Anhui;perfect structure system in the perspective of integration and fostering;strengthen infrastructure construction and regional coordination system;elevate comprehensive competitiveness and guide holistic development of regional economy;promote industrialization process and promote development level of urbanization.

Spatial-temporal Differentiation of Sauna Days with Different Intensities in China from 1961 to 2017

Sauna weather with high temperature, high humidity and long standby time has become one of the main meteorological hazards faced by urban residents. Based on the daily maximum temperature and relative humidity datasets of 545 meteorological observation stations in China from 1961 to 2017, the spatial-temporal evolution characteristics of sauna days with different intensities in China were studied from three aspects: climatic state, trend and fluctuation characteristics, using the standard of sauna days defined by the Central Meteorological Observatory of China Meteorological Administration. The results showed that: firstly, the spatial pattern of sauna days with different intensities in China was high in southeast China and low in northwest China from 1961 to 2017, and the spatial pattern of sauna days with the same intensity in different research periods had little difference, which was in good agreement with the spatial pattern of sauna days with corresponding intensities in the whole research period. With the increase of intensity, the sauna days in China decreases gradually. Secondly, the trend of sauna days with different intensities in China was bounded by Hu Huanyong Line from 1961 to 2017, showing a pattern of increasing or decreasing mosaic in the southeast China and mainly decreasing trend, while the spatial differentiation pattern in the northwest China changed little. The trend of sauna days with different intensities in China increased significantly in 1991-2017 compared with 1961-1990. Thirdly, the fluctuation of sauna days with different intensities in China was bounded by Hu Huanyong Line, showing a spatial pattern of large fluctuations in the southeast China and small fluctuations in the northwest China. And the fluctuation of sauna days and heavy sauna days showed obvious threeblock distribution characteristics. The fluctuation characteristics of sauna days with different intensities in China from 1961 to 1990 and 1991 to 2017 were in good agreement with the whole research period. The fluctuation difference before and after 1990 mainly concentrated in the vicinity of Hu Huanyong Line and its southeast area, and the fluctuation differences increased mainly, indicating that the variation of sauna days with different intensities in the southeast China increased from 1991 to 2017.

A Research Review of the ＂Differential Pattern＂ Theory and Its Contemporary Value

The ＂differential pattern＂ is an important thesis raised by Fei Xiaotong in his early sociology theory and possesses unique theoretical intension and practical value. From different dimensions, the study of the ＂differential pattern＂ theory and its contemporary value has been one of the hot issues in domestic sociology. With these studies, the contents of the ＂differential pattern＂ theory are enriched, and also its value boundary and contemporary significance are revealed.

“差序格局”特征社会网络对养老服务消费行为的影响

基于实地调研数据可知,“差序格局”特征社会网络对老年人养老服务消费行为的影响结果主要有:在自我与家庭层面,收入水平和子女态度是影响老年人养老服务消费意愿转化的核心因素。在社会网络层面,以广场舞、太极拳等集体性文化娱乐活动为代表的弱关系社会参与活动对养老服务消费意愿与行为的积极影响比以亲友关系为代表的强关系社会参与更明显,强关系在涉及日常生活安排和状态改变的养老服务消费决策中发挥重要作用。异质性分析表明:女性、高受教育程度、城市地区人群的养老服务消费意愿转化能力更强;自我层面与社会网络层面对养老服务消费行为的影响呈现出显著的城乡差异。据此,我国在实践中可通过挖掘弱关系社交核心节点带动作用、制定差异化的需求管理策略,带动潜在客群的消费行为。

资源下乡背景下乡村关系的差序格局及其形塑逻辑

以“一乡−多村”为乡村关系的两个主体,突破过去将乡村关系中的“村”视为一个抽象整体的研究进路,提出“乡村关系的差序格局”。在“行政消解自治”乡村一体化的背景下,乡镇与其下辖的各行政村的关系存在“亲疏远近”之别。形塑这种亲疏远近的要素主要有三个:一是特定行政村在中央或地方涉农政策中的重要性。政策性位置越突出,其与乡镇的关系越亲近。二是特定行政村村治情况良善与否。村干部治村能力越强,其与乡镇的关系越亲近。三是特定行政村在体制内有无先赋性外联关系。这种外联关系越重要,其与乡镇的关系越亲近。自上而下的各类资源在各行政村之间的配置,相应由乡村关系的差序格局来形塑。

基于“玄府气液”理论治疗慢性难愈性溃疡

慢性难愈性溃疡是“虚”“瘀”两种致病因素相互交织、相互作用的结果,“虚”“瘀”贯穿疾病发展的始终。而“玄府开阖失司,气液代谢失调”是本病迁延难治的病机关键。刘丽芳教授综合运用煨脓生肌、阳和通玄、托里消毒诸法开玄府、调气液,令玄府开阖有司,气液代谢调和,临床疗效满意,附验案一则加以阐明。

上海数字文化产业空间集聚特征及空间分异格局研究

基于上海数字文化产业兴趣点(POI)数据,运用ArcGIS软件,结合核密度分析、空间自相关分析、标准差椭圆分析等方法,分析上海数字文化产业空间集聚特征与空间分异格局,探讨上海数字文化产业空间分异的影响因素及其交互机制。研究发现:(1)上海数字文化产业总体集聚水平较高,区域集聚程度差异化明显;(2)上海数字文化产业在空间上呈非随机性分布,具有明显的空间自相关性,由南向北呈现出阶梯式分异格局;(3)上海数字文化产业门类集聚程度存在差异,其中应用软件开发类集聚程度最高,创意内容制造服务类类集聚程度最低。

金玫应用木土同调法治疗胸痹心痛经验

金玫教授认为胸痹心痛病常与肝胆、脾胃功能失衡相关,肝胆在五行中属木,脾胃属土,其提出胸痹心痛病木土同调的中医辨证论治方法,肝气乘脾,心气不足证,治以培土泄木,补益心气;肝胃有热,心阴不足证,治以清肝和胃,滋阴清心;脾胃湿热,胆火扰心证,治以清热利胆,健脾燥湿;脾虚肝郁,气虚血瘀证,治以实土御木,益气活血;肝胃气滞,瘀血内停证,治以疏肝理气,活血化瘀;心肝血虚,脾气不足证,治以养肝健脾,补血活血;心虚胆怯,脾阳不足证,治以安神定志,温补脾阳。

猪流行性腹泻病毒变异毒株一步法RT-PCR鉴别检测方法的建立及临床应用

为了建立一种快速鉴别检测猪流行性腹泻病毒(PEDV)变异毒株的病原学方法和掌握洛阳市PEDV变异毒株的流行规律,试验根据GenBank中PEDV变异毒株的特异性序列设计引物,通过优化退火温度、模板添加量、引物添加量建立PEDV变异毒株一步法RT-PCR鉴别检测方法,并分析了该方法的特异性、敏感性和重复性;同时应用该方法检测采集自洛阳市的251份临床样品,并对不同地区、不同年份、不同养殖模式的检测结果进行比较分析。结果表明:优化后的退火温度为51℃,模板添加量为5μL,引物添加量为0.5μL;该方法对PEDV变异毒株能够扩增出550 bp特异性条带,而检测的PEDV经典毒株、猪传染性胃肠炎病毒(TGEV)、猪轮状病毒(RV)、猪繁殖与呼吸综合征病毒(PRRSV)、猪瘟病毒(CSFV)、猪细小病毒(PPV)、猪伪狂犬病病毒(PRV)、猪圆环病毒2型(PCV-2)均为阴性;对PEDV变异毒株RNA的最低检测限达到0.74 ng,对3份PEDV变异毒株阳性病料和3份PEDV变异毒株阴性病料重复检测3次的结果完全一致;检测采集于洛阳市251份临床样品的平均阳性率为29.48%,其中不同地区阳性率介于13.33%~44.44%之间,2018—2022年阳性率介于28.30%~31.58%之间,散养户和规模化猪场的阳性率分别为38.24%和19.13%。说明试验建立的PEDV变异毒株一步法RT-PCR鉴别检测方法特异、敏感、稳定、准确,洛阳市PEDV变异毒株的流行特点为个别地区较严重的情况、近几年流行率基本持平、散养户流行情况较规模化猪场严重。

安徽省村庄开发强度与景观格局的空间分异及耦合关系研究

综合应用村庄开发强度、景观格局指数和双变量空间自相关模型等方法,分析安徽省村庄开发强度与景观格局的空间分布特点、空间耦合关系及影响因素。结果显示:安徽省村庄开发强度呈现皖北>皖中皖南,村庄景观格局破碎度呈现皖中>皖北>皖南,村庄开发强度与景观格局的空间分布存在明显区域差异,二者空间耦合关系上,皖北没有明显主导类型,皖中以低-高和低-低聚类为主,皖南以低-高聚类为主;村庄开发强度与景观格局的空间分异受自然地理、人类活动和土地利用政策的多重因素影响。最后,根据研究结果提出针对性的对策建议,可为村庄国土空间开发保护、村庄规划编制提供理论方法参考和实践应用借鉴。

四川天府新区BGI复合功能空间分异特征及其景观格局驱动机制研究

蓝绿基础设施(Blue-Green Infrastructure, BGI)是实现适应气候变化战略目标的重要工具.研究BGI景观格局和功能的空间关系,旨在为城市气候适应性建设提供依据.以四川天府新区(含协调管控区)为例,基于遥感影像数据,从气候适应性视角出发,进行BGI复合功能评价和空间分异特征分析,并运用地理探测器进一步揭示景观格局主要驱动因子及驱动机制.结果表明:(1)复合功能等级整体呈现从龙泉山脉向东西两侧递减趋势,高服务功能集中分布在龙泉山脉、彭祖山景区和三岔湖景区东南方向的协调管控区域.(2)复合功能等级空间分布格局整体呈显著空间正向自相关关系,具有显著高高(HH)、低低(LL)、高低(HL)聚集特征.(3)景观组成类型、网络结构要素类型、斑块密度指数(PD)和面积加权平均形状指数(AWMSI)是复合功能空间分异的主要驱动因子;景观组成类型、网络结构要素类型是复合功能空间分异的主要交互驱动因子.研究探明了景观格局对BGI复合功能空间分异的驱动机制,可用于指导研究区城市气候适应性建设.

济阳坳陷孤西潜山带构造演化及其对油气差异富集的控制

为明确济阳坳陷孤西潜山带油气差异富集特征,指导下步油气勘探方向优选,综合利用钻井及地震资料,在潜山地质特征分析的基础上,对潜山构造演化及其对油气差异富集的控制作用进行了研究。结果表明,印支期以来,孤西潜山带经历了晚三叠世挤压抬升剥蚀、早—中侏罗世弱挤压到截凸填凹、晚侏罗世挤压抬升剥蚀、早白垩世左行走滑拉张、晚白垩世挤压抬升剥蚀、古近纪右行走滑拉张高位潜山剥蚀等4期挤压、2期拉张、2期走滑、5期剥蚀的演化过程,并于新近纪整体沉降定型,在孤西潜山带形成高位潜山和低位潜山2类潜山,整体具有“NW向断层控带、NE(EW)向断层控山、垒堑相间”的构造格局。多期构造活动作用的叠加,导致2类潜山在源储对接关系、油藏类型和油气富集特征上具有明显差异,高位潜山斜坡带上古生界和中生界地层油藏最为富集,低位潜山各层系均可成藏,且以古生界构造油藏最为富集,同种类型的潜山由于成藏要素配置关系的不同,其油气富集特征也有所差异。埕中、埕东、孤岛等高位潜山斜坡带地层油藏,孤北、垦利等低位潜山下古生界风化壳油藏及内幕构造油藏和上古生界及中生界构造油藏是下步重点勘探目标。

唐文富教授经方治疗慢性胰腺炎临证经验举隅

反复发作、难以缓解的上腹疼痛是慢性胰腺炎的主要症状,尤其合并胰管结石、胰腺假性囊肿时,西医常规止痛治疗效果不佳,是消化系统疾病的治疗难题之一。唐文富教授剖析本病病机,结合伤寒六经辨证,以简驭繁,将慢性胰腺炎急性发作期、恢复期分型辨证论治,以期解决慢性胰腺炎难治性疼痛、脓肿、多发假性囊肿等难题。现总结唐文富教授的临证经验,旨在为慢性胰腺炎的中医诊治提供新的思路。

司法正义的区差规律——基于量刑地区差异的Blinder-Oaxaca分解

司法正义是一个兼具普遍正义和差序正义的复合体。司法正义的普遍性源自法治统一原则的内在规定性,而司法正义的差序性则属于区域发展差序结构之产物。以刑事司法为例,基于量刑地区差异的Blinder-Oaxaca分解,可以客观地呈现司法正义的区差规律:法定因素是导致量刑地区差异的主要原因,罪行严重程度越高的地区,其量刑结果越重;非法定因素即法官的自由裁量对量刑地区差异的影响是有限的;社会经济发展水平深刻影响法官的个案认知,社会经济发展水平越高的地区,法官对相同犯罪数额危害程度的认定越宽松。为此,有必要建立裁判辅助系统,根据地区经济指标对犯罪数额进行折算,引入量刑地区差异的监测模型,并且强化裁判文书的撰写规范,以确保将正义区差控制在合理的范围内。